The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Human Forearm Muscle Metabolism during Exercise II Uptake, release and oxidation of individual FFA and glycerol
Abstract
The uptake, release, and oxidation of individual free fatty acids (FFA) in the human forearm were studied during a 60-min exercise period. Muscular uptake of FFA rose with the arterial concentration. The muscle showed a slight preference for linoleic and oleic acid compared to palmitic acid. The forearm RQ indicated a constant fat oxidation during the period of exercise. The uptake of FFA covered about 50 per cent of the fat oxidation. On the average 60 per cent of the muscular FFA-14C uptake was oxidized to 14CO2. The remaining radioactivity left the muscle as water-soluble metabolite(s). β-Hydroxybutyrate leaving the muscle was shown to be labeled. No release of glycerol accompanied the release of FFA during exercise. Glycerol-1-14C was oxidized by the exercising muscle. Glycerol dehydrogenase activity was demonstrated in human skeletal muscle.
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“Indeed, early studies demonstrated the rate of lipolysis was a key determinant of FFA uptake and oxidation in skeletal muscle and documented a linear relationship between the plasma LCFA concentration and their rate of uptake and oxidation in the muscle [85–87].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [86]
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Sorted by citations
Pathogenesis of insulin resistance in skeletal muscle
Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670
Glucose metabolism during leg exercise in man
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Self-citationSkeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance
Kiens, B. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2004 · Cited by 478
In vivo regulation of lipolysis in humans.
Coppack, S. W., Jensen, M. D., & Miles, J. M. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41207-6 · Cited by 411
Increased plasma FFA uptake and oxidation during prolonged exercise in trained vs. untrained humans
Turcotte, L. P., Richter, E. A., & Kiens, B. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.6.e791 · Cited by 258
Metadata
- Authors
- Hagenfeldt, L., & Wahren, J.
- Affiliations
- Karolinska Institutet (SE)
- ORCID
- Wahren, J.
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 1968-01
- Volume
- 21
- Issue
- 3
- Pages
- 263-276
- ISSN
- 0036-5513 (ISSN-L)
- 1502-7686
- OpenAlex
- W2059186446
- Cited by
- 138
- References
- 32
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 3 · 2020: 4 · 2017: 2 · 2016: 1 · 2015: 3 · 2012: 3
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National University of Singapore
- Vetenskapsrådet
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- free fatty acid uptake, fatty acid oxidation, glycerol oxidation, skeletal muscle metabolism, physical activity, forearm muscles, respiratory quotient, linoleic acid, oleic acid, palmitic acid, beta-hydroxybutyrate, glycerol dehydrogenase, fatty acid release
- MeSH terms
- Adult, Alcohol Oxidoreductases, Arm, Arteries, Carbon Dioxide, Carbon Isotopes, Catheterization, Chromatography, Gas, Physical Exertion, Fatty Acids, Nonesterified, Glycerol, Humans, Hydroxybutyrates, Linoleic Acids, Male, Muscles, Oleic Acids, Oxygen Consumption, Palmitic Acids, Regional Blood Flow, Statistics as Topic, Time Factors, Veins
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