The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Mitogen-activated protein kinase pathways in redox signaling
Open accessAbstract
It has been known for quite some time that proper cellular function requires tight control of the cellular redox state. In recent years, a growing body of literature has provided evidence of a role for reactive oxygen species (ROS) as important mediators of proliferation, acting as second messengers to modulate the activation of various signaling molecules and pathways. In contrast to high levels of ROS that may induce modifications that inhibit the activity of cellular components or result in damage, repair and cell death, the hypothesis that low levels of ROS, produced enzymatically and in a regulated fashion, are required participants of signaling pathways controlling essential cellular function is gaining grounds. The concept that ROS specifically target components of these pathways is only beginning to be examined. The mitogen-activated protein kinases (MAPK) are a large family of proline-directed, serine/threonine kinases that require tyrosine and threonine phosphorylation of a ThrXTyr motif in the activation loop for activation. Receptor-ligand interaction leads to activation of a phosphorylation cascade where the minimal module is formed by MAPK, MAPK kinase and MAPK kinase kinase. Four separate MAPK and activating cascades have been identified, based on the TXY motif and the dual-specificity kinases that strictly phosphorylate their particular TXY sequence. They are the extracellular signal regulated kinases (ERK), c-jun N-terminal kinases (JNK), p38MAPK and ERK5. This review will summarize recent findings regarding the activation of the MAPK and the role played by ROS in their activation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961
Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1
Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., & Ichijo, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2596 · Cited by 2,377
Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886
Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543
Killing activity of neutrophils is mediated through activation of proteases by K+ flux
Reeves, E. P., Lu, H., Jacobs, H. L., Messina, C. G. M., Bolsover, S., Gabella, G., Potma, E. O., Warley, A., Roes, J., & Segal, A. W. (2002) · Nature · doi:10.1038/416291a · Cited by 1,153
The JNK signal transduction pathway
Weston, C. R., & Davis, R. J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.001 · Cited by 1,021
A conserved docking motif in MAP kinases common to substrates, activators and regulators
Tanoue, T., Adachi, M., Moriguchi, T., & Nishida, E. (2000) · Nature Cell Biology · doi:10.1038/35000065 · Cited by 816
A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway
Dickens, M., Rogers, J. S., Cavanagh, J., Raitano, A., Xia, Z., Halpern, J. R., Greenberg, M. E., Sawyers, C. L., & Davis, R. J. (1997) · Science · doi:10.1126/science.277.5326.693 · Cited by 675
Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb
Janssen-Heininger, Y. M. W., Poynter, M. E., & Baeuerle, P. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00218-5 · Cited by 666
Hsu, H.-Y., & Wen, M.-H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111883200 · Cited by 519
Jacobs, D., Glossip, D., Xing, H., Muslin, A. J., & Kornfeld, K. (1999) · Genes & Development · doi:10.1101/gad.13.2.163 · Cited by 439
Trinei, M., Giorgio, M., Cicalese, A., Barozzi, S., Ventura, A., Migliaccio, E., Milia, E., Padura, I. M., Raker, V. A., Maccarana, M., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205513 · Cited by 436
Alessi, D. R., Gomez, N., Moorhead, G., Lewis, T., Keyse, S. M., & Cohen, P. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00059-5 · Cited by 365
Sano, M., Fukuda, K., Sato, T., Kawaguchi, H., Suematsu, M., Matsuda, S., Koyasu, S., Matsui, H., Yamauchi-Takihara, K., Harada, M., et al. (2001) · Circulation Research · doi:10.1161/hh2001.098873 · Cited by 298 · cited 1×
“In cardiac fibroblasts, AngII activated all three MAP kinases in a ROS-dependent manner, resulting in increase in IL-6 gene expression through phosphorylation of the CREB transcription factor by the ERK/RSK and p38MAPK pathways (288).”
BackgroundIto, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., & Yamamoto, K.-I. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7539 · Cited by 279
Requirement of the JIP1 scaffold protein for stress-induced JNK activation
Whitmarsh, A. J., Kuan, C.-Y., Kennedy, N. J., Kelkar, N., Haydar, T. F., Mordes, J. P., Appel, M., Rossini, A. A., Jones, S. N., Flavell, R. A., et al. (2001) · Genes & Development · doi:10.1101/gad.922801 · Cited by 238
Identification of the Critical Features of a Small Peptide Inhibitor of JNK Activity
Barr, R. K., Kendrick, T. S., & Bogoyevitch, M. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107565200 · Cited by 211
Docking interactions in the mitogen-activated protein kinase cascades
Tanoue, T., & Nishida, E. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00188-2 · Cited by 134
Tárrega, C., Blanco-Aparicio, C., Muñoz, J. J., & Pulido, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108874200 · Cited by 33
Cited by
Redox regulation of cell survival
Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781
A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation
Lee, N. K., Choi, Y. G., Baik, J. Y., Han, S. Y., Jeong, D.-W., Bae, Y. S., Kim, N., & Lee, S. Y. (2005) · Blood · doi:10.1182/blood-2004-09-3662 · Cited by 957
The role of reactive oxygen and antioxidant species in periodontal tissue destruction
Chapple, I. L. C., & Matthews, J. B. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00178.x · Cited by 936
Oxidative stress in the placenta
Myatt, L., & Cui, X. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0677-x · Cited by 800
Shen, H.-M., & Liu, Z.-G. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.10.056 · Cited by 629
Metadata
- Authors
- Torres, M.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2003
- Volume
- 8
- Issue
- 4
- Pages
- d369-391
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/999
- OpenAlex
- W2010845266
- Cited by
- 219
- References
- 19
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
