The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Regulation of bone development and maintenance by Runx2
Open accessAbstract
Runx2 and Sp7/Osterix determine the osteoblast lineage from mesenchymal stem cells with canonical Wnt signaling. In the process of osteoblast differentiation, these factors and canonical Wnt signaling molecules inhibit mesenchymal cells from differentiating into chondrocytes and adipocytes. After the commitment to osteoblast lineage, Runx2 maintains the osteoblasts in an immature stage, during which immature bone forms with randomly and loosely packed collagen fibrils and low mineralization. Runx2 must be suppressed for immature osteoblasts to become fully mature osteoblasts, which form mature bone with regularly and densely packed collagen fibrils and high mineralization. During the early stage of osteoblast differentiation, Runx2 regulates the expression of major bone matrix protein genes. However, Runx2 is not essential for the maintenance of the expression of the major bone matrix protein genes in mature osteoblasts. Estrogen and parathyroid hormone (PTH) enhance Runx2 expression and activity through anabolic effects, however, estrogen negatively regulates Runx2 in osteoclastogenesis. Runx2 is also involved in the catabolic effect of PTH through the induction of Tnfsf11. Thus, Runx2 regulates bone development, bone maturation, and bone maintenance through the regulation of osteoblast differentiation and function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
Otto, F., Thornell, A. P., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G. W. H., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,814
Rodda, S. J., & McMahon, A. P. (2006) · Development · doi:10.1242/dev.02480 · Cited by 1,010
Lee, K.-S., Kim, H.-J., Li, Q.-L., Chi, X.-Z., Ueta, C., Komori, T., Wozney, J. M., Kim, E.-G., Choi, J.-Y., Ryoo, H.-M., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8783-8792.2000 · Cited by 865
Self-citationSequential roles of Hedgehog and Wnt signaling in osteoblast development
Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., & Long, F. (2005) · Development · doi:10.1242/dev.01564 · Cited by 682
Ohbayashi, N., Shibayama, M., Kurotaki, Y., Imanishi, M., Fujimori, T., Itoh, N., & Takada, S. (2002) · Genes & Development · doi:10.1101/gad.965702 · Cited by 482
Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18
Liu, Z., Xu, J., Colvin, J. S., & Ornitz, D. M. (2002) · Genes & Development · doi:10.1101/gad.965602 · Cited by 474
Cbfa1 Isoforms Exert Functional Differences in Osteoblast Differentiation
Harada, H., Tagashira, S., Fujiwara, M., Ogawa, S., Katsumata, T., Yamaguchi, A., Komori, T., & Nakatsuka, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.6972 · Cited by 455
Self-citationLiu, W., Toyosawa, S., Furuichi, T., Kanatani, N., Yoshida, C., Liu, Y., Himeno, M., Narai, S., Yamaguchi, A., & Komori, T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105052 · Cited by 455
Self-citation
Cited by
Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits
Chen, L., Qiu, Q., Jiang, Y., Wang, K., Lin, Z., Li, Z., Bibi, F., Yang, Y., Wang, J., Nie, W., et al. (2019) · Science · doi:10.1126/science.aav6202 · Cited by 441
Guerra-Menéndez, L., Sádaba, M. C., Puche, J. E., Lavandera, J. L., de Castro, L. F., de Gortázar, A. R., & Castilla-Cortázar, I. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-271 · Cited by 64
Architecture of bone tissue and its adaptation to pathological conditions
Bilgiç, E., Boyacıoğlu, Ö., Gizer, M., Korkusuz, P., & Korkusuz, F. (2020) · Comparative Kinesiology of the Human Body · doi:10.1016/b978-0-12-812162-7.00006-0 · Cited by 30
Ma, T.-L., Zhu, P., Ke, Z.-R., Chen, J.-X., Hu, Y.-H., & Xie, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.891313 · Cited by 9
Lineage-specific protein repeat expansions and contractions reveal malleable regions of immune genes
Teekas, L., Sharma, S., & Vijay, N. (2022) · Genes & Immunity · doi:10.1038/s41435-022-00186-4 · Cited by 5
Metadata
- Authors
- Komori, T.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2008
- Volume
- 13
- Issue
- 13
- Pages
- 898
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/2730
- OpenAlex
- W1986864292
- Cited by
- 253
- References
- 26
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Regulation of bone development and maintenance by Runx2. https://app.cochat.ai/papers/10.2741/2730
- The paper
- Komori, T. (2008). Regulation of bone development and maintenance by Runx2. Frontiers in Bioscience. https://doi.org/10.2741/2730
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
