The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Growth Factors and Wound Healing
Abstract
This paper is based on the thesis Growth Factors and Formation of Granulation Tissue, University of Göteborg, 1992. For the last decade, it has been acknowledged that growth factors are essential for regulating the cellular events involved in the formation of granulation tissue and in wound healing. Recently, clinical trials were initiated to study the wound healing effect of applying growth factors and growth hormone to human wounds. However, in order to apply growth factors in these trials in an intelligent and effective manner, it is important to understand their physiology and their role in wound healing. This review paper is about the growth factors: IGF-I, IGF-II, PDGF, bFGF, TGF-beta, EGF, TGF-alpha, TNF-alpha, SF-HGF and Growth Hormone and their role and effect in soft tissue wound healing in animals and humans.
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“Elevation of TNFα leads to decreased production of granulation tissue, whereas low doses of TNFα promote collagen disposition,58–61 demonstrating the importance of accurate cytokine regulation during wound healing.”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [60]
Citations
Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Folkman, J., & Klagsbrun, M. (1987) · Science · doi:10.1126/science.2432664 · Cited by 3,491
The biology of platelet-derived growth factor
Ross, R., Raines, E. W., & Bowen‐Pope, D. F. (1986) · Cell · doi:10.1016/0092-8674(86)90733-6 · Cited by 2,023
Sugarman, B. J., Aggarwal, B. B., Hass, P. E., Figari, I. S., Palladino, M. A., & Shepard, H. M. (1985) · Science · doi:10.1126/science.3933111 · Cited by 1,572
Rinderknecht, E., & HUMBEL, R. E. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40889-1 · Cited by 1,545
Growth hormone receptor and serum binding protein: purification, cloning and expression
Leung, D. W., Spencer, S. A., Cachianes, G., Hammonds, R. G., Collins, C., Henzel, W. J., Barnard, R. T., Waters, M. J., & Wood, W. I. (1987) · Nature · doi:10.1038/330537a0 · Cited by 1,520
Cachectin: More Than a Tumor Necrosis Factor
Epstein, F. H., Beutler, B., & Cerami, A. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702123160705 · Cited by 1,423
Induction of c-fos gene and protein by growth factors precedes activation of c-myc
Müller, R., Bravo, R., Burckhardt, J., & Curran, T. (1984) · Nature · doi:10.1038/312716a0 · Cited by 1,369
Structural Characterization and Biological Functions of Fibroblast Growth Factor
Gospodarowicz, D., Ferrara, N., Schweigerer, L., & Neufeld, G. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-2-95 · Cited by 1,273
Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α
Leibovich, S. J., Polverini, P. J., Shepard, H. M., Wiseman, D. M., Shively, V. P., & Nuseir, N. (1987) · Nature · doi:10.1038/329630a0 · Cited by 1,215
Research works printed but not linked: 23
- Broadley K N, 1989, Lab Invest, 61, 571
- Brown G L, 1986, J Exp Med, 163, 319
- Cushing H, J Am Med Assoc 1909;, 53, 250
- Evans H, 1921, Anat Rec, 21, 62
- Hudson-Goodman P, Heart Lung 1990;, 19, 379
- Isgaard J, 1991, Growth hormone enhances insulin-like growth factor I (IGF-I) receptor mRNA levels. Abstract B46, 2nd International Symposium on Insulin-like Growth Factors/Somatomedins, San Francisco
- Jansen M. The human somatomedins. University of Utrecht, Nederland 1987; 1–33, Thesis
- Jørgensen P H, Endocrinology 1987;, 121, 1637
- Knighton D R, 1990, Surg Gynecol Obstet, 170, 56
- Kostyo J, 1974, Handbook of physiology, section 7, Endocrinology, 187
- Lynch S K. In: Clinical and experimental approaches to dermal and epidermal repair: normal and chronic wounds: Interactions of growth factors in tissue repair. Wiley-Liss Inc, New York 1991; 341–357
- Mueller R V, 1991, IGF-I stimulation of wound healing may act by increasing the number of wound macrophages. Abstract A3, 2nd International IGF symposium
- Pierce G F, 1991, Am J Pathol, 138, 629
- Rasmussen L H, 1992, Low frequency growth hormone application stimulates wound healing. Abstract 38, Second Annual Scientific Meeting of the Wound Healing Society
- Spencer E M, 1988, Growth Factors and Other Aspects of Wound Healing: Biological and Clinical Implications, 103
- Sprugel K H, 1987, Am J Pathol, 129, 601
- Steenfos H, 1989, Surg Forum, 40, 68
- Steenfos H H, 1989, Surgery, 106, 171
- Steenfos H H, 1990, Wounds, 2, 218
- Steenfos H H, 1992, Eur J Surg, 158, 327
- Steenfos H H, Increased gene expression of scatter factor-hepatocyte growth factor (SF-HGF) and basic fibroblast growth factor (bFGF) in granulation tissue in the rat. Wound Repair Regen
- Steenfos H H. Growth factors and formation of granulation tissue. University of Göteborg. 1992; 1–55, Thesis
- Suh D Y, 1991, IGF-I repairs the defect in wound healing induced by corticosteroids. Abstract A2, 2nd International IGF symposium
Cited by
Sorted by citations
Wound Healing Dressings and Drug Delivery Systems: A Review
Boateng, J. S., Matthews, K. H., Stevens, H. N. E., & Eccleston, G. M. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21210 · Cited by 3,067
Physiology and healing dynamics of chronic cutaneous wounds
Stadelmann, W. K., Digenis, A. G., & Tobin, G. R. (1998) · The American Journal of Surgery · doi:10.1016/s0002-9610(98)00183-4 · Cited by 910
A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages
Zahedi, P., Rezaeian, I., Siadat, S. O. R., Jafari, S. H., & Supaphol, P. (2009) · Polymers for Advanced Technologies · doi:10.1002/pat.1625 · Cited by 906
On the Nature of Hypertrophic Scars and Keloids: A Review
Niessen, F. B., Spauwen, P. H. M., Schalkwijk, J., & Kon, M. (1999) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199910000-00031 · Cited by 809
Platelet-Rich Plasma and Platelet Gel: A Review
Everts, P. A., Knape, J. T. A., Weibrich, G., Schönberger, J. P. A. M., Hoffmann, J. J. M. L., Overdevest, E. P., Box, H. A. M., & van Zundert, A. A. J. (2006) · Journal of ExtraCorporeal Technology · doi:10.1051/ject/200638174 · Cited by 581
Metadata
- Authors
- Steenfos, H. H.
- Affiliations
- Herlev Hospital (DK)
- Corresponding author
- Steenfos, Henrik H.
- Venue
- Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
- Publisher
- Informa UK Limited
- Published
- 1994-01
- Volume
- 28
- Issue
- 2
- Pages
- 95-105
- ISSN
- 0284-4311 (ISSN-L)
- OpenAlex
- W2040987751
- Cited by
- 192
- References
- 63
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- growth factors, wound healing, granulation tissue, insulin-like growth factor I, insulin-like growth factor II, platelet-derived growth factor, basic fibroblast growth factor, TGF-beta, epidermal growth factor, transforming growth factor-alpha, TNF-α, soft tissue wounds, growth hormone
- MeSH terms
- Animals, Epidermal Growth Factor, Growth Substances, Humans, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Lymphotoxin-alpha, Platelet-Derived Growth Factor, Growth Hormone, Tumor Necrosis Factor-alpha, Wound Healing
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