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Cited by 71Dermatology and Skin DiseasesTrace Elements in HealthContact Dermatitis and Allergies

Hair zinc levels and the efficacy of oral zinc supplementation in patients with atopic dermatitis

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Kim, J, Yoo, S, Jeong, M, Ko, J, Ro, Y·2014·Acta Dermato Venereologica
DOI 10.2340/00015555-1772
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Abstract

Zinc deficiency in patients with atopic dermatitis (AD) and the use of zinc supplementation is still controversial. We measured hair zinc levels in 58 children with AD and 43 controls (age range 2-14 years). We also investigated the efficacy of oral zinc supplementation in AD patients with low hair zinc levels by comparing eczema assessment severity index (EASI), transepidermal water loss (TEWL), and visual analogue scales for pruritus and sleep disturbance in patients receiving zinc supplementation (Group A) and others not receiving supplementation (Group B). At baseline, the mean zinc level was significantly reduced in AD patients (113.1 μg/g vs. 130.9 μg/g, p = 0.012). After 8 weeks of supplement, hair zinc level increased significantly in Group A (p < 0.001), and EASI scores, TEWL, and visual analogue scales for pruritus improved more in Group A than in Group B (p = 0.044, 0.015 and < 0.001, respectively). Thus, oral zinc supplementation may be effective in AD patients with low hair zinc levels.

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Authors
Kim, J., Yoo, S., Jeong, M., Ko, J., & Ro, Y.
Affiliations
Hanyang University Seoul Hospital (KR)
ORCID
Ro, Y
Venue
Acta Dermato Venereologica
Publisher
MJS Publishing, Medical Journals Sweden AB
Published
2014
Volume
94
Issue
5
Pages
558-562
ISSN
0001-5555 (ISSN-L)
DOI
10.2340/00015555-1772
OpenAlex
W2096493634
Cited by
71
References
36
Citations by year
2026: 5 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 9 · 2019: 11 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 1
FWCI
5.13
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Acta Dermato Venereologica (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords
atopic dermatitis, zinc deficiency, oral zinc supplementation, children, pruritus, transepidermal water loss, Eczema Area and Severity Index, sleep disorders
MeSH terms
Administration, Oral, Adolescent, Child, Child, Preschool, Dermatitis, Atopic, Female, Hair, Humans, Sleep Initiation and Maintenance Disorders, Male, Pruritus, Severity of Illness Index, Trace Elements, Water Loss, Insensible, Zinc, Visual Analog Scale

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