Differential iron transport into phagosomes isolated from the RAW264.7 macrophage cell lines transfected with Nramp1Gly169 or Nramp1Asp169
Abstract
The transport of iron by RAW264.7 macrophage cell lines transfected with either Nramp1Gly169 (resistant) or Nramp1Asp169 (susceptible) alleles was assessed. We found no difference between resistant and susceptible cells in the rate of Fe import or export when Fe transport was measured in intact cells. In contrast, the rate of Fe import by latex-bead phagosomes isolated from resistant cells was more than double the rate by latex-bead phagosomes from susceptible cells. Similarly, phagosomes isolated from resistant cells that had been pre-labeled with 55Fe-citrate before phagocytosis contained up to four times as much Fe as the corresponding phagosomes from susceptible cells. Phagocytosis of Mycobacterium avium was accompanied by an increase in the production of hydroxyl radicals by Nramp1Gly169-transfected macrophages but not by macrophages transfected with the susceptible allele. These results are consistent with the hypothesis that Nramp1 functions to transport Fe into the bacterium-containing phagosome where it serves as a catalyst for the Haber-Weiss reaction, which accounts for the increased capacity of these cells to limit mycobacterial growth. J. Leukoc. Biol. 66: 113–119; 1999.
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Some data suggest that Nramp1 pumps iron into the phagolysosome where it may boost ROS generation.
“However, some data suggest that Nramp1 in fact pumps iron into the phagolysosome where it may boost ROS generation [121, 122].”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [121]
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- Authors
- Kuhn, D. E., Baker, B. D., Lafuse, W. P., & Zwilling, B. S.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Zwilling, Bruce S
- ORCID
- Lafuse, William P
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-07-01
- Volume
- 66
- Issue
- 1
- Pages
- 113-119
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2465826357
- Cited by
- 113
- References
- 24
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl059795-05, 5r01mh054966-04, 5r01ai042901-13)
- National Heart, Lung, and Blood Institute (HL-59795)
- National Institute of Mental Health (MH 54966)
- National Institute of Allergy and Infectious Diseases (AI-42901)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- NRAMP1, ferroportin, iron transport, phagosome, macrophages, RAW 264.7 macrophages, Mycobacterium avium, phagocytosis, hydroxyl radicals, Haber-Weiss reaction, iron imports, iron export
- MeSH terms
- Natural Resistance-associated Macrophage Protein 1, Animals, Aspartic Acid, Biological Transport, Carrier Proteins, Cations, Cell Line, Glycine, Iron, Macrophages, Male, Membrane Proteins, Metals, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Microspheres, Phagosomes, Subcellular Fractions, Transfection, Blotting, Western, Hydroxyl Radical, Cation Transport Proteins, Mice
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