Cited by 192Wound Healing and TreatmentsLiver physiology and pathologyTGF-β signaling in diseases

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Growth Factors and Wound Healing

Steenfos, Henrik H.·1994·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery

DOI 10.3109/02844319409071186

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Abstract

This paper is based on the thesis Growth Factors and Formation of Granulation Tissue, University of Göteborg, 1992. For the last decade, it has been acknowledged that growth factors are essential for regulating the cellular events involved in the formation of granulation tissue and in wound healing. Recently, clinical trials were initiated to study the wound healing effect of applying growth factors and growth hormone to human wounds. However, in order to apply growth factors in these trials in an intelligent and effective manner, it is important to understand their physiology and their role in wound healing. This review paper is about the growth factors: IGF-I, IGF-II, PDGF, bFGF, TGF-beta, EGF, TGF-alpha, TNF-alpha, SF-HGF and Growth Hormone and their role and effect in soft tissue wound healing in animals and humans.

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Authors: Steenfos, H. H.
Affiliations: Herlev Hospital (DK)
Corresponding author: Steenfos, Henrik H.
Venue: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
Publisher: Informa UK Limited
Published: 1994-01
Volume: 28
Issue: 2
Pages: 95-105
ISSN: 0284-4311 (ISSN-L)
DOI: 10.3109/02844319409071186
OpenAlex: W2040987751
Cited by: 192
References: 63
Citations by year: 2026: 1 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 1
FWCI: 0.74
Type: journal article
Language: en
Open access: closed
Locations: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: growth factors, wound healing, granulation tissue, insulin-like growth factor I, insulin-like growth factor II, platelet-derived growth factor, basic fibroblast growth factor, TGF-beta, epidermal growth factor, transforming growth factor-alpha, TNF-α, soft tissue wounds, growth hormone
MeSH terms: Animals, Epidermal Growth Factor, Growth Substances, Humans, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Lymphotoxin-alpha, Platelet-Derived Growth Factor, Growth Hormone, Tumor Necrosis Factor-alpha, Wound Healing

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