Transport of drugs across the blood–brain barrier by nanoparticles.

Drug Discovery: A Historical Perspective

Drews, J. (2000) · Science · doi:10.1126/science.287.5460.1960 · Cited by 2,768 · see citing works

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

Reese, T. S., & Karnovsky, M. J. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.34.1.207 · Cited by 2,629 · see citing works

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Cordon‐Cardo, C., O’Brien, J. P., Casals, D., Rittmann-Grauer, L., Biedler, J. L., Melamed, M. R., & Bertino, J. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.695 · Cited by 1,750 · see citing works

Freeze-drying of nanoparticles: Formulation, process and storage considerations

ABDELWAHED, W., DEGOBERT, G., STAINMESSE, S., & FESSI, H. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.017 · Cited by 1,611 · see citing works

Nanocarriers’ entry into the cell: relevance to drug delivery

Hillaireau, H., & Couvreur, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0053-z · Cited by 1,549 · see citing works

Tight junctions of the blood-brain barrier: development, composition and regulation.

Wolburg, H., & Lippoldt, A. (2002) · PubMed · doi:10.1016/s1537-1891(02)00200-8 · Cited by 1,184 · see citing works

Nasal drug delivery—possibilities, problems and solutions

Illum, L. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00363-2 · Cited by 1,107 · see citing works

Nanoparticulate systems for brain delivery of drugs.

Kreuter, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00122-8 · Cited by 1,107 · see citing works

Transferrin receptor on endothelium of brain capillaries

Jefferies, W. A., Brandon, M. R., Hunt, S. V., Williams, A. F., Gatter, K. C., & Mason, D. Y. (1984) · Nature · doi:10.1038/312162a0 · Cited by 1,061 · see citing works

Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects

Maeda, H. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100070g · Cited by 997 · see citing works

Nanoparticulate systems for brain delivery of drugs

Kreuter, J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.015 · Cited by 958 · see citing works

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

Gabathuler, R. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.028 · Cited by 804 · see citing works

Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier.

Kreuter, J., Shamenkov, D., Petrov, V., Ramge, P., Cychutek, K., Koch-Brandt, C., & Alyautdin, R. (2002) · Journal of drug targeting · doi:10.1080/10611860290031877 · Cited by 801 · see citing works

PLGA Nanoparticles in Drug Delivery: The State of the Art;

Bala, I., Hariharan, S., & Kumar, M. R. (2004) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v21.i5.20 · Cited by 739 · see citing works

BLOOD-BRAIN BARRIER DRUG TARGETING: THE FUTURE OF BRAIN DRUG DEVELOPMENT

Pardridge, W. M. (2003) · Molecular Interventions · doi:10.1124/mi.3.2.90 · Cited by 713 · see citing works

Delivery of therapeutic agents to the central nervous system: the problems and the possibilities

Begley, D. J. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.08.001 · Cited by 679 · see citing works

Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)

Ulbrich, K., Hekmatara, T., Herbert, E., & Kreuter, J. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.08.021 · Cited by 591 · see citing works

Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard

Oldendorf, W. H. (1970) · Brain Research · doi:10.1016/0006-8993(70)90123-x · Cited by 550 · see citing works

Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)

Kreuter, J., Alyautdin, R. N., Kharkevich, D. A., & Aa, I. (1995) · Brain Research · doi:10.1016/0006-8993(95)00023-j · Cited by 538 · see citing works

Significant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated Nanoparticles

Gulyaev, A. E., Gelperina, S. E., Skidan, I. N., Antropov, A. S., Kivman, G. Y., & Kreuter, J. (1999) · Pharmaceutical Research · doi:10.1023/a:1018983904537 · Cited by 521 · see citing works

Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain

Yang, S. C., Lu, L. F., Cai, Y., Zhu, J. B., Liang, B. W., & Yang, C. Z. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00007-3 · Cited by 475 · see citing works

Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles

Kreuter, J., Ramge, P., Petrov, V. E., Hamm, S., Gelperina, S. E., Engelhardt, B., Alyautdin, R. N., von Briesen, H., & Begley, D. J. (2003) · Pharmaceutical Research · doi:10.1023/a:1022604120952 · Cited by 469 · see citing works

Capillary Depletion Method for Quantification of Blood–Brain Barrier Transport of Circulating Peptides and Plasma Proteins

Triguero, D., Buciak, J., & Pardridge, W. M. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04886.x · Cited by 463 · see citing works

CNS Drug Design Based on Principles of Blood‐Brain Barrier Transport

Pardridge, W. M. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70051781.x · Cited by 460 · see citing works

Transporting therapeutics across the blood-brain barrier

Abbott, N. J., & Romero, I. A. (1996) · Molecular Medicine Today · doi:10.1016/1357-4310(96)88720-x · Cited by 447 · see citing works

Long-circulating pegylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery.

