Efficacy of milbemycin oxime against naturally acquired or experimentally induced Ancylostoma spp and Trichuris vulpis infections in dogs
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Summary: The efficacy of milbemycin oxime was evaluated at dosages of 0.25, 0.50 and 0.75 mg/kg of body weight in dogs naturally infected with mature Ancylostoma spp, at a dosage of 0.50 mg/kg in dogs with experimentally induced immature and mature A caninum, and at dosages of 0.55 to 0.86 mg/kg in dogs naturally infected with mature Trichuris vulpis. Milbemycin oxime was 95 and 99% effective against mature Ancylostoma spp at dosages of 0.50 and 0.75 mg/kg, respectively, but only 49% effective at a dosage of 0.25 mg/kg. Efficacy was 49% against pulmonary L 3-L 4 stages of A caninum (36 hours after inoculation), > 80% against L 4 (120 hours after inoculation) and early L 5 stages (216 hours after inoculation), and > 90% against experimentally induced mature stages (360 hours after inoculation). Milbemycin oxime was also 97% effective in the removal of mature Tr vulpis from naturally infected dogs. Adverse reactions were not observed following treatment in any of the dogs.
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The efficacy of milbemycin oxime in the removal of whipworms from naturally infected dogs has been shown to be ~96-99%.
“The efficacy of milbemycin oxime in the removal of whipworms from naturally infected dogs has shown to be ~96-99% [73,74].”
From Are we paying too much attention to cardio-pulmonary nematodes and neglecting old-fashioned worms like Trichuris vulpis? (2011) · cites this paper as [73]
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MILBEMYCIN: A FAMILY OF MACROLIDE ANTIBIOTICS WITH INSECTICIDAL ACTIVITY
Mishima, H. (1983) · Elsevier eBooks · doi:10.1016/b978-0-08-029223-6.50025-2 · Cited by 13 · see citing works
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Pet roundworms and hookworms: A continuing need for global worming
Traversa, D. (2012) · Parasites & Vectors · doi:10.1186/1756-3305-5-91 · Cited by 221 · see citing works
Traversa, D. (2011) · Parasites & Vectors · doi:10.1186/1756-3305-4-32 · Cited by 148 · see citing works
- Authors
- Blagburn, B. L., Hendrix, C. M., Lindsay, D. S., Vaughan, J. L., Hepler, D. I., & Wright, J. C.
- Affiliations
- Auburn University (US)
- From the Department of Pathobiology (Blagburn, Hendrix, Lindsay, Vaughan, Wright), College of Veterinary Medicine, Auburn University, AL 36849-5519; and the Animal Health Division, CIBA-GEIGY Corp, Greensboro, NC 27419 (Hepler).
- Venue
- American Journal of Veterinary Research
- Published
- 1992-04-01
- Volume
- 53
- Issue
- 4
- Pages
- 513-516
- ISSN
- 0002-9645 (ISSN-L)
- OpenAlex
- W4391198686
- Cited by
- 18
- References
- 1
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 3 · 2016: 1 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Veterinary Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- milbemycin oxime, Ancylostoma caninum, Ancylostoma, Trichuris vulpis, canine hookworm infection, anthelmintic efficacy, dose comparison, adverse drug reactions, dogs
- MeSH terms
- Ancylostomiasis, Animals, Anthelmintics, Anti-Bacterial Agents, Dog Diseases, Dogs, Feces, Female, Intestinal Diseases, Parasitic, Male, Parasite Egg Count, Trichuriasis, Macrolides
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