Cited by 99Adipokines, Inflammation, and Metabolic DiseasesExercise and Physiological ResponsesAdipose Tissue and Metabolism

The DOI matches its Crossref record; 202 of the 202 references it cites were found in a registry or an index.

Physical inactivity, insulin resistance, and the oxidative-inflammatory loop

Gratas-Delamarche, A., Derbré, F., Vincent, S., Cillard, J.·2014·Free Radical Research

DOI 10.3109/10715762.2013.847528

Open this paper in CoChat — free account

Abstract

Epidemiological data indicate that physical inactivity, a main factor of global energetic imbalance, is involved in the worldwide epidemic of obesity and metabolic disorders such as insulin resistance. Although the complex pathogenesis of insulin resistance is not fully understood, literature data accumulated during the past decades clearly indicate that the activation of the oxidative-inflammatory loop plays a major role. By activating the oxidative-inflammatory loop in insulin-sensitive tissues, fat gain and adipose tissue dysfunction likely contribute to induce insulin resistance during chronic and prolonged physical inactivity. However, in the past years, evidence has emerged showing that early insulin resistance also occurs after very short-term exposure to physical inactivity (1-7 days) without any fat gain or energetic imbalance. The possible role of liver disturbances or endothelial dysfunction is suggested, but further studies are necessary to really conclude. Inactive skeletal muscle probably constitutes the primary triggering tissue for the development of early insulin resistance. In the present review, we discuss on the current knowledge about the effect of physical inactivity on whole-body and peripheral insulin sensitivity, and how local inflammation and oxidative stress arising with physical inactivity could potentially induce insulin resistance. We assume that early muscle insulin resistance allows the excess nutrients to shift in the storage tissues to withstand starvation through energy storage. We also consider when chronic and prolonged, physical inactivity over an extended period of time is an underestimated contributor to pathological insulin resistance and hence indirectly to numerous chronic diseases.

Integrity signals

Registry

Crossref · 10.3109/10715762.2013.847528

Cites

202 of 202 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research.
(1985) · Europe PMC (PubMed Central) · Cited by 9,143
Effect of physical inactivity on major non-communicable diseases worldwide: An analysis of burden of disease and life expectancy
Lee, I.-M., Shiroma, E. J., Lobelo, F., Puska, P., Blair, S. N., & Katzmarzyk, P. T. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61031-9 · Cited by 8,215
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Physical Activity and Public Health: Updated Recommendation for Adults From the American College of Sports Medicine and the American Heart Association
(2007) · Circulation · doi:10.1161/circulationaha.107.185649 · Cited by 6,545
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
Free Radicals in Biology and Medicine
Land, E. J. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,871
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.
Urano, F., Wang, X.-Z., Bertolotti, A., Zhang, Y.-H., Chung, P., Harding, H., & Ron, D. (2000) · Science · doi:10.1126/science.287.5453.664 · Cited by 3,081

Show all 202 references

Research works printed but not linked: 12

Morris JN, 1953, Br J Ind Med, 10, 245
Caspersen CJ, 1985, Public Health Rep, 100, 126
10.1371/journal.pone.0037696.t005 · DOI
Toth PP, 2013, Curr Vasc Pharmacol
Petrie JR, 1996, A physiological link with implications for pathogenesis of cardiovascular disease. Circulation, 93, 1331
Sies H, 1985, Oxidative Stress
Garcia-Ruiz C, 1997, Role of mitochondrial glutathione. J Biol Chem, 272, 11369
Gillery P, 1988, Diabete Metab, 14, 25
Yanagibori R, 1994, Acta Physiol Scand Suppl, 616, 51
Caballero C, 2007, Arch Latinoam Nutr, 57, 231
Ferrannini E, 1997, European Group for the Study of Insulin Resistance (EGIR). J Clin Invest, 100, 1166
Mikines KJ, 1989, Am J Physiol, 257, E43

