The role of particle physico-chemical properties in pulmonary drug delivery for tuberculosis therapy

Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles

Cedervall, T., Lynch, I., Lindman, S., Berggård, T., Thulin, E., Nilsson, H., Dawson, K. A., & Linse, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608582104 · Cited by 3,281 · see citing works

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., & Dawson, K. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805135105 · Cited by 3,037 · see citing works

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

Aggarwal, P., Hall, J. B., McLeland, C. B., Dobrovolskaia, M. A., & McNeil, S. E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.009 · Cited by 1,791 · see citing works

The Immune Response in Tuberculosis

O’Garra, A., Redford, P. S., McNab, F. W., Bloom, C. I., Wilkinson, R. J., & Berry, M. P. R. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095939 · Cited by 1,351 · see citing works

Inhaling medicines: delivering drugs to the body through the lungs

Patton, J. S., & Byron, P. R. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2153 · Cited by 1,329 · see citing works

Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications

Labiris, N. R., & DOLOVICH, M. B. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.01892.x · Cited by 1,250 · see citing works

Large Porous Particles for Pulmonary Drug Delivery

Edwards, D. A., Hanes, J. S., Caponetti, G., Hrkach, J. S., Ben-Jebria, A., Eskew, M. L., Mintzes, J. D., Deaver, D. R., Lotan, N., & Langer, R. (1997) · Science · doi:10.1126/science.276.5320.1868 · Cited by 1,176 · see citing works

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

Stover, C. K., Warrener, P., VanDevanter, D. R., Sherman, D. R., Arain, T. M., Langhorne, M. H., Anderson, S. W., Towell, J. A., Yuan, Y., McMurray, D. N., et al. (2000) · Nature · doi:10.1038/35016103 · Cited by 1,039 · see citing works

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

Greiner, B., Eichelbaum, M. F., Fritz, P., Kreichgauer, H. P., von Richter, O., Zundler, J., & Kroemer, H. K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6663 · Cited by 917 · see citing works

Interaction of high molecular weight kininogen, factor XII, and fibrinogen in plasma at interfaces

Vroman, L., Adams, A., Fischer, G., & Munoz, P. (1980) · Blood · doi:10.1182/blood.v55.1.156.156 · Cited by 781 · see citing works

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module

Goodwin, B. J., Hodgson, E., & Liddle, C. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.6.1329 · Cited by 648 · see citing works

Influence of particle size on regional lung deposition – What evidence is there?

Carvalho, T. C., Peters, J. I., & Williams III, R. O. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.12.040 · Cited by 614 · see citing works

Dry Powder Inhaler Formulation

Telko, M. J., & Hickey, A. J. (2005) · Respiratory Care · doi:10.4187/respcare.05501209 · Cited by 515 · see citing works

Modelling inhaled particle deposition in the human lung—A review

HOFMANN, W. (2011) · Journal of Aerosol Science · doi:10.1016/j.jaerosci.2011.05.007 · Cited by 503 · see citing works

Extrahepatic Metabolism of Drugs in Humans

Krishna, D. R., & Klotz, U. E. (1994) · Clinical Pharmacokinetics · doi:10.2165/00003088-199426020-00007 · Cited by 437 · see citing works

Effect of Adsorbed Proteins on the Wettability of Hydrophilic and Hydrophobic Solids

Vroman, L. (1962) · Nature · doi:10.1038/196476a0 · Cited by 409 · see citing works

In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery

Sakagami, M. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.012 · Cited by 331 · see citing works

Solid lipid particle-based inhalable sustained drug delivery system against experimental tuberculosis

Pandey, R., & Khuller, G. K. (2005) · Tuberculosis · doi:10.1016/j.tube.2004.11.003 · Cited by 318 · see citing works

Role of individual drugs in the chemotherapy of tuberculosis.

Mitchison, D. A. (2000) · PubMed · Cited by 314 · see citing works

Preventing Tuberculosis with Bacillus Calmette-Guérin Vaccine: A Meta-Analysis of the Literature

Brewer, T. F. (2000) · Clinical Infectious Diseases · doi:10.1086/314072 · Cited by 283 · see citing works

Respirable PLGA Microspheres Containing Rifampicin for the Treatment of Tuberculosis: Manufacture and Characterization

O’Hara, P. J., & Hickey, A. J. (2000) · Pharmaceutical Research · doi:10.1023/a:1007527204887 · Cited by 242 · see citing works

Whither short-course chemotherapy?