Calvo, P., Gouritin, B., Chacun, H., Desmaële, D., D'Angelo, J., Noel, J.-P., Georgin, D., Fattal, E., Andreux, J. P., & Couvreur, P. (2001) · Pharmaceutical Research · doi:10.1023/a:1010931127745 · Cited by 443 · see citing works

Is nose-to-brain transport of drugs in man a reality?

Illum, L. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357022539 · Cited by 439 · see citing works

Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones

Zensi, A., Begley, D., Pontikis, C., Legros, C., Mihoreanu, L., Wagner, S., Büchel, C., von Briesen, H., & Kreuter, J. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.03.002 · Cited by 438 · see citing works

PLA/PLGA nanoparticles for sustained release of docetaxel

Musumeci, T., Ventura, C. A., Giannone, I., Ruozi, B., Montenegro, L., Pignatello, R., & Puglisi, G. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.06.023 · Cited by 435 · see citing works

Chemotherapy of glioblastoma in rats using doxorubicin‐loaded nanoparticles

Steiniger, S. C. J., Kreuter, J., Khalansky, A. S., Skidan, I. N., Bobruskin, A. I., Smirnova, Z. S., Severin, E. S., Uhl, R., Kock, M., Geiger, K. D., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20048 · Cited by 434 · see citing works

Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery

Kim, D., & Martin, D. C. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2005.12.021 · Cited by 432 · see citing works

Gliadel® wafer in initial surgery for malignant glioma: long-term follow-up of a multicenter controlled trial

Westphal, M., Ram, Z., Riddle, V., Hilt, D. C., & Bortey, E. B. (2006) · Acta Neurochirurgica · doi:10.1007/s00701-005-0707-z · Cited by 418 · see citing works

Progression-free survival: An important end point in evaluating therapy for recurrent high-grade gliomas

Lamborn, K. R., Yung, W. K. A., Chang, S. M., Wen, P. Y., Cloughesy, T. F., DeAngelis, L. M., Robins, H. I., Lieberman, F. S., Fine, H. A., Fink, K., et al. (2008) · Neuro-Oncology · doi:10.1215/15228517-2007-062 · Cited by 417 · see citing works

Stealth® PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting

Peracchia, M. T., Fattal, E., Desmaële, D., Besnard, M., Noël, J. P., Gomis, J.-M., Appel, M., d’Angelo, J., & Couvreur, P. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00063-2 · Cited by 400 · see citing works

Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease

Wilson, B., Samanta, M. K., Santhi, K., Kumar, K. P. S., Paramakrishnan, N., & Suresh, B. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.039 · Cited by 363 · see citing works

Influence of surface charge density on protein adsorption on polymeric nanoparticles: analysis by two-dimensional electrophoresis

Gessner, A., Lieske, A., Paulke, B., & Müller, R. H. (2002) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(02)00081-4 · Cited by 356 · see citing works

Delivery of Loperamide Across the Blood-Brain Barrier with Polysorbate 80-Coated Polybutylcyanoacrylate Nanoparticles

Alyautdin, R. N., Petrov, V. E., Langer, K., Berthold, A., Kharkevich, D. A., & Kreuter, J. (1997) · Pharmaceutical Research · doi:10.1023/a:1012098005098 · Cited by 352 · see citing works

Covalent Linkage of Apolipoprotein E to Albumin Nanoparticles Strongly Enhances Drug Transport into the Brain

Michaelis, K., Hoffmann, M. M., Dreis, S., Herbert, E., Alyautdin, R. N., Michaelis, M., Kreuter, J., & Langer, K. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.097139 · Cited by 346 · see citing works

Development and Brain Delivery of Chitosan−PEG Nanoparticles Functionalized with the Monoclonal Antibody OX26

Aktaş, Y., Yemişçi, M., Andrieux, K., Gürsoy, R. N., Alonso, M. J., Fernández-Megía, E., Novoa-Carballal, R., Quiñoá, E., Riguera, R., Sargon, M. F., et al. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050217o · Cited by 318 · see citing works

Colloidal carriers and blood–brain barrier (BBB) translocation: A way to deliver drugs to the brain?

