Cited by 118Liver Disease Diagnosis and TreatmentSilymarin and Mushroom PoisoningFood composition and properties

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Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study

Yari, Zahra, Rahimlou, Mehran, Eslamparast, Tannaz, Ebrahimi-Daryani, Naser, Poustchi, Hossein, Hekmatdoost, Azita·2016·International Journal of Food Sciences and Nutrition

DOI 10.3109/09637486.2016.1161011

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Abstract

A two-arm randomized open labeled controlled clinical trial was conducted on 50 patients with non-alcoholic fatty liver disease (NAFLD). Participants were assigned to take either a lifestyle modification (LM), or LM +30 g/day brown milled flaxseed for 12 weeks. At the end of the study, body weight, liver enzymes, insulin resistance and hepatic fibrosis and steatosis decreased significantly in both groups (p< 0.05); however, this reduction was significantly greater in those who took flaxseed supplementation (p < 0.05). The significant mean differences were reached in hepatic markers between flaxseed and control group, respectively: ALT [-11.12 compared with -3.7 U/L; P< 0.001], AST [-8.29 compared with -4 U/L; p < 0.001], GGT [-15.7 compared with -2.62 U/L; p < 0.001], fibrosis score [-1.26 compared with -0.77 kPa; p = 0.013] and steatosis score [-47 compared with -15.45 dB/m; p = 0.022]. In conclusion, flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management.

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Authors: Yari, Z., Rahimlou, M., Eslamparast, T., Ebrahimi-Daryani, N., Poustchi, H., & Hekmatdoost, A.
Affiliations: National Nutrition and Food Technology Research Institute (IR)
Tehran University of Medical Sciences (IR)
Imam Khomeini Hospital (IR)
Digestive Disease Research Institute (IR)
Corresponding author: Hekmatdoost, Azita
ORCID: Yari, Zahra
Rahimlou, Mehran
Eslamparast, Tannaz
Poustchi, Hossein
Hekmatdoost, Azita
Venue: International Journal of Food Sciences and Nutrition
Publisher: Informa UK Limited
Published: 2016-03-17
Volume: 67
Issue: 4
Pages: 461-469
ISSN: 0963-7486 (ISSN-L)
1465-3478
DOI: 10.3109/09637486.2016.1161011
OpenAlex: W2298528870
Cited by: 118
References: 44
Citations by year: 2026: 4 · 2025: 12 · 2024: 11 · 2023: 18 · 2022: 4 · 2021: 21 · 2020: 10 · 2019: 16 · 2018: 10 · 2017: 7 · 2016: 3
FWCI: 11.26
Type: journal article
Language: en
Open access: closed
Locations: International Journal of Food Sciences and Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Silymarin and Mushroom Poisoning
Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Keywords: flaxseed supplementation, non-alcoholic fatty liver disease, lifestyle modification, hepatic steatosis, liver fibrosis, liver enzymes, insulin resistance, body weight, dietary fiber
MeSH terms: Healthy Lifestyle, Adult, Combined Modality Therapy, Female, Follow-Up Studies, Food Handling, Humans, Insulin Resistance, Iran, Liver, Male, Middle Aged, Patient Compliance, Pilot Projects, Seeds, Severity of Illness Index, Biomarkers, Dietary Supplements, Flax, Elasticity Imaging Techniques, Functional Food, Non-alcoholic Fatty Liver Disease

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Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study

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