Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Abstract
Altering the availability of nutrients shapes T cell differentiation and the immune response.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In T cell activation, glutamine deprivation alters activation of naive CD4+ T cells and results in their differentiation into Foxp3+ regulatory T cells, which have suppressor functions.
“In T cell activation, glutamine deprivation has been shown to alter the activation of naive CD4+ T cells and result in their differentiation into forkhead box P3-positive (Foxp3+) regulatory T (Treg) cells, which have suppressor functions109.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [109]
Cites
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622 · see citing works
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · see citing works
Michalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., & Rathmell, J. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003613 · Cited by 2,091 · see citing works
Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001 · see citing works
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature · doi:10.1038/nature12040 · Cited by 1,990 · see citing works
Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803 · see citing works
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798 · see citing works
Glutamine addiction: a new therapeutic target in cancer
Wise, D. R., & Thompson, C. B. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.003 · Cited by 1,770 · see citing works
Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J., & Hill, C. S. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.65 · Cited by 1,636 · see citing works
mTOR differentially regulates effector and regulatory T cell lineage commitment
Delgoffe, G. M., Kole, T., Zheng, Y., Zarek, P. E., Matthews, K., Xiao, B., Worley, P., Kozma, S., & Powell, J. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.014 · Cited by 1,293 · see citing works
Epigenetic Control of the foxp3 Locus in Regulatory T Cells
Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J. K., Schlawe, K., Chang, H., Bopp, T., Schmitt, E., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050038 · Cited by 1,272 · see citing works
Self-citationMacintyre, A. N., Gerriets, V. A., Nichols, A., Michalek, R. D., Rudolph, M. C., Deoliveira, D., Anderson, S. M., Abel, E. D., Chen, B. J., Hale, L. P., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.004 · Cited by 1,129 · see citing works
Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J., Horton, M. R., Xiao, B., Worley, P. F., & Powell, J. D. (2011) · Nature Immunology · doi:10.1038/ni.2005 · Cited by 1,111 · see citing works
Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., Onozuka, H., Kinoshitá, T., Saito, N., Ochiai, A., Tomita, M., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4806 · Cited by 959 · see citing works
Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y.-B., Taylor, P. M., & Cantrell, D. A. (2013) · Nature Immunology · doi:10.1038/ni.2556 · Cited by 930 · see citing works
Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells
Mottet, C., Uhlig, H. H., & Powrie, F. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.3939 · Cited by 928 · see citing works
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
Berod, L., Friedrich, C., Nandan, A., Freitag, J., Hagemann, S., Harmrolfs, K., Sandouk, A., Hesse, C., Castro, C. N., Bähre, H., et al. (2014) · Nature Medicine · doi:10.1038/nm.3704 · Cited by 927 · see citing works
Self-citationNakaya, M., Xiao, Y., Zhou, X., Chang, J., Chang, M., Cheng, X., Blonska, M., Lin, X., & Sun, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.007 · Cited by 870 · see citing works
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
Sauer, S., Bruno, L., Hertweck, A., Finlay, D. K., Leleu, M., Spivakov, M., Knight, Z. A., Cobb, B. S., Cantrell, D. A., O’Connor, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800928105 · Cited by 861 · see citing works
Jacobs, S. R., Herman, C. E., MacIver, N. J., Wofford, J. A., Wieman, H. L., Hammen, J. J., & Rathmell, J. C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4476 · Cited by 853 · see citing works
Murai, M., Turovskaya, O., Kim, G., Madan, R., Karp, C. L., Cheroutre, H., & Kronenberg, M. (2009) · Nature Immunology · doi:10.1038/ni.1791 · Cited by 851 · see citing works
Regulation of Immune Responses by mTOR
Powell, J. D., Pollizzi, K. N., Heikamp, E. B., & Horton, M. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075024 · Cited by 836 · see citing works
