Utility of bronchoalveolar lavage fluid galactomannan alone or in combination with PCR for the diagnosis of invasive aspergillosis in adult hematology patients: A systematic review and meta-analysis

Heng, Siow Chin; Morrissey, Orla; Chen, Sharon C-A; Thursky, Karin; Manser, Renee L; Nation, Roger L; Kong, David C-M; Slavin, Monica

doi:10.3109/1040841x.2013.804033

Cited by 133Antifungal resistance and susceptibilityNeutropenia and Cancer InfectionsImmunodeficiency and Autoimmune Disorders

Utility of bronchoalveolar lavage fluid galactomannan alone or in combination with PCR for the diagnosis of invasive aspergillosis in adult hematology patients: A systematic review and meta-analysis

Heng, Siow Chin, Morrissey, Orla, Chen, Sharon C-A, Thursky, Karin, Manser, Renee L, Nation, Roger L, Kong, David C-M, Slavin, Monica·2015·Critical Reviews in Microbiology

DOI 10.3109/1040841x.2013.804033

Open this paper in CoChat — free account

Abstract

BACKGROUND: The clinical utility of bronchoalveolar lavage (BAL) fluid galactomannan (GM) for the early diagnosis of invasive aspergillosis (IA) varies widely across studies mainly due to heterogeneity of the studied populations. METHODS: We conducted a systematic review and meta-analysis of 16 studies involving 783 adults with hematological malignancies to derive summary estimates of the overall accuracy of BAL-GM for diagnosing IA. FINDINGS: Summary estimates of BAL-GM using an optical density (OD) index cutoff value of 1.5 for proven and probable IA were: sensitivity 0.92 (95% CI = 0.48-0.99), specificity 0.98 (95% CI = 0.78-1.00), positive likelihood ratio 53.7 (95% CI = 3.7-771.8), and negative likelihood ratio 0.08 (95% CI = 0.01-0.83). Comparing serum GM and Aspergillus PCR testing on BAL fluid, BAL-GM conferred greater sensitivity, but lower specificity than the serum GM test, and similar specificity as the PCR assay. The use of BAL-GM with serum GM or BAL-PCR tests increased the sensitivity moderately when a positive result was defined by either assay. INTERPRETATION: GM quantification in BAL fluid at an OD index cutoff value of 1.5 has excellent sensitivity and specificity to assist clinical decision-making in confirming or excluding a diagnosis of IA when results are interpreted with clinical findings. Additional research investigating the effects of antifungal agents, optimal timing and processing of BAL sampling are needed to improve the diagnostic accuracy of BAL-GM testing.

Integrity signals

Registry

Crossref · 10.3109/1040841x.2013.804033

Cites

80 of 80 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Recent studies showed that BAL fluid GM has improved sensitivity compared to serum GM in high-risk patients with IPA, including nonneutropenic patients.
“Recent studies showed that BAL fluid GM has improved sensitivity compared to serum GM in high-risk patients with IPA, including nonneutropenic patients (88, 114–119).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [115]

Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies
Whiting, P. F., Rutjes, A. W. S., Westwood, M. E., Mallett, S., Deeks, J. J., Reitsma, J. B., Leeflang, M. M. G., Sterne, J. A. C., Bossuyt, P. M. M., & the QUADAS-2 Group* (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-8-201110180-00009 · Cited by 14,199 · see citing works
Measuring the Accuracy of Diagnostic Systems
Swets, J. A. (1988) · Science · doi:10.1126/science.3287615 · Cited by 10,058 · see citing works
Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
De Pauw, B., Walsh, T. J., Donnelly, J. P., Stevens, D. A., Edwards, J. E., Calandra, T., Pappas, P. G., Maertens, J., Lortholary, O., Kauffman, C. A., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/588660 · Cited by 4,917 · see citing works
Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews
Reitsma, J. B., Glas, A. S., Rutjes, A. W. S., Scholten, R. J. P. M., Bossuyt, P. M., & Zwinderman, A. H. (2005) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2005.02.022 · Cited by 3,369 · cited 2× · see citing works
“The summary receiver operating characteristic (SROC) curves and the respective area under the curve (AUC) were constructed to visualize data (Reitsma et al., 2005).”
Method
Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative
Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P. P., Irwig, L. M., Lijmer, J. G., Moher, D., Rennie, D., & de Vet, H. C. W. (2003) · BMJ · doi:10.1136/bmj.326.7379.41 · Cited by 3,215
Towards Complete and Accurate Reporting of Studies of Diagnostic Accuracy: The STARD Initiative
Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P., Irwig, L., Lijmer, J. G., Moher, D., Rennie, D., de Vet, H. C. W., et al. (2003) · Clinical Biochemistry · doi:10.1016/s0009-9120(02)00443-5 · Cited by 3,182 · see citing works
Users' guides to the medical literature
Guyatt, G. H. (1993) · JAMA · doi:10.1001/jama.270.17.2096 · Cited by 2,970 · see citing works
The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed
Deeks, J. J., Macaskill, P., & Irwig, L. (2005) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2005.01.016 · Cited by 2,910 · see citing works
Defining Opportunistic Invasive Fungal Infections in Immunocompromised Patients with Cancer and Hematopoietic Stem Cell Transplants: An International Consensus
Aşçıoğlu, S., Rex, J. H., de Pauw, B., Bennett, J. E., Billé, J., Crokaert, F., Denning, D. W., Donnelly, J. P., Edwards, J. E., Erjavec, Z., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/323335 · Cited by 2,315 · see citing works
The diagnostic odds ratio: a single indicator of test performance
Glas, A. S., Lijmer, J. G., Prins, M. H., Bonsel, G. J., & Bossuyt, P. M. M. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00177-x · Cited by 2,261 · see citing works
Users' Guides to the Medical Literature
Jaeschke, R. (1994) · JAMA · doi:10.1001/jama.1994.03510330081039 · Cited by 2,220 · see citing works
Users' guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group
Jaeschke, R. (1994) · JAMA · doi:10.1001/jama.271.9.703 · Cited by 1,823 · see citing works
Prospective Surveillance for Invasive Fungal Infections in Hematopoietic Stem Cell Transplant Recipients, 2001–2006: Overview of the Transplant‐Associated Infection Surveillance Network (TRANSNET) Database
Kontoyiannis, D. P., Marr, K. A., Park, B. J., Alexander, B. D., Anaissie, E. J., Walsh, T. J., Ito, J., Andes, D. R., Baddley, J. W., Brown, J. M., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/651263 · Cited by 1,456 · see citing works
Systematic reviews of evaluations of diagnostic and screening tests
Deeks, J. J. (2001) · BMJ · doi:10.1136/bmj.323.7305.157 · Cited by 1,345 · see citing works
Nomogram for Bayes's Theorem
(1975) · New England Journal of Medicine · doi:10.1056/nejm197507312930513 · Cited by 1,017 · see citing works
Diagnosis of Invasive Aspergillosis Using a Galactomannan Assay: A Meta-Analysis
