The DOI matches its Crossref record; 128 of the 130 references it cites were found in a registry or an index.
Epidemiological and Laboratory Evidence of PCB-lnduced Neurotoxicity
Abstract
The purpose of this review is to provide a selective, but critical, assessment of important findings derived from both epidemiological and laboratory studies suggesting that: (1) exposure to polychlorinated biphenyls (PCBs) and related halogenated aromatic hydrocarbons induces significant neurological and behavioral dysfunctions in humans and laboratory animals, particularly following exposure during gestation and lactation; (2) the neurochemical actions of PCBs depend on their structure and the developmental status of the animal at the time of exposure; and (3) the mechanisms responsible for these changes may involve alterations in basic cellular signaling processes and endocrine function that influence the synthesis and activity of important central nervous system neurotransmitters, the organization of the developing brain, and the behavioral responses to these environmental contaminants.
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“The weight of evidence from epidemiological studies supports a negative association between developmental exposure to PCBs and neuropsychological function in infancy and childhood [ 56 , 95–99 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [95]
Citations
Cites
Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory
Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960
Safe, S. (1990) · Critical Reviews in Toxicology · doi:10.3109/10408449009089873 · Cited by 1,871
Safe, S. H. (1994) · Critical Reviews in Toxicology · doi:10.3109/10408449409049308 · Cited by 1,760
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500
Erickson, M. D. (1986) · Medical Entomology and Zoology · Cited by 810
Electrophysiology of Cognitive Processing
Hillyard, S. A., & Marta Kutas, A. (1983) · Annual Review of Psychology · doi:10.1146/annurev.ps.34.020183.000341 · Cited by 767
Sawaguchi, T., & Goldman‐Rakic, P. S. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.71.2.515 · Cited by 649
Diamond, A., & Goldman-Rakic, P. S. (1989) · Experimental Brain Research · doi:10.1007/bf00248277 · Cited by 628
Jacobson, J. L., Jacobson, S. W., & Humphrey, H. E. B. (1990) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)81642-7 · Cited by 601
Murphy, B. L., Arnsten, A. F., Goldman-Rakic, P. S., & Roth, R. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1325 · Cited by 590
Research works printed but not linked: 39
- Ahlborg U. G., 1992, Eur. J. Pharmacol., 228, 179
- Bellinger D, 1992, Risk Assessment Forum Workshop: Developmental Neurotoxic Effects and PCBs
- Cattabeni F., 1978, GABA Neurotransmitters, 107
- Chishti M. A., 1996, Neurotoxicology
- Chishti M. A., 1992, Toxicologist, 12, 320
- Chui V. W., 1991, Biomed. Environ. Sci., 4, 399
- Eriksson P., 1994, Organohal. Compd., 21, 231
- 1984, Fed. Regist., 49, 21514
- Goldman-Rakic P. S, 1987, Handbook of Physiology — The Nervous System, 373
- Hansen L. G, 1987, Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology, 15
- Harada M, 1976, Bull. Inst. Const. Med., 25, 1
- Hutzinger O., 1974, The Chemistry of PCBs, 7
- Jacobson S. W., 1983, PCBs: Human and Environmental Hazards, 311
- Kittner B., 1987, Arch. Int. Pharma-codyn. Ther., 286, 181
- Korach K. S., 1988, Mol. Pharmacol., 33, 120
- Kuroiwa Y., 1969, Fukuoka Igaku Zasshi, 60, 446
- Lü Y.-C., 1984, PCB Poisoning in Japan and Taiwan
- Masuda Y., 1995, Fukuoka Igaku Zasshi, 86, 178
- Masuda Y., 1993, Fukuoka Igaku Zasshi, 84, 236
- Morse D. C., Neurotoxicology
- 1979, Polychlorinated Biphenyls, 1
- Paneth N, 1991, Health Environ. Dig., 5, 4
- Parkinson A., 1987, Poly chlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology, 49
- Rice D. C, 1995, Toxicologist, 15, 243
- Rogan W. J., 1991, AEP, 1, 407
- Rogan W. J., 1992, Neurotoxicology, 13, 27
- Rosin D. L., 1981, Neurotoxicology, 2, 749
- Schantz S. L, 1996, Neurotoxicol. Teratol.