The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
Haxhinasto, S., Mathis, D., & Benoist, C. (2008) · Journal of Experimental Medicine · doi:10.1084/jem.20071477 · Cited by 775 · see citing works
Ohkura, N., Hamaguchi, M., Morikawa, H., Sugimura, K., Tanaka, A., Ito, Y., Osaki, M., Tanaka, Y., Yamashita, R., Nakano, N., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.010 · Cited by 756 · see citing works
Self-citationMetabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
Gerriets, V. A., Kishton, R. J., Nichols, A., Macintyre, A. N., Inoue, M., Ilkayeva, O., Winter, P. S., Liu, X., Priyadharshini, B., Slawinska, M. E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76012 · Cited by 729 · see citing works
Glutaminolysis Activates Rag-mTORC1 Signaling
Durán, R. V., Oppliger, W., Robitaille, A. M., Heiserich, L., Skendaj, R., Gottlieb, E., & Hall, M. N. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.043 · Cited by 723 · see citing works
Rao, R. R., Li, Q., Odunsi, K., & Shrikant, P. A. (2010) · Immunity · doi:10.1016/j.immuni.2009.10.010 · Cited by 656 · see citing works
Regulation of Glutaminase Activity and Glutamine Metabolism
Curthoys, N. P., & Watford, M. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.001025 · Cited by 643 · see citing works
Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K., & Cantrell, D. A. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112607 · Cited by 596 · see citing works
Metabolic switching and fuel choice during T‐cell differentiation and memory development
van der Windt, G. J. W., & Pearce, E. L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01150.x · Cited by 563 · see citing works
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
Huehn, J., Polansky, J. K., & Hamann, A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2474 · Cited by 527 · see citing works
Self-citationLee, K., Gudapati, P., Dragovic, S. M., Spencer, C. T., Joyce, S., Killeen, N. P., Magnuson, M. A., & Boothby, M. R. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.002 · Cited by 464 · see citing works
Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis
Uhlig, H. H., Coombes, J. L., Mottet, C., Ízcue, A., Thompson, C., Fanger, A., Tannapfel, A., Fontenot, J. D., Ramsdell, F., & Powrie, F. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.5852 · Cited by 463 · see citing works
Metabolic checkpoints in activated T cells
Wang, R., & Green, D. R. (2012) · Nature Immunology · doi:10.1038/ni.2386 · Cited by 457 · see citing works
Metabolic pathways in T cell fate and function
Gerriets, V. A., & Rathmell, J. C. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.01.010 · Cited by 425 · see citing works
Wofford, J. A., Wieman, H. L., Jacobs, S. R., Zhao, Y., & Rathmell, J. C. (2007) · Blood · doi:10.1182/blood-2007-06-096297 · Cited by 424 · see citing works
Halofuginone Inhibits T H 17 Cell Differentiation by Activating the Amino Acid Starvation Response
Sundrud, M. S., Koralov, S. B., Feuerer, M., Calado, D. P., Kozhaya, A. E., Rhule-Smith, A., Lefebvre, R. E., Unutmaz, D., Mazitschek, R., Waldner, H., et al. (2009) · Science · doi:10.1126/science.1172638 · Cited by 422 · see citing works
The efficiency and plasticity of mitochondrial energy transduction.
Brand, M. D. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330897 · Cited by 406 · see citing works
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR
Liu, G., Burns, S., Huang, G., Boyd, K., Proia, R. L., Flavell, R. A., & Chi, H. (2009) · Nature Immunology · doi:10.1038/ni.1743 · Cited by 339 · see citing works
Eos Mediates Foxp3-Dependent Gene Silencing in CD4 + Regulatory T Cells
Pan, F., Yu, H., Dang, E. V., Barbi, J. J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E., Getnet, D., et al. (2009) · Science · doi:10.1126/science.1176077 · Cited by 335 · see citing works
Ichiyama, K., Chen, T., Wang, X., Yan, X., Kim, B.-S., Tanaka, S., Ndiaye-Lobry, D., Deng, Y., Zou, Y., Zheng, P., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.005 · Cited by 327 · see citing works
The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells
Liu, G., Yang, K., Burns, S., Shrestha, S., & Chi, H. (2010) · Nature Immunology · doi:10.1038/ni.1939 · Cited by 324 · see citing works
Barata, J. T., da Silva, A. B. G., Brandão, J. G., Nadler, L. M., Cardoso, A. A., & Boussiotis, V. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040789 · Cited by 283 · see citing works
