Biology and therapy of fibromyalgia. New therapies in fibromyalgia.

Arnold

doi:10.1186/ar1971

Cited by 145Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsMusculoskeletal pain and rehabilitation

Biology and therapy of fibromyalgia. New therapies in fibromyalgia.

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Arnold·2006·Arthritis Research & Therapy

DOI 10.1186/ar1971PMC PMC1779399

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Abstract

Fibromyalgia is a chronic, musculoskeletal pain condition that predominately affects women. Although fibromyalgia is common and associated with substantial morbidity and disability, there are no US Food and Drug Administration-approved treatments. However, progress has been made in identifying pharmacological and non-pharmacological treatments for fibromyalgia. Recent pharmacological treatment studies have focused on selective serotonin and norepinephrine reuptake inhibitors, which enhance serotonin and norepinephrine neurotransmission in the descending pain pathways and lack many of the adverse side effects associated with tricyclic medications. Promising results have also been reported for medications that bind to the alpha2delta subunit of voltage-gated calcium channels, resulting in decreased calcium influx at nerve terminals and subsequent reduction in the release of several neurotransmitters thought to play a role in pain processing. There is also evidence to support exercise, cognitive behavioral therapy, education, and social support in the management of fibromyalgia. It is likely that many patients would benefit from combinations of pharmacological and non-pharmacological treatments, but more study is needed.

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Only about 40% of patients taking dual reuptake inhibitors or anticonvulsants experience a clinically important reduction in pain.
“Despite wide use however, only about 40% of patients taking these medications experiences a clinically important reduction in pain [4].”
From Internet-enhanced management of fibromyalgia: A randomized controlled trial (2010) · cites this paper as [4]

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Authors: Arnold
Venue: Arthritis Research & Therapy
Publisher: Springer Science and Business Media LLC
Published: 2006
Volume: 8
Issue: 4
Pages: 212
ISSN: 1478-6354 (ISSN-L)
DOI: 10.1186/ar1971
PMC: PMC1779399
OpenAlex: W1521322897
Cited by: 145
References: 141
Citations by year: 2026: 1 · 2025: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 3 · 2013: 7 · 2012: 13
FWCI: 2.59
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Arthritis Research & Therapy (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
Keywords: fibromyalgia, chronic musculoskeletal pain, pharmacotherapy, non-pharmacological treatment, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, descending pain modulation, exercise therapy, cognitive behavioral therapy, patient education, social support
MeSH terms: Complementary Therapies, Exercise Therapy, Fibromyalgia, Humans, Ligands, Calcium Channels, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Selective Serotonin Reuptake Inhibitors, Adrenergic Uptake Inhibitors

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