Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression

Hsu, Hsien-Yeh; Wen, Meng-Hsuan

doi:10.1074/jbc.m111883200

Cited by 519Immune Response and InflammationNF-κB Signaling PathwaysInflammasome and immune disorders

Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression

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Hsu, Hsien-Yeh, Wen, Meng-Hsuan·2002·Journal of Biological Chemistry

DOI 10.1074/jbc.m111883200

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Abstract

Lipopolysaccharide (LPS) stimulates macrophages to release inflammatory cytokines, interleukin-1 beta (IL-1), and tumor necrosis factor (TNF). LPS-induced TNF suppresses scavenger receptor functions in macrophages (van Lenten, B. J., and Fogelman, A. M. (1992) J. Immunol. 148, 112-116), which is regulated by TNF-mediated protein kinases (Hsu, H. Y., and Twu, Y. C. (2000) J. Biol. Chem. 275, 41035-41048). To examine the molecular mechanism for LPS induction of IL-1 in macrophages, we demonstrated that LPS quickly stimulated reactive oxygen species (ROS), and 3 h later induced prointerleukin-1 beta (pro-IL-1, precursor of IL-1) production and IL-1 secretion. LPS stimulated pro-IL-1 message/protein between 3 and 10 h; however, there was a 40% reduction of pro-IL-1 in preincubation of the antioxidant, N-acetylcysteine (NAC). Moreover, NAC moderated LPS-induced IL-1 secretion partially via interleukin 1-converting enzyme. The maximal activity of LPS-induced ERK, JNK, and p38 was 12- (30 min), 5- (30 min), and 16-fold (15 min), respectively. In contrast, NAC reduced ERK activity to 60% and decreased p38 activity to the basal level, but JNK activity was induced 2-fold. Furthermore, the pharmacological antagonists LY294002, SB203580, curcumin, calphostin C, and PD98059 revealed the diverse roles of LPS-mediated protein kinases in pro-IL-1. On the other hand, NAC and diphenyleneiodonium chloride partially inhibited LPS-induced Rac activity and protein-tyrosine kinase (PTK), indicating that LPS-mediated ROS and NADPH oxidase correspond to Rac activation and IL-1 expression. Our findings establish for the first time that LPS-mediated PTK/phosphatidylinositol 3-kinase/Rac/p38 pathways play a more important role than pathways of PTK/PKC/MEK/ERK and of PTK/phosphatidylinositol 3-kinase/Rac/JNK in the regulation of pro-IL-1/IL-1. The findings also further elucidate the critical role of LPS-mediated ROS in signal transduction pathways. Our results suggest that understanding LPS-transduced signals in IL-1 induction upon the antibacterial action of macrophages should provide a therapeutic strategy for aberrant inflammatory responses leading to severe cellular injury or concurrent multiorgan septic damage.

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In the NF-κB system, NF-κB is normally held inactive in the cytoplasm by binding to an inhibitor IκB; pro-inflammatory cytokines such as TNF-α, LPS and IL-1 act by binding to receptors at the cell surface and initiating signalling pathways that lead to activation of IKK; IKK phosphorylates IκB causing its release and degradation, allowing NF-κB to translocate to the nucleus where it can activate a
“In the NF-κB system (e.g. [2020-2024]) (Fig 8), NF-κB is normally held inactive in the cytoplasm by binding to an inhibitor IκB (often IκBα). Pro-inflammatory cytokines such as TNF-α, LPS [2025-2030] and IL-1 [2031] act by binding to receptors at the cell surface and initiating signalling pathways that lead to the activation of a particular kinase, IκB kinase or IKK. This kinase phosphorylates the”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [2027]

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“Along with published data showing that p38 inhibitor blocks LPS-induced production of IL-6, TNF and IL-1&beta”
Background
Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease
Begum, A. N., Jones, M. R., Lim, G. P., Morihara, T., Kim, P., Heath, D. D., Rock, C. L., Pruitt, M. A., Yang, F., Hudspeth, B., et al. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.137455 · Cited by 604 · see citing works
NADPH Oxidase Mediates Lipopolysaccharide-induced Neurotoxicity and Proinflammatory Gene Expression in Activated Microglia
Qin, L., Liu, Y., Wang, T., Wei, S.-J., Block, M. L., Wilson, B., Liu, B., & Hong, J.-S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307657200 · Cited by 574 · see citing works