Pfeiffer, C. D., Fine, J. P., & Safdar, N. (2006) · Clinical Infectious Diseases · doi:10.1086/503427 · Cited by 964 · see citing works
Systematic reviews of evaluations of diagnostic and screening tests
(2001) · Europe PMC (PubMed Central) · Cited by 850 · see citing works
Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis
Mennink‐Kersten, M. A. S. H., Donnelly, J. P., & Verweij, P. E. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01045-x · Cited by 482 · see citing works
Detection of Galactomannan Antigenemia by Enzyme Immunoassay for the Diagnosis of Invasive Aspergillosis: Variables That Affect Performance
Marr, K. A., Balajee, S. A., McLaughlin, L., Tabouret, M., Bentsen, C. G., & Walsh, T. J. (2004) · The Journal of Infectious Diseases · doi:10.1086/422009 · Cited by 481 · see citing works
Antifungal Therapy Decreases Sensitivity of theAspergillus Galactomannan Enzyme Immunoassay
Marr, K. A., Laverdière, M., Gugel, A., & Leisenring, W. M. (2005) · Clinical Infectious Diseases · doi:10.1086/429921 · Cited by 473 · see citing works
Approaches to heterogeneity in meta‐analysis
Petitti, D. B. (2001) · Statistics in Medicine · doi:10.1002/sim.1091 · Cited by 469 · see citing works
Exploring sources of heterogeneity in systematic reviews of diagnostic tests
Lijmer, J. G., Bossuyt, P. M., & Heisterkamp, S. H. (2002) · Statistics in Medicine · doi:10.1002/sim.1185 · Cited by 446 · see citing works
Galactomannan detection for invasive aspergillosis in immunocompromized patients
Leeflang, M., Debets-Ossenkopp, Y. J., Visser, C. E., Scholten, R. J. P. M., Hooft, L., Bijlmer, H. A., Reitsma, J. B., Bossuyt, P. M., & Vandenbroucke‐Grauls, C. M. J. E. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007394 · Cited by 362 · see citing works
Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study
Pagano, L., Caira, M., Candoni, A., Offidani, M., Martino, B., Specchia, G., Pastore, D., Stanzani, M., Cattaneo, C. M., Fanci, R., et al. (2009) · Haematologica · doi:10.3324/haematol.2009.012054 · Cited by 317 · see citing works
AspergillusGalactomannan Enzyme Immunoassay and Quantitative PCR for Diagnosis of Invasive Aspergillosis with Bronchoalveolar Lavage Fluid
Musher, B., Fredricks, D. N., Leisenring, W. M., Balajee, S. A., Smith, C. A., & Marr, K. A. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.12.5517-5522.2004 · Cited by 283 · see citing works
Bronchoalveolar Lavage Fluid Galactomannan for the Diagnosis of Invasive Pulmonary Aspergillosis in Patients with Hematologic Diseases
Maertens, J. A., Maertens, V., Theunissen, K., Meersseman, W., Meersseman, P., Meers, S., Verbeken, E. K., Verhoef, G. E. G., Eldere, J. V., & Lagrou, K. (2009) · Clinical Infectious Diseases · doi:10.1086/647935 · Cited by 250 · see citing works
False‐Positive Galactomannan PlateliaAspergillusTest Results for Patients Receiving Piperacillin‐Tazobactam
Viscoli, C., Machetti, M., Cappellano, P., Bucci, B., Bruzzi, P., Lint, M. T. V., & Bacigalupo, A. P. (2004) · Clinical Infectious Diseases · doi:10.1086/382224 · Cited by 244 · see citing works
Use of Real‐Time PCR on Blood Samples for Diagnosis of Invasive Aspergillosis
Kami, M., Fukui, T., Ogawa, S., Kazuyama, Y., Machida, U., Tanaka, Y., Kanda, Y., Kashima, T., Yamazaki, Y., Hamaki, T., et al. (2001) · Clinical Infectious Diseases · doi:10.1086/323337 · Cited by 243 · see citing works
False Positive Test for Aspergillus Antigenemia Related to Concomitant Administration of Piperacillin and Tazobactam
Sulahian, A., Touratier, S., & Ribaud, P. (2003) · New England Journal of Medicine · doi:10.1056/nejm200312113492424 · Cited by 237 · see citing works
Differences in Patterns of Infection and Inflammation for Corticosteroid Treatment and Chemotherapy in Experimental Invasive Pulmonary Aspergillosis
Balloy, V., Huerre, M., Latgé, J.-P., & Chignard, M. (2005) · Infection and Immunity · doi:10.1128/iai.73.1.494-503.2005 · Cited by 231 · see citing works