García-García, E., Andrieux, K., Gil, S., & Couvreur, P. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.03.031 · Cited by 314 · see citing works

Apolipoprotein A-I: structure–function relationships

Frank, P. G., & Marcel, Y. L. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32028-9 · Cited by 308 · see citing works

Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: Revisiting the role of surfactants

Petri, B., Bootz, A., Khalansky, A. S., Hekmatara, T., Müller, R. H., Uhl, R., Kreuter, J., & Gelperina, S. E. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.10.015 · Cited by 299 · see citing works

Polysorbate-stabilized solid lipid nanoparticles as colloidal carriers for intravenous targeting of drugs to the brain: Comparison of plasma protein adsorption patterns

Göppert, T. M., & Müller, R. H. (2005) · Journal of drug targeting · doi:10.1080/10611860500071292 · Cited by 299 · see citing works

Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: Influence of the formulation parameters

Gelperina, S. E., Maksimenko, O., Khalansky, A. S., Vanchugova, L. V., Шипуло, Е. В., Abbasova, K., Berdiev, R. K., Wohlfart, S., Chepurnova, N. E., & Kreuter, J. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2009.09.003 · Cited by 293 · see citing works

Inhibition of P-Glycoprotein by Newer Antidepressants

Weiß, J., Dormann, S.-M. G., Martin‐Facklam, M., Kerpen, C. J., Ketabi‐Kiyanvash, N., & Haefeli, W. E. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046532 · Cited by 293 · see citing works

The Blood-brain Barrier: Principles for Targeting Peptides and Drugs to the Central Nervous System

Begley, D. J. (1996) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1996.tb07112.x · Cited by 291 · see citing works

Fundamental Relationships Between the Composition of Pluronic Block Copolymers and Their Hypersensitization Effect in MDR Cancer Cells

Batrakova, E. V., Lee, S., Li, S., Venne, A., Alakhov, V. Y., & Kabanov, A. V. (1999) · Pharmaceutical Research · doi:10.1023/a:1018942823676 · Cited by 289 · see citing works

Targeting Rat Anti-Mouse Transferrin Receptor Monoclonal Antibodies through Blood-Brain Barrier in Mouse

Lee, H., Engelhardt, B., Lesley, J., Bickel, U., & Pardridge, W. M. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35388-1 · Cited by 287 · see citing works

Characterization of endocytosis of transferrin-coated PLGA nanoparticles by the blood–brain barrier

Chang, J., Jallouli, Y., Kroubi, M., Yuan, X.-B., Feng, W., Kang, C., Pu, P., & Betbeder, D. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.04.035 · Cited by 280 · see citing works

Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles

WILSON, B., Samanta, M. K., Santhi, K., KUMAR, K., Paramakrishnan, N., & Suresh, B. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.03.009 · Cited by 279 · see citing works

Nanoparticle Technology for Delivery of Drugs Across the Blood–Brain Barrier

Schröeder, U., Sommerfeld, P., Ulrich, S., & Sabel, B. A. (1998) · Journal of Pharmaceutical Sciences · doi:10.1021/js980084y · Cited by 275 · see citing works

Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles

Gao, K., & Jiang, X. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.11.040 · Cited by 269 · see citing works

Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain

Kreuter, J., Hekmatara, T., Dreis, S., Vogel, T., Gelperina, S. E., & Langer, K. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.12.012 · Cited by 263 · see citing works

Targeting the insulin receptor: nanoparticles for drug delivery across the blood–brain barrier (BBB)

Ulbrich, K., Knobloch, T., & Kreuter, J. (2011) · Journal of Drug Targeting · doi:10.3109/10611861003734001 · Cited by 259 · see citing works

Design of Biodegradable Nanoparticles for Oral Delivery of Doxorubicin: In vivo Pharmacokinetics and Toxicity Studies in Rats

Kalaria, D. R., Sharma, G., Beniwal, V., & Ravi Kumar, M. N. V. (2009) · Pharmaceutical Research · doi:10.1007/s11095-008-9763-4 · Cited by 246 · see citing works

Poly(ethylene glycol)-Coated Hexadecylcyanoacrylate Nanospheres Display a Combined Effect for Brain Tumor Targeting

Brigger, I., Morizet, J., Aubert, G., Chacun, H., Terrier‐Lacombe, M., Couvreur, P., & Vassal, G. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.039669 · Cited by 234 · see citing works

Targeting the central nervous system: In vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123

Tosi, G., Costantino, L., Rivasi, F., Ruozi, B., Leo, E., Vergoni, A. V., Tacchi, R., Bertolini, A., Vandelli, M. A., & Forni, F. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.022 · Cited by 233 · see citing works

Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80–coated polybutylcyanoacrylate nanoparticles: Anin situbrain perfusion study

Alyautdin, R. N., Tezikov, E. B., Ramge, P., Kharkevich, D. A., Begley, D. J., & Kreuter, J. (1998) · Journal of Microencapsulation · doi:10.3109/02652049809006836 · Cited by 229 · see citing works

Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles

Kurakhmaeva, K. B., Djindjikhashvili, I. A., Petrov, V. E., Balabanyan, V. U., Voronina, T. A., Trofimov, S. S., Kreuter, J., Gelperina, S., Begley, D., & Alyautdin, R. N. (2009) · Journal of Drug Targeting · doi:10.1080/10611860903112842 · Cited by 221 · see citing works

Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration

Gao, X., Wu, B., Zhang, Q., Chen, J., Zhu, J., Zhang, W., Rong, Z., Chen, H., & Jiang, X. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.026 · Cited by 207 · see citing works

Intravenous Administration to Rabbits of Non-stealth and Stealth Doxorubicin-loaded Solid Lipid Nanoparticles at Increasing Concentrations of Stealth Agent: Pharmacokinetics and Distribution of Doxorubicin in Brain and Other Tissues

Zara, G. P., Cavalli, R., Bargoni, A., Fundaro', A., Vighetto, D., & Gasco, M. R. (2002) · Journal of drug targeting · doi:10.1080/10611860290031868 · Cited by 207 · see citing works

Humanization of anti‐human insulin receptor antibody for drug targeting across the human blood–brain barrier

Boado, R. J., Zhang, Y., Zhang, Y., & Pardridge, W. M. (2006) · Biotechnology and Bioengineering · doi:10.1002/bit.21120 · Cited by 204 · see citing works

A review of nanocarrier-based CNS delivery systems.

Tiwari, S. B., & Amiji, M. (2006) · Current Drug Delivery · doi:10.2174/156720106776359230 · Cited by 200 · see citing works

Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood–brain barrier using surfactant-coated nanoparticles

Kreuter, J., Petrov, V. E., Kharkevich, D. A., & Alyautdin, R. N. (1997) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00061-8 · Cited by 196 · see citing works

Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles

Lin, X., Tian, Wei, Feng, Huang, Wang, Ren, R., & Diao (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s16570 · Cited by 189 · see citing works

Toxicological studies of doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma

Gelperina, S. E., Khalansky, A. S., Skidan, I. N., Smirnova, Z. S., Bobruskin, A. I., Severin, E. S., Turowski, B., Zanella, F., & Kreuter, J. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(01)00456-8 · Cited by 185 · see citing works

Translocation of Poly(ethylene glycol-co-hexadecyl)cyanoacrylate Nanoparticles into Rat Brain Endothelial Cells: Role of Apolipoproteins in Receptor-Mediated Endocytosis

Kim, H. R., Andrieux, K., Gil, S., Taverna, M., Chacun, H., Desmaële, D., Taran, F., Georgin, D., & Couvreur, P. (2007) · Biomacromolecules · doi:10.1021/bm060711a · Cited by 183 · see citing works

Formation and function of apolipoprotein E-containing lipoproteins in the nervous system

Vance, J. E., & Hayashi, H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.02.007 · Cited by 178 · see citing works

Effect of Size and Charge on the Passive Diffusion of Peptides Across Caco-2 Cell Monolayers via the Paracellular Pathway

Pauletti, G. M., Okumu, F. W., & Borchardt, R. T. (1997) · Pharmaceutical Research · doi:10.1023/a:1012040425146 · Cited by 177 · see citing works

Brain-targeted solid lipid nanoparticles containing riluzole: preparation, characterization and biodistribution.

Bondì, M. L., Craparo, E. F., Giammona, G., & Drago, F. (2010) · Nanomedicine · doi:10.2217/nnm.09.67 · Cited by 175 · see citing works

Interaction of Poly(butylcyanoacrylate) Nanoparticles with the Blood-Brain Barrierin vivoandin vitro

Alyaudtin, R. N., Reichel, A., Löbenberg, R., Ramge, P., Kreuter, J., & Begley, D. J. (2001) · Journal of drug targeting · doi:10.3109/10611860108997929 · Cited by 166 · see citing works

Low-density lipoprotein receptor-mediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells

Kim, H. R., Gil, S., Andrieux, K., Nicolas, V., Appel, M., Chacun, H., Desmaële, D., Taran, F., Georgin, D., & Couvreur, P. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6390-x · Cited by 163 · see citing works

Efficient Chemotherapy of Rat Glioblastoma Using Doxorubicin-Loaded PLGA Nanoparticles with Different Stabilizers

Wohlfart, S., Khalansky, A. S., Gelperina, S. E., Maksimenko, O., Bernreuther, C., Glatzel, M., & Kreuter, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019121 · Cited by 162 · see citing works

Modification of the body distribution of poly(methyl methacrylate) nanoparticles in rats by coating with surfactants

Tröster, S. D., Müller, U., & Kreuter, J. (1990) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(90)90047-8 · Cited by 161 · see citing works

Transport of stavudine, delavirdine, and saquinavir across the blood–brain barrier by polybutylcyanoacrylate, methylmethacrylate-sulfopropylmethacrylate, and solid lipid nanoparticles

KUO, Y., & SU, F. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.03.012 · Cited by 147 · see citing works

Why is the global CNS pharmaceutical market so under-penetrated?