Fox, W. (1981) · British Journal of Diseases of the Chest · doi:10.1016/0007-0971(81)90022-x · Cited by 216 · see citing works

The Influence of Age, Diagnosis, and Gender on Proper Use of Metered-Dose Inhalers

Goodman, D., Israel, E., Rosenberg, M. H., JOHNSTON, R. G., Weiss, S. T., & Drazen, J. M. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.5.7952549 · Cited by 212 · see citing works

Moxifloxacin, Ofloxacin, Sparfloxacin, and Ciprofloxacin against Mycobacterium tuberculosis : Evaluation of In Vitro and Pharmacodynamic Indices That Best Predict In Vivo Efficacy

Shandil, R. K., Jayaram, R., Kaur, P., Gaonkar, S., Suresh, B. L., Mahesh, B. N., Jayashree, R., Nandi, V., Bharath, S., & Balasubramanian, V. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00414-06 · Cited by 203 · see citing works

Inhalable Microparticles Containing Drug Combinations to Target Alveolar Macrophages for Treatment of Pulmonary Tuberculosis

Sharma, R., Saxena, D., Dwivedi, A. K., & Misra, A. (2001) · Pharmaceutical Research · doi:10.1023/a:1012296604685 · Cited by 201 · see citing works

Novel tobramycin inhalation powder in cystic fibrosis subjects: Pharmacokinetics and safety

Geller, D. E., Konstan, M. W., Smith, J. J., Noonberg, S. B., & Conrad, C. (2007) · Pediatric Pulmonology · doi:10.1002/ppul.20594 · Cited by 195 · see citing works

Antitubercular inhaled therapy: opportunities, progress and challenges

Pandey, R., & Khuller, G. K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki027 · Cited by 188 · see citing works

The chemotherapy of tuberculosis: past, present and future [State of the art]

Mitchison, D. A., & Davies, G. (2012) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.12.0083 · Cited by 185 · see citing works

Inhalable microparticles containing large payload of anti-tuberculosis drugs

Muttil, P., Kaur, J. P., Kumar, K., Yadav, A. B., Sharma, R., & Misra, A. (2007) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2007.06.006 · Cited by 173 · see citing works

Inhaled drug therapy for treatment of tuberculosis

Misra, A., Hickey, A. J., Rossi, C. R., Borchard, G., Terada, H., Makino, K., Fourie, P. B., & Colombo, P. (2010) · Tuberculosis · doi:10.1016/j.tube.2010.08.009 · Cited by 171 · see citing works

In Vitro Activities of Fourteen Antimicrobial Agents Against Drug Susceptible and Resistant Clinical Isolates of Mycobacterium tuberculosis and Comparative Intracellular Activities Against the Virulent H37Rv Strain in Human Macrophages

Rastogi, N., Labrousse, V., & Goh, K. S. (1996) · Current Microbiology · doi:10.1007/s002849900095 · Cited by 171 · see citing works

Effect of Particle Shape on Dry Particle Inhalation: Study of Flowability, Aerosolization, and Deposition Properties

Hassan, M. S., & Lau, R. W. M. (2009) · AAPS PharmSciTech · doi:10.1208/s12249-009-9313-3 · Cited by 165 · see citing works

Respirable PLGA Microspheres Containing Rifampicin for the Treatment of Tuberculosis: Screening in An Infectious Disease Model

Suarez, S., O’Hara, P. J., Kazantseva, M., Newcomer, C. E., Hopfer, R. L., McMurray, D. N., & Hickey, A. J. (2001) · Pharmaceutical Research · doi:10.1023/a:1013094112861 · Cited by 159 · see citing works

Airways delivery of rifampicin microparticles for the treatment of tuberculosis

Suarez, S. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.3.431 · Cited by 156 · see citing works

Dynamic development of the protein corona on silica nanoparticles: composition and role in toxicity

Mortensen, N. P., Hurst, G. B., Wang, W., Foster, C. M., Nallathamby, P. D., & Retterer, S. T. (2013) · Nanoscale · doi:10.1039/c3nr33280b · Cited by 150 · see citing works

Inhaled Drug Delivery for Tuberculosis Therapy

Muttil, P., Wang, C., & Hickey, A. J. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9957-4 · Cited by 145 · see citing works

Inhaled Large Porous Particles of Capreomycin for Treatment of Tuberculosis in a Guinea Pig Model