Sorted by citations

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation
Marchio, P., Guerra‐Ojeda, S., Vila, J. M., Aldasoro, M., Víctor, V. M., & Mauricio, M. D. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8563845 · Cited by 651
Role of mitochondrial reactive oxygen species in homeostasis regulation
Zhang, B., Pan, C., Feng, C., Yan, C., Yu, Y., Chen, Z., Guo, C., & Wang, X. (2022) · Redox Report · doi:10.1080/13510002.2022.2046423 · Cited by 405
Antioxidant and Anti‐Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus
Li, Z., Geng, Y., Jiang, J., & Kong, W. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/289264 · Cited by 400
Berberine and Its Role in Chronic Disease
Cicero, A. F. G., & Baggioni, A. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-41334-1_2 · Cited by 285
The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine
Ma, X., Chen, Z., Wang, L., Wang, G., Wang, Z., Dong, X., Wen, B., & Zhang, Z. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00782 · Cited by 202
Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation
VanderVeen, B. N., Fix, D. K., & Carson, J. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3292087 · Cited by 188
The Relevance of a Physical Active Lifestyle and Physical Fitness on Immune Defense: Mitigating Disease Burden, With Focus on COVID-19 Consequences
Filgueira, T. O., Castoldi, Â., Santos, L. E. R., de Amorim, G. J., Fernandes, M. S. D. S., Anastácio, W. D. L. D. N., Campos, E. Z., Santos, T. M., & Souto, F. O. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.587146 · Cited by 163
Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
Crujeiras, A. B., Zulet, M. Á., Lopez‐Legarrea, P., de la Iglesia, R., Pardo, M., Carreira, M. C., Martínez, J. A., & Casanueva, F. F. (2013) · Metabolism · doi:10.1016/j.metabol.2013.12.007 · Cited by 149
Anti-inflammatory phytochemicals for the treatment of diabetes and its complications: Lessons learned and future promise
Kong, M., Xie, K., Lv, M., Li, J., Yao, J., Yan, K., Wu, X., Xu, Y., & Ye, D. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110975 · Cited by 153
Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation
Xu, Z., Feng, W., Shen, Q., Yu, N., Yu, K., Wang, S., Chen, Z., Shioda, S., & Guo, Y. (2017) · Aging and Disease · doi:10.14336/ad.2016.0620 · Cited by 148
Is immunosenescence influenced by our lifetime “dose” of exercise?
Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112
Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets
Yu, M., Wang, Z., Wang, D., Aierxi, M., Ma, Z., & Wang, Y. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25221 · Cited by 108
Irisin: ‘fat’ or artefact
Crujeiras, A. B., Pardo, M., & Casanueva, F. F. (2014) · Clinical Endocrinology · doi:10.1111/cen.12627 · Cited by 104
Inflammation-induced ROS generation causes pancreatic cell death through modulation of Nrf2/NF-κB and SAPK/JNK pathway
Choudhury, S., Ghosh, S., Gupta, P., Mukherjee, S., & Chattopadhyay, S. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1075016 · Cited by 97
Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories
Stanhope, K. L., Goran, M. I., Bosy‐Westphal, A., King, J. C., Schmidt, L. A., Schwarz, J., Stice, E. M., Sylvetsky, A. C., Turnbaugh, P. J., Bray, G. A., et al. (2018) · Obesity Reviews · doi:10.1111/obr.12699 · Cited by 90
Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties
Huang, M., & Li, J. (2019) · Acta Physiologica · doi:10.1111/apha.13351 · Cited by 67
Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable
Rudwill, F., O’Gorman, D. J., Lefai, É., Chery, I., Zahariev, A., Normand, S., Pagano, A. F., Chopard, A., Damiot, A., Laurens, C., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02267 · Cited by 61
Anti-Hyperglycemic and Anti-Inflammatory Activities of Polyphenolic-Rich Extract of Syzygium cumini Linn Leaves in Alloxan-Induced Diabetic Rats
Ajiboye, B. O., Ojo, O. A., Akuboh, O. S., Okesola, M. A., Idowu, O. T., & Amuzat, A. O. (2018) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x18770630 · Cited by 55
Skeletal muscle as a treatment target for older adults with diabetes mellitus: The importance of a multimodal intervention based on functional category
Omura, T., & Araki, A. (2022) · Geriatrics & Gerontology International · doi:10.1111/ggi.14339 · Cited by 47
Psychophysiological foundations of human physical activity behavior and motivation: theories, systems, mechanisms, evolution, and genetics
Gerber, M., Cheval, B., Cody, R., Colledge, F., Hohberg, V., Klimentidis, Y. C., Lang, C., Looser, V. N., Ludyga, S., Stults‐Kolehmainen, M., et al. (2025) · Physiological Reviews · doi:10.1152/physrev.00021.2024 · Cited by 59
Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats
Ablat, A., Halabi, M. F., Mohamad, J., Hasnan, M. H. H., Hazni, H., Teh, S.-H., Shilpi, J. A., Mohamed, Z., & Awang, K. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1610-x · Cited by 43
Association of circulating irisin levels with normal weight obesity, glycemic and lipid profile
Mehrabian, S., Taheri, E., Karkhaneh, M., Qorbani, M., & Hosseini, S. (2015) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-016-0239-5 · Cited by 41
Physical Activity and Insulin Resistance in 6,500 NHANES Adults: The Role of Abdominal Obesity
Fowler, J. R., Tucker, L. A., Bailey, B. W., & LeCheminant, J. D. (2020) · Journal of Obesity · doi:10.1155/2020/3848256 · Cited by 42
Muscle Regeneration with Intermuscular Adipose Tissue (IMAT) Accumulation Is Modulated by Mechanical Constraints
Pagano, A. F., Demangel, R., Brioche, T., Jublanc, É., Bertrand‐Gaday, C., Candau, R. B., Dechesne, C. A., Dani, C., Bonnieu, A., Py, G., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144230 · Cited by 39
From physical inactivity to immobilization: Dissecting the role of oxidative stress in skeletal muscle insulin resistance and atrophy
Pierre, N., Appriou, Z., Gratas‐Delamarche, A., & Derbré, F. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.028 · Cited by 41
Self-citation
Ethyl acetate fraction of Cissus quadrangularis stem ameliorates hyperglycaemia-mediated oxidative stress and suppresses inflammatory response in nicotinamide/streptozotocin induced type 2 diabetic rats
Lekshmi, R., Rajesh, R., & Mini, S. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.06.014 · Cited by 37
Interaction Between Depression, Obesity, and Type 2 Diabetes: A Complex Picture
Sevilla-González, M. D. R., Quintana-Mendoza, B. M., & Aguilar-Salinas, C. A. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2018.02.004 · Cited by 37
Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats
Ramasamy, C., & Pari, L. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.08.043 · Cited by 29
Insulin-Like Proteins in Plant Sources: A Systematic Review
Costa, I. D. S., de Medeiros, A. F., Piuvezam, G., de Medeiros, G. C. B. S., Maciel, B. L. L., & Morais, A. H. D. A. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s256883 · Cited by 29
Sex differences in the link between blood cobalt concentrations and insulin resistance in adults without diabetes
Chen, Y., Huang, H., He, X., Duan, W., & Mo, X. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00966-w · Cited by 28
