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Development of New Cell Lines for Animal Cell Biotechnology
Abstract
Mammalian cell culture has been an important technique in laboratory-scale experimentation for many decades. Developments in large-scale culture have been due to the need to grow large numbers of cells to support the growth of viruses for vaccine production, and more recently, for growing hybridoma cells as a source of monoclonal antibody. Increasingly, however, pharmaceutical products such as hormones, enzymes, growth factors, and clotting factors are being produced from cell lines which have been manipulated by recombinant DNA techniques. It is clear, therefore, that the high cost of growing mammalian cells on a large scale does not necessarily prohibit their use for biotechnology, and indeed there is considerable evidence to suggest that animal cell biotechnology will continue to be a major growth area in the future.
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“Immortalized cell lines can be used in most research instead of primary cells because they offer several advantages, including cost-effectiveness, ease of use, unlimited availability of materials, and the bypassing of ethical concerns associated with animal and human tissue use [14,15,16].”
From Cell Immortality: In Vitro Effective Techniques to Achieve and Investigate Its Applications and Challenges (2024) · cites this paper as [15]
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200 of 262 shown
Cited by
Chalak, M., Hesaraki, M., Mirbahari, S. N., Yeganeh, M., Abdi, S., Rajabi, S., & Hemmatzadeh, F. (2024) · Life · doi:10.3390/life14030417 · Cited by 66
Metadata
- Authors
- Macdonald, C.
- Affiliations
- Department of Bioscience and Biotechnology, University of Strathclyde, Glasgow, UK
- Venue
- Critical Reviews in Biotechnology
- Publisher
- Informa UK Limited
- Published
- 1990-01
- Volume
- 10
- Issue
- 2
- Pages
- 155-178
- ISSN
- 0738-8551
- 1549-7801
- Cited by
- 25
- References
- 2
- Language
- en
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