The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Recognition of bacterial infection by innate immune sensors
Abstract
Microbial challenges to the host initiate an array of defense processes through the activation of innate and adaptive immunity. Innate immunity consists of sensors or pattern-recognition receptors (PRRs) that are expressed on immune and non-immune cells and sense conserved pathogen-derived molecules or pathogen-associated molecular patterns (PAMPs) in various compartments of the host cells. Recognition of the PAMPs by PRRs triggers antimicrobial effector responses via the induction of proinflammatory cytokines and type I IFNs. Several families of PRRs, such as Toll-like receptors (TLRs), NOD-like receptors (NLRs), RIG-I-like receptors (RLRs), and DNA sensors and their respective PAMPs have been well studied in innate immunity and host defense. Here, we review the recent findings on bacterial recognition by TLRs and NLRs and the signaling pathways activated by these sensors.
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A Toll-like receptor recognizes bacterial DNA
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“The bacterial DNA or CpG motifs serve as a PAMP for TLR9, which is located on the endosomal membrane (Hemmi et al. 2000).”
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Toll-like receptors in innate immunity
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Cryopyrin activates the inflammasome in response to toxins and ATP
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Secundino, I., Lizcano, A., Roupé, K. M., Wang, X., Cole, J. N., Olson, J., Ali, S. R., Dahesh, S., Amayreh, L. K., Henningham, A., et al. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1341-8 · Cited by 92
Metadata
- Authors
- Kumar, S., Ingle, H., Prasad, D. V. R., & Kumar, H.
- Venue
- Critical Reviews in Microbiology
- Publisher
- Informa UK Limited
- Published
- 2012-08-06
- Volume
- 39
- Issue
- 3
- Pages
- 229-246
- ISSN
- 1040-841X (ISSN-L)
- 1549-7828
- OpenAlex
- W2059106230
- Cited by
- 221
- References
- 20
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kumar, S., Ingle, H., Prasad, D. V. R., & Kumar, H. (2013). Recognition of bacterial infection by innate immune sensors. Critical Reviews in Microbiology. https://doi.org/10.3109/1040841x.2012.706249
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