Eco-friendly chitosan-based nanostructures in diabetes mellitus therapy: Promising bioplatforms with versatile therapeutic perspectives
Taheriazam, A., Entezari, M., Firouz, Z. M., Hajimazdarany, S., Heydargoy, M. H., Moghadassi, A. H. A., Moghadaci, A., sadrani, A., Motahhary, M., Nashtifani, A. H., et al. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115912 · Cited by 28
Association between Organophosphate Pesticide Exposure and Insulin Resistance in Pesticide Sprayers and Nonfarmworkers
Seesen, M., Lucchini, R. G., Siriruttanapruk, S., Sapbamrer, R., Hongsibsong, S., Woskie, S., & Kongtip, P. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218140 · Cited by 27
Antidiabetic Activity and Chemical Composition of Sanbai Melon Seed Oil
Wang, F., Hai-li, L., Zhao, H., Zhang, Y. P., Qiu, P., Li, J., & Wang, S. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/5434156 · Cited by 23
Impact of Physical Activity on Oxidative Stress Markers in Patients with Metastatic Breast Cancer
Delrieu, L., Touillaud, M. S., Pérol, O., Morelle, M., Martin, A., Friedenreich, C. M., Mury, P., Dufresne, A., Bachelot, T., Heudel, P., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6694594 · Cited by 22
Gongronema latifolium leaf extract modulates hyperglycaemia, inhibits redox imbalance and inflammation in alloxan-induced diabetic nephropathy
Ojo, O. A., Osukoya, O. A., Ekakitie, L. I., Ajiboye, B. O., Oyinloye, B. E., Agboinghale, P. E., & Kappo, A. P. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00533-0 · Cited by 21
A comprehensive review of recent advances in the extraction and therapeutic potential of berberine
Huang, S., & Huang, G. (2025) · RSC Advances · doi:10.1039/d5ra02170g · Cited by 20
Effects of naringin on learning and memory dysfunction induced by gp120 in rats
Qin, S., Chen, Q., Wu, H., Liu, C., Hu, J., Zhang, D., & Xu, C. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.020 · Cited by 20
Tadalafil Transdermal Delivery with Alpha-lipoic Acid Self Nanoemulsion for Treatment of Erectile Dysfunction by Diabetes Mellitus
Fahmy, U. A., & Aljaeid, B. M. (2018) · International Journal of Pharmacology · doi:10.3923/ijp.2018.945.951 · Cited by 19
Muscle Resting and TGF-β Inhibitor Treatment Prevent Fatty Infiltration Following Skeletal Muscle Injury
Pagano, A. F., Arc‐Chagnaud, C., Brioche, T., Chopard, A., & Py, G. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000121 · Cited by 19
Exercise and Arterial Modulation in Children: The EXAMIN YOUTH Study
Endes, K., Köchli, S., Zahner, L., & Hanssen, H. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00043 · Cited by 18
Mechanisms of action of natural products on type 2 diabetes
Wang, T., Wang, Y., Shi, M.-Y., & Liu, L. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i11.1603 · Cited by 14
Synthesis and anti-inflammatory effects of a series of novel 9-O-substituted berberine derivatives
Liu, Z., Wang, X., Zhang, H., Zhang, S., Li, Y., Liu, Y., & Peng, D. (2017) · Medicinal Chemistry Research · doi:10.1007/s00044-017-1787-z · Cited by 14
Skeletal muscle ceramides do not contribute to physical-inactivity-induced insulin resistance
Appriou, Z., Nay, K., Pierre, N., Saligaut, D., Lefeuvre‐Orfila, L., Martin, B., Cavey, T., Ropert, M., Loréal, O., Rannou‐Bekono, F., et al. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0850 · Cited by 14
Self-citation
Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest
Ward, K., Mulder, E. R., Frings‐Meuthen, P., O’Gorman, D. J., & Cooper, D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.573581 · Cited by 16
Berberine Protests the Heart from Ischemic Reperfusion Injury via Interference with Oxidative and Inflammatory Pathways
