Glutamine, gene expression, and cell function

Curi, Rui

doi:10.2741/2068

Cited by 135Amino Acid Enzymes and MetabolismCancer, Hypoxia, and MetabolismSulfur Compounds in Biology

Glutamine, gene expression, and cell function

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Curi, Rui·2007·Frontiers in Bioscience

DOI 10.2741/2068

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Abstract

Glutamine is the most abundant free amino acid in the body and is known to play a regulatory role at the gene and protein level in several cell specific processes including metabolism (e.g. oxidative fuel, gluconeogenic precursor and lipogenic precursor), cell integrity (survival, cell proliferation), protein synthesis and degradation, redox potential, respiratory burst, insulin resistance, insulin secretion and extracellular matrix synthesis. Glutamine has been shown to regulate the expression of many genes related to metabolism, signal transduction, cell defense and repair and to activate intracellular signaling pathways. Thus, the function of glutamine goes beyond that of a simple metabolic fuel or protein precursor as previously assumed. In this review, we have attempted to identify some of the common mechanisms underlying glutamine dependent changes in gene and protein expression and cellular function.

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High animal protein intake can produce potentially toxic compounds in the gut.
“High animal protein intake can produce potentially toxic compounds in the gut [103]”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [103]
Prolonged exercise is associated with a fall in the plasma concentration of glutamine.
“Prolonged exercise is also associated with a fall in the plasma concentration of glutamine and it has been hypothesized that such a decrease could impair immune function and increase susceptibility to infection and leaky gut in athletes [103].”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [103]

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Corless M., A. Kiely, N. H. McClenaghan, P. R. Flatt & P. Newsholme: Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene and protein expression in a clonal panreatic beta cell line. J Nutrition. In Press (2006)

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Correction: Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling
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A glance at the actual role of glutamine metabolism in thyroid tumorigenesis
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Glutamine and Skeletal Muscle
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Molecular mechanisms of glutamine action
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Glutamine‐dependent changes in gene expression and protein activity
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Authors: Curi, R.
Affiliations: Universidade de São Paulo (BR)
Corresponding author: Curi, Rui
ORCID: Curi, Rui
Venue: Frontiers in Bioscience
Publisher: IMR Press
Published: 2007
Volume: 12
Issue: 1
Pages: 344
ISSN: 1093-4715 (ISSN-L)
1093-9946
DOI: 10.2741/2068
OpenAlex: W2045308286
Cited by: 135
References: 90
Citations by year: 2026: 3 · 2025: 2 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 10 · 2019: 6 · 2018: 14 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 8 · 2013: 6 · 2012: 8
FWCI: 0.34
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Frontiers in bioscience (publishedVersion)
PubMed (publishedVersion)
Funders: Health Research Board
Fundação de Amparo à Pesquisa do Estado de São Paulo
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
Keywords: glutamine, gene expression regulation, protein expression, cell proliferation, cell survival, redox potential, respiratory burst, insulin resistance, insulin secretion, extracellular matrix synthesis, signal transduction, intracellular signaling, metabolism, gluconeogenesis, lipogenesis, protein synthesis and degradation
MeSH terms: Insulin Secretion, Animals, Cells, Extracellular Matrix, Gene Expression Regulation, Glutamine, Humans, Immune System, Insulin, Proteins, Reactive Oxygen Species, Cell Proliferation

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Glutamine, gene expression, and cell function

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