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S100 proteins structure functions and pathology

Heizmann, Claus W·2002·Frontiers in Bioscience

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Abstract

S100 proteins regulate intracellular processes such as cell growth and motility, cell cycle regulation, transcription and differentiation. Twenty members have been identified so far, and altogether, S100 proteins represent the largest subgroup in the EF-hand Ca2+ -binding protein family. A unique feature of these proteins is that individual members are localized in specific cellular compartments from which some are able to relocate upon Ca2+ activation, transducing the Ca2+ signal in a temporal and spacial manner by interacting with different targets specific for each S100 protein. Some members are even secreted from cells exerting extracellular, cytokine-like activities partially via the surface receptor RAGE (receptor for advanced glycation endproducts) with paracrine effects e.g. on neurons, promoting their survival during development or after injury. Another important aspect is that 14 bona fide S100 genes are found in a gene cluster on human chromosome 1q21 where a number of chromosomal abnormalities occur. This results in a deregulated expression of some S100 genes associated with neoplasias. Recently, S100 proteins have received increasing attention due to their close association with several human diseases including cardiomyopathy, neurodegenerative disorders and cancer. They have also been proven to be valuable in the diagnostic of these diseases, as predictive markers of improving clinical management, outcome and survival of patients and are considered having a potential as drug targets to improve therapies.

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Ehlermann, P., Remppis, A., Guddat, O., Weimann, J., Schnabel, P. A., Motsch, J., Heizmann, C. W., & Katus, H. A. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(99)00106-4 · Cited by 61
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Learning and Memory in S100-β Transgenic Mice: An Analysis of Impaired and Preserved Function
Winocur, G., Roder, J., & Lobaugh, N. J. (2001) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2000.3961 · Cited by 59
The Crystal Structure of Metal-free Human EF-hand Protein S100A3 at 1.7-Å Resolution
Fritz, G., Mittl, P. R. E., Vašák, M., ̈tter, M. G. G., & Heizmann, C. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200574200 · Cited by 56
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Molecular Characterization and Tissue Distribution of a Novel Member of the S100 Family of EF-Hand Proteins,
Gribenko, A. V., Hopper, J. E., & Makhatadze, G. I. (2001) · Biochemistry · doi:10.1021/bi0114731 · Cited by 54
S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells
Hsieh, H., Schäfer, B. W., Cox, J. A., & Heizmann, C. W. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.15.3149 · Cited by 53
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High resolution solution structure of apo calcyclin and structural variations in the S100 family of calcium-binding proteins
Mäler, L., Potts, B. C. M., & Chazin, W. (1999) · Journal of Biomolecular NMR · doi:10.1023/a:1008315517955 · Cited by 53
Differential expression of S100 calcium‐binding proteins characterizes distinct clinical entities in both WHO grade II and III astrocytic tumours
Camby, I., Lefranc, F., Titeca, G., Neuci, S., Fastrez, M., Dedecken, L., Schäfer, B. W., Brotchi, J., Heizmann, C. W., Pochet, R., et al. (2000) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2000.00223.x · Cited by 52
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Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cells.
Guo, X., Chambers, A. F., Parfett, C. L. J., Waterhouse, P. D., Murphy, L. C., Reid, R. E., Craig, A. M., Edwards, D. R., & Denhardt, D. T. (1990) · PubMed · Cited by 52
Transcriptional regulation of S100A1 and expression during mouse heart development
Kiewitz, R., Lyons, G. E., Schäfer, B. W., & Heizmann, C. W. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(00)00097-5 · Cited by 48
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Human S100A11 Exhibits Differential Steady-State RNA Levels in Various Tissues and a Distinct Subcellular Localization
Inada, H., Naka, M., Tanaka, T., Davey, G. E., & Heizmann, C. W. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1319 · Cited by 43
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S100A6, a calcium- and zinc-binding protein, is overexpressed in SOD1 mutant mice, a model for amyotrophic lateral sclerosis
Hoyaux, D., Alao, J. M., Fuchs, J., Robert Kiss, A., Keller, B. U., Heizmann, C. W., Pochet, R., & Frermann, D. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(00)00101-4 · Cited by 43
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Calgranulin C is Overexpressed in Lesional Psoriasis
Mirmohammadsadegh, A., Tschakarjan, E., Ljoljic, A., Bohner, K., Goos, M., Hengge, U. R., Michel, G., & Ruzicka, T. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00005-2.x · Cited by 42
Abnormal exploratory behavior in transgenic mice carrying multiple copies of the human gene for S100 beta.
Gerlai, R. T., & Roder, J. (1995) · PubMed · Cited by 38
Acute exacerbation of multiple sclerosis increases plasma levels of S-100 protein
Missler, U., Wandinger, K.-P., Wiesmann, M., et al. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1997.tb00256.x · Cited by 32
S100A1 modulates skeletal muscle contraction by desensitizing calcium activation of isometric tension, stiffness and ATPase
Adhikari, B. B., & Wang, K. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02444-9 · Cited by 20
Translocation of S100A1 Calcium Binding Protein during Heart Surgery
Brett, W., Mandinova, A., Remppis, A., Sauder, U., Rüter, F., Heizmann, C. W., Aebi, U., & Zerkowski, H.-R. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4996 · Cited by 18
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A Unique Exon–Intron Organization of a Porcine S100C Gene: Close Evolutionary Relationship to Calmodulin Genes
Nakamura, T., Hayashi, M., Kato, A., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8158 · Cited by 8
[7] Calcium-binding proteins and their assessment in ocular diseases
Polans, A. S., Gee, R. L., Walker, T. M., & van Ginkel, P. R. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)16719-9 · Cited by 4

HMGB1 and RAGE in Inflammation and Cancer
Sims, G. P., Rowe, D. C., Rietdijk, S. T., Herbst, R., & Coyle, A. J. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132603 · Cited by 1,436
S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)
Marenholz, I., Heizmann, C. W., & Fritz, G. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.096 · Cited by 848
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The endogenous Toll–like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer
Ehrchen, J. M., Sunderkötter, C., Foell, D., Vogl, T., & Roth, J. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008647 · Cited by 846
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
Weaver, I. C. G., Meaney, M. J., & Szyf, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507526103 · Cited by 771
S100B's double life: Intracellular regulator and extracellular signal
Donato, R., Sorci, G., Riuzzi, F., Arcuri, C., Bianchi, R., Brozzi, F., Tubaro, C., & Giambanco, I. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.11.009 · Cited by 731

See all 706

Authors: Heizmann, C. W.
Venue: Frontiers in Bioscience
Publisher: IMR Press
Published: 2002
Volume: 7
Issue: 4
Pages: d1356-1368
ISSN: 1093-4715 (ISSN-L)
1093-9946
DOI: 10.2741/a846
OpenAlex: W173643440
Cited by: 706
References: 93
Type: conference abstract
Language: en
Open access: closed

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S100 proteins structure functions and pathology

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