Point-of-care sensors for the management of sepsis
Abstract
Point-of-care sensors that enable the fast collection of information relevant to a patient's health state can facilitate improved health access, reduce healthcare costs and improve the quality of healthcare delivery. In the diagnosis of sepsis - defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, and the leading cause of in-patient death and of hospital readmission in the United States - predicting which infections will lead to life-threatening organ dysfunction and developing specific anti-sepsis treatments remain challenging because of the significant heterogeneity of the host response. Yet the use of point-of-care devices could reduce the time from the onset of a patient's infection to the administration of appropriate therapeutics. In this Perspective, we describe the current state of point-of-care sensors for the diagnosis and monitoring of sepsis, and outline opportunities in the use of these devices to dramatically improve patient care.
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- Authors
- Reddy, B., Hassan, U., Seymour, C., Angus, D. C., Isbell, T. S., White, K., Weir, W., Yeh, L., Vincent, A., & Bashir, R.
- Affiliations
- Carle Foundation Hospital (US)
- University of Pittsburgh (US)
- Saint Louis University (US)
- OSF Saint Francis Medical Center (US)
- Corresponding author
- Bashir, R.
- Venue
- Nature Biomedical Engineering
- Published
- 2018-09-11
- Volume
- 2
- Issue
- 9
- Pages
- 640-648
- ISSN
- 2157-846X (ISSN-L)
- OpenAlex
- W2889613240
- Cited by
- 142
- References
- 50
- Citations by year
- 2026: 7 · 2025: 21 · 2024: 14 · 2023: 17 · 2022: 17 · 2021: 25 · 2020: 23 · 2019: 16 · 2018: 2
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- sepsis, sepsis diagnosis, sepsis monitoring, organ dysfunction, host response to infection, infection severity prediction, health care access, health care costs
- MeSH terms
- Patient Care, Humans, Sepsis, Point-of-Care Systems
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