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
“Sepsis leading to organ failure and death: severe inflammatory response syndrome It is well known that one consequence of bacterial infection (sepsis) can be septic shock, that this can be mimicked by the Gram-negative bacterial outer membrane component LPS (lipopolysaccharide), and that in the worst cases this leads…”
BackgroundInfluential
Neuroprotective effects of curcumin
Cole, G. M., Teter, B., & Frautschy, S. A. (2007) · ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY · doi:10.1007/978-0-387-46401-5_8 · Cited by 516 · see citing works
Berberine suppresses proinflammatory responses through AMPK activation in macrophages
Jeong, H. W., Hsu, K. C., Lee, J.-W., Ham, M., Huh, J. Y., Shin, H. J., Kim, W. S., & Kim, J. B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90599.2008 · Cited by 454 · see citing works
“It has been well established that proinflammatory stimuli such as LPS and TNF- promote an early and acute increase of cellular ROS levels (13, 21) that stimulate MAPK cascade and downstream transcriptional factors to mediate inflammatory responses (13, 21, 50).”
BackgroundResult
TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization
Gouin, O., L’Hérondelle, K., Lebonvallet, N., Gall‐Ianotto, C. L., Sakka, M., Buhé, V., Plée‐Gautier, E., Carré, J., Lefeuvre, L., Misery, L., et al. (2017) · Protein & Cell · doi:10.1007/s13238-017-0395-5 · Cited by 430 · see citing works
Redox regulation of glial inflammatory response to lipopolysaccharide and interferonγ
Pawate, S., Shen, Q., Fan, F., & Bhat, N. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20180 · Cited by 428 · see citing works
Eicosapentaenoic Acid Prevents LPS-Induced TNF-α Expression by Preventing NF-κB Activation
Zhao, Y., Joshi-Barve, S., Barve, S., & Chen, L. H. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719345 · Cited by 405 · see citing works
“Pre-treating cells with antioxidants reduces LPS-induced NF- B transcription activity [51,52] and the activities of upstream Rac1 and protein tyrosine kinases [53,54].”
Background
Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophages
Chen, C.-Y., Peng, W.-H., Tsai, K.-D., & Hsu, S.-L. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.09.028 · Cited by 358 · see citing works
“It has been reported that LPS rapidly induces the generation of ROS especially H 2 O 2 in macrophages (Hsu and Wen, 2002; Lu and Wahl, 2005) .”
Background
Reactive oxygen species mediate RANK signaling in osteoclasts
Ha, H., Bok Kwak, H., Woong Lee, S., Mi Jin, H., Kim, H.-M., Kim, H.-H., & Hee Lee, Z. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.07.035 · Cited by 347 · see citing works
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection
Yuan, H., Perry, C. N., Huang, C., Iwai‐Kanai, E., Carreira, R., Glembotski, C. C., & Gottlieb, R. A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01051.2008 · Cited by 265 · see citing works
Dual Roles of Graphene Oxide To Attenuate Inflammation and Elicit Timely Polarization of Macrophage Phenotypes for Cardiac Repair
Han, J., Kim, Y. S., Lim, M.-Y., Kim, H. Y., Kong, S., Kang, M., Choo, Y. W., Jun, J. H., Ryu, S., Jeong, H.-Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b09107 · Cited by 261 · see citing works
NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain
Kim, D., You, B., Jo, E., Han, S., Simon, M. I., & Lee, S. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009926107 · Cited by 251 · see citing works
“It has been reported that ROS works as an upstream signaling molecule for the expression of proinflammatory cytokines in macrophages (14).”
Background
Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-κB and JNK/AP-1 activation
Shan, J., Fu, J., Zhao, Z., Kong, X., Huang, H., Luo, L., & Yin, Z. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.04.011 · Cited by 251 · see citing works
Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling
Chao, L. K., Hua, K.-F., Hsu, H.-Y., Cheng, S.-S., Lin, I.-F., Chen, C.-J., Chen, S.-T., & Chang, S.-T. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.07.016 · Cited by 250 · see citing works
“MAPKs play important roles in the regulation of cytokines gene expression, such regulation including TNF and IL-1 release within cultured human and murine macrophages (Hsu and Wen, 2002).”
