The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Growth Factors and Wound Healing
Abstract
This paper is based on the thesis Growth Factors and Formation of Granulation Tissue, University of Göteborg, 1992. For the last decade, it has been acknowledged that growth factors are essential for regulating the cellular events involved in the formation of granulation tissue and in wound healing. Recently, clinical trials were initiated to study the wound healing effect of applying growth factors and growth hormone to human wounds. However, in order to apply growth factors in these trials in an intelligent and effective manner, it is important to understand their physiology and their role in wound healing. This review paper is about the growth factors: IGF-I, IGF-II, PDGF, bFGF, TGF-beta, EGF, TGF-alpha, TNF-alpha, SF-HGF and Growth Hormone and their role and effect in soft tissue wound healing in animals and humans.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Elevation of TNFα leads to decreased production of granulation tissue, whereas low doses of TNFα promote collagen disposition,58–61 demonstrating the importance of accurate cytokine regulation during wound healing.”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [60]
Citations
Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Folkman, J., & Klagsbrun, M. (1987) · Science · doi:10.1126/science.2432664 · Cited by 3,491
The biology of platelet-derived growth factor
Ross, R., Raines, E. W., & Bowen‐Pope, D. F. (1986) · Cell · doi:10.1016/0092-8674(86)90733-6 · Cited by 2,023
Sugarman, B. J., Aggarwal, B. B., Hass, P. E., Figari, I. S., Palladino, M. A., & Shepard, H. M. (1985) · Science · doi:10.1126/science.3933111 · Cited by 1,572
Rinderknecht, E., & HUMBEL, R. E. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40889-1 · Cited by 1,545
Growth hormone receptor and serum binding protein: purification, cloning and expression
Leung, D. W., Spencer, S. A., Cachianes, G., Hammonds, R. G., Collins, C., Henzel, W. J., Barnard, R. T., Waters, M. J., & Wood, W. I. (1987) · Nature · doi:10.1038/330537a0 · Cited by 1,520
Cachectin: More Than a Tumor Necrosis Factor
Epstein, F. H., Beutler, B., & Cerami, A. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702123160705 · Cited by 1,423
Induction of c-fos gene and protein by growth factors precedes activation of c-myc
Müller, R., Bravo, R., Burckhardt, J., & Curran, T. (1984) · Nature · doi:10.1038/312716a0 · Cited by 1,369
Structural Characterization and Biological Functions of Fibroblast Growth Factor
Gospodarowicz, D., Ferrara, N., Schweigerer, L., & Neufeld, G. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-2-95 · Cited by 1,273
Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α
Leibovich, S. J., Polverini, P. J., Shepard, H. M., Wiseman, D. M., Shively, V. P., & Nuseir, N. (1987) · Nature · doi:10.1038/329630a0 · Cited by 1,215
D’Ercole, A. J., Stiles, A. D., & Underwood, L. E. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.3.935 · Cited by 1,179
Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping
Rappolee, D. A., Mark, D., Banda, M. J., & Werb, Z. (1988) · Science · doi:10.1126/science.3041594 · Cited by 1,105
Primary structure of human insulin‐like growth factor II
Rinderknecht, E., & HUMBEL, R. E. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)80237-3 · Cited by 782
Massagué, J., & Czech, M. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34631-3 · Cited by 711
Enhancement of Wound Healing by Topical Treatment with Epidermal Growth Factor
Brown, G. L., Nanney, L. B., Griffen, J., Cramer, A. B., Yancey, J. M., Curtsinger, L. J., Holtzin, L., Schultz, G. S., Jurkiewicz, M. J., & Lynch, J. B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198907133210203 · Cited by 682
Role of platelet‐derived growth factor in wound healing
Pierce, G. F., Mustoe, T. A., Altrock, B. W., Deuel, T. F., & Thomason, A. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240450403 · Cited by 617
Mechanism of the Stimulatory Effect of Growth Hormone on Longitudinal Bone Growth*
Isaksson, O. G. P., Lindahl, A. H., NILSSON, A., & Isgaard, J. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-4-426 · Cited by 579
Regulation of insulin-like growth factor I gene expression by growth hormone.
