Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (bbb).

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Cordon‐Cardo, C., O’Brien, J. P., Casals, D., Rittmann-Grauer, L., Biedler, J. L., Melamed, M. R., & Bertino, J. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.695 · Cited by 1,750

Nanoparticulate systems for brain delivery of drugs.

Kreuter, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00122-8 · Cited by 1,107

Nanoparticulate systems for brain delivery of drugs

Kreuter, J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.015 · Cited by 965

Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier.

Kreuter, J., Shamenkov, D., Petrov, V., Ramge, P., Cychutek, K., Koch-Brandt, C., & Alyautdin, R. (2002) · Journal of drug targeting · doi:10.1080/10611860290031877 · Cited by 801

Transport of drugs across the blood–brain barrier by nanoparticles.

Wohlfart, S., Gelperina, S., & Kreuter, J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.017 · Cited by 715

Delivery of therapeutic agents to the central nervous system: the problems and the possibilities

Begley, D. J. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.08.001 · Cited by 679

Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)

Ulbrich, K., Hekmatara, T., Herbert, E., & Kreuter, J. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.08.021 · Cited by 591

Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)

Kreuter, J., Alyautdin, R. N., Kharkevich, D. A., & Aa, I. (1995) · Brain Research · doi:10.1016/0006-8993(95)00023-j · Cited by 538

Significant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated Nanoparticles

Gulyaev, A. E., Gelperina, S. E., Skidan, I. N., Antropov, A. S., Kivman, G. Y., & Kreuter, J. (1999) · Pharmaceutical Research · doi:10.1023/a:1018983904537 · Cited by 521

Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles

Kreuter, J., Ramge, P., Petrov, V. E., Hamm, S., Gelperina, S. E., Engelhardt, B., Alyautdin, R. N., von Briesen, H., & Begley, D. J. (2003) · Pharmaceutical Research · doi:10.1023/a:1022604120952 · Cited by 469

Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle

Saptarshi, S. R., Duschl, A., & Lopata, A. L. (2013) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-11-26 · Cited by 1,113

Current Strategies for Brain Drug Delivery

Dong, X. (2018) · Theranostics · doi:10.7150/thno.21254 · Cited by 954

Cancer nanomedicine: A review of recent success in drug delivery

Tran, S., DeGiovanni, P., Piel, B., & Rai, P. (2017) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0175-0 · Cited by 879

Effect of the surface modification, size, and shape on cellular uptake of nanoparticles

Salatin, S., Dizaj, S. M., & Khosroushahi, A. Y. (2015) · Cell Biology International · doi:10.1002/cbin.10459 · Cited by 626

Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?

Kreuter, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.008 · Cited by 554

Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges

Zhang, W., Mehta, A., Tong, Z., Esser, L., & Voelcker, N. H. (2021) · Advanced Science · doi:10.1002/advs.202003937 · Cited by 430

Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs

Naqvi, S., Panghal, A., & Flora, S. J. S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00494 · Cited by 305

Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes

Ghadiri, M., Young, P. M., & Traini, D. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030113 · Cited by 286

Nano carriers for drug transport across the blood–brain barrier

Li, X., Tsibouklis, J., Weng, T., Zhang, B., Yin, G., Feng, G., Cui, Y., Savina, I. N., Mikhalovska, L. I., Sandeman, S. R., et al. (2016) · Journal of drug targeting · doi:10.1080/1061186x.2016.1184272 · Cited by 289

The protein corona and its effects on nanoparticle-based drug delivery systems

Li, H., Wang, Y., Tang, Q., Yin, D., Tang, C., He, E., Zou, L., & Peng, Q. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.019 · Cited by 265

PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood–brain barrier

Fornaguera, C., Dols-Pérez, A., Calderó, G., García, M. J. N., Camarasa, J., & Solans, C. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.002 · Cited by 221

The Influence of Nanoparticle Shape on Protein Corona Formation

Visalakshan, R. M., García, L. E. G., Benzigar, M. R., Ghazaryan, A., Simon, J., Mierczynska-Vasilev, A. M., Michl, T. D., Vinu, A., Mailänder, V., Morsbach, S., et al. (2020) · Small · doi:10.1002/smll.202000285 · Cited by 202