InfluentialSelf-citation
Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation
Ip, W., & Medzhitov, R. M. (2015) · Nature Communications · doi:10.1038/ncomms7931 · Cited by 243 · see citing works
“5b), although this effect is compounded by the effect of NAC on IL-1 gene transcription 31 .”
Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1β production
Kim, S. H., Smith, C. J., & Eldik, L. J. V. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00126-x · Cited by 234 · see citing works
Influence of fluoride, hydrogen peroxide and lactic acid on the corrosion resistance of commercially pure titanium
Mabilleau, G., Bourdon, S., Joly‐Guillou, M., Filmon, R., Baslé, M. F., & Chappard, D. (2005) · Acta Biomaterialia · doi:10.1016/j.actbio.2005.09.004 · Cited by 229 · see citing works
Cisplatin Cytotoxicity of Auditory Cells Requires Secretions of Proinflammatory Cytokines via Activation of ERK and NF-κB
So, H., Kim, H., Lee, J.-H., Park, C., Kim, Y., Kim, E., Kim, J.-K., Yun, K.-J., Lee, K.-M., Lee, H.-Y., et al. (2007) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-007-0084-9 · Cited by 229 · see citing works
“It has also been reported that p38 and ERK pathways play an important role in IL-1b and TNF-a production, respectively (Hsu and Wen 2002; Shi et al. 2002).”
Recent Insights into the Role of the Innate Immune System in the Development of Alcoholic Liver Disease
Nagy, L. E. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322800803 · Cited by 227 · see citing works
Nrf2-mediated induction of p62 controls Toll-like receptor-4–driven aggresome-like induced structure formation and autophagic degradation
Fujita, K.-I., Maeda, D., Xiao, Q., & Srinivasula, S. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014156108 · Cited by 225 · see citing works
“Given that LPS-induced ROS selectively activates p38, but not JNK (23), we speculated that the ROS-p38 axis might be involved in the induction of p62 and ALIS formation.”
BackgroundInfluential
Study on the Antiinflammatory Activity of Essential Oil from Leaves of Cinnamomum osmophloeum
Chao, L. K., Hua, K.-F., Hsu, H.-Y., Cheng, S.-S., Liu, J.-Y., & Chang, S.-T. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051151u · Cited by 221 · see citing works
Self-citation
Lactate Boosts TLR4 Signaling and NF-κB Pathway-Mediated Gene Transcription in Macrophages via Monocarboxylate Transporters and MD-2 Up-Regulation
Samuvel, D. J., Sundararaj, K. P., Nareika, A., Lopes-Virella, M. F., & Huang, Y. Q. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802059 · Cited by 220 · see citing works
“It has been shown that ROS modulates NF- B-dependent transcription of inflammatory gene expression through their involvement in the early TLR4-mediated cellular responses (45, 46).”
Background
Mitogen-activated protein kinase pathways in redox signaling
Torrès, M. (2003) · Frontiers in bioscience · doi:10.2741/999 · Cited by 218 · see citing works
Role of reactive oxygen species in LPS‐induced production of prostaglandin E2in microglia
Wang, T., Qin, L., Liu, B., Liu, Y., Wilson, B. C., Eling, T. E., Langenbach, R. I., Taniura, S., & Hong, J. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02242.x · Cited by 218 · see citing works
A Review on Anti-Inflammatory Activity of Phenylpropanoids Found in Essential Oils
Sá, R. D. C. D. S. E., Andrade, L., de Oliveira, R. D. R. B., & de Sousa, D. P. (2014) · Molecules · doi:10.3390/molecules19021459 · Cited by 219 · see citing works
“As these subtypes of MAPKs have been implicated in the regulation of cytokines gene expression, such as TNF and IL-1, as evidenced in culture human and murine macrophages [45], it is believed that cinnamaldehyde inhibitory action on cytokines synthesis could be related to the reduction of ERK 1/2 and JNK 1/2 activatio…”
Background
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation
Gandhirajan, R. K., Meng, S., Chandramoorthy, H. C. K., Mallilankaraman, K. B., Mancarella, S., Gao, H., Razmpour, R., Yang, X. F., Houser, S. R., Chen, J., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65647 · Cited by 208 · see citing works
“LPS is a major component of the bacterial cell wall widely used to induce ALI in murine models (41).”
