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Cited by 252Fibromyalgia and Chronic Fatigue Syndrome ResearchPsychosomatic Disorders and Their TreatmentsMusculoskeletal pain and rehabilitation

The DOI matches its Crossref record.

A Double-blind Placebo Controlled Trial of Fluoxetine in Fibromyalgia

Wolfe, F., Cathey, M. A., Hawley, D. J.·1994·Scandinavian Journal of Rheumatology
DOI 10.3109/03009749409103725
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Abstract

42 women were randomized to receive either placebo or fluoxetine at 20 mgs per day. Inter and intra group differences in clinical variables were evaluated after 3 and 6 weeks of treatment. Except for self rated anxiety which improved in the placebo treated group at 3 weeks, no differences between groups were noted. For those receiving fluoxetine both AIMS Anxiety (4.0 baseline vs. 3.3, p = 0.04) and Depression scores (2.6 baseline vs. 1.9, p = 0.03) improved at 3 weeks; however, improvement in the Beck Depression Scale did not reach significance (11.8 vs. 9.4, p = 0.34). At 6 weeks, both AIMS Depression (2.6 at baseline and 1.5 at 6 weeks, p = 0.03) and Beck Depression Scales (11.8 at baseline vs. 8.3 at 6 weeks, p = 0.04) showed improvement, as did sleep quality (9.6 vs. 7.6, p = 0.03). But no other variable had a significant change from baseline at either the 3 or 6 week point. Our data do not suggest that fluoxetine improves the signs and symptoms of fibromyalgia.

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  • Self-reported sleep quality perceptions were significantly better with fluoxetine (20mg) than placebo for patients with fibromyalgia.

    “(Wolfe et al., 1994) found that self-reported sleep quality perceptions were significantly better with fluoxetine (20mg) than placebo for patients with fibromyalgia.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Wolfe et al., 1994

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Research works printed but not linked: 37

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Metadata

Authors
Wolfe, F., Cathey, M. A., & Hawley, D. J.
Affiliations
  • University of Kansas (US)
  • Wichita State University (US)
ORCID
Wolfe, F.
Venue
Scandinavian Journal of Rheumatology
Publisher
Informa UK Limited
Published
1994-01
Volume
23
Issue
5
Pages
255-259
ISSN
  • 0300-9742 (ISSN-L)
  • 1502-7732
DOI
10.3109/03009749409103725
OpenAlex
W2017836712
Cited by
252
References
0
Citations by year
2026: 1 · 2025: 4 · 2024: 20 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 7 · 2012: 10
FWCI
3.95
Type
journal article
Language
en
Open access
closed
Locations
  • Scandinavian Journal of Rheumatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eli Lilly and Company
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords
fluoxetine, fibromyalgia, selective serotonin reuptake inhibitors, depression, anxiety, sleep quality, women, antidepressant efficacy
MeSH terms
Adult, Aged, Anxiety, Depression, Double-Blind Method, Female, Fibromyalgia, Fluoxetine, Humans, Middle Aged, Pain Measurement, Psychiatric Status Rating Scales

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