Mathews, L. S., Norstedt, G., & Palmiter, R. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9343 · Cited by 560
Montesano, R., & Orci, L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.13.4894 · Cited by 560
Classification and Treatment of Chronic Nonhealing Wounds
Knighton, D. R., Ciresi, K. F., Fiegel, V. D., AUSTIN, L. L., & BUTLER, E. L. (1986) · Annals of Surgery · doi:10.1097/00000658-198609000-00011 · Cited by 544
Lynch, S. E., Colvin, R. B., & Antoniades, H. N. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114210 · Cited by 530
Lynch, S. E., Nixon, J. C., Colvin, R. B., & Antoniades, H. N. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7696 · Cited by 440
Platelet-derived growth factor BB for the treatment of chronic pressure ulcers
Robson, M. C., Phillips, L. G., Robson, L. E., Thomason, A., & Pierce, G. F. (1992) · The Lancet · doi:10.1016/0140-6736(92)90143-q · Cited by 379
An epithelial scatter factor released by embryo fibroblasts
Stoker, M. G. P., & Perryman, M. (1985) · Journal of Cell Science · doi:10.1242/jcs.77.1.209 · Cited by 374
EGF and TGF‐α in wound healing and repair
Schultz, G., Clark, W., & Rotatori, D. S. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240450407 · Cited by 357
Nanney, L. B., Magid, M., Stoscheck, C. M., & King, L. E. (1984) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12264708 · Cited by 320
Schlechter, N., Russell, S. M., Spencer, E., & Nicoll, C. S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.20.7932 · Cited by 307
Pierce, G. F., Mustoe, T. A., Lingelbach, J., Masakowski, V. R., Gramates, P. H., & Deuel, T. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2229 · Cited by 301
Acceleration of Tensile Strength of Incisions Treated with EGF and TGF-β
Brown, G. L., Curtsinger, L. J., WHITE, M., Mitchell, R. O., Pietsch, J. D., Nordquist, R., FRAUNHOFER, A. V., & Schultz, G. S. (1988) · Annals of Surgery · doi:10.1097/00000658-198812000-00019 · Cited by 277
Grotendorst, G. R., Martin, G. R., Pencev, D., Sodek, J., & Harvey, A. K. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112243 · Cited by 275
Recombinant basic fibroblast growth factor accelerates wound healing
McGee, G. S., Davidson, J. M., Buckley, A., Sommer, A., Woodward, S. C., Aquino, A. M., Barbour, R. L., & Demetriou, A. A. (1988) · Journal of Surgical Research · doi:10.1016/0022-4804(88)90034-0 · Cited by 265
Basic fibroblast growth factor (FGF) promotes cartilage repair in vivo
Cuevas, P., Burgos, J., & Baird, A. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80887-8 · Cited by 257
Epidermal growth factor and transforming growth factor α
Burgess, A. W. (1989) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072331 · Cited by 248
Sporn, M. B. (1989) · JAMA · doi:10.1001/jama.1989.03430070086036 · Cited by 246
Goldstein, R. H., Poliks, C. F., Pilch, P. F., Smith, B. D., & Fine, A. (1989) · Endocrinology · doi:10.1210/endo-124-2-964 · Cited by 232
Evidence indicating trophic importance of IGF‐1 in regenerating peripheral nerves
Hansson, H., Dahlin, L. B., Danielsen, N., Fryklund, L., NACHEMSON, A. K., POLLERYD, P., Rozell, B., Skottner, A., Stemme, S., & Lundborg, G. (1986) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1986.tb07862.x · Cited by 222
Topical Use of Human Recombinant Epidermal Growth Factor (h‐EGF) in Venous Ulcers
Falanga, V., Eaglstein, W. H., BUCALO, B. D., Katz, M. H. G., HARRIS, B., & Carson, P. A. (1992) · The Journal of Dermatologic Surgery and Oncology · doi:10.1111/j.1524-4725.1992.tb03514.x · Cited by 221
Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factor
Matsumoto, K., Hashimoto, K., Yoshikawa, K., & Nakamura, T. (1991) · Experimental Cell Research · doi:10.1016/0014-4827(91)90462-4 · Cited by 212
POSTOPERATIVE POSITIVE NITROGEN BALANCE WITH INTRAVENOUS HYPONUTRITION AND GROWTH HORMONE
Ponting, G. A., Teale, T., Halliday, D., & Sim, A. J. W. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91232-9 · Cited by 176
The Isolation of Pituitary Growth Hormone
Li, C. H., & Evans, H. M. (1944) · Science · doi:10.1126/science.99.2566.183 · Cited by 165
Transforming growth factor β levels in rat wound chambers
