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Noninvasive Glucose Monitoring of the Aqueous Humor of the Eye: Part I. Measurement of Very Small Optical Rotations
Abstract
We have described the concept of using the aqueous humor glucose as a measure of the blood glucose concentration, with a view to developing a noninvasive glucose monitor for diabetic individuals. We have conceived of a scleral lens that houses a light source, polarizers, other electro-optic units, and a light detector, and which measures the optical rotation of the aqueous humor continuously. We have built an optical bench mock-up of the glucose sensor and assessed the limits of its capabilities. We have described a physical method, employing the Faraday effect, that modulates the incident light and uses a compensator to introduce a feedback mechanism giving a null-point technique capable of measuring extremely small rotations with an accuracy of 0.4 s of arc. We have used this and have measured the optical rotations of glucose solutions from 0.02 to 0.1%, and have demonstrated linearity in both cases. Miniaturization of the technique is discussed.
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Citations
Cited by
Glucose Biosensors: An Overview of Use in Clinical Practice
Yoo, E.-H., & Lee, S.-Y. (2010) · Sensors · doi:10.3390/s100504558 · Cited by 1,137
Noninvasive Blood Glucose Monitoring With Optical Coherence Tomography
Larin, K. V., Eledrisi, M. S., Motamedi, M., & Esenaliev, R. O. (2002) · Diabetes Care · doi:10.2337/diacare.25.12.2263 · Cited by 293
Technologies for Continuous Glucose Monitoring: Current Problems and Future Promises
Vaddiraju, S., Burgess, D. J., Tomazos, I., Jain, F. C., & Papadimitrakopoulos, F. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400632 · Cited by 285
Tura, A., Maran, A., & Pacini, G. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.10.027 · Cited by 283
A flexible and wearable glucose sensor based on functional polymers with Soft-MEMS techniques
Kudo, H., Sawada, T., Kazawa, E., Yoshida, H., Iwasaki, Y., & Mitsubayashi, K. (2006) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2006.05.006 · Cited by 255
Metadata
- Authors
- Rabinovitch, B., March, W. F., & Adams, R. L.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1982-05-01
- Volume
- 5
- Issue
- 3
- Pages
- 254-258
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2059081738
- Cited by
- 179
- References
- 0
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Noninvasive Glucose Monitoring of the Aqueous Humor of the Eye: Part I. Measurement of Very Small Optical Rotations. https://app.cochat.ai/papers/10.2337/diacare.5.3.254
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- Rabinovitch, B., March, W. F., & Adams, R. L. (1982). Noninvasive Glucose Monitoring of the Aqueous Humor of the Eye: Part I. Measurement of Very Small Optical Rotations. Diabetes Care. https://doi.org/10.2337/diacare.5.3.254
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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