Garcia‐Contreras, L., Fiegel, J., Telko, M. J., Elbert, K. J., Hawi, A. A., Thomas, M., VerBerkmoes, J. L., Germishuizen, W. A., Fourie, P. B., Hickey, A. J., et al. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01164-06 · Cited by 139 · see citing works

Phase II Dose-Ranging Trial of the Early Bactericidal Activity of PA-824

Diacon, A. H., Dawson, R., du Bois, J., Narunsky, K., Venter, A., Donald, P. R., van Niekerk, C., Erondu, N., Ginsberg, A. M., Becker, P., et al. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.06125-11 · Cited by 136 · see citing works

Phase I, Single-Dose, Dose-Escalating Study of Inhaled Dry Powder Capreomycin: a New Approach to Therapy of Drug-Resistant Tuberculosis

Dharmadhikari, A., Kabadi, M. B., Gerety, B., Hickey, A. J., Fourie, P. B., & Nardell, E. A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02346-12 · Cited by 135 · see citing works

Delivery of rifampicin–PLGA microspheres into alveolar macrophages is promising for treatment of tuberculosis

Hirota, K., Hasegawa, T., Nakajima, T., Inagawa, H., Kohchi, C., Soma, G., Makino, K., & Terada, H. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.11.020 · Cited by 129 · see citing works

Isoniazid Proliposome Powders for Inhalation—Preparation, Characterization and Cell Culture Studies

Rojanarat, W., Changsan, N., Tawithong, E., Pinsuwan, S., Chan, H., & Srichana, T. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12074414 · Cited by 120 · see citing works

Delivery of ofloxacin to the lung and alveolar macrophages via hyaluronan microspheres for the treatment of tuberculosis

Hwang, S., Kim, D. D., Chung, S., & Shim, C. K. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.04.009 · Cited by 103 · see citing works

A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics

Chan, J. G. Y., Chan, H., Prestidge, C. A., Denman, J. A., Young, P. M., & Traini, D. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.08.007 · Cited by 100 · see citing works

Preparation and in Vivo Evaluation of a Dry Powder for Inhalation of Capreomycin

Fiegel, J., Garcia‐Contreras, L., Thomas, M., VerBerkmoes, J. L., Elbert, K. J., Hickey, A. J., & Edwards, D. A. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9381-6 · Cited by 95 · see citing works

Respiratory Tract Uptake of Inhalants and Metabolism of Xenobiotics

Dahl, A. R., & Lewis, J. L. (1993) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.33.040193.002123 · Cited by 80 · see citing works

Inhaled pyrazinamide proliposome for targeting alveolar macrophages

Rojanarat, W., Nakpheng, T., Thawithong, E., Yanyium, N., & Srichana, T. (2012) · Drug Delivery · doi:10.3109/10717544.2012.721144 · Cited by 79 · see citing works

Dry Powder PA-824 Aerosols for Treatment of Tuberculosis in Guinea Pigs

Garcia‐Contreras, L., Sung, J. C., Muttil, P., Padilla, D., Telko, M., VerBerkmoes, J. L., Elbert, K. J., Hickey, A. J., & Edwards, D. A. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01471-09 · Cited by 76 · see citing works

Testing of Mycobacterium tuberculosis susceptibility to ethambutol, isoniazid, rifampin, and streptomycin by using Etest

Wanger, A. R., & Mills, K. (1996) · Journal of Clinical Microbiology · doi:10.1128/jcm.34.7.1672-1676.1996 · Cited by 73 · see citing works

Direct lung delivery of para-aminosalicylic acid by aerosol particles

Tsapis, N., Bennett, D., O'Driscoll, K. M., Shea, K., Lipp, M., Fu, K., Clarke, R. W., Deaver, D. R., Yamins, D. L. K., Wright, J. E., et al. (2003) · Tuberculosis · doi:10.1016/j.tube.2003.08.016 · Cited by 72 · see citing works

Dry Powder Nitroimidazopyran Antibiotic PA-824 Aerosol for Inhalation

Sung, J. C., Garcia‐Contreras, L., VerBerkmoes, J. L., Peloquin, C. A., Elbert, K. J., Hickey, A. J., & Edwards, D. A. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01389-08 · Cited by 72 · see citing works

CD4 and CD8 T Cell Responses to the M. tuberculosis Ag85B-TB10.4 Promoted by Adjuvanted Subunit, Adenovector or Heterologous Prime Boost Vaccination