Advances in nanocarriers enabled brain targeted drug delivery across blood brain barrier

Sharma, G., Sharma, A. R., Lee, S., Bhattacharya, M., Nam, J., & Chakraborty, C. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.01.056 · Cited by 202

Intranasal Delivery of Nanoformulations: A Potential Way of Treatment for Neurological Disorders

Islam, S. U., Shehzad, A., Ahmed, M. B., & Lee, Y. S. (2020) · Molecules · doi:10.3390/molecules25081929 · Cited by 193

Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment

Esmaeili, Y., Yarjanli, Z., Paknia, F., Bidram, E., Łoś, M., Eshraghi, M., Klionsky, D. J., Ghavami, S., & Zarrabi, A. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.001 · Cited by 184

Delivery of cancer therapeutics to extracellular and intracellular targets: Determinants, barriers, challenges and opportunities

Au, J. L. ‐., Yeung, B. Z., Wientjes, M. G., Lu, Z., & Wientjes, M. G. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.002 · Cited by 163

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Cook, A. B., & Perrier, S. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201901001 · Cited by 164

A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents across the Blood–Brain Barrier Targeting Brain Metastases of Breast Cancer

Li, J., Cai, P., Shalviri, A., Henderson, J. T., He, C., Foltz, W. D., Prasad, P., Brodersen, P. M., Chen, Y., DaCosta, R. S., et al. (2014) · ACS Nano · doi:10.1021/nn501069c · Cited by 158

Nanostructures: a platform for brain repair and augmentation

Vidu, R., Rahman, M., Mahmoudi, M., Enăchescu, M., Potecă, T. D., & Opriș, I. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00091 · Cited by 140

Nanoparticles as carriers for drug delivery of macromolecules across the blood-brain barrier

Tosi, G., Duskey, J. T., & Kreuter, J. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1698544 · Cited by 133

Glycocalyx degradation leads to blood–brain barrier dysfunction and brain edema after asphyxia cardiac arrest in rats

Zhu, J., Li, X., Yin, J., Hu, Y., Gu, Y., & Pan, S. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17726062 · Cited by 125

Stabilising cubosomes with Tween 80 as a step towards targeting lipid nanocarriers to the blood–brain barrier

Azhari, H. N., Strauss, M., Hook, S. M., Boyd, B. J., & Rizwan, S. B. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.05.001 · Cited by 121

Molybdenum Disulfide Nanoparticles as Multifunctional Inhibitors against Alzheimer’s Disease

Han, Q., Cai, S., Yang, L., Wang, X., Cui, Q., Yang, R., & Wang, C. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b03816 · Cited by 118

Brain imaging with near-infrared fluorophores

Wang, H., Mu, X., Jiang, Y., Liang, Y., Zhang, X., & Ming, D. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.11.003 · Cited by 119

Encapsulation of temozolomide in a tumor-targeting nanocomplex enhances anti-cancer efficacy and reduces toxicity in a mouse model of glioblastoma

Kim, S. S., Rait, A. S., Kim, E. H., DEMARCO, J. P., Pirollo, K. F., & Chang, E. H. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.08.022 · Cited by 115

Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications and enhanced translational potential

Agrahari, V., Burnouf, P., Burnouf, T., & Agrahari, V. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.02.008 · Cited by 115

Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy – an illustration with firsthand examples

Zhang, R., Li, J., Zhang, T., Amini, M. A., He, C., Lu, B., Ahmed, T., Lip, H., Rauth, A. M., & Wu, X. Y. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2018.33 · Cited by 112

Transferrin and the transferrin receptor for the targeted delivery of therapeutic agents to the brain and cancer cells

Dufès, C., Al Robaian, M., & Somani, S. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.21 · Cited by 110

Targeting receptor-ligand chemistry for drug delivery across blood-brain barrier in brain diseases

Anthony, D. P., Hegde, M., Shetty, S. S., Rafic, T., Mutalik, S., & Rao, B. S. S. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119326 · Cited by 110

