Metal ion transport and regulation in mycobacterium tuberculosis

Agranoff, Daniel

doi:10.2741/1454

Cited by 68Tuberculosis Research and EpidemiologyBacterial Genetics and BiotechnologyIron Metabolism and Disorders

Metal ion transport and regulation in mycobacterium tuberculosis

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Agranoff, Daniel·2004·Frontiers in Bioscience

DOI 10.2741/1454

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Abstract

The regulation of metal ion concentrations is central to the physiology of the interaction between pathogenic bacteria and their hosts. Apart from the NRAMP orthologue, MntH, metal ion transporters in Mycobacterium tuberculosis have not been studied. Mn, the physiological substrate of MntH in other bacteria, may play an important role as a structural and redox-active cofactor in a wide range of metabolic processes. Fe, Cu and Zn play structural and catalytic roles in metalloenzymes involved in oxidative stress responses. Fe and Mg are required for growth in macrophages. Genomic analyses reveal 28 sequences encoding a broad repertoire of putative metal ion transporters (or transporter subunits), representing 24% of all transporters in this organism. These comprise 8 families of secondary active transporters and 3 families of primary active transporters, including 12,P, type ATPases. Potential metal ion specificities include K+, Na+, Cu2+, Cd2+, Zn2+, Mn2+, Mg2+, Ca2+, Co2+, Ni2+, Fe2+/3+, Hg2+, AsO2- and AsO4(2-). 17 of these transporters are also encoded as complete open reading frames in Mycobacterium leprae, suggesting a role in intracellular survival. Iron transcriptionally regulates a diverse set of genes via the iron-dependent DNA-binding proteins, Fur and IdeR. Changes in Fe and Mg concentrations signal entry into the intracellular compartment and potentially trigger up-regulation of virulence determinants. The plethora of putative transport systems encoded by the M. tuberculosis genome contrasts strikingly with the paucity of experimental data on these systems. The detailed analysis of the temporal pattern of M. tuberculosis transporter gene expression during infection will provide important insights into the basic biology of intracellular parasitism and may help to shape novel therapeutic strategies.

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Identification of two genes annotated as fecB and fecB2 coding proteins similar to E. coli FecB suggests M. tuberculosis may also utilize ferric dicitrate as an Fe source.
“The identification of two genes that are annotated as fecB and fecB2 and that code proteins similar to FecB of Escherichia coli suggests that M. tuberculosis may also utilize ferric dicitrate as an Fe source [61].”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [61]

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Authors: Agranoff, D.
Affiliations: St George's Hospital (GB)
Corresponding author: Agranoff, Daniel
ORCID: Agranoff, Daniel
Venue: Frontiers in Bioscience
Publisher: IMR Press
Published: 2004
Volume: 9
Issue: 1-3
Pages: 2996
ISSN: 1093-4715 (ISSN-L)
1093-9946
DOI: 10.2741/1454
OpenAlex: W1999294120
Cited by: 68
References: 77
Citations by year: 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 6
FWCI: 0.31
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Frontiers in bioscience (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (063634)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: Mycobacterium tuberculosis, metal ion transport, metal homeostasis, MntH, NRAMP, iron regulation, Fur protein, IdeR, copper transport, zinc transport, magnesium transport, manganese transport, arsenic transport, cadmium transport, mercury transport, secondary active transporters, Mycobacterium leprae, intracellular survival, virulence gene expression, macrophage infection, host-pathogen interaction
MeSH terms: Natural Resistance-associated Macrophage Protein 1, Adenosine Triphosphatases, Bacterial Proteins, Biological Transport, Ions, Iron, Magnesium, Metals, Mycobacterium tuberculosis, Virulence, Signal Transduction, Up-Regulation, Gene Expression Regulation, Bacterial, Genome, Ion Transport, Oxidative Stress, Cation Transport Proteins, Iron-Binding Proteins

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Metal ion transport and regulation in mycobacterium tuberculosis

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