Psychological stress enhances the colonization of the stomach by Helicobacter pylori in the BALB/c mouse
Open accessAbstract
Helicobacter pylori infection is a risk factor for development of peptic ulcers, and psychological stress (PS) may have a role in the pathogenesis of this condition. However, no interaction between PS and H. pylori infection (HI) has been established in the development of peptic ulcer, because colonization by H. pylori is the first step in the infection of the gastric mucosa, we examined H. pylori colonization of the stomach in BALB/c mice after PS. The mice were subjected to PS in a communication box test, in which they observed other mice experiencing a physical stressor (electrical) before they were inoculated with H. pylori. We found that the H. pylori colonization in the stomach of psychologically stressed mice was significantly greater than in the control mice (P < 0.05), and histological examination showed that the gastric mucosal injury in the stressed mice was more extensive than in the control mice (P < 0.05). To explore the underlying mechanisms, we administered RU486 (a type II glucocorticoid (GC) receptor antagonist) to antagonize the effect of endogenous corticosterone: this treatment decreased colonization by H. pylori in the psychologically stressed mice. We conclude that HI of the stomach of BALB/c mice is enhanced by PS, and the effect may be mediated by GCs.
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In mice, chronic psychosocial stress induced an increase of Helicobacter pylori in the gastric mucosa concurrent with an increase in serum corticosterone levels.
“In one instance, chronic psychosocial stress induced an increase of Helicobacter pylori in the gastric mucosa, concurrent with an increase in serum corticosterone levels in mice (Guo et al., 2009).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Guo et al., 2009
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- Authors
- Guo, G., Jia, K.-R., Shi, Y., Liu, X.-F., Liu, K.-Y., Qi, W., Guo, Y., Zhang, W.-J., Wang, T., Xiao, B., & Zou, Q.-M.
- Affiliations
- Army Medical University (CN)
- Corresponding author
- Zou, Quan-Ming
- Venue
- Stress
- Publisher
- Informa UK Limited
- Published
- 2009-11
- Volume
- 12
- Issue
- 6
- Pages
- 478-485
- ISSN
- 1025-3890 (ISSN-L)
- 1607-8888
- OpenAlex
- W2050114069
- Cited by
- 44
- References
- 32
- Citations by year
- 2025: 6 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 4 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stress (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- Helicobacter pylori, psychological stress, gastric colonization, peptic ulcer, glucocorticoid receptor, corticosterone, RU486, gastric mucosal injury, BALB/c mice
- MeSH terms
- Animals, Female, Gastric Mucosa, Mice, Inbred BALB C, Peptic Ulcer, Receptors, Glucocorticoid, Stomach, Stomach Diseases, Stress, Psychological, Mifepristone, Helicobacter pylori, Helicobacter Infections, Mice
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