Elvang, T. T., Christensen, J. P., Billeskov, R., Hoang, T. T. K. T., Holst, P. J., Thomsen, A. R., Andersen, P. L., & Dietrich, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005139 · Cited by 71 · see citing works

Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824

Li, X., Manjunatha, U. H., Goodwin, M. B., Knox, J. E., Lipinski, C. A., Keller, T. H., Barry, C. E., & Dowd, C. S. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.03.011 · Cited by 70 · see citing works

Dry Powder Antibiotic Aerosol Product Development: Inhaled Therapy for Tuberculosis

Hickey, A. J., Misra, A., & Fourie, P. B. (2013) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23705 · Cited by 68 · see citing works

Chitosan microspheres as an alveolar macrophage delivery system of ofloxacin via pulmonary inhalation

Park, J.-H., Jin, H., Kim, D., Chung, S., Shim, W., & Shim, C. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.10.044 · Cited by 68 · see citing works

The near future: Improving the activity of rifamycins and pyrazinamide

Mitchison, D. A., & Fourie, P. B. (2010) · Tuberculosis · doi:10.1016/j.tube.2010.03.005 · Cited by 68 · see citing works

KINETIC ASPECTS OF DRUG DISPOSITION IN THE LUNGS

Upton, R. N., & Doolette, D. (1999) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.1999.03048.x · Cited by 63 · see citing works

Development of a spray-drying method for the formulation of respirable microparticles containing ofloxacin–palladium complex

Palazzo, F., Giovagnoli, S., Schoubben, A., Blasi, P., Rossi, C. R., & Ricci, M. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.05.045 · Cited by 63 · see citing works

Inhaled Microparticles Containing Clofazimine Are Efficacious in Treatment of Experimental Tuberculosis in Mice

Verma, R. K., Germishuizen, W. A., Motheo, M. P., Agrawal, A. K., Singh, A. K., Mohan, M., Gupta, P., Gupta, U. D., Cholo, M. C., Anderson, R., et al. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01897-12 · Cited by 62 · see citing works

Generation and Respiratory Deposition of Therapeutic Aerosols

Swift, D. L. (1980) · American Review of Respiratory Disease · doi:10.1164/arrd.1980.122.5p2.71 · Cited by 61 · see citing works

Preclinical evidence for implementing a prime-boost vaccine strategy for tuberculosis

Brennan, M. J., Clagett, B., Fitzgerald, H., Chen, V., Williams, A., Izzo, A. A., & Barker, L. F. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.02.036 · Cited by 60 · see citing works

In vitro and in vivo activities of the benzoxazinorifamycin KRM-1648 against Mycobacterium tuberculosis

Hirata, T., Saito, H., Tomioka, H., Sato, K., Jidoi, J., Hosoe, K., & HIDAKA, T. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.10.2295 · Cited by 60 · see citing works

Capreomycin supergenerics for pulmonary tuberculosis treatment: Preparation, in vitro, and in vivo characterization

Schoubben, A., Blasi, P., Marenzoni, M. L., Barberini, L., Giovagnoli, S., Cirotto, C., & Ricci, M. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.11.005 · Cited by 48 · see citing works

Drug Delivery to the Lung: Permeability and Physicochemical Characteristics of Drugs as the Basis for a Pulmonary Biopharmaceutical ClassificationSystem (pBCS)

Eixarch, H., Haltner‐Ukomadu, E., Beißwenger, C., & Bock, U. (2010) · Journal of Epithelial Biology & Pharmacology · Cited by 48 · see citing works

Pharmaceutical aerosols for the treatment and prevention of Tuberculosis

Hanif, S. N. M., & Garcia‐Contreras, L. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00118 · Cited by 45 · see citing works

Pharmacokinetics of Sequential Doses of Capreomycin Powder for Inhalation in Guinea Pigs

Garcia‐Contreras, L., Muttil, P., Fallon, J. K., Kabadi, M. B., Gerety, R., & Hickey, A. J. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.06145-11 · Cited by 41 · see citing works

Targeting the small airways asthma phenotype: if we can reach it, should we treat it?