Abdulredha, A. J., Abosaooda, M., Al-Amran, F. G., & Hadi, N. R. (2021) · Medical Archives · doi:10.5455/medarh.2021.75.174-179 · Cited by 13
Relationship of Chronic Systemic Inflammation to Both Chronic Lifestyle-Related Diseases and Osteoarthritis: The Case for Lifestyle Medicine for Osteoarthritis
Prather, H., & Cheng, J. (2023) · HSS Journal® The Musculoskeletal Journal of Hospital for Special Surgery · doi:10.1177/15563316231193753 · Cited by 17
Regular exercise, overweight/obesity and sedentary lifestyle cause adaptive changes in thiol–disulfide homeostasis
Göl, M., ÖZKAYA, B., Yıldırım, C., & Bal, R. (2019) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201920180547 · Cited by 12
Relationship between quality of life, depression and anxiety in type 1 and type 2 diabetes
Çakmak, S. (2020) · Dusunen Adam The Journal of Psychiatry and Neurological Sciences · doi:10.14744/dajpns.2020.00075 · Cited by 11
Exercise and the Immune System
Gomes, E. C., & Florida-James, G. D. (2016) · Springer eBooks · doi:10.1007/978-3-7091-1890-0_6 · Cited by 12
Molecular stress and chronic metabolic disorders
Yurieva, E. A., Novikova, N. N., Длин, В. В., & Vozdvizhenskaya, E. S. (2020) · Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) · doi:10.21508/1027-4065-2020-65-5-12-22 · Cited by 10
Araliasaponin II isolated from leaves of Acanthopanax henryi (Oliv.) Harms inhibits inflammation by modulating the expression of inflammatory markers in murine macrophages
Seo, Y., Lee, S.-J., Li, Z., Kang, O., Kong, R., Kim, S.-A., Zhou, T., Song, Y., Liu, X., & Kwon, D. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6656 · Cited by 10
When Should the Treatment of Obesity in Thyroid Disease Begin?
Sutkowska, E., Kisiel, M., & Zubkiewicz‐Kucharska, A. (2025) · Biomedicines · doi:10.3390/biomedicines13010157 · Cited by 11
Impacts of Physical Inactivity Models on Endothelial Function: A Systematic Review
Harden, J. E., Branch, J. D., & Reynolds, L. J. (2025) · Sports Medicine · doi:10.1007/s40279-025-02238-x · Cited by 16
Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study
Wang, Y., Han, Q., Han, X., Dong, Y., Mao, M., Wang, C., Wang, X., Tang, S. H., Liu, C., Li, Y., et al. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00363-7 · Cited by 8
Physical activity has a more beneficial effect on the risk of all-cause mortality in patients with metabolic syndrome than in those without
Lee, C., Han, K.-D., & Kwak, M. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01227-2 · Cited by 8
Combination of HPLC-Q-TOF-MS/MS, Network Pharmacology, and Molecular Docking to Reveal the Mechanism of Apple Pollen in the Treatment of Type 2 Diabetes Mellitus
Wang, Y., & Chen, P. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/3221196 · Cited by 8
The role of the hippocampus in the pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Saury, J.-M. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.11.024 · Cited by 8
Effectiveness of game‐based exercise interventions on modifiable cardiovascular risk factors of individuals with type two diabetes mellitus: A systematic review and meta‐analysis
Lim, Y. S., Ho, B., & Goh, Y. S. (2022) · Worldviews on Evidence-Based Nursing · doi:10.1111/wvn.12615 · Cited by 8
Structure-based molecular docking and molecular dynamics simulations study for the identification of dipeptidyl peptidase 4 inhibitors in type 2 diabetes
Chen, X., Xue, B., Wahab, S., Sultan, A., Khalid, M., & Yang, S. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2291831 · Cited by 9
Protective effects of naringin against gp120-induced injury mediated by P2X7 receptors in BV2 microglial cells