- Schantz S. L., 1992, Teratology, 45, 524
- Scheel-Kruger J, 1986, Acta Neurol. Scand., 73, 9
- Seegal R. F, 1994, Archives of Toxicology., 128
- Seegal R. F., 1989, Neurotoxicology, 10, 757
- Seegal R. F., 1991, Neurotoxicology, 12, 55
- Seegal R. F., 1941, Chemosphere, 23, 1991
- Seo B. W., 1995, Toxicologist, 15, 65
- Tanaka K., 1995, Fukuoka lgaku Zasshi, 86, 202
- Winneke G., 1995, Int. Neurotoxicol. Assoc. Conf. Proc., 21
- 1976, Environmental Health Criteria 2
- Zigmond R. E., 1989, Annual Review of Neuro-science, 415
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Items 201–242 of 242
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Ryzhenko, N. O., Bondar, O. I., Chetverykov, V. V., & Fedorenko, Y. O. (2020) · Regulatory Mechanisms in Biosystems · doi:10.15421/022005 · Cited by 5
Cellular and Molecular Mechanisms of PCB Developmental Neurotoxicity
Panesar, H. K., Wilson, R. J., & Lein, P. J. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_204 · Cited by 5
Apoptosis as a Mechanism of Developmental Neurotoxicity
Lein, P. J., Supasai, S., & Guignet, M. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809405-1.00009-2 · Cited by 5
Ryanodine receptor-dependent mechanisms of PCB developmental neurotoxicity
Lein, P. J. (2023) · Advances in neurotoxicology · doi:10.1016/bs.ant.2023.09.003 · Cited by 5
Ekuase, E. J., Erve, T. J. V. ‘., Rahaman, A., Robertson, L. W., Duffel, M. W., & Luthe, G. M. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-4886-8 · Cited by 4
Konduru, L. (2012) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 4
Lutz, P., Wiaderna, D., Gralewicz, S., & Świercz, R. (2008) · Polish Journal of Environmental Studies · Cited by 4
Channelopathies: Summary of the hot topic keynotes session
Magby, J. P., Neal, A. P., Atchison, W. D., Pessah, I. P., & Shafer, T. J. (2011) · NeuroToxicology · doi:10.1016/j.neuro.2011.06.002 · Cited by 3
Cellular and Molecular Mechanisms of PCB Developmental Neurotoxicity
Panesar, H. K., Wilson, R. J., & Lein, P. J. (2022) · Springer eBooks · doi:10.1007/978-3-030-71519-9_204-1 · Cited by 3
Mariussen, E., Andersson, P. L., Ølstørn, H. B., Voie, Ø. A., & Fonnum, F. (2003) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(03)00009-7 · Cited by 3
Mukerjee, D. (2001) · Patty's Toxicology · doi:10.1002/0471435139.tox066 · Cited by 3
In vitro biomarkers of developmental neurotoxicity
Sachana, M., Flaskos, J., & Hargreaves, A. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382032-7.10019-0 · Cited by 2
Tissue damage after acute intoxication by polychlorinated biphenyls in cockroaches.