Systematic Review and Meta-Analysis of Detecting Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosing Invasive Aspergillosis
Zou, M., Tang, L., Zhao, S., Zhao, Z., Chen, L., Chen, P., Huang, Z., Li, J., Chen, L., & Fan, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043347 · Cited by 226 · see citing works
Specificity of a sandwich enzyme-linked immunosorbent assay for detecting Aspergillus galactomannan
Swanink, C. M. A., Meis, J. F. G. M., Rijs, A. J. M. M., Donnelly, J. P., & Verweij, P. E. (1997) · Journal of Clinical Microbiology · doi:10.1128/jcm.35.1.257-260.1997 · Cited by 222 · see citing works
Galactomannan detection in computerized tomography‐based broncho‐alveolar lavage fluid and serum in haematological patients at risk for invasive pulmonary aspergillosis
Becker, M. J., Lugtenburg, E. J., Cornelissen, J. J., van der Schee, C., Hoogsteden, H. C., & de Marie, S. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04308.x · Cited by 216 · see citing works
Accuracy of BAL Galactomannan in Diagnosing Invasive Aspergillosis
Guo, Y., Chen, Y., Wang, K., Qin, S., Wu, C., & Kong, J. (2010) · CHEST Journal · doi:10.1378/chest.10-0488 · Cited by 197 · see citing works
Treatment with Piperacillin‐Tazobactam and False‐Positive Aspergillus Galactomannan Antigen Test Results for Patients with Hematological Malignancies
Adam, O., Auperin, A., Wilquin, F., et al. (2004) · Clinical Infectious Diseases · doi:10.1086/383148 · Cited by 186 · see citing works
Detection of galactomannan in bronchoalveolar lavage fluid samples of patients at risk for invasive pulmonary aspergillosis: analytical and clinical validity
D'Haese, J., Theunissen, K., Vermeulen, E., Schoemans, H., De Vlieger, G., Lammertijn, L., Meersseman, P., Meersseman, W., Lagrou, K., & Maertens, J. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.06423-11 · Cited by 186 · see citing works
Cross-Reactivity of Fusarium spp. in the Aspergillus Galactomannan Enzyme-Linked Immunosorbent Assay
Tortorano, A. M., Esposto, M. C., Prigitano, A., Grancini, A., Ossi, C. M., Cavanna, C., & Cascio, G. L. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.05946-11 · Cited by 185 · see citing works
Utility of Galactomannan Enzyme Immunoassay and (1,3) β- d -Glucan in Diagnosis of Invasive Fungal Infections: Low Sensitivity for Aspergillus fumigatus Infection in Hematologic Malignancy Patients
Hachem, R. Y., Kontoyiannis, D. P., Chemaly, R. F., Jiang, Y., Reitzel, R. A., & RAAD, I. I. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.00506-08 · Cited by 184 · see citing works
Pathogenesis of Pulmonary Aspergillosis. Granulocytopenia Versus Cyclosporine and Methylprednisolone-Induced Immunosuppression
Berenguer, J., Allende, M. C., Lee, J. W., Garrett, K., Lyman, C., Ali, N. M., Bacher, J., Pizzo, P. A., & Walsh, T. J. (1995) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.152.3.7663787 · Cited by 183 · see citing works
Comparison of antigen detection and PCR assay using bronchoalveolar lavage fluid for diagnosing invasive pulmonary aspergillosis in patients receiving treatment for hematological malignancies
Verweij, P. E., Latgé, J., Rijs, A. J. M. M., et al. (1995) · Journal of Clinical Microbiology · doi:10.1128/jcm.33.12.3150-3153.1995 · Cited by 163 · see citing works
Histoplasmosis-Associated Cross-Reactivity in the BioRad Platelia Aspergillus Enzyme Immunoassay
Wheat, L. J., Hackett, E., Durkin, M., Connolly, P., Petraitienė, R., Walsh, T. J., Knox, K. S., & Hage, C. A. (2007) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00479-06 · Cited by 162 · see citing works
Detection of Galactomannan Antigenemia in Patients Receiving Piperacillin-Tazobactam and Correlations between In Vitro, In Vivo, and Clinical Properties of the Drug-Antigen Interaction
Walsh, T. J., Shoham, S., Petraitienė, R., Sein, T., Schaufele, R. L., Kelaher, A. M., Murray, H., Mya-San, C., Bacher, J. D., & Petraitis, V. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.10.4744-4748.2004 · Cited by 151 · see citing works
