Effect of sleeve gastrectomy bariatric surgery-induced weight loss on serum AMH levels in reproductive aged women
Abstract
OBJECTIVE: This study aims to evaluate the change in serum anti-Mullerian hormone (AMH) levels in patients with morbid obesity undergoing bariatric surgery for weight loss. MATERIAL AND METHODS: In this prospective observational study, 75 patients of reproductive age (20-35 years) undergoing bariatric surgery for morbid obesity were followed up after six months to determine the changes in weight, Body Mass Index (BMI), menstrual pattern and serum AMH. The results were further studied on basis of pre operative classification of patients in polycystic ovary syndrome (PCOS) and non-PCOS group. RESULT: The serum AMH levels were statistically higher in patients of PCOS group pre operatively and at the end of six months in comparison to non-PCOS patients. The AMH values reduced post operatively in both groups significantly so much in the values though not significant statistically. Non-PCOS patients had lower AMH values pre operatively and showed a trend towards reducing ovarian reserve after six months. The overall change in AMH values in both groups was statistically significant as was the normalization of menstrual irregularity. CONCLUSION: Morbidly obese patients with PCOS appear to benefit from bariatric surgery both in terms of regularization of menstrual function and normalization of serum AMH values.
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One study reported a statistically significant difference in BMI following bariatric surgery (p = 0.013), with women with PCOS having a lower BMI post-surgery than women without PCOS.
“One study reported a statistically significant difference in BMI following bariatric surgery (p = 0.013), with women with PCOS having a lower BMI post-surgery than women without PCOS [45].”
From Weight management interventions in women with and without PCOS: a systematic review (2017) · cites this paper as [45]
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- Authors
- Bhandari, S., Ganguly, I., Bhandari, M., Agarwal, P., Singh, A., Gupta, N., & Mishra, A.
- Affiliations
- Sri Aurobindo Institute of Medical Sciences (IN)
- Corresponding author
- Bhandari, Shilpa
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2016-04-17
- Volume
- 32
- Issue
- 10
- Pages
- 799-802
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W2339324311
- Cited by
- 45
- References
- 21
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 1
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- sleeve gastrectomy, bariatric surgery, anti-Müllerian hormone, morbid obesity, polycystic ovary syndrome, ovarian reserve, menstrual irregularity, weight loss, women of reproductive age
- MeSH terms
- Adult, Female, Gastrectomy, Humans, Menstruation Disturbances, Obesity, Morbid, Polycystic Ovary Syndrome, Weight Loss, Treatment Outcome, Bariatric Surgery, Anti-Mullerian Hormone, Young Adult
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