Cited by 127Luminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsMolecular Sensors and Ion Detection

Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics

Wang, Leichen, Li, Na, Wang, Weili, Mei, Anqing, Shao, Jinjun, Wang, Wenjun, Dong, Xiaochen·2024·ACS Nano

Abstract

Organic fluorescent molecules with emission in the second near-infrared (NIR-II) biological window have aroused increasing investigation in cancer phototheranostics. Among these studies, Benzobisthiadiazole (BBT), with high electron affinity, is widely utilized as the electron acceptor in constructing donor-acceptor-donor (D-A-D) structured fluorophores with intensive near-infrared (NIR) absorption and NIR-II fluorescence. Until now, numerous BBT-based NIR-II dyes have been employed in tumor phototheranostics due to their exceptional structure tunability, biocompatibility, and photophysical properties. This review systematically overviews the research progress of BBT-based small molecular NIR-II dyes and focuses on molecule design and bioapplications. First, the molecular engineering strategies to fine-tune the photophysical properties in constructing the high-performance BBT-based NIR-II fluorophores are discussed in detail. Then, their biological applications in optical imaging and phototherapy are highlighted. Finally, the current challenges and future prospects of BBT-based NIR-II fluorescent dyes are also summarized. This review is believed to significantly promote the further progress of BBT-derived NIR-II fluorophores for cancer phototheranostics.

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Crossref · 10.1021/acsnano.3c12316

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143 of 143 references verified0 citation errors · 0 not checkable

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  • Symmetric donor-acceptor-donor architectures are superior to donor-acceptor configurations for facilitating efficient intramolecular charge transfer.

    “Further optimization has shown that symmetric donor-acceptor-donor (D-A-D) architectures are superior to D-A configurations for facilitating efficient ICT151.”

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Authors
Wang, L., Li, N., Wang, W., Mei, A., Shao, J., Wang, W., & Dong, X.
Affiliations
  • Nanjing Tech University (CN)
  • Jiangsu Normal University (CN)
Corresponding author
  • Shao, Jinjun
  • Dong, Xiaochen
Venue
ACS Nano
Published
2024-01-31
Volume
18
Issue
6
Pages
4683-4703
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
OpenAlex
W4391380548
Cited by
127
References
143
Citations by year
2026: 36 · 2025: 63 · 2024: 28
FWCI
3.03
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Nano (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Jiangsu Provincial Key Research and Development Program (BE2021711)
  • Taishan Scholar Project of Shandong Province
  • National Natural Science Foundation of China (62235007, 62288102, 22175089, 62275119, 62120106002)
  • Natural Science Foundation of Shandong Province (ZR2020KB018)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Keywords
benzobisthiadiazole, NIR-II fluorescence, small-molecule fluorophores, donor-acceptor-donor structure, electron acceptors, molecular engineering, photophysical properties, optical imaging, phototherapy
MeSH terms
Fluorescence, Fluorescent Dyes, Humans, Neoplasms, Phototherapy, Nanoparticles, Optical Imaging

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