The A-Z of bacterial translation inhibitors

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Crystal structure of the ribosome at 5.5 Å resolution

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Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

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Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

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Structure of the A Site of Escherichia coli 16 S Ribosomal RNA Complexed with an Aminoglycoside Antibiotic

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Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form

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Thiopeptide Antibiotics

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Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death

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Macrolide Resistance Conferred by Base Substitutions in 23S rRNA

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The Oxazolidinone Linezolid Inhibits Initiation of Protein Synthesis in Bacteria

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Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3

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The structures of four macrolide antibiotics bound to the large ribosomal subunit.

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Mechanism of bactericidal action of aminoglycosides

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Initiation of mRNA translation in prokaryotes

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Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites

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Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA

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tRNA selection and kinetic proofreading in translation

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The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome

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A structural understanding of the dynamic ribosome machine

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Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance

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Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.

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Initiation of Protein Synthesis from the A Site of the Ribosome

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Inhibitors of protein synthesis

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Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit

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Insights into the decoding mechanism from recent ribosome structures

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Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation

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Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions

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Fidelity at the Molecular Level: Lessons from Protein Synthesis

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Crystal Structure of Paromomycin Docked into the Eubacterial Ribosomal Decoding A Site

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Streptogramins, Oxazolidinones, and Other Inhibitors of Bacterial Protein Synthesis

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Structural basis for aminoglycoside inhibition of bacterial ribosome recycling

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An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA

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Ribosome-inactivating proteins: progress and problems

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Visualization of elongation factor Tu on the Escherichia coli ribosome

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Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA

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A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503

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Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy

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Electrostatics in the Ribosomal Tunnel Modulate Chain Elongation Rates

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The Ribosome, Structure, Function, Antibiotics, and Cellular Interactions

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Visualization of elongation factor G on the Escherichia coli 70S ribosome: The mechanism of translocation

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The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

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Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit

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Resistance to Linezolid: Characterization of Mutations in rRNA and Comparison of Their Occurrences in Vancomycin-Resistant Enterococci

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EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome.

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Cryo‐EM reveals an active role for aminoacyl‐tRNA in the accommodation process

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Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.

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The macrolide–ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA

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Structural Basis of the Ribosomal Machinery for Peptide Bond Formation, Translocation, and Nascent Chain Progression

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The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli

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Simulating movement of tRNA into the ribosome during decoding

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Structural insights into peptide bond formation

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The Site of Action of Oxazolidinone Antibiotics in Living Bacteria and in Human Mitochondria

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Mechanism of bactericidal action of aminoglycosides.

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Altered Methylation of Ribosomal RNA in an Erythromycin-Resistant Strain of Staphylococcus aureus

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Paromomycin binding induces a local conformational change in the A-site of 16 s rRNA

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From Amino Acids to Heteroaromatics—Thiopeptide Antibiotics, Nature's Heterocyclic Peptides

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Insights into erythromycin action from studies of its activity as inducer of resistance

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Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics.

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Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction.

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The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin

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Folding zones inside the ribosomal exit tunnel

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Capreomycin Binds across the Ribosomal Subunit Interface Using tlyA-Encoded 2′-O-Methylations in 16S and 23S rRNAs

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Regulatory Nascent Peptides in the Ribosomal Tunnel

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Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin

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Inhibitors of Protein Biosynthesis

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Macrolide Antibiotics: Binding Site, Mechanism of Action, Resistance

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Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis

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Structural Basis for the Antibiotic Activity of Ketolides and Azalides

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Interaction of antibiotics with A- and P-site-specific bases in 16S ribosomal RNA

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Recent Advances in the Chemistry and Biology of Naturally Occurring Antibiotics

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Quality control by the ribosome following peptide bond formation

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Fusidic Acid: a New Antibiotic

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The Ribosomal Peptidyl Transferase Center: Structure, Function, Evolution, Inhibition

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Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center 1 1Edited by D. E. Draper

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The Weird and Wonderful World of Bacterial Ribosome Regulation

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The Highly Conserved LepA Is a Ribosomal Elongation Factor that Back-Translocates the Ribosome

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Conformational switch in the decoding region of 16S rRNA during aminoacyl-tRNA selection on the ribosome.

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Throwing a spanner in the works: antibiotics and the translation apparatus

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A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits

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Elongation Factor 2 as a Novel Target for Selective Inhibition of Fungal Protein Synthesis

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Kinetically Competent Intermediates in the Translocation Step of Protein Synthesis

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Macrolide–ketolide inhibition of MLS‐resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA

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Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

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Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity

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Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome

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Conformational Changes of the Small Ribosomal Subunit During Elongation Factor G-dependent tRNA–mRNA Translocation

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