Nanotechnology-based drug delivery for the treatment of CNS disorders

Mittal, K. R., Pharasi, N., Sarna, B., Singh, M., Rachana, R., Haider, S., Singh, S. K., Dua, K., Jha, S. K., Dey, A., et al. (2022) · Translational Neuroscience · doi:10.1515/tnsci-2022-0258 · Cited by 118

Blood-brain barrier-penetrating amphiphilic polymer nanoparticles deliver docetaxel for the treatment of brain metastases of triple negative breast cancer

He, C., Cai, P., Li, J., Zhang, T., Lin, L. Q., Abbasi, A. Z., Henderson, J. T., Rauth, A. M., & Wu, X. Y. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.12.019 · Cited by 103

The biocorona: a challenge for the biomedical application of nanoparticles

Shannahan, J. H. (2016) · Nanotechnology Reviews · doi:10.1515/ntrev-2016-0098 · Cited by 107

Systemic delivery to central nervous system by engineered PLGA nanoparticles.

Cai, Q., Wang, L., Deng, G., Liu, J., Chen, Q., & Chen, Z. (2016) · PubMed Central · Cited by 98

Brain and bone cancer targeting by a ferrofluid composed of superparamagnetic iron-oxide/silica/carbon nanoparticles (earthicles)

Wu, V., Huynh, E., Tang, S., & Uskoković, V. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.01.064 · Cited by 93

Endothelial glycocalyx as an important factor in composition of blood‐brain barrier

Zhao, F., Zhong, L., & Luo, Y. (2020) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13560 · Cited by 95

Targeting neurotransmitter receptors with nanoparticles in vivo allows single-molecule tracking in acute brain slices

Varela, J. A., Dupuis, J. P., Etchepare, L., Espana, A., Cognet, L., & Groc, L. (2016) · Nature Communications · doi:10.1038/ncomms10947 · Cited by 87

Tailored theranostic apolipoprotein E3 porphyrin-lipid nanoparticles target glioblastoma

Rajora, M. A., Ding, L., Valic, M. S., Jiang, W., Overchuk, M., Chen, J., & Zheng, G. (2017) · Chemical Science · doi:10.1039/c7sc00732a · Cited by 88

Paclitaxel/methotrexate co-loaded PLGA nanoparticles in glioblastoma treatment: Formulation development and in vitro antitumor activity evaluation

Madani, F., Esnaashari, S. S., Bergonzi, M. C., Webster, T. J., Younes, H. M., Khosravani, M., & Adabi, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117943 · Cited by 82

Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood–Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor‐Associated Macrophages

Zhang, T., Lip, H., He, C., Cai, P., Wang, Z., Henderson, J. T., Rauth, A. M., & Wu, X. Y. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900543 · Cited by 83

Novel 3D analysis of Claudin-5 reveals significant endothelial heterogeneity among CNS microvessels

Paul, D., Cowan, A. E., Ge, S., & Pachter, J. S. (2012) · Microvascular Research · doi:10.1016/j.mvr.2012.12.001 · Cited by 77

Dense poly(ethylene glycol) coatings maximize nanoparticle transport across lymphatic endothelial cells and accumulate in the skindraining lymph nodes

McCright, J., Skeen, C., Yarmovsky, J., & Maisel, K. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.03.054 · Cited by 79

Comparative examination of adsorption of serum proteins on HSA- and PLGA-based nanoparticles using SDS–PAGE and LC–MS

Gossmann, R., Fahrländer, E., Hummel, M., Mulac, D., Brockmeyer, J., & Langer, K. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.03.021 · Cited by 80

Stealth and Cationic Nanoliposomes as Drug Delivery Systems to Increase Andrographolide BBB Permeability

Piazzini, V., Landucci, E., Graverini, G., Pellegrini-Giampietro, D. E., Bilia, A. R., & Bergonzi, M. C. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030128 · Cited by 78

PEGylated solid lipid nanoparticles for brain delivery of lipophilic kiteplatin Pt(IV) prodrugs: An in vitro study

Arduino, I., Depalo, N., Re, F., Magro, R. D., Panniello, A., Margiotta, N., Fanizza, E., Lopalco, A., Laquintana, V., Cutrignelli, A., et al. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119351 · Cited by 70