Lipworth, B. J. (2013) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2013.02.009 · Cited by 39 · see citing works

Screening for Potential Adjuvants Administered by the Pulmonary Route for Tuberculosis Vaccines

Wang, C., Muttil, P., Lu, D., Beltran-Torres, A. A., Garcia‐Contreras, L., & Hickey, A. J. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9089-0 · Cited by 33 · see citing works

On the fate of inhaled particles in the human: A comparison of experimental data with theoretical computations based on a symmetric and asymmetric lung

Martonen, T. B. (1983) · Bulletin of Mathematical Biology · doi:10.1016/s0092-8240(83)80063-9 · Cited by 31 · see citing works

Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells

Juarrero, M. G., & O’Sullivan, M. P. (2010) · Tuberculosis · doi:10.1016/j.tube.2010.08.007 · Cited by 26 · see citing works

Deposition of inhaled particulate matter in the upper respiratory tract, larynx, and bronchial airways: A mathematical description

Martonen, T. B. (1983) · Journal of Toxicology and Environmental Health · doi:10.1080/15287398309530470 · Cited by 24 · see citing works

On the fate of inhaled particles in the human: A comparison of experimental data with theoretical computations based on a symmetric and asymmetric lung

Martonen, T. B. (1983) · Bulletin of Mathematical Biology · doi:10.1007/bf02459399 · Cited by 23 · see citing works

Inhaled Therapies for Tuberculosis and the Relevance of Activation of Lung Macrophages By Particulate drug-delivery Systems

Verma, R. K., Singh, A. K., Mohan, M., Agrawal, A. K., & Misra, A. (2011) · Therapeutic Delivery · doi:10.4155/tde.11.34 · Cited by 18 · see citing works

Do inhaled corticosteroid/long-acting beta2-agonist fixed combinations provide superior clinical benefits compared with separate inhalers? A literature reappraisal

Barnes, P. J., Nicolini, G., Bizzi, A., Spinola, M., & Singh, D. (2012) · Allergy and Asthma Proceedings · doi:10.2500/aap.2012.33.3512 · Cited by 17 · see citing works

Aerosolized Gentamicin Reduces the Burden of Tuberculosis in a Murine Model

Roy, C. J., Sivasubramani, S. K., Dutta, N. K., Mehra, S., Golden, N., Killeen, S. Z., Talton, J. D., Hammoud, B. E., Didier, P. J., & Kaushal, D. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05633-11 · Cited by 16 · see citing works

Targeting small airways in asthma: improvement in clinical benefit?

Ulrik, C. S., & Lange, P. (2010) · The Clinical Respiratory Journal · doi:10.1111/j.1752-699x.2010.00235.x · Cited by 11 · see citing works

[PAS inhalation therapy of respiratory tuberculosis in the sanatorium LIBANI; preliminary communication].

Ta, B. (2003) · PubMed · Cited by 2 · see citing works

Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works

Composite CD-MOF nanocrystals-containing microspheres for sustained drug delivery

Li, H., Lv, N., Li, X., Liu, B., Feng, J., Ren, X., Guo, T., Chen, D., Stoddart, J. F., Gref, R., et al. (2017) · Nanoscale · doi:10.1039/c6nr07593b · Cited by 278 · see citing works

The formulation of nanomedicines for treating tuberculosis

Costa, A., Pinheiro, M., Magalhães, J., Ribeiro, R., Seabra, V., Reis, S., & Sarmento, B. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.012 · Cited by 123 · see citing works

Effects of nanoparticles on the mechanical functioning of the lung

Arick, D. Q., Choi, Y. H., Kim, H. C., & Won, Y. (2015) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2015.10.002 · Cited by 85 · see citing works

Nanotechnology‐Based Targeted Drug Delivery: An Emerging Tool to Overcome Tuberculosis

Baranyai, Z., Soria‐Carrera, H., Alleva, M., Millán-Placer, A. C., Lucía, A., Martín‐Rapún, R., Aínsa, J. A., & de la Fuente, J. M. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000113 · Cited by 85 · see citing works

Inhaled drug treatment for tuberculosis: Past progress and future prospects

Hickey, A. J., Durham, P. G., Dharmadhikari, A., & Nardell, E. A. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.11.018 · Cited by 81 · see citing works

Microencapsulated Solid Lipid Nanoparticles as a Hybrid Platform for Pulmonary Antibiotic Delivery

Gaspar, D. P., Gaspar, M. M., Eleutério, C., Grenha, A., Blanco, M., Gonçalves, L., Taboada, P., Almeida, A. J., & Remuñán‐López, C. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00169 · Cited by 77 · see citing works

An Inhalable Theranostic System for Local Tuberculosis Treatment Containing an Isoniazid Loaded Metal Organic Framework Fe-MIL-101-NH2—From Raw MOF to Drug Delivery System

