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Cited by 118Liver Disease Diagnosis and TreatmentSilymarin and Mushroom PoisoningFood composition and properties

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study

Yari, Zahra, Rahimlou, Mehran, Eslamparast, Tannaz, Ebrahimi-Daryani, Naser, Poustchi, Hossein, Hekmatdoost, Azita·2016·International Journal of Food Sciences and Nutrition
DOI 10.3109/09637486.2016.1161011
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Abstract

A two-arm randomized open labeled controlled clinical trial was conducted on 50 patients with non-alcoholic fatty liver disease (NAFLD). Participants were assigned to take either a lifestyle modification (LM), or LM +30 g/day brown milled flaxseed for 12 weeks. At the end of the study, body weight, liver enzymes, insulin resistance and hepatic fibrosis and steatosis decreased significantly in both groups (p< 0.05); however, this reduction was significantly greater in those who took flaxseed supplementation (p < 0.05). The significant mean differences were reached in hepatic markers between flaxseed and control group, respectively: ALT [-11.12 compared with -3.7 U/L; P< 0.001], AST [-8.29 compared with -4 U/L; p < 0.001], GGT [-15.7 compared with -2.62 U/L; p < 0.001], fibrosis score [-1.26 compared with -0.77 kPa; p = 0.013] and steatosis score [-47 compared with -15.45 dB/m; p = 0.022]. In conclusion, flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management.

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Crossref · 10.3109/09637486.2016.1161011

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Research works printed but not linked: 3

  1. Ghaffarpour M, Houshiar-Rad A, Kianfar H. 1999. The manual for household measures, cooking yields factors and edible portion of foods. Tehran: Nashre Olume Keshavarzy. p. 1–40.
  2. Kelishadi R, Rabiei K, Khosravi A, Famouri F, Sadeghi M, Rouhafza H, Shirani SH. 2001. Assessment of physical activity of adolescents in Isfahan. Shahrekord Univ Med Sci J. 3:55–66.
  3. World Health Organization. 2012. STEPwise approach to surveillance (STEPS). Geneva, Switzerland: World Health Organization.

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Metadata

Authors
Yari, Z., Rahimlou, M., Eslamparast, T., Ebrahimi-Daryani, N., Poustchi, H., & Hekmatdoost, A.
Affiliations
  • National Nutrition and Food Technology Research Institute (IR)
  • Tehran University of Medical Sciences (IR)
  • Imam Khomeini Hospital (IR)
  • Digestive Disease Research Institute (IR)
Corresponding author
Hekmatdoost, Azita
ORCID
Venue
International Journal of Food Sciences and Nutrition
Publisher
Informa UK Limited
Published
2016-03-17
Volume
67
Issue
4
Pages
461-469
ISSN
  • 0963-7486 (ISSN-L)
  • 1465-3478
DOI
10.3109/09637486.2016.1161011
OpenAlex
W2298528870
Cited by
118
References
44
Citations by year
2026: 4 · 2025: 12 · 2024: 11 · 2023: 18 · 2022: 4 · 2021: 21 · 2020: 10 · 2019: 16 · 2018: 10 · 2017: 7 · 2016: 3
FWCI
11.26
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Food Sciences and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Hepatology › Silymarin and Mushroom Poisoning
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Keywords
flaxseed supplementation, non-alcoholic fatty liver disease, lifestyle modification, hepatic steatosis, liver fibrosis, liver enzymes, insulin resistance, body weight, dietary fiber
MeSH terms
Healthy Lifestyle, Adult, Combined Modality Therapy, Female, Follow-Up Studies, Food Handling, Humans, Insulin Resistance, Iran, Liver, Male, Middle Aged, Patient Compliance, Pilot Projects, Seeds, Severity of Illness Index, Biomarkers, Dietary Supplements, Flax, Elasticity Imaging Techniques, Functional Food, Non-alcoholic Fatty Liver Disease

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