The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.
Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (bbb).
Abstract
In 1995 it was reported for the first time that nanoparticles could be used for the delivery of drugs across the blood-brain barrier (BBB) following intravenous injection. In vitro and in vivo experiments show that the underlying mechanism is receptor-mediated endocytosis followed by transcytosis. No opening of the tight junctions was observed. Due to the overcoating of the nanoparticles with polysorbate 80 or poloxamers 188, apolipoproteins A-I and/or E are adsorbed from the blood on to the particle surface after injection. These apolipoproteins mediate the interaction with LDL or scavenger receptors on the BBB followed by the above brain uptake processes. Likewise, covalent attachment of these apolipoproteins or of transferrin, insulin or antibodies against the respective receptors also enables a similar nanoparticle-mediated drug transport across the BBB. From these results it can be concluded that the nanoparticles act as "Trojan Horses" taking advantage of physiological receptor-mediated transport processes across the BBB.
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“A possible mechanism of such delivery is adsorption of PS80-coated PACA nanoparticles on ApoE and B from the bloodstream upon intravenous injection followed by transcytosis across BBB using the low-density lipoprotein receptors (Kreuter, 2013).”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Kreuter, 2013
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Cites
Cordon‐Cardo, C., O’Brien, J. P., Casals, D., Rittmann-Grauer, L., Biedler, J. L., Melamed, M. R., & Bertino, J. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.695 · Cited by 1,750
Nanoparticulate systems for brain delivery of drugs.
Kreuter, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00122-8 · Cited by 1,107
Self-citationNanoparticulate systems for brain delivery of drugs
Kreuter, J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.015 · Cited by 965
Self-citationApolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier.
Kreuter, J., Shamenkov, D., Petrov, V., Ramge, P., Cychutek, K., Koch-Brandt, C., & Alyautdin, R. (2002) · Journal of drug targeting · doi:10.1080/10611860290031877 · Cited by 801
Self-citationTransport of drugs across the blood–brain barrier by nanoparticles.
Wohlfart, S., Gelperina, S., & Kreuter, J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.017 · Cited by 715
Self-citationDelivery of therapeutic agents to the central nervous system: the problems and the possibilities
Begley, D. J. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.08.001 · Cited by 679
Ulbrich, K., Hekmatara, T., Herbert, E., & Kreuter, J. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.08.021 · Cited by 591
Self-citationPassage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
Kreuter, J., Alyautdin, R. N., Kharkevich, D. A., & Aa, I. (1995) · Brain Research · doi:10.1016/0006-8993(95)00023-j · Cited by 538
Self-citationSignificant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated Nanoparticles
Gulyaev, A. E., Gelperina, S. E., Skidan, I. N., Antropov, A. S., Kivman, G. Y., & Kreuter, J. (1999) · Pharmaceutical Research · doi:10.1023/a:1018983904537 · Cited by 521
Self-citationKreuter, J., Ramge, P., Petrov, V. E., Hamm, S., Gelperina, S. E., Engelhardt, B., Alyautdin, R. N., von Briesen, H., & Begley, D. J. (2003) · Pharmaceutical Research · doi:10.1023/a:1022604120952 · Cited by 469
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Research works printed but not linked: 2
- Alyautdin R, 1995, Eur J Pharm Biopharm, 41, 44
- Lück M, 1997. Plasmaproteinadsorption als möglicher Schlüsselfaktor für eine kontrollierte Arzneistoffapplikation mit partikulären Trägern. PhD Thesis, Berlin, Freie Universität, pp. 14–24, 137–54
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Sorted by citations
Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle
Saptarshi, S. R., Duschl, A., & Lopata, A. L. (2013) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-11-26 · Cited by 1,113
Current Strategies for Brain Drug Delivery
Dong, X. (2018) · Theranostics · doi:10.7150/thno.21254 · Cited by 954
“Nanoparticles Actively targeted delivery; brain targeting using specific physiological conditions Crossing the BBB [30-31], [33], [36-39], [44], [46], [47], [50]”
BackgroundCancer nanomedicine: A review of recent success in drug delivery
Tran, S., DeGiovanni, P., Piel, B., & Rai, P. (2017) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0175-0 · Cited by 879
Effect of the surface modification, size, and shape on cellular uptake of nanoparticles
Salatin, S., Dizaj, S. M., & Khosroushahi, A. Y. (2015) · Cell Biology International · doi:10.1002/cbin.10459 · Cited by 626
Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?
Kreuter, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.008 · Cited by 554
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Metadata
- Authors
- Kreuter, J.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Kreuter, Jörg
- Venue
- Journal of Microencapsulation
- Publisher
- Informa UK Limited
- Published
- 2012-06-07
- Volume
- 30
- Issue
- 1
- Pages
- 49-54
- ISSN
- 0265-2048 (ISSN-L)
- 1464-5246
- OpenAlex
- W2139835982
- Cited by
- 172
- References
- 50
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 10 · 2023: 14 · 2022: 11 · 2021: 11 · 2020: 20 · 2019: 13 · 2018: 10 · 2017: 10 · 2016: 23 · 2015: 20 · 2014: 7 · 2013: 7 · 2012: 2
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Microencapsulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- blood-brain barrier, polymeric nanoparticles, nanoparticle drug delivery, receptor-mediated endocytosis, transcytosis, tight junctions, apolipoprotein A-I, apolipoprotein E, LDL receptor, scavenger receptors, transferrin, insulin, poloxamer 188, Tween 80, Trojan horse
- MeSH terms
- Animals, Blood-Brain Barrier, Doxorubicin, Polymers, Nerve Growth Factor, Mice, Nanoparticles
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