Cited by 332Reproductive System and PregnancyMonoclonal and Polyclonal Antibodies ResearchPregnancy and preeclampsia studies

An IgG‐transporting Fc receptor expressed in the syncytiotrophoblast of human placenta

Simister, Neil E., Story, Craig M., Chen, Hua‐Liu, Hunt, Joan S.·1996·European Journal of Immunology

Abstract

During normal human pregnancy, maternal IgG crosses the placenta and provides passive immunity for the fetus. In so doing, IgG passes through two cellular barriers: the syncytiotrophoblast and the fetal capillary endothelium. The Fc region of IgG is required for its transport across the placenta, but the Fc receptors responsible have not been identified definitively. We recently reported the isolation from a placental cDNA library of clones encoding the alpha chain of a human homologue of the major histocompatibility complex class I-related Fc receptor, the neonatal Fc receptor (FcRn). In mice, FcRn is essential for the transport of maternal IgG to the fetus and the neonate. We report here the localization of human FcRn mRNA within the placenta by in situ hybridization, and of human FcRn protein by immunohistochemistry. Both methods show that human FcRn is expressed in syncytiotrophoblast, and is, thus, appropriately located to transport maternal IgG across the first barrier. We confirm previous findings that specific binding of IgG to placental membranes is greater at pH 6.0 than pH 7.5. This corresponds with the pH dependence of IgG binding to FcRn and is consistent with the presence of FcRn in syncytiotrophoblast. We propose a transport model in which maternal IgG binds FcRn at low pH in endosomes within the syncytiotrophoblast. FcRn is not expressed in fetal capillary endothelia, and the mechanism of IgG transport across the second barrier remains unknown.

Integrity signals

Registry

Crossref · 10.1002/eji.1830260718

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Simister, N. E., Story, C. M., Chen, H., & Hunt, J. S.
Affiliations
  • Brandeis University (US)
  • University of Kansas Medical Center (US)
Corresponding author
Simister, Neil E.
Venue
European Journal of Immunology
Publisher
Wiley
Published
1996-07
Volume
26
Issue
7
Pages
1527-1531
ISSN
  • 0014-2980 (ISSN-L)
  • 1521-4141
OpenAlex
W1986652140
Cited by
332
References
43
Citations by year
2026: 14 · 2025: 14 · 2024: 14 · 2023: 7 · 2022: 18 · 2021: 16 · 2020: 14 · 2019: 15 · 2018: 17 · 2017: 13 · 2016: 13 · 2015: 10 · 2014: 13 · 2013: 10 · 2012: 14
FWCI
4.27
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hd026429-08)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 26429, R01HD027691, HD27691)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
neonatal Fc receptor, syncytiotrophoblast, placenta, IgG transport, endosomal recycling
MeSH terms
Amino Acid Sequence, Binding Sites, Antibody, Biological Transport, Female, Humans, Hydrogen-Ion Concentration, Immunoglobulin Fc Fragments, Membranes, Molecular Sequence Data, Pregnancy, RNA, Messenger, Trophoblasts, Receptors, IgG

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review