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Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study
Abstract
A two-arm randomized open labeled controlled clinical trial was conducted on 50 patients with non-alcoholic fatty liver disease (NAFLD). Participants were assigned to take either a lifestyle modification (LM), or LM +30 g/day brown milled flaxseed for 12 weeks. At the end of the study, body weight, liver enzymes, insulin resistance and hepatic fibrosis and steatosis decreased significantly in both groups (p< 0.05); however, this reduction was significantly greater in those who took flaxseed supplementation (p < 0.05). The significant mean differences were reached in hepatic markers between flaxseed and control group, respectively: ALT [-11.12 compared with -3.7 U/L; P< 0.001], AST [-8.29 compared with -4 U/L; p < 0.001], GGT [-15.7 compared with -2.62 U/L; p < 0.001], fibrosis score [-1.26 compared with -0.77 kPa; p = 0.013] and steatosis score [-47 compared with -15.45 dB/m; p = 0.022]. In conclusion, flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management.
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“Six RCTs indicated the method for random sequence generation was low risk [29, 34, 44, 47, 48, 52], three other studies indicated high risk [21, 41, 53], and the remaining studies have unclear risk of bias.”
From Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials (2021) · cites this paper as [48]
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Cites
1 retracted
Cassani, R. S. L., Fassini, P. G., Silvah, J. H., de Lima, C. M. M., & Marchini, J. S. (2015) · Nutrition Journal · doi:10.1186/1475-2891-14-5 · Cited by 69
RetractedMatthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Vilar-Gomez, E., Martinez-Perez, Y., Calzadilla-Bertot, L., Torres-Gonzalez, A., Gra-Oramas, B., Gonzalez-Fabian, L., Friedman, S. L., Diago, M., & Romero-Gomez, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.005 · Cited by 2,492
Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis
Farrell, G. C., & Larter, C. Z. (2006) · Hepatology · doi:10.1002/hep.20973 · Cited by 2,428
Nonalcoholic Fatty Liver Disease
Rinella, M. E. (2015) · JAMA · doi:10.1001/jama.2015.5370 · Cited by 2,320
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
Xu, H. E., Lambert, M. H., Montana, V. G., Parks, D. J., Blanchard, S. G., Brown, P. J., Sternbach, D. D., Lehmann, J. M., Wisely, G. B., Willson, T. M., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80467-0 · Cited by 1,169
Caughey, G. E., Mantzioris, E., Gibson, R. A., Cleland, L., & James, M. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.1.116 · Cited by 866
Flax and flaxseed oil: an ancient medicine & modern functional food
Goyal, A., Sharma, V., Upadhyay, N., Gill, S., & Sihag, M. K. (2014) · Journal of Food Science and Technology · doi:10.1007/s13197-013-1247-9 · Cited by 797
The Practical Guide: Identification, Evaluation, and Treatment of Overweight and Obesity in Adults
(2000) · PsycEXTRA Dataset · doi:10.1037/e565692010-001 · Cited by 621
Marx, N., Duez, H., Fruchart, J.-C., & Staels, B. (2004) · Circulation Research · doi:10.1161/01.res.0000127122.22685.0a · Cited by 501
N-3 polyunsaturated fatty acid regulation of hepatic gene transcription
Jump, D. B. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282ffaf6a · Cited by 443
Eslamparast, T., Poustchi, H., Zamani, F., Sharafkhah, M., Malekzadeh, R., & Hekmatdoost, A. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.068890 · Cited by 412
Self-citationAssociation between dietary fiber and serum C-reactive protein
Ma, Y., Griffith, J. A., Chasan-Taber, L., Olendzki, B. C., Jackson, E., Stanek, E. J., Li, W., Pagoto, S. L., Hafner, A. R., & Ockene, I. S. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.4.760 · Cited by 396
Nonalcoholic Fatty Liver Disease: Cytokine-Adipokine Interplay and Regulation of Insulin Resistance
Tilg, H., & Hotamışlıgil, G. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.054 · Cited by 391
Faghihzadeh, F., Adibi, P., Rafiei, R., & Hekmatdoost, A. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.09.005 · Cited by 349
Self-citationDentin, R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25256 · Cited by 315
Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease
Torres, D. M., Williams, C. D., & Harrison, S. A. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.03.011 · Cited by 275
Meta-analysis of the effects of flaxseed interventions on blood lipids
Pan, A., Yu, D., Demark-Wahnefried, W., Franco, O. H., & Lin, X. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27469 · Cited by 264 · cited 5×
“grain, flaxseed oil or lignan), dosage and type of disease (Patade et al. 2008; Pan et al. 2009; Patenaude et al., 2009; Fukumitsu et al. 2010; Gillingham et al. 2011).”
