The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics
Open accessAbstract
Nearly 350 IgG-based therapeutics are approved for clinical use or are under development for many diseases lacking adequate treatment options. These include molecularly engineered biologicals comprising the IgG Fc-domain fused to various effector molecules (so-called Fc-fusion proteins) that confer the advantages of IgG, including binding to the neonatal Fc receptor (FcRn) to facilitate in vivo stability, and the therapeutic benefit of the specific effector functions. Advances in IgG structure-function relationships and an understanding of FcRn biology have provided therapeutic opportunities for previously unapproachable diseases. This article discusses approved Fc-fusion therapeutics, novel Fc-fusion proteins and FcRn-dependent delivery approaches in development, and how engineering of the FcRn-Fc interaction can generate longer-lasting and more effective therapeutics.
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Cites
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Recent advances in (therapeutic protein) drug development
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Therapies for rare diseases: therapeutic modalities, progress and challenges ahead
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The Ever-Expanding Myokinome: Discovery Challenges and Therapeutic Implications
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Metadata
- Authors
- Rath, T., Baker, K., Dumont, J. A., Peters, R. T., Jiang, H., Qiao, S.-W., Lencer, W. I., Pierce, G. F., & Blumberg, R. S.
- Venue
- Critical Reviews in Biotechnology
- Publisher
- Informa UK Limited
- Published
- 2013-10-24
- Volume
- 35
- Issue
- 2
- Pages
- 235-254
- ISSN
- 0738-8551 (ISSN-L)
- 1549-7801
- OpenAlex
- W2094058129
- Cited by
- 281
- References
- 14
- FWCI
- 17.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Rath, T., Baker, K., Dumont, J. A., Peters, R. T., Jiang, H., Qiao, S.-W., Lencer, W. I., Pierce, G. F., & Blumberg, R. S. (2015). Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics. Critical Reviews in Biotechnology. https://doi.org/10.3109/07388551.2013.834293
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