Pardridge, W. M. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(01)02082-7 · Cited by 144 · see citing works

Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacrylate) nanoparticles as a parenteral controlled release system

Friese, A. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00073-9 · Cited by 140 · see citing works

Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery.

Neuwelt, E. A., Maravilla, K. R., Frenkel, E. P., Rapaport, S. I., Hill, S. A., & Barnett, P. A. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109509 · Cited by 136 · see citing works

Physico-chemical characterisation of PLGA nanoparticles after freeze-drying and storage

Holzer, M., Vogel, V., Mäntele, W., et al. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2009.02.002 · Cited by 134 · see citing works

Biodistribution of polysorbate 80-coated doxorubicin-loaded [14C]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to glioblastoma-bearing rats

Ambruosi, A., Khalansky, A. S., Yamamoto, H., Gelperina, S. E., Begley, D. J., & Kreuter, J. (2006) · Journal of drug targeting · doi:10.1080/10611860600636135 · Cited by 134 · see citing works

Etoposide-incorporated tripalmitin nanoparticles with different surface charge: Formulation, characterization, radiolabeling, and biodistribution studies

Reddy, L. H., Sharma, R. K., Chuttani, K., et al. (2004) · The AAPS Journal · doi:10.1208/aapsj060323 · Cited by 132 · see citing works

Use of Nanoparticles for Cerebral Cancer

Kreuter, J., & Gelperina, S. E. (2008) · Tumori Journal · doi:10.1177/030089160809400220 · Cited by 131 · see citing works

Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6 glioma cells of a brain tumor model

Wang, C., Le-song, H., Hou, L., Jiang, L., Yan, Z.-T., Wang, Y.-L., & Chen, Z.-L. (2009) · Brain Research · doi:10.1016/j.brainres.2009.01.011 · Cited by 129 · see citing works

Human serum albumin nanoparticles modified with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain

Zensi, A., Begley, D. J., Pontikis, C., Legros, C., Mihoreanu, L., Büchel, C., & Kreuter, J. (2010) · Journal of drug targeting · doi:10.3109/1061186x.2010.513712 · Cited by 119 · see citing works

Freeze drying of human serum albumin (HSA) nanoparticles with different excipients

Anhorn, M. G., Mahler, H., & Langer, K. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.07.004 · Cited by 119 · see citing works

Double-Coated Poly (Butylcynanoacrylate) Nanoparticulate Delivery Systems for Brain Targeting of Dalargin Via Oral Administration

Das, D., & Lin, S. (2005) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20357 · Cited by 117 · see citing works

Quaternary Ammonium β-Cyclodextrin Nanoparticles for Enhancing Doxorubicin Permeability across the In Vitro Blood−Brain Barrier

Gil, E. S., Li, J., Xiao, H., et al. (2009) · Biomacromolecules · doi:10.1021/bm801026k · Cited by 107 · see citing works

Apolipoprotein A-I coating of protamine–oligonucleotide nanoparticles increases particle uptake and transcytosis in an in vitro model of the blood–brain barrier

Kratzer, I., Wernig, K., Panzenboeck, U., Bernhart, E. M., Reicher, H., Wronski, R., Windisch, M., Hammer, A., Malle, E., Zimmer, A., et al. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.11.020 · Cited by 104 · see citing works

Influence of surfactants, polymer and doxorubicin loading on the anti-tumour effect of poly(butyl cyanoacrylate) nanoparticles in a rat glioma model

Ambruosi, A., Gelperina, S. E., Khalansky, A. S., Tanski, S., Theisen, A., & Kreuter, J. (2006) · Journal of Microencapsulation · doi:10.1080/02652040600788080 · Cited by 100 · see citing works

Enhancing the Delivery of Anti Retroviral Drug “Saquinavir” Across the Blood Brain Barrier Using Nanoparticles

Mahajan, S. D., Roy, I., Xu, G., Yong, K., Ding, H. Y., Aalinkeel, R., Reynolds, J. L., Sykes, D. E., Nair, B. B., Lin, E. Y., et al. (2010) · Current HIV Research · doi:10.2174/157016210791330356 · Cited by 95 · see citing works

Delivery of nanoparticles to the brain detected by fluorescence microscopy

Reimold, I., Domke, D., Bender, J., Seyfried, C. A., Radunz, H.-E., & Fricker, G. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.05.007 · Cited by 89 · see citing works