The influence of the blood–brain barrier in the treatment of brain tumours

Rathi, S., Griffith, J. I. G., Zhang, W., Zhang, W., Oh, J., Talele, S., Sarkaria, J. N., & Elmquist, W. F. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13440 · Cited by 71

Targeting Glioblastoma: Advances in Drug Delivery and Novel Therapeutic Approaches

Yeini, E., Ofek, P., Albeck, N., Ajamil, D. R., Neufeld, L., Eldar‐Boock, A., Kleiner, R., Vaskovich‐Koubi, D., Koshrovski‐Michael, S., Dangoor, S. I., et al. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000124 · Cited by 70

Addressing BBB Heterogeneity: A New Paradigm for Drug Delivery to Brain Tumors

Griffith, J. I. G., Rathi, S., Zhang, W., Zhang, W., Drewes, L. R., Sarkaria, J. N., & Elmquist, W. F. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121205 · Cited by 68

Stimuli‐Responsive Self‐Assembled DNA Nanomaterials for Biomedical Applications

Dai, Z., Leung, H. M., & Lo, P. K. (2016) · Small · doi:10.1002/smll.201602881 · Cited by 68

Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimer’s Disease

Del Amo, L., Cano, A., Ettcheto, M., Souto, E. B., Espina, M., Camins, A., García, M. L., & Sánchez-López, E. (2021) · Applied Sciences · doi:10.3390/app11094305 · Cited by 67

Nanotechnology: Toxicologic Pathology

Hubbs, A. F., Sargent, L. M., Porter, D. W., Sager, T. M., Chen, B. T., Frazer, D. G., Castranova, V., Sriram, K., Nurkiewicz, T. R., Reynolds, S. H., et al. (2013) · Toxicologic Pathology · doi:10.1177/0192623312467403 · Cited by 68

Nanoparticle-mediated growth factor delivery systems: A new way to treat Alzheimer's disease

Lauzon, M.-A., Daviau, A., Marcos, B., & Faucheux, N. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.024 · Cited by 66

Tissue inhibitor of matrix metalloproteinases-1 loaded poly(lactic-co-glycolic acid) nanoparticles for delivery across the blood–brain barrier

Chaturvedi, M., Molino, Y., Sreedhar, B., Khrestchatisky, M., & Kaczmarek, L. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s54750 · Cited by 65

The use of polymer-based nanoparticles and nanostructured materials in treatment and diagnosis of cardiovascular diseases: Recent advances and emerging designs

Wang, Y.-J., Larsson, M., Huang, W.-T., Chiou, S., Nicholls, S. J., Chao, J., & Liu, D.-M. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.01.002 · Cited by 65

Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: At a glance

Rhaman, M. M., Islam, M. R., Akash, S., Mim, M., Noor alam, M., Nepovimova, E., Valis, M., Kuca, K., & Sharma, R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.989471 · Cited by 63

Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors – An update

Power, E. A., Rechberger, J. S., Gupta, S. K., Schwartz, J., Daniels, D. J., & Khatua, S. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114303 · Cited by 63

Enhancing paracellular and transcellular permeability using nanotechnological approaches for the treatment of brain and retinal diseases

Khalil, A., Barras, A., Boukherroub, R., Tseng, C., Devos, D., Burnouf, T. P. R., Neuhaus, W., & Szunerits, S. (2023) · Nanoscale Horizons · doi:10.1039/d3nh00306j · Cited by 62

Optimization of Curcumin-Loaded PEG-PLGA Nanoparticles by GSH Functionalization: Investigation of the Internalization Pathway in Neuronal Cells

Paka, G. D., & Ramassamy, C. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00738 · Cited by 62

Nano‐Biotechnology and Challenges of Drug Delivery System in Cancer Treatment Pathway: Review Article

Asadipour, E., Asgari, M., Mousavi, P., Gharaghie, T. P., Ghajari, G., & Mirzaie, A. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202201072 · Cited by 58

In vivo Functional Evaluation of Increased Brain Delivery of the Opioid Peptide DAMGO by Glutathione-PEGylated Liposomes

Lindqvist, A., Rip, J., van Kregten, J., Gaillard, P. J., & Hammarlund‐Udenaes, M. (2015) · Pharmaceutical Research · doi:10.1007/s11095-015-1774-3 · Cited by 56

Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines

Mallapragada, S. K., Brenza, T. M., McMillan, J., Narasimhan, B., Sakaguchi, D. S., Sharma, A. D., Zbarska, S., & Gendelman, H. E. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.12.013 · Cited by 55

Effects of Particle Hydrophobicity, Surface Charge, Media pH Value and Complexation with Human Serum Albumin on Drug Release Behavior of Mitoxantrone-Loaded Pullulan Nanoparticles

Tao, X., Jin, S., Wu, D., Ling, K., Yuan, L., Lin, P., Xie, Y., & Yang, X. (2015) · Nanomaterials · doi:10.3390/nano6010002 · Cited by 53

Evaluation of brain-targeted chitosan nanoparticles through blood–brain barrier cerebral microvessel endothelial cells

Şahin, A., Yöyen-Ermiş, D., Caban-Toktas, S., Horzum, U., Aktaş, Y., Couvreur, P., Esendağlı, G., & Çapan, Y. (2017) · Journal of Microencapsulation · doi:10.1080/02652048.2017.1375039 · Cited by 52

Transferrin-Coated Gadolinium Nanoparticles as MRI Contrast Agent

Korkusuz, H., Ulbrich, K., Welzel, K., Koeberle, V., Watcharin, W., Bahr, U., Chernikov, V. P., Knobloch, T., Petersen, S., Huebner, F., et al. (2012) · Molecular Imaging and Biology · doi:10.1007/s11307-012-0579-6 · Cited by 49

Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line

Guccione, C., Oufir, M., Piazzini, V., Eigenmann, D. E., Jähne, E. A., Zabela, V., Faleschini, M. T., Bergonzi, M. C., Smieško, M., Hamburger, M. O., et al. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.06.018 · Cited by 48

The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems

Fonseca‐Santos, B., & Chorilli, M. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119832 · Cited by 47

Crossing the blood–brain barrier with graphene nanostructures

Tabish, T. A., & Narayan, R. J. (2021) · Materials Today · doi:10.1016/j.mattod.2021.08.013 · Cited by 47

Biodegradable Nanoparticles for Delivery of Therapeutics in CNS Infection

DeMarino, C., Schwab, A., Pleet, M. L., Mathiesen, A. H., Friedman, J. M., El‐Hage, N., & Kashanchi, F. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9692-7 · Cited by 42

Surface-modified gatifloxacin nanoparticles with potential for treating central nervous system tuberculosis

Marcianes, P., Negro, S., García‐García, L., Montejo, C., Barcia, E., & Fernández-Carballido, A. M. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s130908 · Cited by 42

Application of isothermal titration calorimetry in evaluation of protein–nanoparticle interactions

Omanović-Mikličanin, E., Manfield, I. W., & Wilkins, T. (2016) · Journal of Thermal Analysis and Calorimetry · doi:10.1007/s10973-016-5764-4 · Cited by 40

Preparation and Drug Release Study of Novel Nanopharmaceuticals with Polysorbate 80 Surface Adsorption

Tao, X., Yu, L., Hu, Q., Zhu, L., Huang, Z., Yi, J., Yang, X., Hu, J., & Feng, X. (2018) · Journal of Nanomaterials · doi:10.1155/2018/4718045 · Cited by 41

Lactoferrin-conjugated pH and redox-sensitive polymersomes based on PEG-S-S-PLA-PCL-OH boost delivery of bacosides to the brain

Goyal, K., Konar, A., Kumar, B. S. H., & Koul, V. (2018) · Nanoscale · doi:10.1039/c8nr03828g · Cited by 38

Diagnostic and Therapeutic Uses of Nanomaterials in the Brain

Garbayo, E., de Mendoza, A. E., & Blanco‐Prieto, M. J. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140815124246 · Cited by 38

Comparative whole corona fingerprinting and protein adsorption thermodynamics of PLGA and PCL nanoparticles in human serum

Ndumiso, M., Buchtová, N., Hüsselmann, L., Mohamed, G., Klein, A., Aucamp, M. E., Canevet, D., D’Souza, S., Maphasa, R. E., Boury, F., et al. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.110816 · Cited by 37

Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats

Sun, D., Xue, A., Zhang, B., Lou, H., Shi, H., & Zhang, X. (2015) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12481 · Cited by 35

Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection

Pashirova, T. N., Braïki, A., Zueva, I. V., Petrov, K. A., Babaev, V. M., Burilova, E. A., Kuznetsova, D. A., Rizvanov, I. K., Souto, E. B., Jean, L., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.10.010 · Cited by 34

The Use of Anthracyclines for Therapy of CNS Tumors

Ros, M. D., Iorio, A. L., Lucchesi, M., Stival, A., de Martino, M., & Sardi, I. (2015) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520615666150407155319 · Cited by 33

Role of Nanotechnology for Enzyme Replacement Therapy in Lysosomal Diseases. A Focus on Gaucher’s Disease

Martín‐Banderas, L., Holgado, M. A., Durán‐Lobato, M., Infante, J. J., Álvarez‐Fuentes, J., & Arévalo, M. F. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666160210130608 · Cited by 33

Berberine-loaded zein/hyaluronic acid composite nanoparticles for efficient brain uptake to alleviate neuro-degeneration in the pilocarpine model of epilepsy

El-Nahas, A. E., Elbedaiwy, H. M., Masoud, I. M., Aly, R. G. M., Helmy, M. W., & El-Kamel, A. H. (2023) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2023.04.008 · Cited by 32

Poly(lactic- co -glycolic acid): The most ardent and flexible candidate in biomedicine!

Roointan, A., Kianpour, S., Memari, F., Gandomani, M., Hayat, S. M. G., & Mohammadi‐Samani, S. (2018) · International Journal of Polymeric Materials · doi:10.1080/00914037.2017.1405350 · Cited by 33

Amifostine-Loaded Nanocarrier Traverses the Blood–Brain Barrier and Prevents Radiation-Induced Brain Injury

Zhao, X., Cheng, J., Gui, S., Jiang, M., Qi, D., Huang, J., Fu, L., Liu, S., Ma, Y., Shi, J., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c00502 · Cited by 30

Gelsolin Amyloidogenesis Is Effectively Modulated by Curcumin and Emetine Conjugated PLGA Nanoparticles

Srivastava, A., Arya, P., Goel, S., Kundu, B., Mishra, P., & Ashish, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127011 · Cited by 30

Thin platelet-like COF nanocomposites for blood brain barrier transport and inhibition of brain metastasis from renal cancer

Zhang, G., Jiang, B., Wu, C., Liu, Y., He, Y., Huang, X., Chen, W., Xi, K., Guo, H., Zhao, X., et al. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00724b · Cited by 29

Combinatorial therapeutic strategies for enhanced delivery of therapeutics to brain cancer cells through nanocarriers: current trends and future perspectives

Wang, X., Wu, C., Liu, S., & Peng, D. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2069881 · Cited by 31

Nanomedicine and Nanotoxicology: The Pros and Cons for Neurodegeneration and Brain Cancer

Catalan, J., Palma-Florez, S., Álvarez, G., Fritz, H. F., Jara, M. O., & Morales, J. O. (2015) · Nanomedicine · doi:10.2217/nnm.15.189 · Cited by 29

Novel functionalization strategies of polymeric nanoparticles as carriers for brain medications

Portioli, C., Bovi, M., Benati, D., Donini, M., Perduca, M., Romeo, A., Dusi, S., Monaco, H. L., & Bentivoglio, M. (2016) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35961 · Cited by 31

Selective Targeting of Cancer Signaling Pathways with Nanomedicines: Challenges and Progress

Barkat, H. A., Das, S. S., Barkat, M. A., Beg, S., & Hadi, H. A. (2020) · Future Oncology · doi:10.2217/fon-2020-0198 · Cited by 29

Optimizing the Design of Blood–Brain Barrier-Penetrating Polymer-Lipid-Hybrid Nanoparticles for Delivering Anticancer Drugs to Glioblastoma

Ahmed, T., Liu, F.-C. F., He, C., Abbasi, A. Z., Cai, P., Rauth, A. M., Henderson, J. T., & Wu, X. Y. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03122-9 · Cited by 28

The removal of percutaneous Kirschner wires used in the stabilisation of fractures in children.

