The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Upregulation of miR-146a contributes to the suppression of inflammatory responses in LPS-induced acute lung injury
Abstract
Despite the critical role of microRNA in inflammatory response, little is known about its function in inflammation-induced Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS). To investigate the potential role of microRNA146a (miR-146a) in ALI, we used lipopolysaccharide (LPS)-induced ALI rat model. Our data revealed that LPS-induced lung injury in rats resulted in significant upregulation of proinflammatory cytokine tumor necrosis factor-alpha (TNF-α), IL-6, IL-1β, and miR-146a expression. LPS treatment also leads to higher expression of miR-146a as well as increase in secretion of TNF-α, IL-6, and IL-1β in alveolar macrophage (AM) NR8383 cells in a time-dependent manner. Manipulation with miR146a mimic significantly suppressed LPS-mediated TNF-α, IL-6, and IL-1β induction in NR8383 cells by repressing expression of IRAK-1 and TRAF-6. These data clearly indicate that the upregulation of miR146a suppresses inflammatory mediators in LPS induced-ALI model. Therefore, miR-146a may be therapeutically targeted as a mean to repress inflammatory response following ALI.
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“and the findings of others showing that miR-146a suppressed the inflammatory response to LPS in macrophages/monocytes (45, 46).”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [46]
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Absence of miRNA-146a Differentially Alters Microglia Function and Proteome
Martin, N. A., Hyrlov, K. H., Elkjaer, M. L., Thygesen, E. K., Wlodarczyk, A., Elbaek, K. J., Aboo, C., Okarmus, J., Benedikz, E., Reynolds, R., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01110 · Cited by 36
Metadata
- Authors
- Zeng, Z., Gong, H., Li, Y., Jie, K., Ding, C., Shao, Q., Liu, F., Zhan, Y., Nie, C., Zhu, W., & Qian, K.
- Venue
- Experimental Lung Research
- Publisher
- Informa UK Limited
- Published
- 2013-07-12
- Volume
- 39
- Issue
- 7
- Pages
- 275-282
- ISSN
- 0190-2148
- 1521-0499
- Cited by
- 128
- References
- 4
- Language
- en
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