Wyszogrodzka, G., Dorożyński, P., Giovagnoli, S., Strzempek, W., Pesta, E., Węglarz, W. P., Gil, B., Menaszek, E., & Kulinowski, P. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11120687 · Cited by 75 · see citing works

Recent Advances in Research on the Effect of Physicochemical Properties on the Cytotoxicity of Metal–Organic Frameworks

Hao, F., Yan, Z., & Yan, X. (2022) · Small Science · doi:10.1002/smsc.202200044 · Cited by 62 · see citing works

Controlled delivery of inhaled therapeutic agents

Hickey, A. J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.058 · Cited by 53 · see citing works

High dose dry powder inhalers to overcome the challenges of tuberculosis treatment

Momin, M. A. M., Tucker, I. G., & Das, S. C. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.08.061 · Cited by 53 · see citing works

Lung surfactant-particles at fluid interfaces for toxicity assessments

Guzmán, E., & Santini, E. (2019) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2019.01.003 · Cited by 53 · see citing works

Dry powder formulation of kanamycin with enhanced aerosolization efficiency for drug-resistant tuberculosis

Momin, M. A. M., Sinha, S., Tucker, I. G., Doyle, C., & Das, S. C. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.06.004 · Cited by 47 · see citing works

Effective nebulization of interferon-γ using a novel vibrating mesh

Sweeney, L., McCloskey, A. P., Higgins, G., Ramsey, J. M., Cryan, S., & MacLoughlin, R. J. (2019) · Respiratory Research · doi:10.1186/s12931-019-1030-1 · Cited by 43 · see citing works

Microencapsulated SLN: An innovative strategy for pulmonary protein delivery

Gaspar, D. P., Serra, C., Lino, P. R., Gonçalves, L., Taboada, P., Remuñán‐López, C., & Almeida, A. J. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.11.037 · Cited by 42 · see citing works

Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery

Miranda, M. S., Rodrigues, M. T., Domingues, R. M. A., Torrado, E., Reis, R. L., Pedrosa, J., & Gomes, M. E. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.09.004 · Cited by 42 · see citing works

A Review on Recent Technologies for the Manufacture of Pulmonary Drugs

Hadiwinoto, G. D., Kwok, P. C. L., & Lakerveld, R. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0083 · Cited by 41 · see citing works

Manipulation of spray-drying conditions to develop dry powder particles with surfaces enriched in hydrophobic material to achieve high aerosolization of a hygroscopic drug

Momin, M. A. M., Tucker, I. G., Doyle, C., Denman, J. A., & Das, S. C. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.04.003 · Cited by 40 · see citing works

Immobilization and Intracellular Delivery of Structurally Nanoengineered Antimicrobial Peptide Polymers Using Polyphenol‐Based Capsules

Song, J., Cortez‐Jugo, C., Shirbin, S. J., Lin, Z., Pan, S., Qiao, G. G., & Caruso, F. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202107341 · Cited by 40 · see citing works

Development and characterization of meropenem dry powder inhaler formulation for pulmonary drug delivery

Muneer, S., Wang, X., Rintoul, L., Ayoko, G. A., Islam, N., & Izake, E. L. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119684 · Cited by 38 · see citing works

Pulmonary drug delivery devices and nanosystems as potential treatment strategies for acute respiratory distress syndrome (ARDS)

Dhege, C. T., Kumar, P., & Choonara, Y. E. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124182 · Cited by 37 · see citing works

Polysaccharide-based formulations as potential carriers for pulmonary delivery – A review of their properties and fates

Valente, S. A., Silva, L. M., Lopes, G. R., Sarmento, B. F. C. C., Coimbra, M. A., & Passos, C. P. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118784 · Cited by 35 · see citing works

Sodium Hyaluronate Nanocomposite Respirable Microparticles to Tackle Antibiotic Resistance with Potential Application in Treatment of Mycobacterial Pulmonary Infections

Rossi, I., Buttini, F., Sonvico, F., Affaticati, F., Martinelli, F., Annunziato, G., Machado, D., Viveiros, M., Pieroni, M., & Bettini, R. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11050203 · Cited by 32 · see citing works

Strategies for lipid-based nanocomposites with potential activity against Mycobacterium tuberculosis: Microbial resistance challenge and drug delivery trends

Hatae, A. C., Roque‐Borda, C. A., & Pavan, F. R. (2023) · OpenNano · doi:10.1016/j.onano.2023.100171 · Cited by 28 · see citing works