Symons, S., Persad, R., & Paterson, M. (2005) · PubMed · Cited by 27

Bionanotechnology and the Future of Glioma

Chiarelli, P., Kievit, F. M., Zhang, M., & Ellenbogen, R. G. (2015) · Surgical Neurology International · doi:10.4103/2152-7806.151334 · Cited by 27

Exosomes for neurodegenerative diseases: diagnosis and targeted therapy

Tao, H., & Gao, B. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12329-w · Cited by 27

Polymeric nanoparticles assembled with microfluidics for drug delivery across the blood-brain barrier

Tavares, M. R., de Menezes, L. R., do Nascimento, D. F., Souza, D. H. S., Reynaud, F., Marques, M. D. F. V., & Tavares, M. I. B. (2016) · The European Physical Journal Special Topics · doi:10.1140/epjst/e2015-50266-2 · Cited by 26

A new preparation strategy for surface modified PLA nanoparticles to enhance uptake by endothelial cells

Raudszus, B., Mulac, D., & Langer, K. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.11.047 · Cited by 22

Influence of Chronobiology on the Nanoparticle-Mediated Drug Uptake into the Brain

Kreuter, J. (2015) · Pharmaceutics · doi:10.3390/pharmaceutics7010003 · Cited by 22

Carbohydrate Nanoparticles for Brain Delivery

Lalatsa, A., & Barbu, E. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.05.004 · Cited by 22

Benefits of Nanomedicine for Therapeutic Intervention in Malignant Diseases

Sevastre, A.-S., Horescu, C., Baloi, C., Cioc, C. E., Vatu, B. I., Tuţă, C., Artene, Ş.-A., Dănciulescu, M. M., Tudorache, Ş., & Dricu, A. (2019) · Coatings · doi:10.3390/coatings9100628 · Cited by 22

Artificial intelligence and guidance of medicine in the bubble

Akbar, A., Pillalamarri, N., Jonnakuti, S. T., & Ullah, M. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00623-3 · Cited by 21

Small Particles, Big Potential: Polymeric Nanoparticles for Drug Delivery in Parkinson's Disease

Virameteekul, S., Lees, A. J., & Bhidayasiri, R. (2024) · Movement Disorders · doi:10.1002/mds.29939 · Cited by 23

Behavior of P85 and P188 Poloxamer Molecules: Computer Simulations Using United-Atom Force-Field

Goliaei, A., Lau, E. Y., Adhikari, U., Schwegler, E., & Berkowitz, M. L. (2016) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6b03030 · Cited by 20

Nanomedicine metaphors: From war to care. Emergence of an oecological approach

Loeve, S., Bensaude‐Vincent, B., & Gazeau, F. (2013) · Nano Today · doi:10.1016/j.nantod.2013.08.003 · Cited by 22

Recent Advancements in Nanocarrier-assisted Brain Delivery of Phytochemicals Against Neurological Diseases

Mishra, K., Rana, R., Tripathi, S., Siddiqui, S., Yadav, P. K., Yadav, P. N., & Chourasia, M. K. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03955-3 · Cited by 18

Influence of the Surface Properties on Nanoparticle-Mediated Transport of Drugs to the Brain

Kreuter, J. (2004) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2003.077 · Cited by 363

From Adsorption to Covalent Bonding: Apolipoprotein E Functionalization of Polymeric Nanoparticles for Drug Delivery Across the Blood–Brain Barrier

Hartl, N., Adams, F., & Merkel, O. M. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000092 · Cited by 157

Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier.

Kreuter, J., Shamenkov, D., Petrov, V., Ramge, P., Cychutek, K., Koch-Brandt, C., & Alyautdin, R. (2002) · Journal of drug targeting · doi:10.1080/10611860290031877 · Cited by 801

Transport of drugs across the blood–brain barrier by nanoparticles.

Wohlfart, S., Gelperina, S., & Kreuter, J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.017 · Cited by 715

Nanoparticulate systems for brain delivery of drugs.

Kreuter, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00122-8 · Cited by 1,107