In Vivo Imaging of Macrophage Activity in the Coronary Arteries Using 68Ga-DOTATATE PET/CT: Correlation with Coronary Calcium Burden and Risk Factors
Open accessAbstract
UNLABELLED: We measured the uptake of the somatostatin receptor ligand (68)Ga-[1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid]-D-Phe(1),Tyr(3)-octreotate (DOTATATE) in the left anterior descending coronary artery (LAD) in association with calcified plaques (CPs) and cardiovascular risk factors. METHODS: Seventy consecutive tumor patients were examined by whole-body (68)Ga-DOTATATE contrast-enhanced PET/CT. Blood-pool-corrected standardized uptake value (target-to-background ratio) was measured in the LAD, and CT images were used to detect CP. Cardiovascular risk factors and history of prior cardiovascular events were recorded. RESULTS: (68)Ga-DOTATATE uptake was detectable in the LAD of all patients. Target-to-background ratio in the LAD correlated significantly with the presence of CP (R = 0.34; P < 0.01), prior vascular events (R = 0.26; P < 0.05), and male sex (R = 0.29; P < 0.05), whereas CP correlated with these parameters but also with age (R = 0.34; P < 0.01) and hypertension (R = 0.25; P < 0.05). CONCLUSION: In a series of oncologic patients, those with prior cardiovascular events and calcified atherosclerotic plaques showed significantly increased (68)Ga-DOTATATE uptake in the LAD, suggesting a potential role of this tracer for plaque imaging in the coronary arteries.
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Various radioactive tracers have been developed to detect different aspects of atherosclerotic disease more specifically.
“To detect different aspects of atherosclerotic disease more specifically, various radioactive tracers have been developed145–147.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [146]
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Perspectives and opportunities for nanomedicine in the management of atherosclerosis
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- Authors
- Rominger, A., Saam, T., Vogl, E., Übleis, C., la Fougère, C., Förster, S., Haug, A., Cumming, P., Reiser, M. F., Nikolaou, K., Bartenstein, P., & Hacker, M.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Hacker, Marcus
- ORCID
- Venue
- Journal of Nuclear Medicine
- Publisher
- Society of Nuclear Medicine
- Published
- 2010-01-15
- Volume
- 51
- Issue
- 2
- Pages
- 193-197
- ISSN
- 0161-5505 (ISSN-L)
- 2159-662X
- OpenAlex
- W2065733196
- Cited by
- 159
- References
- 24
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 12 · 2019: 11 · 2018: 9 · 2017: 7 · 2016: 19 · 2015: 18 · 2014: 11 · 2013: 12 · 2012: 8
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Nuclear Medicine (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Funders
- Novartis
- Novartis Pharma
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- 68Ga-DOTATATE, somatostatin receptor imaging, calcified coronary plaque, left anterior descending artery, cardiovascular risk factors, atherosclerosis, PET/CT, cancer patients
- MeSH terms
- Adult, Aged, Aged, 80 and over, Calcium, Coronary Artery Disease, Coronary Vessels, Female, Gallium Radioisotopes, Humans, Macrophages, Male, Middle Aged, Organometallic Compounds, Retrospective Studies, Risk Factors, Tomography, X-Ray Computed, Coronary Angiography, Neuroendocrine Tumors, Radiopharmaceuticals, Positron-Emission Tomography
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