Non-invasive drug delivery to the human brain using endogenous blood–brain barrier transport systems

Pardridge, W. M. (1999) · Pharmaceutical Science & Technology Today · doi:10.1016/s1461-5347(98)00117-5 · Cited by 81 · see citing works

Body distribution of polysorbate‐80 and doxorubicin-loaded [14C]poly(butyl cyanoacrylate) nanoparticles after i.v. administration in rats

Ambruosi, A., Yamamoto, H., & Kreuter, J. (2005) · Journal of drug targeting · doi:10.1080/10611860500411043 · Cited by 79 · see citing works

Influence of the formulation on the tolerance profile of nanoparticle-bound doxorubicin in healthy rats: Focus on cardio- and testicular toxicity

Переверзева, Э. Р., Трещалин, И. Д., Бодягин, Д. А., Максименко, О. О., Langer, K., Dreis, S., Asmussen, B., Kreuter, J., & Gelperina, S. E. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.01.031 · Cited by 76 · see citing works

Nanoparticulate Transport of Oximes over an In Vitro Blood-Brain Barrier Model

Wagner, S., Kufleitner, J., Zensi, A., Dadparvar, M., Wien, S., Bungert, J., Vogel, T., Worek, F., Kreuter, J., & von Briesen, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014213 · Cited by 69 · see citing works

Efficacy of surface charge in targeting pegylated nanoparticles of sulpiride to the brain

Parikh, T., Bommana, M. M., & Squillante, E. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2009.11.001 · Cited by 66 · see citing works

Kinetic profile in blood and brain of the cholinesterase reactivating oxime HI-6 after intravenous administration to the rat

Ligtenstein, D. A., & Kossen, S. P. (1983) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(83)90334-4 · Cited by 63 · see citing works

Uptake of Adriamycin in tumour and surrounding brain tissue in patients with malignant gliomas

von Holst, H., Knochenhauer, E., Blomgren, H., et al. (1990) · Acta Neurochirurgica · doi:10.1007/bf01842886 · Cited by 63 · see citing works

Recent Developments in Peptide Drug Delivery to the Brain

Pardridge, W. M. (1992) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1992.tb00512.x · Cited by 63 · see citing works

Efficient systemic therapy of rat glioblastoma by nanoparticle-bound doxorubicin is due to antiangiogenic effects

Hekmatara, T., Bernreuther, C., Khalansky, A. S., Theisen, A., Weissenberger, J., Matschke, J., Gelperina, S. E., Kreuter, J., & Glatzel, M. (2009) · Clinical Neuropathology · doi:10.5414/npp28153 · Cited by 61 · see citing works

The blood-brain barrier and drug delivery to the CNS

Begley, D. J., Bradbury, M. W. B., & Kreuter, J. (2001) · European Journal of Medicinal Chemistry · doi:10.1016/s0223-5234(01)01310-1 · Cited by 60 · see citing works

Aclarubicin‐loaded cationic albumin‐conjugated pegylated nanoparticle for glioma chemotherapy in rats

Lü, W., Wan, J., Zhang, Q., She, Z., & Jiang, X. (2006) · International Journal of Cancer · doi:10.1002/ijc.22296 · Cited by 53 · see citing works

Lipid composition determines interaction of liposome membranes with Pluronic L61

Zhirnov, A. E., Demina, T. V., Krylova, O. O., Grozdova, I. D., & Melik‐Nubarov, N. S. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.11.010 · Cited by 50 · see citing works

Cytotoxicity of doxorubicin bound to poly(butyl cyanoacrylate) nanoparticles in rat glioma cell lines using different assays

Juan, B. S. D., von Briesen, H., Gelperina, S. E., & Kreuter, J. (2006) · Journal of drug targeting · doi:10.1080/10611860600866872 · Cited by 49 · see citing works

Uptake of apolipoprotein E fragment coupled liposomes by cultured brain microvessel endothelial cells and intact brain capillaries

Hülsermann, U., Hoffmann, M. M., Massing, U., & Fricker, G. (2009) · Journal of drug targeting · doi:10.1080/10611860903105986 · Cited by 49 · see citing works

Intravenous tolerance of a nanoparticle-based formulation of doxorubicin in healthy rats

Переверзева, Э. Р., Трещалин, И. Д., Бодягин, Д. А., Максименко, О. О., Kreuter, J., & Gelperina, S. E. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.01.020 · Cited by 47 · see citing works

Radiation sterilisation of doxorubicin bound to poly(butyl cyanoacrylate) nanoparticles