Influential
Reactive Oxygen and Nitrogen Species Differentially Regulate Toll-Like Receptor 4-Mediated Activation of NF-κB and Interleukin-8 Expression
Ryan, K. A., Smith, M. F., Sanders, M. K., & Ernst, P. B. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2123-2130.2004 · Cited by 198 · see citing works
“It has long been known that ROS play a role in intracellular signaling, but the various mechanisms by which the cellular redox state can influence signaling pathways are extremely complex (2, 14, 19).”
Background
Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-α production
Thakur, V., Pritchard, M. T., McMullen, M. R., Wang, Q., & Nagy, L. E. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1005613 · Cited by 196 · see citing works
“For example, Hsu and Wen [28] demonstrated that LPS-stimulated ROS production acts via p38 and ERK1/2 MAPKs to enhance interleukin-1 gene expression.”
Background
Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy
Qiu, Y.-Y., & Tang, L. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.004 · Cited by 196 · see citing works
“1 murine macrophage cell ine described the significant regulatory role of MAPK signalling olecules, such as p38, JNK and ERK, in the expression of IL-1 and nflammasome components [33,71,72].”
Background
Mycobacterium tuberculosis secretory proteins CFP‐10, ESAT‐6 and the CFP10:ESAT6 complex inhibit lipopolysaccharide‐induced NF‐κB transactivation by downregulation of reactive oxidative species (ROS) production
Ganguly, N., Giang, P. H., Gupta, C., Basu, S. K., Siddiqui, I., Salunke, D. M., & Sharma, P. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100117 · Cited by 183 · see citing works
ATR-dependent radiation-induced γH2AX foci in bystander primary human astrocytes and glioma cells
Burdak‐Rothkamm, S., Short, S. C., Folkard, M., Rothkamm, K., & Prise, K. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209863 · Cited by 190 · see citing works
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2
Plantinga, T., Crișan, T., Oosting, M., van de Veerdonk, F. L., de Jong, D. D., Philpott, D., van der Meer, J. V. D., Girardin, S., Joosten, L., & Netea, M. (2011) · Gut · doi:10.1136/gut.2010.228908 · Cited by 207 · see citing works
Near-Infrared Fluorescence Probe for in Situ Detection of Superoxide Anion and Hydrogen Polysulfides in Mitochondrial Oxidative Stress
Huang, Y. L., Yu, F., Wang, J., & Chen, L. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b00458 · Cited by 188 · see citing works
The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer’s Disease
Cole, G. M., & Frautschy, S. A. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.08.009 · Cited by 189 · see citing works
“For example, rac activation is implicated in NADPH oxidase production in reactive microglia (Hsu and Wen, 2002) and COX-2 induction (Wang et al.”
Background
Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages
Budai, M. M., Varga, A., Milesz, S., Tőzsér, J., & Benkő, S. (2013) · Molecular Immunology · doi:10.1016/j.molimm.2013.05.005 · Cited by 180 · see citing works
“…Nlrp3 and caspase-1 and studies on J774A.1 murine macrophage cell line described the significant regulatory role of MAPK signaling such as p38, JNK and ERK in the expression of IL-1␤ and inflammasome components (Bauernfeind et al., 2009; Qiao et al., 2012; Hsu and Wen, 2002; Liao et al., 2012).”
Background
Inhibition of MMP‐3 or ‐9 suppresses lipopolysaccharide‐induced expression of proinflammatory cytokines and iNOS in microglia
Woo, M., Park, J., Choi, I., Kim, W., & Kim, H. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05430.x · Cited by 160 · see citing works
“Cross-regulation between reactive oxygen species production and MMP expression in LPS-stimulated microglia Reactive oxygen species plays an important role in inducing inflammatory mediators in microglia (Hsu and Wen 2002; Jian and Rosenberg 2005).”