Chen, Q., Hu, J., Qin, S.-L., Liu, C. L., Wu, H., Wang, J. R., Lu, X., Wang, J.-G., Chen, G. Q., Liu, Y., et al. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15028649 · Cited by 7
Multi-scale neural homeostasis mechanisms: Insights into neurodegenerative diseases and therapeutic approaches, including exercise
Wang, Y., Chen, X., Zhang, C., & Gao, S. (2025) · Advanced Exercise and Health Science · doi:10.1016/j.aehs.2025.02.002 · Cited by 8
Combined Effects of Metals, PCBs, Dioxins, and Furans on Cardiovascular Dysfunction
Akinyemi, B., & Obeng-Gyasi, E. (2025) · Journal of Xenobiotics · doi:10.3390/jox15030094 · Cited by 6
Genetic Susceptibility to Insulin Resistance and Its Association with Estimated Longevity in the Hungarian General and Roma Populations
Pikó, P., Werissa, N. A., & Ádány, R. (2022) · Biomedicines · doi:10.3390/biomedicines10071703 · Cited by 6
Comparing the Effects of Saccharomyces boulardii and Selenium-Enriched S. boulardii on Hematological Parameters and Total Antioxidant Capacity in Aluminum Induced Toxicity in Rats
Yaghchi, S. S., Fatemi, M., & Ghandehari, F. (2018) · Journal of Kermanshah University of Medical Sciences · doi:10.5812/jkums.80282 · Cited by 6
Holistic approach to opioid use disorder: Think nitric oxide!
Sackner, M. A., Lopez, J. R., Banderas, V., & Adams, J. A. (2019) · Journal of Opioid Management · doi:10.5055/jom.2019.0543 · Cited by 6
Dietary nutrients and their control of the redox bioenergetic networks as therapeutics in redox dysfunctions sustained pathologies
Bhotla, H. K., Meyyazhagan, A., Pappuswamy, M., Park, S., Arumugam, V. A., Pushparaj, K., Rengasamy, K. R. R., Liu, W., & Balasubramanian, B. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105709 · Cited by 8
Synergistic harmful interaction between sustained physical inactivity and hypertension/diabetes mellitus on the risk of all-cause mortality: a retrospective observational cohort study
Lee, C., Han, K.-D., Yoo, J., & Kwak, M. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002905 · Cited by 6
Natural Products
Pentón‐Arias, E., & Haines, D. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803302-9.00011-7 · Cited by 5
Transplantation of adipose derived stem cells in diabetes mellitus; limitations and achievements
Tajali, R., Eidi, A., Tafti, H. A., Pazouki, A., Kamarul, T., & Sharifi, A. M. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01280-8 · Cited by 6
Sex-specific impact of GCKR rs1260326 polymorphism on metabolic traits in an older Japanese population: the Bunkyo Health Study
Sakamoto, S., Kakehi, S., Abudurezake, A., Kaga, H., Someya, Y., Tabata, H., Yoshizawa, Y., Naito, H., Tajima, T., Ito, N., et al. (2024) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188241280540 · Cited by 3
FORUM ISSUE: “Free Radicals and Physical Exercise”
Viña, J., & Gómez‐Cabrera, M. C. (2013) · Free Radical Research · doi:10.3109/10715762.2014.853421 · Cited by 3
Effects of Aerobic Exercise Combined with Berberine Chloride Hydrate Supplementation on the Mitochondrial Biogenesis of Cardiac Muscles in Diabetic Male Rats
Mehrpuya, E., Keshavarz, S., Banitalebi, E., Naghizadeh, H., & Ramezani, J. (2023) · Zahedan Journal of Research in Medical Sciences · doi:10.5812/zjrms-132725 · Cited by 2
Avocado Peel Polyphenolic-Rich Extract Attenuates Inflammatory Responses in Alloxan-Induced Diabetic Male Wistar Rats
Eidangbe, G. O., & Oluba, O. M. (2024) · Asian Journal of Advanced Research and Reports · doi:10.9734/ajarr/2024/v18i12841 · Cited by 2
Astaxanthin attenuates DNA fragmentation and cognitive decline in type 2 diabetic rats
