Looking in the Porphyromonas gingivalis cabinet of curiosities: the microbium, the host and cancer association
Open accessAbstract
The past decades of biomedical research have yielded massive evidence for the contribution of the microbiome in the development of a variety of chronic human diseases. There is emerging evidence that Porphyromonas gingivalis, a well-adapted opportunistic pathogen of the oral mucosa and prominent constituent of oral biofilms, best known for its involvement in periodontitis, may be an important mediator in the development of a number of multifactorial and seemingly unrelated chronic diseases, such as rheumatoid arthritis and orodigestive cancers. Orodigestive cancers represent a large proportion of the total malignancies worldwide, and include cancers of the oral cavity, gastrointestinal tract and pancreas. For prevention and/or enhanced prognosis of these diseases, a good understanding of the pathophysiological mechanisms and the interaction between P. gingivalis and host is much needed. With this review, we introduce the currently accumulated knowledge on P. gingivalis's plausible association with cancer as a risk modifier, and present the putative cancer-promoting cellular and molecular mechanisms that this organism may influence in the oral mucosa.
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More recent work has linked Porphyromonas gingivalis to atherosclerosis, smoking, and several cancers.
“while more recent work has linked Porphyromonas gingivalis to atherosclerosis[185], smoking[186], and several cancers[187].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [187]
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- Authors
- Atanasova, K. R., & Yilmaz, Ö.
- Affiliations
- University of Florida Health (US)
- Corresponding author
- Yilmaz, Ö.
- Venue
- Molecular Oral Microbiology
- Publisher
- Wiley
- Published
- 2014-02-08
- Volume
- 29
- Issue
- 2
- Pages
- 55-66
- ISSN
- 2041-1006 (ISSN-L)
- 2041-1014
- PMC
- PMC3949145
- OpenAlex
- W2077226878
- Cited by
- 129
- References
- 80
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 9 · 2023: 13 · 2022: 8 · 2021: 11 · 2020: 16 · 2019: 14 · 2018: 11 · 2017: 11 · 2016: 7 · 2015: 12 · 2014: 3
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Oral Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R56DE016593, R01DE016593)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Porphyromonas gingivalis, oral microbiota, periodontitis, dental plaque, cancer risk factors, host-pathogen interaction, chronic inflammation, oral mucosa, rheumatoid arthritis, gastrointestinal cancer, pancreatic cancer, oral cancer
- MeSH terms
- Digestive System Neoplasms, Humans, Mouth Mucosa, Periodontitis, Porphyromonas gingivalis, Microbiota
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