Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics
Abstract
Organic fluorescent molecules with emission in the second near-infrared (NIR-II) biological window have aroused increasing investigation in cancer phototheranostics. Among these studies, Benzobisthiadiazole (BBT), with high electron affinity, is widely utilized as the electron acceptor in constructing donor-acceptor-donor (D-A-D) structured fluorophores with intensive near-infrared (NIR) absorption and NIR-II fluorescence. Until now, numerous BBT-based NIR-II dyes have been employed in tumor phototheranostics due to their exceptional structure tunability, biocompatibility, and photophysical properties. This review systematically overviews the research progress of BBT-based small molecular NIR-II dyes and focuses on molecule design and bioapplications. First, the molecular engineering strategies to fine-tune the photophysical properties in constructing the high-performance BBT-based NIR-II fluorophores are discussed in detail. Then, their biological applications in optical imaging and phototherapy are highlighted. Finally, the current challenges and future prospects of BBT-based NIR-II fluorescent dyes are also summarized. This review is believed to significantly promote the further progress of BBT-derived NIR-II fluorophores for cancer phototheranostics.
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Symmetric donor-acceptor-donor architectures are superior to donor-acceptor configurations for facilitating efficient intramolecular charge transfer.
“Further optimization has shown that symmetric donor-acceptor-donor (D-A-D) architectures are superior to D-A configurations for facilitating efficient ICT151.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [151]
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- Authors
- Wang, L., Li, N., Wang, W., Mei, A., Shao, J., Wang, W., & Dong, X.
- Affiliations
- Nanjing Tech University (CN)
- Jiangsu Normal University (CN)
- Corresponding author
- Shao, Jinjun
- Dong, Xiaochen
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2024-01-31
- Volume
- 18
- Issue
- 6
- Pages
- 4683-4703
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W4391380548
- Cited by
- 127
- References
- 143
- Citations by year
- 2026: 36 · 2025: 63 · 2024: 28
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jiangsu Provincial Key Research and Development Program (BE2021711)
- Taishan Scholar Project of Shandong Province
- National Natural Science Foundation of China (62235007, 62288102, 22175089, 62275119, 62120106002)
- Natural Science Foundation of Shandong Province (ZR2020KB018)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- benzobisthiadiazole, NIR-II fluorescence, small-molecule fluorophores, donor-acceptor-donor structure, electron acceptors, molecular engineering, photophysical properties, optical imaging, phototherapy
- MeSH terms
- Fluorescence, Fluorescent Dyes, Humans, Neoplasms, Phototherapy, Nanoparticles, Optical Imaging
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