Saleh, S. A., Hanna, G. S., El‐Naby, S., Ewida, S. F., Elseadawy, R. S. A., Ghoneim, B. S., & Motawea, S. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-04402-9 · Cited by 2
Effect of Aerobic Exercise on the Expression of Ppargc-1α and SIRT1 in Cardiac Muscle of Diabetic Male Wistar Rats
Mehrpuya, E., Keshavarz, S., Banitalebi, E., Naghizadeh, H., & Ramezani, J. (2021) · Research in Molecular Medicine · doi:10.32598/rmm.9.4.1230.1 · Cited by 2
Supportive Therapie: Ernährung und Sport bei onkologischen Patienten
Zopf, Y., Herrmann, H. J., Neurath, M. F., & Reljic, D. (2019) · Deutsches Ärzteblatt · doi:10.3238/personko.2019.06.10.04 · Cited by 2
Associations between Allergic Rhinitis and Frequency of Muscular Exercise and Sitting Time in Korean Adolescent from the 2016 Korean Youth's Risk Behavior Web-Based Study
Kim, G., Park, D. Y., Lee, O., & Kim, Y. S. (2019) · The Korean Journal of Sports Medicine · doi:10.5763/kjsm.2019.37.2.47 · Cited by 2
Resisting decline: the neuroprotective role of resistance exercise in supporting cerebrovascular function and brain health in aging
Allison, E. Y., Bedi, A. M., Rourke, A. J., Mizzi, V., Walsh, J. J., Heisz, J. J., & Al‐Khazraji, B. K. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1606267 · Cited by 1
Explainable and interpretable models for predicting early-onset hypertension in the Tlalpan 2020 cohort
Gutiérrez-Esparza, G. O., Martínez-García, M., Amezcua-Guerra, L. M., Rivera, M. M., & Lemus, E. H. (2026) · Frontiers in Digital Health · doi:10.3389/fdgth.2026.1805107 · Cited by 1
Microcirculation
Wiernsperger, N. F. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-800093-9.00023-5
Moving more: our heart cares but do our lungs?
Evans, R. A. (2018) · Thorax · doi:10.1136/thoraxjnl-2017-211428
Preoperative Physical Conditioning
McAnally, H. B. (2019) · Oxford University Press eBooks · doi:10.1093/med/9780190920142.003.0007
Biochemical aspects of KB-28 compound on physically loaded study subjects
Toziuk, O., Krasna, O., Kryvoviaz, O. V., Rodinkova, V., Melnyk, A. V., Іvko, Т. I., Voronkina, A., & Hutsol, V. V. (2019) · Current Issues in Pharmacy and Medical Sciences · doi:10.2478/cipms-2019-0030
Bases fondamentales de l’activité physique
Carré, F., & Delamarche, P. (2021) · Elsevier eBooks · doi:10.1016/b978-2-294-77133-0.00002-6
Algerian Capparis spinosa n-BuOH Extract Alleviates Diabetic Neuropathy Induced with Streptozotocin in Ratss
Sekrani, I., Ameddah, S., Benrebaia, M., Bouaroudge, A., Erenler, R., Benkiniouar, R., Çaçan, E., & Menad, A. (2022) · Egyptian Journal of Chemistry · doi:10.21608/ejchem.2022.156714.6790
The effect of stress on the thyroid morphofunctional status (literature review)
Chernyavska, I. V., Дубовик, В., Гончарова, О. А., & Ashurov, E. M. (2023) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.19.6.2023.1314
Functional exercise rehabilitation guidance improves the prognosis for COVID-19 patients
Qian, H., Seongno, L. E. E., Tianwei, L. I., Dong, L. I., & Shu, W. (2024) · Gazzetta Medica Italiana Archivio per le Scienze Mediche · doi:10.23736/s0393-3660.23.05106-9
Effect of Type 2 Diabetes Milletus on Glycemic State, Cognitive Brain Functions and Hippocampus DNA in Adult Male Rats
Saleh, S. A., Hanna, G. S., El-Naby, S. E. H., Ewieda, S. F., Elseadawy, R. S. A., Ghoneim, B. S., & Motawea, S. M. (2024) · Menoufia Medical Journal · doi:10.59204/2314-6788.1153
Enhancement of Breast Cancer Chemotherapy and Radiotherapy Responses by Modulation of Ferroptosis
Al-Zufairi, A. A. M. (2024) · Sheffield Hallam University · doi:10.7190/shu-thesis-00623