Максименко, О. О., Pavlov, E. P., Toushov, E., et al. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.01.010 · Cited by 46 · see citing works

Influence of Nanoparticles on the Brain-to-serum Distribution and the Metabolism of Valproic Acid in Mice

Darius, J., Meyer, F. P., Sabel, B. A., & Schröeder, U. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774958 · Cited by 45 · see citing works

Antiparkinsonian effect of nerve growth factor adsorbed on polybutylcyanoacrylate nanoparticles coated with polysorbate-80

Курахмаева, К. Б., Воронина, Т. А., Капица, И. Г., Kreuter, J., Неробкова, Л. Н., Середенин, С. Б., Балабаньян, В. Ю., & Alyautdin, R. N. (2008) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-008-0065-y · Cited by 41 · see citing works

Trafficking of Intracerebroventricularly Injected Antisense Oligonucleotides in the Mouse Brain

Chauhan, N. B. (2002) · Antisense and Nucleic Acid Drug Development · doi:10.1089/108729002761381320 · Cited by 38 · see citing works

Pharmacokinetics and blood-brain barrier transport of an anti-transferrin receptor monoclonal antibody (OX26) in rats after chronic treatment with the antibody.

Wu, D., & Pardridge, W. M. (1998) · PubMed · Cited by 31 · see citing works

Effects of apolipoproteins on dalargin transport across the blood-brain barrier

Shamenkov, D. A., Petrov, V. E., & Alyautdin, R. N. (2006) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-006-0456-x · Cited by 16 · see citing works

Specific Mechanisms for Transporting Drugs Into Brain

Tsuji, A. (2000) · CRC Press eBooks · doi:10.1201/9780824741990.ch8 · Cited by 14 · see citing works

Solid Lipid Nanoparticles Carrying Oligonucleotides Inhibit Vascular Endothelial Growth Factor Expression in Rat Glioma Models

Brioschi, A. M., Calderoni, S., Pradotto, L., et al. (2009) · Journal of Nanoneuroscience · doi:10.1166/jns.2009.007 · Cited by 11 · see citing works

Colloidal Carriers: A Promising Way to Treat Central Nervous System Diseases

Andrieux, K., García-García, E., Kim, H. R., et al. (2009) · Journal of Nanoneuroscience · doi:10.1166/jns.2009.003 · Cited by 11 · see citing works

Increased Numbers of Injections of Doxorubicin Bound to Nanoparticles Lead to Enhanced Efficacy Against Rat Glioblastoma 101/8

Wohlfart, S., Bernreuther, C., Khalansky, A. S., Theisen, A., Weissenberger, J., Gelperina, S. E., Glatzel, M., & Kreuter, J. (2009) · Journal of Nanoneuroscience · doi:10.1166/jns.2009.1003 · Cited by 11 · see citing works

Current Strategies for Brain Drug Delivery

Dong, X. (2018) · Theranostics · doi:10.7150/thno.21254 · Cited by 954 · see citing works

PCL and PCL-based materials in biomedical applications

Malikmammadov, E., Tanir, T. E., Kiziltay, A., Hasirci, V., & Hasirci, N. (2018) · Journal of Biomaterials Science, Polymer Edition · doi:10.1080/09205063.2017.1394711 · Cited by 894 · see citing works

Crossing the blood-brain barrier with nanoparticles

Zhou, Y., Peng, Z., Seven, E. S., & Leblanc, R. M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.12.015 · Cited by 837 · see citing works

Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?

Kreuter, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.008 · Cited by 554 · see citing works

Nanotechnology for protein delivery: Overview and perspectives

Yu, M., Wu, J., Shi, J., & Farokhzad, O. C. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.10.012 · Cited by 410 · see citing works

Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs

Naqvi, S., Panghal, A., & Flora, S. J. S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00494 · Cited by 305 · see citing works

Nanoscale drug delivery systems and the blood–brain barrier

Khalin, I., Alyautdin, R., Ismail, N. M., Haron, M. H., & Kuznetsov, D. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s52236 · Cited by 204 · see citing works

Effect of Nanoparticle Composition, Size, Shape, and Stiffness on Penetration Across the Blood–Brain Barrier

Brown, T. D., Habibi, N., Wu, D., Lahann, J., & Mitragotri, S. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00743 · Cited by 182 · see citing works

Resveratrol Brain Delivery for Neurological Disorders Prevention and Treatment

Andrade, S., Ramalho, M. J., Pereira, M. D. C., & Loureiro, J. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01261 · Cited by 173 · see citing works

Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (bbb).