Background
Extract of Reishi Polysaccharides Induces Cytokine Expression via TLR4-Modulated Protein Kinase Signaling Pathways
Hsu, H., Hua, K., Lin, C., Lin, C., Hsu, J., & Wong, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.10.5989 · Cited by 161 · see citing works
Self-citation
On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death
Kell, D. B., & Pretorius, E. (2015) · Integrative Biology · doi:10.1039/c5ib00158g · Cited by 160 · see citing works
Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases
Ballance, W. C., Qin, E. C., Chung, H. J., Gillette, M. U., & Kong, H. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119292 · Cited by 156 · see citing works
“Bacterial lipopolysaccharides (LPS)-mediated ROS, for instance, has been shown to stimulate macrophages to release pro-inflammatory cytokine interleukin 1 (IL-1β) and tumor necrosis factor (TNF) [48].”
Background
Increased production of inflammatory cytokines in mild cognitive impairment
Magaki, S., Mueller, C., DICKSON, C., & Kirsch, W. M. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.09.015 · Cited by 156 · see citing works
“In general, PHA stimulates lymphocyte proliferation, while LPS stimulates monocytes to release IL-1 and TNF-α (Hsu and Wen, 2002; Tyrsted and Munch-Petersen, 1977; Zhu et al., 2000).”
Background
Tissue factor mediates inflammation
Chu, A. J. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.06.005 · Cited by 156 · see citing works
Terminalia bellirica (Gaertn.) Roxb. Extract and Gallic Acid Attenuate LPS‐Induced Inflammation and Oxidative Stress via MAPK/NF‐κB and Akt/AMPK/Nrf2 Pathways
Tanaka, M., Kishimoto, Y., Sasaki, M., Sato, A., Kamiya, T., Kondo, K., & Iida, K. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9364364 · Cited by 154 · see citing works
“inflammatory mediator expression in macrophages [9].”
Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress
Li, L., Shoji, W., Takano, H., Nishimura, N., Aoki, Y., Takahashi, R., Goto, S., Kaifu, T., Takai, T., & Obinata, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.022 · Cited by 153 · see citing works
Microglia-aging: Roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging
Nakanishi, H., & Wu, Z. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.02.001 · Cited by 149 · see citing works
Hsp70 inhibits lipopolysaccharide‐induced NF‐κB activation by interacting with TRAF6 and inhibiting its ubiquitination
Chen, H., Wu, Y., Zhang, Y., Jin, L., Luo, L., Xue, B., Chen, L., Zhang, X., & Yin, Z. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.066 · Cited by 149 · see citing works
Role of selenium-containing proteins in T-cell and macrophage function
Carlson, B. A., Yoo, M., Shrimali, R. K., Irons, R., Gladyshev, V. N., Hatfield, D. L., & Park, J. M. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s002966511000176x · Cited by 143 · see citing works
“The fact that several inflammatory stimuli such as lipopolysaccharide (LPS) cause transient ROS accumulation as part of cellular signalling events((32,33)), and several selenoproteins, e.”
Background
Awareness and current knowledge of Parkinson’s disease: a neurodegenerative disorder
Khan, A. U., Akram, M., Daniyal, M., & Zainab, R. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1486837 · Cited by 145 · see citing works
“The existence of synuclein accumulation in the SN was identified, whereas neither group revealed an advanced motor malfunction [175].”
Background
Gasdermin D pore-forming activity is redox-sensitive
Devant, P., Boršić, E., Ngwa, E. M., Xiao, H., Chouchani, E. T., Thiagarajah, J. R., Hafner‐Bratkovič, I., Evavold, C. L., & Kagan, J. C. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112008 · Cited by 145 · see citing works
Obstacles against the Marketing of Curcumin as a Drug
Hassanzadeh, K., Buccarello, L., Dragotto, J., Mohammadi, A., Corbo, M., & Feligioni, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186619 · Cited by 145 · see citing works
ICAM-1 induction by TNFα and IL-6 is mediated by distinct pathways via Rac in endothelial cells
Wung, B., Ni, C., & Wang, D. L. (2005) · Journal of Biomedical Science · doi:10.1007/s11373-004-8170-z · Cited by 138 · see citing works
“Inhibition of Rac1mediated ROS production has been shown to attenuate cytokine-induced endothelial responses [ 47 , 48].”
