The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Evidence for Distinct Signaling Properties and Biological Responses Induced by the PDGF Receptor α and β Subtypes
Abstract
Platelet-derived growth factor (PDGF) acts as a potent mitogen, chemoattractant and survival factor for mesenchymal cells. In addition to its importance in mammalian development, PDGF plays a critical role in physiological repair mechanisms and in the pathogenesis of various proliferative diseases. The biological effects of PDGF are initiated via two related receptor tyrosine kinases, termed alpha and betaPDGF receptors. Recent observations provide increasing evidence for distinct roles of the two PDGF receptor subtypes in both embryogenesis and disease formation. Moreover, characterization of the signal relay mechanisms indicates, that the alpha and betaPDGF receptors are not identical in their ability to bind intracellular effector molecules. Furthermore, the two PDGF receptors initiate overlapping, yet distinct signal transduction pathways. These differences may account for some of the variabilities in biological responses resulting from activation of these two receptors.
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Citations
Cites
Protein modules and signalling networks
Pawson, T. (1995) · Nature · doi:10.1038/373573a0 · Cited by 2,420
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81270-2 · Cited by 864
Wong, L., Yamasaki, G., Johnson, R. J., & Friedman, S. L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117497 · Cited by 304
Grotendorst, G. R., Martin, G. R., Pencev, D., Sodek, J., & Harvey, A. K. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112243 · Cited by 275
Cited by
Roles of PDGF in animal development
Hoch, R. V., & Soriano, P. (2003) · Development · doi:10.1242/dev.00721 · Cited by 585
Sun, L., Liang, C., Shirazian, S., Zhou, Y., Miller, T., Cui, J., Fukuda, J. Y., Chu, J.-Y., Nematalla, A., Wang, X., et al. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm0204183 · Cited by 521
Growth factor‐dependent signaling and cell cycle progression
Jones, S. M., & Kazlauskas, A. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02113-5 · Cited by 124
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Metadata
- Authors
- Rosenkranz, S., & Kazlauskas, A.
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 1999-01
- Volume
- 16
- Issue
- 3
- Pages
- 201-216
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W2087224363
- Cited by
- 198
- References
- 5
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosenkranz, S., & Kazlauskas, A. (1999). Evidence for Distinct Signaling Properties and Biological Responses Induced by the PDGF Receptor α and β Subtypes. Growth Factors. https://doi.org/10.3109/08977199909002130
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