Kreuter, J. (2013) · Journal of Microencapsulation · doi:10.3109/02652048.2012.692491 · Cited by 172 · see citing works

Antisense oligonucleotides: treating neurodegeneration at the level of RNA

DeVos, S. L., & Miller, T. M. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0194-5 · Cited by 164 · see citing works

Theranostic USPIO‐Loaded Microbubbles for Mediating and Monitoring Blood‐Brain Barrier Permeation

Lammers, T., Koczera, P., Fokong, S., Gremse, F., Ehling, J., Vogt, M., Pich, A., Storm, G., van Zandvoort, M., & Kiessling, F. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201401199 · Cited by 156 · see citing works

Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics

Mukherjee, S., Madamsetty, V. S., Bhattacharya, D., Roy Chowdhury, S., Paul, M. K., & Mukherjee, A. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202003054 · Cited by 152 · see citing works

Preparation, characterization,<i>in vivo</i>biodistribution and pharmacokinetic studies of donepezil-loaded PLGA nanoparticles for brain targeting

Md, S., Ali, M., Baboota, S., Sahni, J. K., Bhatnagar, A., & Ali, J. (2014) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2012.758130 · Cited by 138 · see citing works

Neurotheranostics as Personalized Medicines

Kevadiya, B. D., Ottemann, B. M., Thomas, M. B., Mukadam, I., Nigam, S., McMillan, J., Gorantla, S., Bronich, T. K., Edagwa, B., & Gendelman, H. E. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.011 · Cited by 124 · see citing works

Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies

Wang, J., Garancher, A., Ramaswamy, V., & Wechsler-Reya, R. J. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-013838 · Cited by 113 · see citing works

Using Multifunctional Peptide Conjugated Au Nanorods for Monitoring β-Amyloid Aggregation and Chemo-Photothermal Treatment of Alzheimer’s Disease

Li, M., Guan, Y., Zhao, A., Ren, J., & Qu, X. (2017) · Theranostics · doi:10.7150/thno.18459 · Cited by 90 · see citing works

Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport

Tosi, G., Vilella, A., Chhabra, R., Schmeisser, M. J., Boeckers, T. M., Ruozi, B., Vandelli, M. A., Forni, F., Zoli, M., & Grabrucker, A. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.01.004 · Cited by 56 · see citing works

Targeted Nanoparticles for Drug Delivery Across the Blood–Brain Barrier in Early and Late Stages of Alzheimer's Disease: A Review

Kochman, U., Sitka, H., Kuźniar, J., Czaja, M., Kozubek, P., Beszłej, J. A., & Leszek, J. (2026) · Molecular Neurobiology · doi:10.1007/s12035-025-05417-z · Cited by 60 · see citing works

A Promising Approach: Magnetic Nanosystems for Alzheimer’s Disease Theranostics

Chaparro, C. I. P., Simões, B. T., Borges, J. P., Castanho, M. A. R. B., Soares, P. I. P., & Neves, V. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092316 · Cited by 40 · see citing works

Design of Polyhydroxyalkanoate (PHA) Microbeads with Tunable Functional Properties and High Biodegradability in Seawater

Volant, C., Balnois, E., Vignaud, G., Magueresse, A., & Bruzaud, S. (2022) · Journal of Polymers and the Environment · doi:10.1007/s10924-021-02345-6 · Cited by 33 · see citing works

Potential Alzheimer's disease therapeutic nano-platform: Discovery of amyloid-beta plaque disaggregating agent and brain-targeted delivery system using porous silicon nanoparticles

Kim, J., Um, H., Kim, N. H., & Kim, D. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.01.006 · Cited by 33 · see citing works

Shape and surface modification dependent cellular interactions of gold nanoparticles in a 3D blood-brain-barrier supported neurospheroid model

Tomak, A., Saglam-Metiner, P., Coban, R., Oksel-Karakus, C., & Yesil-Celiktas, O. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103080 · Cited by 6 · see citing works

Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution

Vergoni, A. V., Tosi, G., Tacchi, R., Vandelli, M. A., Bertolini, A., & Costantino, L. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.02.005 · Cited by 147 · see citing works

Colloidal systems for drug delivery: from design to therapy

Beija, M., Salvayre, R., Viguerie, N. L., & Marty, J. (2012) · Trends in biotechnology · doi:10.1016/j.tibtech.2012.04.008 · Cited by 162 · see citing works

Biomimetic mesoporous silica nanoparticles for drug delivery in a synthetic lethality approach

Marino, M. (2018)

Particle characterisation in drug delivery

Vllasaliu, D., & Singh, I. S. (2014) · Lincoln Repository (University of Lincoln) · Cited by 2 · see citing works

Inorganic nanobiomaterial drug carriers for medicine

Singh, R. K., & Kim, H. (2013) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-013-1092-y · Cited by 31 · see citing works