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Cited by 45Oral microbiology and periodontitis researchDental Research and COVID-19Gut microbiota and health

From the acta prize lecture 2014: the periodontal-systemic connection seen from a microbiological standpoint: Summary of the Acta Odontologica Scandinavia Price Lecture 2014 presented at the meeting of the IADR/Pan European Region in Dubrovnik, September 10–13. 2014

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Olsen, Ingar·2015·Acta Odontologica Scandinavica
DOI 10.3109/00016357.2015.1007480
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Abstract

OBJECTIVE: To give an overview of the periodontal-systemic connection seen from a microbiologist. METHODS: Original research papers, review articles and workshop proceedings were consulted. RESULTS: Periodontal bacteria can cross epithelial cells, enter the circulation, invade endothelial cells, induce endothelial cell dysfunction and activate inflammatory and immune responses. Several studies support the association between periodontitis (PD) and cardiovascular disease. Severe PD involves a risk for development of type 2 diabetes. Maternal PD is moderately associated with adverse pregnancy outcome and pre-eclampsia. Dental plaque can contain respiratory pathogens able to promote chronic obstructive pulmonary disease and pneumonia. Periodontal bacterial DNA has been detected in synovial fluid of patients with rheumatoid arthritis. Minor evidence exists for associations between PD and chronic kidney disease, obesity, cancer, metabolic syndrome and cognitive impairment. Concerns can be raised as to the interpretation of some study results due to heterogeneity in definitions used for PD, too much weight upon in vitro studies with a few selected organisms and failing recognition that the majority of the periodontal microbiota is not yet cultivated. CONCLUSION: Periodontal bacteria may participate in extra-oral infections such as CVD, diabetes, APO, pre-eclampsia, COPD, pneumonia, RA, CKD, obesity, cancer, MetS and cognitive impairment. Most knowledge is based on associations which do not necessarily imply causality. Future studies should reach consensus on the definition of PD and systemic disease outcomes, recognize the full spectrum of the microbiota in PD and bacteremia, including not-yet-cultivated organisms and delineate the clinical significance of genetic strain variations and the role of periodontopathogenic vs gut organisms within atheromatous lesions. For demonstration of causality, large, long-term clinical studies should use well-defined criteria for PD and robust disease outcomes to elucidate the importance of PD intervention and prevention.

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  • Many associations between oral microbes, specifically those implicated in periodontal disease, and other common chronic conditions, such as cardiovascular disease and high blood pressure, have been established.

    “Many associations between oral microbes, specifically those implicated in periodontal disease, and other common chronic conditions, such as cardiovascular disease and high blood pressure, have been established.40”

    From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [40]

  • Dental plaques contain pathogens which could aggravate the state of pneumonia, including P. gingivalis, which can synergistically enhance pathogenicity.

    “Dental plaques contain pathogens which could aggravate the state of pneumonia (Olsen, 2015), including P. gingivalis, which can synergistically enhance pathogenicity (Miller et al., 2018).”

    From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Olsen, 2015

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Authors
Olsen, I.
Affiliations
University of Oslo (NO)
Corresponding author
Olsen, Ingar
ORCID
Olsen, Ingar
Venue
Acta Odontologica Scandinavica
Publisher
MJS Publishing, Medical Journals Sweden AB
Published
2015-04-20
Volume
73
Issue
8
Pages
563-568
ISSN
  • 0001-6357 (ISSN-L)
  • 1502-3850
DOI
10.3109/00016357.2015.1007480
OpenAlex
W2133398111
Cited by
45
References
56
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 6
FWCI
0.98
Type
journal article
Language
en
Open access
Locations
  • Acta Odontologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
periodontitis, periodontal pathogens, cardiovascular disease, type 2 diabetes, preeclampsia, adverse pregnancy outcomes, chronic obstructive pulmonary disease, pneumonia, rheumatoid arthritis, synovial fluid, chronic kidney disease, obesity, cancer, metabolic syndrome, cognitive impairment, periodontal microbiota, bacteremia, endothelial dysfunction, inflammation
MeSH terms
Disease, Focal Infection, Dental, Humans, Periodontitis, Risk Factors, Bacteremia

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