Background
Adiponectin normalizes LPS-stimulated TNF-α production by rat Kupffer cells after chronic ethanol feeding
Thakur, V., Pritchard, M. T., McMullen, M. R., & Nagy, L. E. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00553.2005 · Cited by 138 · see citing works
“LPS-stimulated production of ROS has been implicated in the activation of ERK1/2 in macrophages and monocytes (12, 17).”
Background
Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophages
Okugawa, S., Ota, Y., Kitazawa, T., Nakayama, K., Yanagimoto, S., Tsukada, K., Kawada, M., & Kimura, S. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00026.2003 · Cited by 132 · see citing works
“A recent study demonstrated that the PI3K/Akt pathway positively regulates NF- B-dependent gene expression (21, 51).”
BackgroundInfluential
Cyclooxygenase‐2 Regulates NLRP3 Inflammasome‐Derived IL‐1β Production
Hua, K., Chou, J., Ka, S., Tasi, Y., Chen, A., Wu, S., Chiu, H., Wong, W.-T., Wang, Y., Tsai, C., et al. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24815 · Cited by 132 · see citing works
Reactive oxygen species up-regulate CD11b in microglia via nitric oxide: Implications for neurodegenerative diseases
Roy, A., Jana, A., Yatish, K., Freidt, M. B., Fung, Y. K., Martinson, J., & Pahan, K. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.026 · Cited by 131 · see citing works
Protective Role of Ternatin Anthocyanins and Quercetin Glycosides from Butterfly Pea (Clitoria ternatea Leguminosae) Blue Flower Petals against Lipopolysaccharide (LPS)-Induced Inflammation in Macrophage Cells
Nair, V., Bang, W. Y., Schreckinger, E., Andarwulan, N., & Cisneros‐Zevallos, L. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b00928 · Cited by 130 · see citing works
Evidence that Cisplatin-induced Auditory Damage is Attenuated by Downregulation of Pro-inflammatory Cytokines Via Nrf2/HO-1
So, H., Kim, H., Kim, Y., Kim, E., Pae, H., Chung, H., Kim, H. J., Kwon, K., Lee, K., Lee, H.-Y., et al. (2008) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-008-0126-y · Cited by 130 · see citing works
“For example, it has been reported that the p38 and ERK pathways play an important role in IL-1β and TNF-α production, respectively (Hsu and Wen 2002; Shi et al. 2002).”
Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation
Bağdaş, D., Gül, Z., Meade, J. A., Çam, B., Çinkılıç, N., & Gurun, M. S. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191021111809 · Cited by 126 · see citing works
Luteolin and chicoric acid synergistically inhibited inflammatory responses via inactivation of PI3K-Akt pathway and impairment of NF-κB translocation in LPS stimulated RAW 264.7 cells
Park, C. M., Jin, K.-S., Lee, Y., & Song, Y. S. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.04.007 · Cited by 122 · see citing works
“This was stimulated by LPS treatment in RAW 264.7 cells as previously described (Hsu and Wen, 2002) and free radical production was analyzed using DCF-DA.”
MethodInfluential
Positive Role of CCAAT/Enhancer-Binding Protein Homologous Protein, a Transcription Factor Involved in the Endoplasmic Reticulum Stress Response in the Development of Colitis
Namba, T., Tanaka, K., Ito, Y., Ishihara, T., Hoshino, T., Gotoh, T., Endo, M., Sato, K., & Mizushima, T. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080864 · Cited by 121 · see citing works
“Treatment of WT macrophages with LPS stimulated ROS production (Figure 8C), as has been described previously.(46) However, this stimulation was not clearly observed in CHOPnull macrophages, indicating that CHOP is responsible for LPS-stimulated ROS production (Figure 8C).”