Cromack, D. T., Sporn, M. B., Roberts, A. B., Merino, M. J., Dart, L. L., & Norton, J. A. (1987) · Journal of Surgical Research · doi:10.1016/0022-4804(87)90005-9 · Cited by 159
Goodlad, R. A., Wilson, T. J., Lenton, W., Gregory, H., McCullagh, K. G., & Wright, N. A. (1987) · Gut · doi:10.1136/gut.28.5.573 · Cited by 147
Stimulation of Healing of Chronic Wounds by Epidermal Growth Factor
Brown, G. L., Curtsinger, L. J., Jurkiewicz, M. J., Nahai, F., & Schultz, G. S. (1991) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199108000-00001 · Cited by 131
Furlong, R. A., Takehara, T., Taylor, W. G., Nakamura, T., & Rubin, J. S. (1991) · Journal of Cell Science · doi:10.1242/jcs.100.1.173 · Cited by 127
Basic Mechanisms in the Healing Cutaneous Wound
Kanzler, M., Gorsulowsky, D. C., & Swanson, N. A. (1986) · The Journal of Dermatologic Surgery and Oncology · doi:10.1111/j.1524-4725.1986.tb02099.x · Cited by 114
Localization of the growth hormone receptor/binding protein in skin
Lobie, P. E., Breipohl, W., Lincoln, D. T., García-Aragón, J., & Waters, M. J. (1990) · Journal of Endocrinology · doi:10.1677/joe.0.1260467 · Cited by 108
Histochemical localization of IGF-I and IGF-II mRNA in the rat between birth and adulthood
Beck, F., Samani, N. J., Byrne, S., Morgan, K., Gebhard, R., & Brammar, W. J. (1988) · Development · doi:10.1242/dev.104.1.29 · Cited by 101
The effect of the epidermal growth factor (EGF) on the corneal epithelium in humans
Daniele, S., Frati, L., Fiore, C., & Santoni, G. (1979) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf00414564 · Cited by 96
Cook, J. J., Haynes, K., & Werther, G. A. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113296 · Cited by 88
Werner, H., STANNARD, B. S., Bach, M. A., LeRoith, D., & Roberts, C. T. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91996-6 · Cited by 84
The Local Effects of Cachectin/Tumor Necrosis Factor on Wound Healing
SALOMON, G. D., KASID, A., CROMACK, D. T., DIRECTOR, E., TALBOT, T. L., SANK, A., & NORTON, J. A. (1991) · Annals of Surgery · doi:10.1097/00000658-199108000-00012 · Cited by 84
Platelet-derived growth factors: A family of isoforms that bind to two disticnt receptors
Heldin, C., & Westermark, B. (1989) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072334 · Cited by 63
Inhibitory effects of tumor necrosis factor alpha on fracture healing in rats
Hashimoto, J., Yoshikawa, H., Takaoka, K., Shimizu, N., Masuhara, K., Tsuda, T., Miyamoto, S., & Ono, K. (1989) · Bone · doi:10.1016/8756-3282(89)90078-1 · Cited by 62
Enhancement of Wound Healing by Growth Factors
Hunt, T. K., & Van, F. B. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198907133210209 · Cited by 60
Vollberg, T. M., George, M. D., & Jetten, A. M. (1991) · Experimental Cell Research · doi:10.1016/0014-4827(91)90542-3 · Cited by 60
Basic fibroblast growth factor accelerates tissue repair in models of impaired wound healing.
Klingbeil, C., Cesar, L. B., & Fiddes, J. C. (1991) · PubMed · Cited by 49
Knighton, D. R., Phillips, G. D., & Fiegel, V. D. (1990) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199012001-00027 · Cited by 49
Steenfos, H. H., & Jansson, J.-O. (1992) · Journal of Endocrinology · doi:10.1677/joe.0.1320293 · Cited by 41
Self-citationTopical Human Growth Hormone Treatment of Chronic Leg Ulcers
Rasmussen, L. H., Karlsmark, T., Avnstorp, C., Peters, K. M., Jørgensen, M., & Jensen, L. T. (1991) · Phlebology The Journal of Venous Disease · doi:10.1177/026835559100600105 · Cited by 30
Zaizen, Y., Ford, E. G., Costin, G., & Atkinson, J. B. (1990) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(05)80166-6 · Cited by 29
Stimulation of wound bursting strength during protein malnutrition
Zaizen, Y., Ford, E. G., Costin, G., & Atkinson, J. B. (1990) · Journal of Surgical Research · doi:10.1016/0022-4804(90)90032-w · Cited by 29
Insulin-like growth factors: biochemistry and physiology
Herington, A. C. (1991) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(10)80002-3 · Cited by 23
Early gene induction by growh factors
Woodgett, J. R. (1989) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072340 · Cited by 21
