The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Toxicity of lead: a review with recent updates
Open accessAbstract
Lead poisoning has been recognized as a major public health risk, particularly in developing countries. Though various occupational and public health measures have been undertaken in order to control lead exposure, cases of lead poisoning are still reported. Exposure to lead produces various deleterious effects on the hematopoietic, renal, reproductive and central nervous system, mainly through increased oxidative stress. These alterations play a prominent role in disease manifestations. Modulation of cellular thiols for protection against reactive oxygen species (ROS) has been used as a therapeutic strategy against lead poisoning. N-acetylcysteine, α-lipoic acid, vitamin E, quercetin and a few herbal extracts show prophylaxis against the majority of lead mediated injury in both invitro and in vivo studies. This review provides a comprehensive account of recent updates describing health effects of lead exposure, relevant biomarkers and mechanisms involved in lead toxicity. It also updates the readers about recent advances in chelation therapy and newer therapeutic strategies, like nanoencapsulation, to treat lead induced toxic manifestations.
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Cites
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543 · cited 1×
“These approaches include improved formulations for better delivery such as liposomes, micelles, phospholipid complexes and nanoparticles (Anand et al., 2007).”
BackgroundDugas, A. J., Castañeda-Acosta, J., Bonin, G. C., Price, K. L., Fischer, N. H., & Winston, G. W. (2000) · Journal of Natural Products · doi:10.1021/np990352n · Cited by 319
Cited by
Wani, A. L., Ara, A., & Usmani, J. A. (2015) · Interdisciplinary Toxicology · doi:10.1515/intox-2015-0009 · Cited by 1,964
Trace Elements in Human Nutrition (II)—An Update
Mehri, A. (2020) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_48_19 · Cited by 395
Clinical and molecular aspects of lead toxicity: An update
Mitra, P., Sharma, S., Purohit, P., & Sharma, P. (2017) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2017.1408562 · Cited by 389
A review with recent advancements on bioremediation-based abolition of heavy metals
Gaur, N., Flora, G., Yadav, M., & Tiwari, A. (2014) · Environ. Sci.: Processes Impacts · doi:10.1039/c3em00491k · Cited by 273
Self-citationA Review of Metal Exposure and Its Effects on Bone Health
Rodríguez, J., & Mandalunis, P. M. (2018) · Journal of Toxicology · doi:10.1155/2018/4854152 · Cited by 248
Metadata
- Authors
- Flora, G., Gupta, D., & Tiwari, A.
- Venue
- Interdisciplinary Toxicology
- Publisher
- Walter de Gruyter GmbH
- Published
- 2012-11-09
- Volume
- 5
- Issue
- 2
- Pages
- 47-58
- ISSN
- 1337-6853 (ISSN-L)
- 1337-9569
- OpenAlex
- W2151699770
- Cited by
- 2,144
- References
- 2
- FWCI
- 30.01
- Type
- journal article
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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