Method
Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: A review
Ouyang, Y., Zhao, J., & Wang, S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.12.032 · Cited by 119 · see citing works
Endosomal Nox2 Facilitates Redox-Dependent Induction of NF-κB by TNF-α
Li, Q., Spencer, N. Y., Oakley, F. D., Buettner, G. R., & Engelhardt, J. F. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2407 · Cited by 120 · see citing works
“…be induced in cells after receptor stimulation with various ligands such as tumor necrosis factor alpha (TNF-a ) (12, 39), lipopolysaccharide (LPS) (24, 51), angiotensin II (18), platelet-derived growth factor (PDGF) (56), insulin (37), epidermal growth factor (EGF) (2), and interleukin-1 b (IL-1…”
Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression
Kim, J. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.11.004 · Cited by 120 · see citing works
Redox-Sensing Release of Human Thioredoxin from T Lymphocytes with Negative Feedback Loops
Kondo, N., Ishii, Y., Kwon, Y.-W., Tanito, M., Horita, H., Nishinaka, Y., Nakamura, H., & Yodoi, J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.442 · Cited by 116 · see citing works
“In support of this hypothesis, it is reported that LPS-induced pro-IL-1 production and IL-1 secretion corresponded to the production of ROS and activation of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase (33).”
Background
Early Growth Response-1 Transcription Factor Is Essential for Ethanol-Induced Fatty Liver Injury in Mice
McMullen, M. R., Pritchard, M. T., Wang, Q., Millward, C. A., Croniger, C. M., & Nagy, L. E. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.065 · Cited by 116 · see citing works
Anti-Inflammatory and Anti-Oxidative Activity of Indole-3-Acetic Acid Involves Induction of HO-1 and Neutralization of Free Radicals in RAW264.7 Cells
Ji, Y. S., Yin, W., Liang, Y., Sun, L., Yin, Y., & Zhang, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051579 · Cited by 115 · see citing works
“, reactive oxidative species (ROS) and nitric oxide (NO)) [4,5].”
Background
AMPK Activation Inhibits Expression of Proinflammatory Mediators Through Downregulation of PI3K/p38 MAPK and NF-κB Signaling in Murine Macrophages
Huang, B., Lin, C.-H., Chen, H., Lin, J., Cheng, Y., & Kao, S. (2014) · DNA and Cell Biology · doi:10.1089/dna.2014.2630 · Cited by 113 · see citing works
“LPS binds to toll-like receptor (TLR)-4 and induces secretion of a variety of proin-ﬂammatory cytokines, such as interleukin (IL)-1 b , IL-6, and tumor necrosis factor (TNF)- a (Raabe et al. , 1998; Hsu and Wen, 2002).”
Fucoidan induces Toll-like receptor 4-regulated reactive oxygen species and promotes endoplasmic reticulum stress-mediated apoptosis in lung cancer
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Authors: Hsu, H.-Y., & Wen, M.-H.
Affiliations: National Yang Ming University (TW)
Corresponding author: Hsu, Hsien-Yeh
ORCID: Wen, Meng-Hsuan
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2002-06
Volume: 277
Issue: 25
Pages: 22131-22139
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m111883200
OpenAlex: W2016146035
Cited by: 519
References: 72
Citations by year: 2026: 13 · 2025: 17 · 2024: 20 · 2023: 21 · 2022: 21 · 2021: 27 · 2020: 22 · 2019: 23 · 2018: 25 · 2017: 33 · 2016: 27 · 2015: 21 · 2014: 18 · 2013: 19 · 2012: 14
FWCI: 7.22
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6719 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: lipopolysaccharide, IL-1β, reactive oxygen species, N-acetylcysteine, macrophages, Rac, p38 MAPK, JNK, ERK, phosphatidylinositol 3-kinase, tyrosine kinase, NADPH oxidase, signal transduction, inflammatory cytokines, TNF-α
MeSH terms: Animals, Carrier Proteins, Cell Line, Chromones, Curcumin, Enzyme Activation, Enzyme Inhibitors, Enzyme-Linked Immunosorbent Assay, Flavonoids, Gene Expression Regulation, Genes, Dominant, Imidazoles, Interleukin-1, Lipopolysaccharides, Macrophages, Models, Biological, Morpholines, Naphthalenes, Oxygen, Protein Binding, Pyridines, Time Factors, Transfection, Signal Transduction, Reactive Oxygen Species, rac1 GTP-Binding Protein, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase Kinases, Intracellular Signaling Peptides and Proteins, JNK Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, MAP Kinase Kinase 4, Mice

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Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression

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