Research works printed but not linked: 23
- Broadley K N, 1989, Lab Invest, 61, 571
- Brown G L, 1986, J Exp Med, 163, 319
- Cushing H, J Am Med Assoc 1909;, 53, 250
- Evans H, 1921, Anat Rec, 21, 62
- Hudson-Goodman P, Heart Lung 1990;, 19, 379
- Isgaard J, 1991, Growth hormone enhances insulin-like growth factor I (IGF-I) receptor mRNA levels. Abstract B46, 2nd International Symposium on Insulin-like Growth Factors/Somatomedins, San Francisco
- Jansen M. The human somatomedins. University of Utrecht, Nederland 1987; 1–33, Thesis
- Jørgensen P H, Endocrinology 1987;, 121, 1637
- Knighton D R, 1990, Surg Gynecol Obstet, 170, 56
- Kostyo J, 1974, Handbook of physiology, section 7, Endocrinology, 187
- Lynch S K. In: Clinical and experimental approaches to dermal and epidermal repair: normal and chronic wounds: Interactions of growth factors in tissue repair. Wiley-Liss Inc, New York 1991; 341–357
- Mueller R V, 1991, IGF-I stimulation of wound healing may act by increasing the number of wound macrophages. Abstract A3, 2nd International IGF symposium
- Pierce G F, 1991, Am J Pathol, 138, 629
- Rasmussen L H, 1992, Low frequency growth hormone application stimulates wound healing. Abstract 38, Second Annual Scientific Meeting of the Wound Healing Society
- Spencer E M, 1988, Growth Factors and Other Aspects of Wound Healing: Biological and Clinical Implications, 103
- Sprugel K H, 1987, Am J Pathol, 129, 601
- Steenfos H, 1989, Surg Forum, 40, 68
- Steenfos H H, 1989, Surgery, 106, 171
- Steenfos H H, 1990, Wounds, 2, 218
- Steenfos H H, 1992, Eur J Surg, 158, 327
- Steenfos H H, Increased gene expression of scatter factor-hepatocyte growth factor (SF-HGF) and basic fibroblast growth factor (bFGF) in granulation tissue in the rat. Wound Repair Regen
- Steenfos H H. Growth factors and formation of granulation tissue. University of Göteborg. 1992; 1–55, Thesis
- Suh D Y, 1991, IGF-I repairs the defect in wound healing induced by corticosteroids. Abstract A2, 2nd International IGF symposium
Cited by
Sorted by citations
Wound Healing Dressings and Drug Delivery Systems: A Review
Boateng, J. S., Matthews, K. H., Stevens, H. N. E., & Eccleston, G. M. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21210 · Cited by 3,067
Physiology and healing dynamics of chronic cutaneous wounds
Stadelmann, W. K., Digenis, A. G., & Tobin, G. R. (1998) · The American Journal of Surgery · doi:10.1016/s0002-9610(98)00183-4 · Cited by 910
A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages
Zahedi, P., Rezaeian, I., Siadat, S. O. R., Jafari, S. H., & Supaphol, P. (2009) · Polymers for Advanced Technologies · doi:10.1002/pat.1625 · Cited by 906
On the Nature of Hypertrophic Scars and Keloids: A Review
Niessen, F. B., Spauwen, P. H. M., Schalkwijk, J., & Kon, M. (1999) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199910000-00031 · Cited by 809
Platelet-Rich Plasma and Platelet Gel: A Review
Everts, P. A., Knape, J. T. A., Weibrich, G., Schönberger, J. P. A. M., Hoffmann, J. J. M. L., Overdevest, E. P., Box, H. A. M., & van Zundert, A. A. J. (2006) · Journal of ExtraCorporeal Technology · doi:10.1051/ject/200638174 · Cited by 581
Metadata
- Authors
- Steenfos, H. H.
- Affiliations
- Herlev Hospital (DK)
- Corresponding author
- Steenfos, Henrik H.
- Venue
- Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
- Publisher
- Informa UK Limited
- Published
- 1994-01
- Volume
- 28
- Issue
- 2
- Pages
- 95-105
- ISSN
- 0284-4311 (ISSN-L)
- OpenAlex
- W2040987751
- Cited by
- 192
- References
- 63
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- growth factors, wound healing, granulation tissue, insulin-like growth factor I, insulin-like growth factor II, platelet-derived growth factor, basic fibroblast growth factor, TGF-beta, epidermal growth factor, transforming growth factor-alpha, TNF-α, soft tissue wounds, growth hormone
- MeSH terms
- Animals, Epidermal Growth Factor, Growth Substances, Humans, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Lymphotoxin-alpha, Platelet-Derived Growth Factor, Growth Hormone, Tumor Necrosis Factor-alpha, Wound Healing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