Comparison of Real-Time PCR, Conventional PCR, and Galactomannan Antigen Detection by Enzyme-Linked Immunosorbent Assay Using Bronchoalveolar Lavage Fluid Samples from Hematology Patients for Diagnosis of Invasive Pulmonary Aspergillosis
Sanguinetti, M., Posteraro, B., Pagano, L., Pagliari, G., Fianchi, L., Mele, L., Sorda, M. L., Franco, A., & Fadda, G. M. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.8.3922-3925.2003 · Cited by 150 · see citing works
Diagnosis of Invasive Aspergillosis by a Commercial Real-Time PCR Assay for Aspergillus DNA in Bronchoalveolar Lavage Fluid Samples from High-Risk Patients Compared to a Galactomannan Enzyme Immunoassay
Torelli, R., Sanguinetti, M., Moody, A., Pagano, L., Caira, M., Carolis, E. D., Fuso, L., PASCALE, G. D., Bello, G., Antonelli, M. M., et al. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.05026-11 · Cited by 133 · see citing works
The pathogenesis of fatal outcome in murine pulmonary aspergillosis depends on the neutrophil depletion strategy.
Stephens-Romero, S. D., Mednick, A. J., & Feldmesser, M. (2005) · Infection and Immunity · doi:10.1128/iai.73.1.114-125.2005 · Cited by 131 · see citing works
Aspergillosis: From Diagnosis to Prevention
Pasqualotto, A. C. (2009) · Springer eBooks · doi:10.1007/978-90-481-2408-4 · Cited by 131 · see citing works
Pathogenesis of Aspergillus fumigatus and the Kinetics of Galactomannan in an In Vitro Model of Early Invasive Pulmonary Aspergillosis: Implications for Antifungal Therapy
Hope, W. W., Kruhlak, M. J., Lyman, C. A., Petraitienė, R., Petraitis, V., Francesconi, A., Kasai, M., Mickiene, D., Sein, T., Peter, J., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/510535 · Cited by 128 · see citing works
Prospective clinical evaluation of a LightCyclerTM‐mediated polymerase chain reaction assay, a nested‐PCR assay and a galactomannan enzyme‐linked immunosorbent assay for detection of invasive aspergillosis in neutropenic cancer patients and haematological stem cell transplant recipients
Buchheidt, D., Hummel, M., Schleiermacher, D., et al. (2004) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.04904.x · Cited by 124 · see citing works
Cross-reactivity of non-Aspergillus fungal species in the Aspergillus galactomannan enzyme immunoassay
Cummings, J. R., Jamison, G. R., Boudreaux, J. W., Howles, M. J., Walsh, T. J., & Hayden, R. T. (2007) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2007.04.022 · Cited by 116 · see citing works
Prospective Evaluation of a Polymerase Chain Reaction–ELISA Targeted toAspergillus fumigatusandAspergillus flavusfor the Early Diagnosis of Invasive Aspergillosis in Patients with Hematological Malignancies
Florent, M., Katsahian, S., Vekhoff, A., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/500466 · Cited by 109 · see citing works
Piperacillin/tazobactam (TazocinTM) seems to be no longer responsible for false-positive results of the galactomannan assay
Mikulska, M., Furfaro, E., Bono, V. D., Raiola, A. M., Ratto, S., Bacigalupo, A. P., & Viscoli, C. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks111 · Cited by 104 · see citing works
New cause for false-positive results with the Pastorex Aspergillus antigen latex agglutination test
Kappe, R., & Schulze‐Berge, A. (1993) · Journal of Clinical Microbiology · doi:10.1128/jcm.31.9.2489-2490.1993 · Cited by 96 · see citing works
Evaluation of PCR on Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Aspergillosis: A Bivariate Metaanalysis and Systematic Review
Sun, W., Wang, K., Gao, W., Su, X., Qian, Q., Lu, X., Song, Y., Guo, Y., & Shi, Y. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028467 · Cited by 86 · see citing works
Galactomannan Testing in Bronchoalveolar Lavage Fluid Facilitates the Diagnosis of Invasive Pulmonary Aspergillosis in Patients with Hematologic Malignancies and Stem Cell Transplant Recipients
