Cited by 322RNA and protein synthesis mechanismsMicrobial Natural Products and BiosynthesisAntibiotic Resistance in Bacteria

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The A-Z of bacterial translation inhibitors

Wilson, Daniel N.·2009·Critical Reviews in Biochemistry and Molecular Biology

DOI 10.3109/10409230903307311

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Abstract

Protein synthesis is one of the major targets in the cell for antibiotics. This review endeavors to provide a comprehensive "post-ribosome structure" A-Z of the huge diversity of antibiotics that target the bacterial translation apparatus, with an emphasis on correlating the vast wealth of biochemical data with more recently available ribosome structures, in order to understand function. The binding site, mechanism of action, and modes of resistance for 26 different classes of protein synthesis inhibitors are presented, ranging from ABT-773 to Zyvox. In addition to improving our understanding of the process of translation, insight into the mechanism of action of antibiotics is essential to the development of novel and more effective antimicrobial agents to combat emerging bacterial resistance to many clinically-relevant drugs.

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Authors: Wilson, D. N.
Affiliations: Center for Integrated Protein Science Munich (DE)
Corresponding author: Wilson, Daniel N.
ORCID: Wilson, Daniel N.
Venue: Critical Reviews in Biochemistry and Molecular Biology
Publisher: Informa UK Limited
Published: 2009-11-20
Volume: 44
Issue: 6
Pages: 393-433
ISSN: 0045-6411 (ISSN-L)
1040-9238
1549-7798
DOI: 10.3109/10409230903307311
OpenAlex: W2104276827
Cited by: 322
References: 369
Citations by year: 2026: 13 · 2025: 12 · 2024: 16 · 2023: 16 · 2022: 14 · 2021: 17 · 2020: 17 · 2019: 19 · 2018: 28 · 2017: 13 · 2016: 34 · 2015: 22 · 2014: 22 · 2013: 21 · 2012: 21
FWCI: 1.45
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Keywords: translation inhibitors, antibiotics, bacterial translation, ribosome structure, protein synthesis inhibitors, antibiotic binding sites, mechanism of action, antibiotic resistance, antimicrobial drug development, ribosome-targeted antibiotics
MeSH terms: Animals, Anti-Bacterial Agents, Bacteria, Bacterial Proteins, Humans, Protein Binding, Protein Synthesis Inhibitors, Protein Biosynthesis, Gene Expression Regulation, Bacterial, Drug Resistance, Bacterial

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