BackgroundInfluentialFaghihzadeh, F., Adibi, P., & Hekmatdoost, A. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002433 · Cited by 188 · cited 2×
“2014) properties can enhance the effects of lifestyle modification in treatment of NAFLD, and its related cardiovascular risk factors (Faghihzadeh et al. 2015).”
BackgroundSelf-citationAskari, F., Rashidkhani, B., & Hekmatdoost, A. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.11.005 · Cited by 167
Self-citationHutchins, A. M., Brown, B. D., Cunnane, S. C., Domitrovich, S. G., Adams, E. R., & Bobowiec, C. E. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.02.012 · Cited by 166
Flaxseed Reduces Total and LDL Cholesterol Concentrations in Native American Postmenopausal Women
Patade, A., Devareddy, L., Lucas, E. A., Korlagunta, K., Daggy, B. P., & Arjmandi, B. H. (2008) · Journal of Women's Health · doi:10.1089/jwh.2007.0359 · Cited by 164
Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?
Larter, C. Z., & Farrell, G. C. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.11.030 · Cited by 155
Gillingham, L. G., Gustafson, J. A., Han, S.-Y., Jassal, D. S., & Jones, P. J. H. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510003697 · Cited by 143
Rhee, Y. S., & Brunt, A. R. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-44 · Cited by 128
Fukumitsu, S., Aida, K., Shimizu, H., & Toyoda, K. (2010) · Nutrition Research · doi:10.1016/j.nutres.2010.06.004 · Cited by 128
Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject
Patenaude, A. F., Rodriguez–Leyva, D., Edel, A. L., Dibrov, E., Dupasquier, C. M. C., Austria, J. A., Richard, M. N., Chahine, M. N., Malcolmson, L., & Pierce, G. N. (2009) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2009.41 · Cited by 88
Mani, U. V., Mani, I., Biswas, M., & Kumar, S. N. (2011) · Journal of Dietary Supplements · doi:10.3109/19390211.2011.593615 · Cited by 85
Flaxseed dietary fibers suppress postprandial lipemia and appetite sensation in young men
Kristensen, M., Savorani, F., Christensen, S., Engelsen, S. B., Bügel, S., Toubro, S., Tetens, I., & Astrup, A. V. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.03.004 · Cited by 84
How Much Weight Loss is Effective on Nonalcoholic Fatty Liver Disease?
Ghaemi, A., Taleban, F. A., Hekmatdoost, A., Rafiei, A., Hosseini, V., Amiri, Z., Homayounfar, R., & Fakheri, H. T. (2013) · Hepatitis Monthly · doi:10.5812/hepatmon.15227 · Cited by 80
Self-citationMachado, A. M., de Paula, H., Cardoso, L. D., & Costa, N. M. B. (2014) · Nutrition · doi:10.1016/j.nut.2014.05.002 · Cited by 79
Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease
Eslamparast, T. (2014) · World Journal of Hepatology · doi:10.4254/wjh.v7.i2.204 · Cited by 76
Self-citationNutritional Management of Insulin Resistance in Nonalcoholic Fatty Liver Disease (NAFLD)
Conlon, B. A., Beasley, J. M., Aebersold, K., Jhangiani, S. S., & Wylie‐Rosett, J. (2013) · Nutrients · doi:10.3390/nu5104093 · Cited by 74
Barre, D. E., Mizier-Barre, K. A., Griscti, O., & Hafez, K. K. (2008) · Journal of Oleo Science · doi:10.5650/jos.57.269 · Cited by 68
Leyva, D. R., Zahradka, P. C., Ramjiawan, B., Guzman, R., Aliani, M., & Pierce, G. N. (2011) · Contemporary Clinical Trials · doi:10.1016/j.cct.2011.05.005 · Cited by 64
Transient elastography in non-alcoholic fatty liver disease
Abenavoli, L., & Beaugrand, M. (2012) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31021-x · Cited by 59
Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice
Kelley, D. S., Vemuri, M., Adkins, Y. C., Gill, S. H. S., Fedor, D. M., & Mackey, B. E. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508027451 · Cited by 49
Paschos, G. K., Yiannakouris, N., Rallidis, L. S., Davies, I. G., Griffin, B. A., Panagiotakos, D. B., Skopouli, F. N., Votteas, V., & Zampelas, A. (2005) · Angiology · doi:10.1177/000331970505600107 · Cited by 44
Fibroscan for assessing liver fibrosis: An acceptable alternative for liver biopsy
