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Protein-mediated Enamel Mineralization

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Moradian-Oldak, Janet·2012·Frontiers in Bioscience

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Abstract

Enamel is a hard nanocomposite bioceramic with significant resilience that protects the mammalian tooth from external physical and chemical damages. The remarkable mechanical properties of enamel are associated with its hierarchical structural organization and its thorough connection with underlying dentin. This dynamic mineralizing system offers scientists a wealth of information that allows the study of basic principels of organic matrix-mediated biomineralization and can potentially be utilized in the fields of material science and engineering for development and design of biomimetic materials. This chapter will provide a brief overview of enamel hierarchical structure and properties and the process and stages of amelogenesis. Particular emphasis is given to current knowledge of extracellular matrix protein and proteinases, and the structural chemistry of the matrix components and their putative functions. The chapter will conclude by discussing the potential of enamel for regrowth.

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Vymětal, J., Slabý, I., Spahr, A., Vondrášek, J., & Lyngstadaas, S. P. (2008) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2008.00526.x · Cited by 42
Exclusion of candidate genes in two families with autosomal dominant hypocalcified amelogenesis imperfecta
Hart, P. S., Wright, J. T., Savage, M., Kang, G., Bensen, J. T., Gorry, M. C., & Hart, T. C. (2003) · European Journal Of Oral Sciences · doi:10.1034/j.1600-0722.2003.00046.x · Cited by 40
Mapping of the Locus for Autosomal Dominant Amelogenesis Imperfecta (AIH2) to a 4-Mb YAC Contig on Chromosome 4q11–q21
Kärrman, C., Bäckman, B., Dixon, M. J., Holmgren, G., & Forsman, K. (1997) · Genomics · doi:10.1006/geno.1996.4485 · Cited by 37
The Biomimetics of Enamel: A Paradigm for Organized Biomaterials Synthesis
Mann, S. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515303.ch18 · Cited by 34
Splicing Determines the Glycosylation State of Ameloblastin
Kobayashi, K., Yamakoshi, Y., Hu, J., Gomi, K., Arai, T., Fukae, M., Krebsbach, P. H., & Simmer, J. P. (2007) · Journal of Dental Research · doi:10.1177/154405910708601009 · Cited by 34
Sites of Asparagine-Linked Oligosaccharides in Porcine 32 kDa Enamelin
Yamakoshi, Y., Pinheiro, F., Tanabe, T., Fukae, M., & Shimizu, M. (1998) · Connective Tissue Research · doi:10.3109/03008209809023910 · Cited by 34
Self-aligning amelogenin nanoribbons in oil–water system
He, X., Wu, S., Martínez‐Ávila, O., Cheng, Y., & Habelitz, S. (2010) · Journal of Structural Biology · doi:10.1016/j.jsb.2010.11.027 · Cited by 32
Identification of Tuftelin-and Amelogenin-Interacting Proteins Using the Yeast Two-Hybrid System
Paine, C. T., Paine, M. L., & Snead, M. L. (1998) · Connective Tissue Research · doi:10.3109/03008209809017046 · Cited by 31
Perturbed Amelogenin Secondary Structure Leads to Uncontrolled Aggregation in Amelogenesis Imperfecta Mutant Proteins
Lakshminarayanan, R., Bromley, K. M., Lei, Y., Snead, M. L., & Moradian‐Oldak, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.131136 · Cited by 29
Self-citation
Does Amelogenin Nanosphere Assembly Proceed through Intermediary-sized Structures?
Fincham, A. G., Leung, W., Tan, J., & Moradian‐Oldak, J. (1998) · Connective Tissue Research · doi:10.3109/03008209809017042 · Cited by 29
Self-citation
Probing the self‐association, intermolecular contacts, and folding propensity of amelogenin
Ndao, M., Dutta, K., Bromley, K. M., Lakshminarayanan, R., Sun, Z., Rewari, G., Moradian‐Oldak, J., & Evans, J. S. (2011) · Protein Science · doi:10.1002/pro.603 · Cited by 27
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Amelogenin “nanorods” formation during proteolysis by Mmp-20
Yang, X., Sun, Z., Ma, R., Fan, D., & Moradian‐Oldak, J. (2011) · Journal of Structural Biology · doi:10.1016/j.jsb.2011.07.016 · Cited by 21
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Tooth Enamel Defects in Mice with a Deletion at the Arhgap6/AmelX Locus
Prakash, S. K., Gibson, C. W., Wright, J. T., Boyd, C., Cormier, T. A., Sierra, R., Li, Y., Abrams, W. R., Aragon, M. A., Yuan, Z., et al. (2005) · Calcified Tissue International · doi:10.1007/s00223-004-1213-7 · Cited by 18
Mammalian Enamel Formation
Moradian‐Oldak, J., & Paine, M. L. (2008) · Wiley eBooks · doi:10.1002/9780470986325.ch15 · Cited by 10
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Dental Enamel Formation and Implications for Oral Health and Disease
Lacruz, R. S., Habelitz, S., Wright, J. T., & Paine, M. L. (2017) · Physiological Reviews · doi:10.1152/physrev.00030.2016 · Cited by 599
State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management
Philip, N. (2019) · Caries Research · doi:10.1159/000493031 · Cited by 341
Quantitative affinity parameters of synthetic hydroxyapatite and enamel surfaces in vitro
Fabritius-Vilpoux, K., Enax, J., Herbig, M., Raabe, D., & Fabritius, H.-O. (2019) · Bioinspired, Biomimetic and Nanobiomaterials · doi:10.1680/jbibn.18.00035 · Cited by 53
Biomimetic supramolecular protein matrix restores structure and properties of human dental enamel
Hasan, A., Chuvilin, A., Van Teijlingen, A., Rouco, H., Parmenter, C., Venturi, F., Fay, M., Greco, G., Pugno, N. M., Ruben, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64982-y · Cited by 15

See all 321

Authors: Moradian-Oldak, J.
Venue: Frontiers in Bioscience
Publisher: IMR Press
Published: 2012
Volume: 17
Issue: 7
Pages: 1996
ISSN: 1093-4715 (ISSN-L)
1093-9946
DOI: 10.2741/4034
OpenAlex: W1979876637
Cited by: 321
References: 103
FWCI: 9.80
Type: journal article
Language: en
Open access: bronze

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Protein-mediated Enamel Mineralization

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