Lambiase, S., Zhang, Y., Morbini, P., Fasola, M., Bernocchi, G., Roda, E., & Grigolo, A. (2005) · PubMed · Cited by 2
Exposure to POPs and other congeners
Safe, S. H. (2002) · CRC Press eBooks · doi:10.1201/9781420032208.ch31 · Cited by 2
Fischer, C. (2008) · Uppsala University Publications (Uppsala University) · Cited by 2
Differential retention of PCB congeners in cockroaches Blattella germanica
Zhang, Y., Gandini, C., Sabuneti, A., Fasola, M., Lambiase, S., & Grigolo, A. (2007) · Journal of Environmental Science and Health Part A · doi:10.1080/10934520701304377 · Cited by 1
Kodavanti, P. R. S., Valdez, M. C., Yang, J., Currás‐Collazo, M., & Loganathan, B. G. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89773-0.00037-0 · Cited by 1
Brain Morphogenesis and Developmental Neurotoxicology
Jensen, K. F., & Catalano, S. M. (1998) · Elsevier eBooks · doi:10.1016/b978-012648860-9.50004-2 · Cited by 7
Hayes, A. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-373593-5.00019-7
Steinberg, R. M., Walker, D. M., Juenger, T., & Gore, A. C. (2011) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-642-22775-2_1
Role Played by Mitochondria in Neurotoxic Effects Induced by Polychlorinated Biphenyls
Cocco, S. (2009) · Università degli Studi di Napoli Federico II · doi:10.6092/unina/fedoa/3931
Elnar, A. A. (2012) · Publications of the UdS (Saarland University) · doi:10.22028/d291-22848
Aydın, M., Canpolat, S., Seyran, A. D., Bulmuş, Ö., & Yılmaz, B. (2007) · DergiPark (Istanbul University)
Berntsen, H. F. (2010) · NORA - Norwegian Open Research Archives
Stenberg, M. (2012) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Desai, A. (2007) · OhioLink ETD Center (Ohio Library and Information Network)
Pan, I. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/eazz-e742
Schmidt, K., Pflugmacher, S., Staaks, G. B. O., & Steinberg, C. E. W. (2005) · Umweltwissenschaften und Schadstoff-Forschung · doi:10.1065/uwsf2004.12.090
Brominated Organohalogens and Neurodevelopment: Different Mechanisms, Same Consequence
Ibhazehiebo, K., Iwasaki, T., & Koibuchi, N. (2016) · Contemporary clinical neuroscience · doi:10.1007/978-1-4939-3737-0_3
PCB i miljøet som mulig årsak til utvikling av ADHD
Dervola, K.-S. N. (2009)
Miller, M. M., & Sable, H. J. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809405-1.00041-9
Uwimana, E., Cagle, B., Yeung, C., Li, X., Patterson, E. V., Doorn, J. A., & Lehmler, H. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/373837
Exposition aux organochlorés et démence dans la population âgée du Canada
Medehouenou, T. C. M. (2013)
Fonnum, F. (2009) · General, Applied and Systems Toxicology · doi:10.1002/9780470744307.gat058
Mukerjee, D., & Ruiz, P. (2012) · Patty's Toxicology · doi:10.1002/0471435139.tox066.pub2
Muthusamy, S., & Narayanan, R. (2022) · Research Square · doi:10.21203/rs.3.rs-1425455/v1
Hayes, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813724-6.00022-0
Kodavanti, P. R. S., Valdez, J. M., & Yang, J. (2023) · Advances in neurotoxicology · doi:10.1016/bs.ant.2023.09.004 · Cited by 1
Muthusamy, S., & Narayanan, R. (2024) · Research Square · doi:10.21203/rs.3.rs-4715900/v1
Muthusamy, S., & Narayanan, R. (2026) · Xenobiotica · doi:10.1080/00498254.2026.2621365
The impact of chemical residues: the case of polychlorinated biphenyls (PCBs)
Gallagher, H. C., Souza, I. E. J. D., & Regan, C. M. (2004) · Elsevier eBooks · doi:10.1533/9781855739109.1.66
Metadata
- Authors
- Seegal, R. F.
- Affiliations
- New York State Department of Health (US)
- Corresponding author
- Seegal, Richard F.
- Venue
- Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 1996-01
- Volume
- 26
- Issue
- 6
- Pages
- 709-737
- ISSN
- 0045-6446 (ISSN-L)
- 1040-8444
- 1547-6898
- OpenAlex
- W1975003944
- Cited by
- 242
- References
- 130
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 8
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Keywords
- polychlorinated biphenyls, neurotoxicity, developmental neurotoxicity, prenatal exposure, lactational exposure, halogenated aromatic hydrocarbons, brain development, neurotransmitter synthesis, endocrine disruption, signal transduction, behavioral dysfunction, structure-activity relationship
- MeSH terms
- Adult, Animals, Humans, Infant, Nervous System Diseases, Polychlorinated Biphenyls
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