Cited by 554Nanoparticle-Based Drug DeliveryBarrier Structure and Function StudiesAdvanced Drug Delivery Systems

Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?

Kreuter, Jörg·2014·Advanced Drug Delivery Reviews

Abstract

Nanoparticles enable the delivery of a great variety of drugs including anticancer drugs, analgesics, anti-Alzheimer's drugs, cardiovascular drugs, protease inhibitors, and several macromolecules into the brain after intravenous injection of animals. The mechanism of the nanoparticle-mediated drug transport across the BBB appears to be receptor-mediated endocytosis followed by transcytosis into the brain or by drug release within the endothelial cells. Modification of the nanoparticle surface with covalently attached targeting ligands or by coating with certain surfactants that lead to the adsorption of specific plasma proteins after injection is necessary for this receptor-mediated uptake. A very critical and important requirement for nanoparticulate brain delivery is that the employed nanoparticles are biocompatible and, moreover, rapidly biodegradable, i.e. over a time frame of a few days. In addition to enabling drug delivery to the brain, nanoparticles, as with doxorubicin, may importantly reduce the drug's toxicity and adverse effects due to an alteration of the body distribution. Because of the possibility to treat severe CNS diseases such as brain tumours and to even transport proteins and other macromolecules across the blood-brain barrier, this technology holds great promise for a non-invasive therapy of these diseases.

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Crossref · 10.1016/j.addr.2013.08.008

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Authors
Kreuter, J.
Affiliations
Goethe University Frankfurt (DE)
Corresponding author
Kreuter, Jörg
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2014-05
Volume
71
Pages
2-14
ISSN
0169-409X (ISSN-L)
OpenAlex
W1975495109
Cited by
554
References
157
Citations by year
2026: 27 · 2025: 33 · 2024: 27 · 2023: 42 · 2022: 37 · 2021: 43 · 2020: 42 · 2019: 56 · 2018: 54 · 2017: 51 · 2016: 67 · 2015: 57 · 2014: 16 · 2013: 1
FWCI
3.19
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
polymeric nanoparticles, blood-brain barrier, brain drug delivery, receptor-mediated endocytosis, transcytosis, nanoparticle surface modification, targeting ligands, protein adsorption, biodegradable nanoparticles, biocompatibility, doxorubicin, brain tumors, macromolecule transport, central nervous system disorders
MeSH terms
Animals, Biological Transport, Blood-Brain Barrier, Brain, Endocytosis, Humans, Polymers, Time Factors, Drug Delivery Systems, Nanoparticles, Transcytosis, Drug-Related Side Effects and Adverse Reactions

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