Hypothalamo-Pituitary-Adrenocortical Regulation Following Lesions of the Central Nucleus of the Amygdala
Abstract
Previous reports indicate that the central nucleus of the amygdala (CeA) stimulates adrenocorticotropin and corticosterone secretion, suggesting a role for this region in central hypothalamo-pituitary-adrenocortical (HPA) stress regulation. To evaluate this hypothesis, this study assessed the impact of CeA lesion on the response of hypophysiotrophic paraventricular nucleus (PVN) neurons to acute restraint and chronic unpredictable stress exposure. In contrast to previous reports, CeA lesions did not affect corticosterone or ACTH secretion induced by acute stress. Acute restraint increased PVN corticotropin releasing hormone (CRH) mRNA expression, increased the number of parvocellular PVN neurons expressing the co-secretagogue arginine vasopressin (AVP), and induced cFOS mRNA expression in the parvocellular PVN. However, there was no additional effect of CeA lesion on any measure of PVN activation. Chronic unpredictable stress exposure induced long-term activation of the HPA axis, noted by thymic involution, adrenal hypertrophy and increased PVN CRH mRNA expression. Stress-induced changes in thymus and adrenal weights were not affected by CeA lesion. Further, CeA lesion rats did not differ from controls in post-stress CRH mRNA expression. However, basal CRH mRNA expression was increased in the PVN of CeA rats, suggesting that the CeA plays a role in long-term inhibition of the PVN. The results of these studies are not consistent with the hypothesis that the CeA is necessary fo…
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Stimulation to central nuclei of the amygdala causes overexpression of CRH resulting in an increase in HPA axis activity.
“Stimulation to central nuclei causes overexpression of CRH resulting in an increase in HPA axis activity (68–70).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [68]
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- Authors
- Prewitt, C. M. F., & Herman, J. P.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Herman, James P.
- ORCID
- Herman, James P.
- Venue
- Stress
- Publisher
- Informa UK Limited
- Published
- 1997-01
- Volume
- 1
- Issue
- 4
- Pages
- 263-279
- ISSN
- 1025-3890 (ISSN-L)
- 1607-8888
- OpenAlex
- W2144807520
- Cited by
- 80
- References
- 2
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 7 · 2012: 6
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stress (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- central amygdala, hypothalamic-pituitary-adrenal axis, stress regulation, paraventricular nucleus, corticotropin-releasing factor, vasopressin, acute restraint stress, chronic unpredictable mild stress, thymic involution, adrenal hypertrophy, c-fos, ACTH, corticosterone
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