Liposomes-and niosomes-based drug delivery systems for tuberculosis treatment

Bekraki, A. I. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819811-7.00007-2 · Cited by 28 · see citing works

A Spray-Dried Combination of Capreomycin and CPZEN-45 for Inhaled Tuberculosis Therapy

Pitner, R. A., Durham, P. G., Stewart, I. E., Reed, S. G., Cassell, G. H., Hickey, A. J., & Carter, D. (2019) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2019.05.024 · Cited by 25 · see citing works

Integrated Continuous Plug-Flow Crystallization and Spray Drying of Pharmaceuticals for Dry Powder Inhalation

Hadiwinoto, G. D., Kwok, P. C. L., Tong, H. H. Y., Wong, S. N., Chow, S. F., & Lakerveld, R. (2019) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.9b01730 · Cited by 24 · see citing works

The long and winding road to inhaled TB therapy: not only the bug’s fault

Giovagnoli, S., Schoubben, A., & Ricci, M. (2016) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2016.1272119 · Cited by 17 · see citing works

Current trends in inhaled pharmaceuticals: challenges and opportunities in respiratory infections treatment

Shah, K. A., Razzaq, A., Dormocara, A., You, B., Elbehairi, S. E. I., Shati, A. A., Alfaifi, M. Y., Iqbal, H., & Cui, J.-H. (2025) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-025-00729-7 · Cited by 15 · see citing works

Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers

Guzmán, E. (2022) · Coatings · doi:10.3390/coatings12020277 · Cited by 13 · see citing works

Protective effect of magnolol-loaded polyketal microparticles on lipopolysaccharide-induced acute lung injury in rats

Tsai, T., Kao, C., Chou, C.-L., Liu, L.-C., & Chou, T.-C. (2016) · Journal of Microencapsulation · doi:10.1080/02652048.2016.1202344 · Cited by 11 · see citing works

Fluid Interfaces as Models for the Study of Lipid-Based Films with Biophysical Relevance

Argudo, P. G., Maestro, A., & Guzmán, E. (2023) · Coatings · doi:10.3390/coatings13091560 · Cited by 10 · see citing works

Polysaccharide-Based Carriers for Pulmonary Insulin Delivery: The Potential of Coffee as an Unconventional Source

Valente, S. A., Lopes, G. R., Ferreira, I., Galrinho, M. F., Almeida, M. M., Ferreira, P., Cruz, M. T., Coimbra, M. A., & Passos, C. P. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041213 · Cited by 10 · see citing works

The study of galactomannans with different molecular weights and their ability to form microparticles suitable for pulmonary delivery

Galrinho, M. F., Silva, L. M., Lopes, G. R., Ferreira, B. A. C., Valente, S. A., Ferreira, I., Pinheiro, B., Palma, A. S., Evtuguin, D. V., Lopes‐da‐Silva, J. A., et al. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122268 · Cited by 9 · see citing works

Glucosamine/L-lactide copolymers as potential carriers for the development of a sustained rifampicin release system using Mycobacterium smegmatis as a tuberculosis model

Ragusa, J., Gonzalez, D., Li, S., Noriega, S. E., Skotak, M., & Larsen, G. F. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01539 · Cited by 10 · see citing works

The Pharmacokinetics of CPZEN-45, a Novel Anti-Tuberculosis Drug, in Guinea Pigs

Garcia‐Contreras, L., Hanif, S. N. M., Ibrahim, M., Durham, P. G., & Hickey, A. J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122758 · Cited by 8 · see citing works

Potential of surface-eroding poly(ethylene carbonate) for drug delivery to macrophages

Bohr, A., Water, J. J., Wang, Y., Arnfast, L., & Beck‐Broichsitter, M. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.07.075 · Cited by 8 · see citing works

Development of inhaled moxifloxacin-metformin formulation as an alternative for pulmonary tuberculosis treatment

Simon, A., Velloso-Junior, S. O., Mesquita, R. D., Fontão, A. P. G. A., Costa, T. E. M. M., Honório, T. D. S., Guimarães, T. F., de Sousa, E. G. R., Viçosa, A. L., Sampaio, A. L. F., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124740 · Cited by 7 · see citing works

Consideration of Metal Organic Frameworks for Respiratory Delivery

Stewart, I. E., Luz, I., & Mortensen, N. P. (2020) · KONA Powder and Particle Journal · doi:10.14356/kona.2021013 · Cited by 6 · see citing works

