Cited by 522T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmune cells in cancer

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

Klysz, Dorota, Tai, Xuguang, Robert, Philippe A., Craveiro, Marco, Cretenet, Gaspard, Oburoglu, Leal, Mongellaz, Cédric, Floess, Stefan +10 more·2015·Science Signaling

Abstract

Altering the availability of nutrients shapes T cell differentiation and the immune response.

Integrity signals

Registry

Crossref · 10.1126/scisignal.aab2610

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64 of 64 references verified0 citation errors · 0 not checkable

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  • In T cell activation, glutamine deprivation alters activation of naive CD4+ T cells and results in their differentiation into Foxp3+ regulatory T cells, which have suppressor functions.

    “In T cell activation, glutamine deprivation has been shown to alter the activation of naive CD4+ T cells and result in their differentiation into forkhead box P3-positive (Foxp3+) regulatory T (Treg) cells, which have suppressor functions109.”

    From Glutamine reliance in cell metabolism (2020) · cites this paper as [109]

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Authors
Klysz, D., Tai, X., Robert, P. A., Craveiro, M., Cretenet, G., Oburoglu, L., Mongellaz, C., Floess, S., Fritz, V., Matias, M. I., Yong, C., Surh, N., Marie, J. C., Huehn, J., Zimmermann, V., Kinet, S., Dardalhon, V., & Taylor, N.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • National Cancer Institute (US)
  • Helmholtz Centre for Infection Research (DE)
  • Lyon 1 Université (FR)
Corresponding author
  • Tai, Xuguang
  • Robert, Philippe A.
  • Dardalhon, Valérie
  • Taylor, Naomi
Venue
Science Signaling
Published
2015-09-29
Volume
8
Issue
396
Pages
ra97-ra97
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W2243760265
Cited by
522
References
64
Citations by year
2026: 43 · 2025: 52 · 2024: 60 · 2023: 54 · 2022: 60 · 2021: 71 · 2020: 63 · 2019: 38 · 2018: 33 · 2017: 29 · 2016: 16 · 2015: 2 · 2014: 1
FWCI
13.15
Type
journal article
Language
en
Open access
closed
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • European Marie Curie fellowship (ATTACK)
  • University of Montpellier II
  • Ligue Contre le Cancer
  • Association de la Recherche contre le Cancer (ARC)
  • Portuguese Foundation for Science and Technology
  • Association Francaise contre les Myopathies (AFM)
  • Cancer Therapeutics CRC
  • Australian Postgraduate Award
  • NIH
  • CNRS
  • INSERM
  • European Community (LSHC-CT-2005-018914, PIRG5-GA-2009-249227)
  • CNRS-NIH International Laboratory
  • ARC
  • ANR
  • INCa
  • German Research Foundation (KFO250)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
alpha-ketoglutarate, glutamine deprivation, regulatory T cells, Th1 cells, CD4+ T cell differentiation, Foxp3, T-bet, mTORC1 signaling, T cell metabolism, TCA cycle, Treg differentiation, T cell activation
MeSH terms
Mechanistic Target of Rapamycin Complex 1, Animals, Cell Differentiation, Glutamine, Ketoglutaric Acids, Th1 Cells, Multiprotein Complexes, T-Lymphocytes, Regulatory, Mice, TOR Serine-Threonine Kinases

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