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MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells
Abstract
In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-derived dendritic cells. Among these miRNAs, miR-155 is highly up-regulated during maturation. Using LNA silencing combined to microarray technology, we have identified the Toll-like receptor/interleukin-1 (TLR/IL-1) inflammatory pathway as a general target of miR-155. We further demonstrate that miR-155 directly controls the level of TAB2, an important signal transduction molecule. Our observations suggest, therefore, that in mature human DCs, miR-155 is part of a negative feedback loop, which down-modulates inflammatory cytokine production in response to microbial stimuli.
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The same pathway was inhibited when the miR-155 expression level went up significantly, ultimately reflecting an altered immune profile.
“However, the same pathway was inhibited when the miR-155 expression level went up significantly, ultimately reflecting an altered immune profile.”
From miR-155 induction in microglial cells suppresses Japanese encephalitis virus replication and negatively modulates innate immune responses (2014) · cites this paper as [41]
Ceppi et al. showed that low level miR-155 expression enables the activation of p38 MAPK pathway, favoring IL-1β expression, which induces inflammation in an autocrine manner.
“Ceppi et al.[41] showed that low level miR-155 expression enables the activation of p38 MAPK pathway, favoring IL-1β expression, which induces inflammation in an autocrine manner.”
From miR-155 induction in microglial cells suppresses Japanese encephalitis virus replication and negatively modulates innate immune responses (2014) · cites this paper as [41]
miR-155 is a multifunctional microRNA and it can modulate inflammatory responses in both a positive and negative way.
“The miR-155 is a multifunctional microRNA and it can modulate inflammatory responses in both a positive and negative way [40-48].”
From miR-155 induction in microglial cells suppresses Japanese encephalitis virus replication and negatively modulates innate immune responses (2014) · cites this paper as [41]
Besides its positive role in NF-κB activation and subsequent pro-inflammatory response, accumulating evidence has demonstrated that miR-155 can constitute a negative feedback loop in the NF-κB signaling pathway by targeting multiple key proteins, which ultimately leads to repression of, or at least the limitation of NF-κB activation in response to viral or microbial stimuli.
“Besides its positive role in NF-κB activation and subsequent pro-inflammatory response, accumulating evidence has demonstrated that it can constitute a negative feedback loop in the NF-κB signaling pathway by targeting multiple key proteins, which ultimately leads to repression of, or at least the limitation of NF-κB activation in response to viral or microbial stimuli [41,42,45-48].”
From miR-155 induction in microglial cells suppresses Japanese encephalitis virus replication and negatively modulates innate immune responses (2014) · cites this paper as [41]
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Metadata
- Authors
- Ceppi, M., Pereira, P. M., Dunand-Sauthier, I., Barras, E., Reith, W., Santos, M. A., & Pierre, P.
- Affiliations
- Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Case 906, 13288 Marseille cedex 9, France;
- Department of Biology and Centre for Environmental and Marine Studies, University of Aveiro, Aveiro, Portugal;
- Department of Pathology and Immunology, University of Geneva Medical School, CH-1211 Geneva, Switzerland
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-02-24
- Volume
- 106
- Issue
- 8
- Pages
- 2735-2740
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 631
- References
- 7
- Language
- en
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