Physical inactivity, overweight and cardiovascular risk: COVID-Inconfidentes StudyPreprint
de Moura, S. S., de Menezes-Júnior, L. A. A., Batista, A. P., Machado-Coelho, G. L. L., Carraro, J. C. C., & Meireles, A. L. (2024) · Research Square · doi:10.21203/rs.3.rs-5313928/v1
Short-Term Removal of Exercise Impairs Flow-Mediated Dilation Similarly in Older and Younger Adults
Harden, J. E., Akhter, T., Pokojovy, M., & Reynolds, L. J. (2025) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2024-0500
Additional file 2 of Sex differences in the link between blood cobalt concentrations and insulin resistance in adults without diabetes
Chen, Y., Huang, H., He, X., Duan, W., & Mo, X. (2021) · Figshare · doi:10.6084/m9.figshare.14330611
Additional file 3 of Sex differences in the link between blood cobalt concentrations and insulin resistance in adults without diabetes
Chen, Y., Huang, H., He, X., Duan, W., & Mo, X. (2021) · Figshare · doi:10.6084/m9.figshare.14330614
Additional file 1 of Sex differences in the link between blood cobalt concentrations and insulin resistance in adults without diabetes
Chen, Y., Huang, H., He, X., Duan, W., & Mo, X. (2021) · Figshare · doi:10.6084/m9.figshare.14330608
Additional file 1 of Physical activity has a more beneficial effect on the risk of all-cause mortality in patients with metabolic syndrome than in those without
Lee, C.-H., Han, K.-D., & Kwak, M.-S. (2024) · Figshare · doi:10.6084/m9.figshare.26650584
What Combinations of Modifiable Risk Factors Are Most Prevalent and Most Strongly Associated with Low Cognition? Results from Canadian Longitudinal Study on Aging
Son, S., Speechley, M., Zou, G., & Montero‐Odasso, M. (2026) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000550244
Natural products in the management of type 2 diabetes mediated neurological complications
Kumar, R., Devi, A., Sharma, A., Karadagatla, S., & Ranjan, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-32848-0.00022-4
Déconditionnement et régénération du muscle strié squelettique : rôle du niveau d’activité contractile sur le développement d’infiltrations graisseuses
Pagano, A. F. (2016) · theses.fr (ABES) · doi:10.70675/b2e8ea4ez5cd3z43a4zae84z3a8e6d8c661f
Effet d'une contremesure nutritionnelle sur l'inflexibilité métabolique induite par simulation d'impesanteur chez l'homme
Damiot, A. (2018) · theses.fr (ABES) · doi:10.70675/f11e654ezacacz44edz9462zc8a4447db7b2

Authors: Gratas-Delamarche, A., Derbré, F., Vincent, S., & Cillard, J.
Affiliations: École Normale Supérieure Paris-Saclay (FR)
Corresponding author: Derbré, F.
ORCID: Derbré, F.
Venue: Free Radical Research
Publisher: Informa UK Limited
Published: 2013-10-17
Volume: 48
Issue: 1
Pages: 93-108
ISSN: 1029-2470 (ISSN-L)
1071-5762
DOI: 10.3109/10715762.2013.847528
OpenAlex: W2154187478
Cited by: 99
References: 202
Citations by year: 2026: 3 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 11 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 3 · 2013: 2
FWCI: 0.75
Type: journal article
Language: en
Open access: closed
Locations: Free Radical Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: physical inactivity, insulin resistance, oxidative stress, inflammation, skeletal muscle insulin sensitivity, adipose tissue dysfunction, obesity, energy imbalance, endothelial dysfunction, liver dysfunction, energy storage
MeSH terms: Animals, Humans, Inflammation, Insulin Resistance, Motor Activity, Oxidation-Reduction, Sedentary Behavior

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Physical inactivity, insulin resistance, and the oxidative-inflammatory loop

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks