Cited by 135Herpesvirus Infections and TreatmentsAnimal Virus Infections StudiesVeterinary Equine Medical Research

Risk factors for development of neurologic disease after experimental exposure to equine herpesvirus-1 in horses.

Allen, George P.·2008·American Journal of Veterinary Research

Abstract

OBJECTIVE: To identify risk factors associated with development of clinical neurologic signs in horses exposed to equine herpesvirus-1 (EHV-1). ANIMALS: 36 adult horses. PROCEDURES: Blood samples collected before and after challenge inoculation with nonneuropathogenic or neuropathogenic EHV-1 were analyzed for leukocyte-associated viremia, serum neutralizing antibody, and EHV-1-specific cytotoxic T-lymphocyte precursors (CTLPs). Associations between variables and neurologic disease and correlations between age category or breed and development of neurologic disease were examined. RESULTS: 9 horses developed CNS signs (ataxia, hind limb paresis or paralysis, bladder atony, or recumbency). Neurologic deficits were correlated with infection by a neuropathogenic strain of EHV-1, age>20 years, high postexposure viremic load, and low preexposure concentration of CTLPs. No significant correlations were observed between preinfection titers or horse breed and postinfection development of neurologic signs. CONCLUSIONS AND CLINICAL RELEVANCE: Horses with high concentrations of preexisting CTLPs, regardless of age, strain of virus, or titer, were more likely to control the magnitude of postinfection leukocyte-associated viremia and subsequent development of neurologic disease; therefore, CTLPs appear to be a critical requirement for protective immunity against EHV-1-induced myeloencephalopathy. The importance of achieving immunity related to high concentrations of vaccine-induced CTLPs in horses at high risk for exposure to neuropathogenic strains of EHV-1 is indicated.

Integrity signals

Registry

Crossref · 10.2460/ajvr.69.12.1595

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Several risk factors, including older age, Standardbred breed, female gender, late autumn/winter/spring season, and neurovirulent EHV-1 strain, have been associated with an increased risk to develop equine herpes myeloencephalopathy.

    “Several risks factors, including the age (elder), breed (Standardbred), gender (female), season (late autumn, winter, spring), and type of EHV-1 strain (neurovirulent) have been associated with an increased risk to develop EHM (Goehring et al., 2006; Henninger et al., 2007; Allen, 2008; Perkins et al., 2009; Pusterla et al., 2016).”

Cites

Flagged first, then by citations

2 of the 25 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Allen, G. P.
Affiliations
University of Kentucky (US)
Corresponding author
Allen, George P.
Venue
American Journal of Veterinary Research
Published
2008-12
Volume
69
Issue
12
Pages
1595-1600
ISSN
0002-9645 (ISSN-L)
OpenAlex
W2077063970
Cited by
135
References
25
Citations by year
2026: 4 · 2025: 8 · 2024: 5 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 8 · 2019: 11 · 2018: 6 · 2017: 6 · 2016: 2 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 10
FWCI
4.45
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Veterinary Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
  • Health Sciences › Veterinary › Equine › Veterinary Equine Medical Research
Keywords
equine herpesvirus 1, horses, risk factors, cytotoxic T lymphocyte precursors, myeloencephalopathy, age, vaccine-induced immunity, neutralizing antibodies, challenge inoculation
MeSH terms
Aging, Animals, Herpesvirus 1, Equid, Female, Horse Diseases, Horses, Nervous System Diseases, Risk Factors, T-Lymphocytes, Cytotoxic, Viremia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review