The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Bioactivation of Halogenated Hydrocarbons by Cytochrome P4502E1
Abstract
Numerous halogenated hydrocarbons of the alkane, alkene, and alkyne classes are metabolized by P450 enzymes to products that elicit cytotoxic and/or carcinogenic effects. Such halogenated hydrocarbons include anesthetics (e.g., halothane and enflurane) and industrial solvents (e.g., carbon tetrachloride, chloroform, and vinylidine chloride). Formation of reaction intermediates from these compounds occurs via P450-promoted dehalogenation, reduction, or reductive oxygenation, with certain hydrocarbons undergoing all three reaction types. Of the multiple forms of P450 present in liver microsomes, P4502E1 has been identified as the primary catalyst of hydrocarbon bioactivation in animals and, most likely, in humans as well. As hepatic concentrations of this P450 enzyme are highly inducible by ethanol and similar agents, prior exposure to 2E1-inducing compounds can play a pivotal role in halogenated hydrocarbon toxicity. Considering that metabolism governs the cytotoxicity and carcinogenicity of halogenated hydrocarbons, an understanding of the mechanism(s) underlying 2E1 induction in man becomes all the more important.
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Cites
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Gonzalez, F. J. (1988) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00021-3 · Cited by 1,301
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects
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The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature
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The Human Hepatic Cytochromes P450 Involved in Drug Metabolism
Wrighton, S. A., & Stevens, J. C. (1992) · Critical Reviews in Toxicology · doi:10.3109/10408449209145319 · Cited by 944
Hepatic Microsomal Ethanol-oxidizing System
Lieber, C. S., & DeCarli, L. M. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63099-6 · Cited by 812
Bioactivation of foreign compounds
Anders, M. W. (1985) · Academic Press eBooks · Cited by 728
Carbon Tetrachloride Hepatotoxicity: An Example of Lethal Cleavage
Rechnagel, R. O., Glende, E. A., & Plaa, G. L. (1973) · CRC Critical Reviews in Toxicology · doi:10.3109/10408447309082019 · Cited by 715
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Cited by
CYP2E1 and oxidative liver injury by alcohol
Lu, Y., & Cederbaum, A. I. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.11.004 · Cited by 805
Disinfection Byproducts and Bladder Cancer: A Pooled Analysis
Villanueva, C. M., Cantor, K. P., Cordier, S., Jaakkola, J. J. K., King, W. D., Lynch, C. F., Porru, S., & Kogevinas, M. (2004) · Epidemiology · doi:10.1097/01.ede.0000121380.02594.fc · Cited by 522
Biotransformation of Xenobiotics
Timbrell, J. A., & Marrs, T. C. (2009) · General, Applied and Systems Toxicology · doi:10.1002/9780470744307.gat004 · Cited by 435
Multigenerational epigenetic adaptation of the hepatic wound-healing response
Zeybel, M., Hardy, T., Wong, Y. K., Mathers, J. C., Fox, C. R., Gackowska, A., Oakley, F., Burt, A. D., Wilson, C. L., Anstee, Q. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2893 · Cited by 279
Metadata
- Authors
- Raucy, J. L., Kraner, J. C., & Lasker, J. M.
- Venue
- Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 1993-01
- Volume
- 23
- Issue
- 1
- Pages
- 1-20
- ISSN
- 0045-6446 (ISSN-L)
- 1040-8444
- 1547-6898
- OpenAlex
- W2166848521
- Cited by
- 265
- References
- 97
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Raucy, J. L., Kraner, J. C., & Lasker, J. M. (1993). Bioactivation of Halogenated Hydrocarbons by Cytochrome P4502E1. Critical Reviews in Toxicology. https://doi.org/10.3109/10408449309104072
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