Wang, Y., Kissenpfennig, A., Mingueneau, M., Richelme, S., Perrin, P., Chevrier, S., Genton, C., Lucas, B., Santo, J. P. D., Acha‐Orbea, H., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1565 · Cited by 188 · see citing works
Glutamine Metabolism in Sepsis and Infection
Karinch, A. M., Pan, M., Lin, C., Strange, R., & Souba, W. W. (2001) · Journal of Nutrition · doi:10.1093/jn/131.9.2535s · Cited by 173 · see citing works
Li, Q., Rao, R. R., Araki, K., Pollizzi, K. N., Odunsi, K. O., Powell, J. D., & Shrikant, P. A. (2011) · Immunity · doi:10.1016/j.immuni.2011.04.006 · Cited by 160 · see citing works
Chakrabarti, R., Jung, C. Y., Lee, T. P., Liu, H., & Mookerjee, B. K. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.6.2660 · Cited by 149 · see citing works
PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors
Merkenschlager, M., & von Boehmer, H. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101156 · Cited by 144 · see citing works
Darrasse-Jèze, G., Bergot, A., Durgeau, A., Billiard, F., Salomon, B. L., Cohen, J. L., Bellier, B., Podsypanina, K., & Klatzmann, D. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36628 · Cited by 139 · see citing works
Glutamine, gene expression, and cell function
Curi, R. (2007) · Frontiers in Bioscience · doi:10.2741/2068 · Cited by 135 · see citing works
Fuchs, B. C., Finger, R., Onan, M. C., & Bode, B. (2007) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00330.2006 · Cited by 133 · see citing works
Cutting Edge: CD4+CD25+ Regulatory T Cells Impaired for Intestinal Homing Can Prevent Colitis
Denning, T. L., Kim, G., & Kronenberg, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7487 · Cited by 125 · see citing works
Role of Oxidative Stress and Glutathione in Busulfan Toxicity in Cultured Murine Hepatocytes
DeLeve, L. D., & Wang, X. (2000) · Pharmacology · doi:10.1159/000028359 · Cited by 118 · see citing works
IL-7–induced proliferation of recent thymic emigrants requires activation of the PI3K pathway
Swainson, L. A., Kinet, S., Mongellaz, C., Sourisseau, M., Henriques, T., & Taylor, N. N. (2006) · Blood · doi:10.1182/blood-2006-06-027912 · Cited by 116 · see citing works
Self-citationAmmonia production and glutamine incorporation into glutathione in the functioning rat kidney
Welbourne, T. C. (1979) · Canadian Journal of Biochemistry · doi:10.1139/o79-029 · Cited by 115 · see citing works
Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance
Lyssiotis, C. A., Son, J., Cantley, L. C., & Kimmelman, A. C. (2013) · Cell Cycle · doi:10.4161/cc.25307 · Cited by 83 · see citing works
Manel, N., Kinet, S., Battini, J., Kim, F. J., Taylor, N. N., & Sitbon, M. (2003) · Blood · doi:10.1182/blood-2002-09-2681 · Cited by 74 · see citing works
Self-citationKinet, S., Swainson, L. A., Lavanya, M., Mongellaz, C., Montel‐Hagen, A., Craveiro, M., Manel, N., Battini, J., Sitbon, M., & Taylor, N. N. (2007) · Retrovirology · doi:10.1186/1742-4690-4-31 · Cited by 70 · see citing works
Self-citationFacile syntheses of the enantiomers of sulcatol
Johnston, B. D., & Slessor, K. N. (1979) · Canadian Journal of Chemistry · doi:10.1139/v79-038 · Cited by 60 · see citing works
Todorova, V., Vanderpool, D. R., Blossom, S. J., Nwokedi, E., Hennings, L. J., Mrak, R. E., & Klimberg, V. S. (2009) · Nutrition · doi:10.1016/j.nut.2009.01.004 · Cited by 58 · see citing works
Lin, Y., Chang, L.-Y., Huang, C., Peng, H., Dutta, A., Chen, T., Yeh, C., & Lin, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803829 · Cited by 52 · see citing works
Glutamine Transport and Human Hepatocellular Transformation
Bode, B. P., & Souba, W. W. (1999) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719902300509 · Cited by 39 · see citing works
Abraham, P., Isaac, B., Ramamoorthy, H., & Natarajan, K. (2010) · Journal of Medical Toxicology · doi:10.1007/s13181-010-0103-9 · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
From Krebs to clinic: glutamine metabolism to cancer therapy
Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119 · see citing works
Glutamine reliance in cell metabolism
Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021 · see citing works
Identification of bioactive metabolites using activity metabolomics
Rinschen, M. M., Ivanisevic, J., Giera, M., & Siuzdak, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0108-4 · Cited by 1,008 · see citing works
Metabolism of immune cells in cancer
Leone, R. D., & Powell, J. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-020-0273-y · Cited by 877 · see citing works
Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine
Zhang, J., Pavlova, N. N., & Thompson, C. B. (2017) · The EMBO Journal · doi:10.15252/embj.201696151 · Cited by 651 · see citing works
Metabolites and the Tumour Microenvironment: From Cellular Mechanisms to Systemic Metabolism
Elia, I., & Haigis, M. C. (2021) · Nature Metabolism · doi:10.1038/s42255-020-00317-z · Cited by 651 · see citing works
Metabolic regulation of inflammation
Gaber, T., Strehl, C., & Buttgereit, F. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.37 · Cited by 320 · see citing works
Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy
Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2019 · Cited by 310 · see citing works
CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
Chatterjee, S., Daenthanasanmak, A., Chakraborty, P., Wyatt, M. W., Dhar, P., Selvam, S. P., Fu, J., Zhang, J., Nguyen, H., Kang, I., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.006 · Cited by 270 · see citing works
Glutamine Links Obesity to Inflammation in Human White Adipose Tissue
Petrus, P., Lecoutre, S., Dollet, L., Wiel, C., Sulen, A., Gao, H., Tavira, B., Laurencikiene, J., Rooyackers, O., Checa, A., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.019 · Cited by 254 · see citing works
The Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases
Zhang, S., Gang, X., Yang, S., Cui, M., Sun, L., Li, Z., & Wang, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.678355 · Cited by 263 · see citing works
Tumor hypoxia: From basic knowledge to therapeutic implications
Liao, C., Liu, X., Zhang, C., & Zhang, Q. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.12.011 · Cited by 223 · see citing works
Metabolic coordination of cell fate by α-ketoglutarate-dependent dioxygenases
Baksh, S. C., & Finley, L. W. S. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.09.010 · Cited by 165 · see citing works
Plitas, G., & Rudensky, A. Y. (2020) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033428 · Cited by 148 · see citing works
Allison, K. E., Coomber, B. L., & Bridle, B. W. (2017) · Immunology · doi:10.1111/imm.12777 · Cited by 109 · see citing works
Metabolic reprogramming: a bridge between aging and tumorigenesis
Drapela, S., Ilter, D., & Gomes, A. P. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13261 · Cited by 41 · see citing works
Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis
Ferreira, C., Mesquita, I., Barbosa, A. M., Osório, N. S., Torrado, E., Beauparlant, C.-J., Droit, A., Cunha, C., Carvalho, A., Saha, B., et al. (2020) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0008125 · Cited by 35 · see citing works
- Authors
- Klysz, D., Tai, X., Robert, P. A., Craveiro, M., Cretenet, G., Oburoglu, L., Mongellaz, C., Floess, S., Fritz, V., Matias, M. I., Yong, C., Surh, N., Marie, J. C., Huehn, J., Zimmermann, V., Kinet, S., Dardalhon, V., & Taylor, N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- National Cancer Institute (US)
- Helmholtz Centre for Infection Research (DE)
- Lyon 1 Université (FR)
- Corresponding author
- Tai, Xuguang
- Robert, Philippe A.
- Dardalhon, Valérie
- Taylor, Naomi
- ORCID
- Venue
- Science Signaling
- Published
- 2015-09-29
- Volume
- 8
- Issue
- 396
- Pages
- ra97-ra97
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- OpenAlex
- W2243760265
- Cited by
- 522
- References
- 64
- Citations by year
- 2026: 43 · 2025: 52 · 2024: 60 · 2023: 54 · 2022: 60 · 2021: 71 · 2020: 63 · 2019: 38 · 2018: 33 · 2017: 29 · 2016: 16 · 2015: 2 · 2014: 1
- FWCI
- 13.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- European Marie Curie fellowship (ATTACK)
- University of Montpellier II
- Ligue Contre le Cancer
- Association de la Recherche contre le Cancer (ARC)
- Portuguese Foundation for Science and Technology
- Association Francaise contre les Myopathies (AFM)
- Cancer Therapeutics CRC
- Australian Postgraduate Award
- NIH
- CNRS
- INSERM
- European Community (LSHC-CT-2005-018914, PIRG5-GA-2009-249227)
- CNRS-NIH International Laboratory
- ARC
- ANR
- INCa
- German Research Foundation (KFO250)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- alpha-ketoglutarate, glutamine deprivation, regulatory T cells, Th1 cells, CD4+ T cell differentiation, Foxp3, T-bet, mTORC1 signaling, T cell metabolism, TCA cycle, Treg differentiation, T cell activation
- MeSH terms
- Mechanistic Target of Rapamycin Complex 1, Animals, Cell Differentiation, Glutamine, Ketoglutaric Acids, Th1 Cells, Multiprotein Complexes, T-Lymphocytes, Regulatory, Mice, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review