Preparation and characterization of slow dissolving linezolid salts for direct pulmonary delivery

Mori, D., jaroli, T., Dudhat, K. R., Vaishnav, D. J., Parmar, R., Kotadiya, N., Bhalodiya, M., & Pashavan, C. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103741 · Cited by 6 · see citing works

Testing Inhaled Drug Therapies for Treating Tuberculosis

Young, E., Hickey, A. J., & Braunstein, M. (2016) · doi:10.1002/9781118943182.ch6 · Cited by 5 · see citing works

Piper regnellii extract biopolymer-based microparticles: production, characterization and antifungal activity

Brambilla, L. Z. S., Endo, E. H., Cortez, D. A. G., Lima, M. M. D. S., & Filho, B. P. D. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13618 · Cited by 4 · see citing works

Quantitative assay of capreomycin oleate levels in a drug formulation for inhalation with a fully validated HPLC method

Ianni, F., Schoubben, A., Montesano, D., Wauthoz, N., Cossignani, L., Sardella, R., & Natalini, B. (2015) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2015.11.040 · Cited by 2 · see citing works

Spray Drying Strategies to Stop Tuberculosis

Jennifer, W., Ricci, M., & Chan, H. (2016) · doi:10.1002/9781118943182.ch9 · Cited by 2 · see citing works

Therapeutic potential of nano assisted delivery in tuberculosis and its management

Singh, R., Jadhav, K., Jhilta, A., & Verma, R. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13337-4.00019-7 · Cited by 1 · see citing works

Low Molecular Weight Glucosamine/L-lactide Copolymers as Potential Carriers for the Development of a Sustained Rifampicin Release System: Mycobacterium Smegmatis as a Tuberculosis Model

Ragusa, J. (2015) · Lincoln (University of Nebraska)

Spray drying strategies to stop tuberculosis

Jennifer, W., Maurizio, R., & Chan, H. (2016)

Introduction

Hickey, A. J. (2016) · doi:10.1002/9781118943182.ch1

Targeting Delivery of Magnetic Aerosol Particles to Specific Regions in the Lung

Ghosh, A. (2018) · Queensland University of Technology · doi:10.5204/thesis.eprints.117195

Inhalation Therapy in Pulmonary Tuberculosis

Manning, T. J., Thomas-Richardson, J., Johnson, C. W., Patel, K., Thaker, Y., Thomas-Richardson, G., Philips, D., & Wylie, G. (2023) · Integrated science · doi:10.1007/978-3-031-15955-8_16

Biopharmaceutical studies and formulation of chloramphenicol and thiamphenicol for the treatment of pulmonary infections by inhalation route

Nurbaeti, S. N. (2017) · doi:10.70675/57e225a8z44bfz4801z94c0z47c9e77a7e09

Innovative ethosomal nanocarriers for transdermal delivery of antifungal agents: A systematic review of physicochemical advances to overcome drug resistance

Mahajan, K., Goswami, D. M., Kumar, S., Thakur, N., & Abbot, V. (2026) · Nano Trends · doi:10.1016/j.nwnano.2026.100211

Particulate Pulmonary Delivery Systems Containing Anti-Tuberculosis Agents

Gupta, A., Pandya, S. M., Siddiqi, M. I., Agrawal, A. K., Mohan, M., & Misra, A. (2013) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2013005684 · Cited by 14 · see citing works

Pharmaceutical aerosols for the treatment and prevention of Tuberculosis

Hanif, S. N. M., & Garcia‐Contreras, L. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00118 · Cited by 45 · see citing works

Spray-dried particles as pulmonary delivery system of anti-tubercular drugs: design, optimization, in vitro and in vivo evaluation

Garg, T., Goyal, A. K., Rath, G., & Murthy, R. S. R. (2015) · Pharmaceutical Development and Technology · doi:10.3109/10837450.2015.1081613 · Cited by 26 · see citing works

Inhalable nanoparticles delivery targeting alveolar macrophages for the treatment of pulmonary tuberculosis

Chae, J., Choi, Y., Tanaka, M., & Choi, J. H. (2021) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2021.08.009 · Cited by 56 · see citing works

Advancement in pulmonary drug delivery systems for treatment of tuberculosis

Goyal, A. K., Garg, T., Bhandari, S., & Rath, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-46143-6.00022-1 · Cited by 25 · see citing works