Nguyen, M. H., Leather, H. L., Clancy, C. J., Cline, C. L., Jantz, M. A., Kulkarni, V., Wheat, L. J., & Wingard, J. R. (2010) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2010.11.013 · Cited by 83 · see citing works
False-positive serum and bronchoalveolar lavage Aspergillus galactomannan assays caused by different antibiotics
Boonsarngsuk, V., Niyompattama, A., Teosirimongkol, C., et al. (2010) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365541003602064 · Cited by 81 · see citing works
Contribution of Galactomannan Antigen Detection in BAL to the Diagnosis of Invasive Pulmonary Aspergillosis in Patients With Hematologic Malignancies
Bergeron, A., Belle, A., Sulahian, A., Lacroix, C., Chevret, S., Raffoux, E., Arnulf, B., Socié, G., Ribaud, P., & Tazi, A. (2009) · CHEST Journal · doi:10.1378/chest.09-0701 · Cited by 78 · see citing works
Steady-state plasma and intrapulmonary concentrations of piperacillin/tazobactam 4 g/0.5 g administered to critically ill patients with severe nosocomial pneumonia
Boselli, E., Breilh, D., Cannesson, M. P., Xuereb, F., Rimmele, T. R., CHASSARD, D., Saux, M., & Allaouchiche, B. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2222-8 · Cited by 77 · see citing works
Characterization and Comparison of Galactomannan Enzyme Immunoassay and Quantitative Real-Time PCR Assay for Detection of Aspergillus fumigatus in Bronchoalveolar Lavage Fluid from Experimental Invasive Pulmonary Aspergillosis
Francesconi, A., Kasai, M., Petraitienė, R., Petraitis, V., Kelaher, A. M., Schaufele, R. L., Hope, W. W., M.S., Y. R. S., Bacher, J. D., & Walsh, T. J. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.02693-05 · Cited by 76 · see citing works
Prospective Evaluation of Clinical and Biological Markers To Predict the Outcome of Invasive Pulmonary Aspergillosis in Hematological Patients
Bergeron, A., Porcher, R., Ménotti, J., POIROT, J. L., Chagnon, K., Vekhoff, A., Cornet, M., Isnard, F., Raffoux, E., Brethon, B., et al. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.00750-11 · Cited by 75 · see citing works
In Vitro Release by Aspergillus fumigatus of Galactofuranose Antigens, 1,3-β- d -Glucan, and DNA, Surrogate Markers Used for Diagnosis of Invasive Aspergillosis
Mennink‐Kersten, M. A. S. H., Ruegebrink, D., Wasei, N., Melchers, W. J. G., & Verweij, P. E. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.44.5.1711-1718.2006 · Cited by 75 · see citing works
Use of Real-Time PCR To Process the First Galactomannan-Positive Serum Sample in Diagnosing Invasive Aspergillosis
Millon, L., Piarroux, R., Deconinck, É., Bulabois, C., Grenouillet, F., Rohrlich, P., Costa, J., & Bretagne, S. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.10.5097-5101.2005 · Cited by 72 · see citing works
The Role of Bronchoalveolar Lavage Galactomannan in the Diagnosis of Pediatric Invasive Aspergillosis
Desai, R., Ross, L. A., & Hoffman, J. A. (2009) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e31818f0934 · Cited by 71 · see citing works
Aspergillus galactomannan antigen assay in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis
Park, S. Y., Lee, S., Choi, S., Sung, H., Kim, M., Choi, C., Hong, S., Oh, Y., Shim, T. S., Koh, Y., et al. (2010) · Journal of Infection · doi:10.1016/j.jinf.2010.08.014 · Cited by 68 · see citing works
Diagnosing pulmonary aspergillosis in patients with hematological malignancies: a multicenter prospective evaluation of an <i><scp>A</scp>spergillus </i><scp>PCR</scp> assay and a galactomannan <scp>ELISA</scp> in bronchoalveolar lavage samples
Reinwald, M., Spiess, B., Heinz, W. J., Vehreschild, J. J., Lass‐Flörl, C., Kiehl, M., Schultheis, B., Krause, S. W., Wolf, H., Bertz, H., et al. (2012) · European Journal of Haematology · doi:10.1111/j.1600-0609.2012.01806.x · Cited by 67 · see citing works
Aspergillus galactomannan testing in patients with long-term neutropenia: implications for clinical management
Penack, O., Rempf, P., Graf, B., et al. (2008) · Annals of Oncology · doi:10.1093/annonc/mdm571 · Cited by 64 · see citing works
Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological diseases—the role of factors affecting assay performance
Ráčil, Z., Kocmanová, I., Tošková, M., Burešová, L., Weinbergerová, B., Lengerová, M., Rolencová, M., Winterová, J., Hrnčířová, K., Volfová, P., et al. (2011) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2011.09.011 · Cited by 54 · see citing works
Comparison of PCR-ELISA and galactomannan detection for the diagnosis of invasive aspergillosis
Scotter, J. M., Campbell, P., Anderson, T. P., et al. (2005) · Pathology · doi:10.1080/00313020500099148 · Cited by 49 · see citing works
Galactomannan testing of bronchoalveolar lavage fluid is useful for diagnosis of invasive pulmonary aspergillosis in hematology patients
Hsu, L. Y., Ding, Y., Phua, J., Koh, L., Chan, D. S. G., Khoo, K., & Tambyah, P. A. (2010) · BMC Infectious Diseases · doi:10.1186/1471-2334-10-44 · Cited by 49 · see citing works
Disseminated Penicillium marneffei infection in an HIV‐positive female from Thailand in Germany
Rimek, D., Zimmermann, T., Hartmann, M., Prariyachatigul, C., & Kappe, R. (1999) · Mycoses · doi:10.1111/j.1439-0507.1999.tb00008.x · Cited by 45 · see citing works
Diagnosis of invasive aspergillosis using bronchoalveolar lavage in haematology patients: influence of bronchoalveolar lavage human DNA content on real-time PCR performance
Fréalle, É., Decrucq, K., Botterel, F., Bouchindhomme, B., Camus, D., Dei‐Cas, E., Costa, J., Yakoub‐Agha, I., Bretagne, S., & Delhaès, L. (2008) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-008-0616-1 · Cited by 43 · see citing works
Clinical utility and prognostic value of bronchoalveolar lavage galactomannan in patients with hematologic malignancies
Luong, M., Filion, C. A., Labbé, A., Roy, J., Pépin, J., Cadrin‐Tourigny, J., Carignan, S., Sheppard, D. C., & Laverdière, M. (2010) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2010.03.017 · Cited by 42 · see citing works
Comparison of PCR-ELISA and Real-Time PCR for invasive aspergillosis diagnosis in patients with hematological malignancies
Hadrich, I., Mary, C., Makni, F., et al. (2010) · Medical Mycology · doi:10.3109/13693786.2010.540724 · Cited by 42 · see citing works
False positive galactomannan Platelia due to piperacillin-tazobactam
Fernandez‐Gerlinger, M., Rousselot, P. H., Rigaudeau, S., Billon, C., Touratier, S., Castaigné, S., & Eloy, O. (2011) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2011.10.018 · Cited by 40 · see citing works
Detection of sputum Aspergillus galactomannan for diagnosis of invasive pulmonary aspergillosis in haematological patients
Kimura, S., Odawara, J., Aoki, T., Yamakura, M., Takeuchi, M., & Matsue, K. (2009) · International Journal of Hematology · doi:10.1007/s12185-009-0429-8 · Cited by 37 · see citing works
False-positive Aspergillus galactomannan (GM) assay in histoplasmosis
Narreddy, S., & Chandrasekar, P. H. (2007) · Journal of Infection · doi:10.1016/j.jinf.2007.09.013 · Cited by 29 · see citing works
Clinical utility and prognostic value of galactomannan in neutropenic patients with invasive aspergillosis
Hadrich, I., Makni, F., Cheikhrouhou, F., Neji, S., Amouri, I., Sellami, H., Trabelsi, H., Bellâaj, H., Elloumi, M., & Ayadi, M. A. (2011) · Pathologie Biologie · doi:10.1016/j.patbio.2011.10.011 · Cited by 22 · see citing works
Impact of bronchoalveolar lavage galactomannan on the outcome of patients at risk for invasive pulmonary aspergillosis.
Danpornprasert, P., Foongladda, S., & Tscheikuna, J. (2010) · PubMed · Cited by 13 · see citing works
Diagnosis and Antimicrobial Therapy of Lung Infiltrates in Febrile Neutropenic Cancer Patients
Maschmeyer, G. (2011) · Current Infectious Disease Reports · doi:10.1007/s11908-011-0219-3 · Cited by 5 · see citing works
Defining Invasive Aspergillosis: What the Revised EORTC/MSG Definitions Have in Store
Donnelly, J. P. (2009) · Springer eBooks · doi:10.1007/978-90-481-2408-4_25 · Cited by 2 · see citing works