Malekzadeh, R., & Poustchi, H. (2011) · Hepatitis Monthly · Cited by 31
Self-citationMalekzadeh, R., & Poustchi, H. (2011) · PubMed · Cited by 31
Self-citationXu, J., Gao, H. Y., Song, L., Yang, W. Q., Chen, C., Deng, Q., Huang, Q., Yang, J., & Huang, F. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-58 · Cited by 29
Recent advances in dietary supplementation, in treatingnon-alcoholic fatty liver disease
Tannaz, Eslamparast, Sareh, Eghtesad, Hossein, H., Poustchi, Azita, A., & Hekmatdoost (2015) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 28
Impact of flaxseed intake upon metabolic syndrome indicators in female Wistar rats
Brant, L. H. C., Cardozo, L., Velarde, L. G. C., & Boaventura, G. T. (2012) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-86502012000800004 · Cited by 24
Zong, G., Demark‐Wahnefried, W., Wu, H., & Xu, L. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0461-y · Cited by 23
Flagged first, then by citations
Research works printed but not linked: 3
- Ghaffarpour M, Houshiar-Rad A, Kianfar H. 1999. The manual for household measures, cooking yields factors and edible portion of foods. Tehran: Nashre Olume Keshavarzy. p. 1–40.
- Kelishadi R, Rabiei K, Khosravi A, Famouri F, Sadeghi M, Rouhafza H, Shirani SH. 2001. Assessment of physical activity of adolescents in Isfahan. Shahrekord Univ Med Sci J. 3:55–66.
- World Health Organization. 2012. STEPwise approach to surveillance (STEPS). Geneva, Switzerland: World Health Organization.
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Sorted by citations
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Safari, Z., & Gérard, P. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03011-w · Cited by 522
Bagherniya, M., Nobili, V., Blesso, C. N., & Sahebkar, A. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.020 · Cited by 225
Impact of Nutritional Changes on Nonalcoholic Fatty Liver Disease
Perdomo, C. M., Frühbeck, G., & Escalada, J. (2019) · Nutrients · doi:10.3390/nu11030677 · Cited by 222
Intestinal Microbiome Shifts, Dysbiosis, Inflammation, and Non-alcoholic Fatty Liver Disease
Saltzman, E., Palacios, T., Thomsen, M., & Vitetta, L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00061 · Cited by 197
Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence
Cicero, A. F. G., Colletti, A., & Bellentani, S. (2018) · Nutrients · doi:10.3390/nu10091153 · Cited by 185
Metadata
- Authors
- Yari, Z., Rahimlou, M., Eslamparast, T., Ebrahimi-Daryani, N., Poustchi, H., & Hekmatdoost, A.
- Affiliations
- National Nutrition and Food Technology Research Institute (IR)
- Tehran University of Medical Sciences (IR)
- Imam Khomeini Hospital (IR)
- Digestive Disease Research Institute (IR)
- Corresponding author
- Hekmatdoost, Azita
- Venue
- International Journal of Food Sciences and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2016-03-17
- Volume
- 67
- Issue
- 4
- Pages
- 461-469
- ISSN
- 0963-7486 (ISSN-L)
- 1465-3478
- OpenAlex
- W2298528870
- Cited by
- 118
- References
- 44
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 11 · 2023: 18 · 2022: 4 · 2021: 21 · 2020: 10 · 2019: 16 · 2018: 10 · 2017: 7 · 2016: 3
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Food Sciences and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Silymarin and Mushroom Poisoning
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- flaxseed supplementation, non-alcoholic fatty liver disease, lifestyle modification, hepatic steatosis, liver fibrosis, liver enzymes, insulin resistance, body weight, dietary fiber
- MeSH terms
- Healthy Lifestyle, Adult, Combined Modality Therapy, Female, Follow-Up Studies, Food Handling, Humans, Insulin Resistance, Iran, Liver, Male, Middle Aged, Patient Compliance, Pilot Projects, Seeds, Severity of Illness Index, Biomarkers, Dietary Supplements, Flax, Elasticity Imaging Techniques, Functional Food, Non-alcoholic Fatty Liver Disease
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