Flagged first, then by citations

Sorted by citations

Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America
Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J. A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw326 · Cited by 2,926 · see citing works
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline
Ullmann, A. J., Aguado, J. M., Arikan-Akdagli, S., Denning, D. W., Groll, A. H., Lagrou, K., Lass-Flörl, C., Lewis, R. E., Munoz, P., Verweij, P. E., et al. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.01.002 · Cited by 1,556 · see citing works
Aspergillus fumigatus and Aspergillosis in 2019
Latgé, J.-P., & Chamilos, G. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00140-18 · Cited by 1,400 · see citing works
Invasive Fungal Infections in the Intensive Care Unit
Ostrosky-Zeichner, L., & Al-Obaidi, M. (2017) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2017.05.005 · Cited by 76 · see citing works
Diagnosis of invasive aspergillosis: recent developments and ongoing challenges
Arvanitis, M., & Mylonakis, E. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12448 · Cited by 56 · see citing works
The current management landscape: aspergillosis: Table 1.
Maertens, J. A., Blennow, O., Duarte, R. F., & Muñoz, P. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw393 · Cited by 29 · see citing works
Evaluating the use of PCR for diagnosing invasive aspergillosis
Buchheidt, D., Reinwald, M., Hofmann, W.-K., Boch, T., & Spiess, B. (2017) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2017.1325735 · Cited by 17 · see citing works

Practical value of bronchoalveolar lavage fluid galactomannan detection in diagnosing of invasive pulmonary aspergillosis
Zhang, X., & Lin, Q.-C. (2011) · Chinese Journal of Asthma · doi:10.3760/cma.j.issn.1673-436x.2011.015.019
Faculty Opinions recommendation of Diagnosis of invasive pulmonary aspergillosis in children with bronchoalveolar lavage galactomannan.
Goldman, D. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717969085.793468760
Galactomannan-Antigen Testing from Non-Directed Bronchial Lavage for Rapid Detection of Invasive Pulmonary Aspergillosis in Critically Ill Patients: A Proof-of-Concept Study
Rothe, K., Dibos, M., Haschka, S. J., Schmid, R. M., Busch, D. H., Rasch, S., & Lahmer, T. (2023) · Diagnostics · doi:10.3390/diagnostics13061190 · Cited by 6 · see citing works
[Usefulness of galactomannan detection in the diagnosis and follow-up of hematological patients with invasive aspergillosis].
Moragues, M. D., Amutio, E., García‐Ruiz, J. C., et al. (2003) · PubMed · Cited by 22 · see citing works
Evaluation of the diagnostic accuracy of galactomannan from the bronchoalveolar lavage fluid of patients with suspected invasive pulmonary aspergillosis
Bernardi, R. M., Holler, S. R., de Almeida, E. G. C., Anton, C., Machado, F. D., & Silva, D. R. (2022) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2021.07.002

Authors: Heng, S. C., Morrissey, O., Chen, S. C.-A., Thursky, K., Manser, R. L., Nation, R. L., Kong, D. C.-M., & Slavin, M.
Affiliations: Monash University (AU)
The Alfred Hospital (AU)
Westmead Hospital (AU)
Peter MacCallum Cancer Centre (AU)
Corresponding author: Slavin, Monica
ORCID: Chen, Sharon C-A
Thursky, Karin
Nation, Roger L
Kong, David C-M
Slavin, Monica
Venue: Critical Reviews in Microbiology
Publisher: Informa UK Limited
Published: 2013-06-25
Volume: 41
Issue: 1
Pages: 124-134
ISSN: 1040-841X (ISSN-L)
1549-7828
DOI: 10.3109/1040841x.2013.804033
OpenAlex: W2084293582
Cited by: 133
References: 80
Citations by year: 2026: 1 · 2025: 10 · 2024: 6 · 2023: 12 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 13 · 2018: 15 · 2017: 11 · 2016: 11 · 2015: 11 · 2014: 16
FWCI: 1.64
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Microbiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords: invasive aspergillosis, bronchoalveolar lavage fluid, galactomannan, Aspergillus PCR, hematologic malignancies, diagnostic accuracy, sensitivity and specificity, serum galactomannan
MeSH terms: Adult, Aspergillosis, Bronchoalveolar Lavage Fluid, Galactose, Humans, Mannans, Sensitivity and Specificity, Polymerase Chain Reaction, Hematologic Neoplasms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Utility of bronchoalveolar lavage fluid galactomannan alone or in combination with PCR for the diagnosis of invasive aspergillosis in adult hematology patients: A systematic review and meta-analysis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks