Cited by 99Adipokines, Inflammation, and Metabolic DiseasesExercise and Physiological ResponsesAdipose Tissue and Metabolism

The DOI matches its Crossref record; 202 of the 202 references it cites were found in a registry or an index.

Physical inactivity, insulin resistance, and the oxidative-inflammatory loop

Gratas-Delamarche, A., Derbré, F., Vincent, S., Cillard, J.·2014·Free Radical Research

DOI 10.3109/10715762.2013.847528

Open this paper in CoChat — free account

Abstract

Epidemiological data indicate that physical inactivity, a main factor of global energetic imbalance, is involved in the worldwide epidemic of obesity and metabolic disorders such as insulin resistance. Although the complex pathogenesis of insulin resistance is not fully understood, literature data accumulated during the past decades clearly indicate that the activation of the oxidative-inflammatory loop plays a major role. By activating the oxidative-inflammatory loop in insulin-sensitive tissues, fat gain and adipose tissue dysfunction likely contribute to induce insulin resistance during chronic and prolonged physical inactivity. However, in the past years, evidence has emerged showing that early insulin resistance also occurs after very short-term exposure to physical inactivity (1-7 days) without any fat gain or energetic imbalance. The possible role of liver disturbances or endothelial dysfunction is suggested, but further studies are necessary to really conclude. Inactive skeletal muscle probably constitutes the primary triggering tissue for the development of early insulin resistance. In the present review, we discuss on the current knowledge about the effect of physical inactivity on whole-body and peripheral insulin sensitivity, and how local inflammation and oxidative stress arising with physical inactivity could potentially induce insulin resistance. We assume that early muscle insulin resistance allows the excess nutrients to shift in the storage tissues to withstand starvation through energy storage. We also consider when chronic and prolonged, physical inactivity over an extended period of time is an underestimated contributor to pathological insulin resistance and hence indirectly to numerous chronic diseases.

Integrity signals

Registry

Crossref · 10.3109/10715762.2013.847528

Cites

202 of 202 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research.
(1985) · Europe PMC (PubMed Central) · Cited by 9,143
Effect of physical inactivity on major non-communicable diseases worldwide: An analysis of burden of disease and life expectancy
Lee, I.-M., Shiroma, E. J., Lobelo, F., Puska, P., Blair, S. N., & Katzmarzyk, P. T. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61031-9 · Cited by 8,215
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Physical Activity and Public Health: Updated Recommendation for Adults From the American College of Sports Medicine and the American Heart Association
(2007) · Circulation · doi:10.1161/circulationaha.107.185649 · Cited by 6,545
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
Free Radicals in Biology and Medicine
Land, E. J. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,871
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.
Urano, F., Wang, X.-Z., Bertolotti, A., Zhang, Y.-H., Chung, P., Harding, H., & Ron, D. (2000) · Science · doi:10.1126/science.287.5453.664 · Cited by 3,081
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus.
DeFronzo, R. A. (2009) · Diabetes · doi:10.2337/db09-9028 · Cited by 3,016
Critical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Tumor necrosis factor signaling
Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401189 · Cited by 2,422
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884
Redefining Oxidative Stress
Jones, D. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1865 · Cited by 1,726
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677
NF-κB activation by reactive oxygen species: Fifteen years later
Gloire, G., Legrand-Poels, S., & Piette, J. G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,561
The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307
Aguirre, V., Uchida, T., Yenush, L., Davis, R., & White, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.9047 · Cited by 1,487
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232
Interleukin-6-deficient mice develop mature-onset obesity
Wallenius, V., Wallenius, K., Ahrén, B., Rudling, M., Carlsten, H., Dickson, S. L., Ohlsson, C., & Jansson, J.-O. (2002) · Nature Medicine · doi:10.1038/nm0102-75 · Cited by 1,213
Radical-free biology of oxidative stress
Jones, D. P. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00283.2008 · Cited by 1,213
Lipid-induced insulin resistance: unravelling the mechanism
Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60408-4 · Cited by 1,189
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.
DeFronzo, R. A., Gunnarsson, R., Björkman, O., Olsson, M., & Wahren, J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111938 · Cited by 1,167
Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss
Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J.-L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2277 · Cited by 1,164
Objectively Measured Sedentary Time, Physical Activity, and Metabolic Risk
Healy, G. N., Wijndaele, K., Dunstan, D. W., Shaw, J. E., Salmon, J., Zimmet, P. Z., & Owen, N. (2008) · Diabetes Care · doi:10.2337/dc07-1795 · Cited by 1,100
How many steps/day are enough? for adults
Tudor-Locke, C., Craig, C. L., Brown, W. J., Clemes, S. A., De Cocker, K., Giles-Corti, B., Hatano, Y., Inoue, S., Matsudo, S. M., Mutrie, N., et al. (2011) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-8-79 · Cited by 1,087
Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant Subjects
Rotter, V., Nagaev, I., & Smith, U. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301977200 · Cited by 1,062
Exercise, Glucose Transport, and Insulin Sensitivity
Goodyear, L. J., & Kahn, B. B. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.235 · Cited by 1,056
Oxidative Stress: Introductory Remarks
Sies, H. (1985) · Elsevier eBooks · doi:10.1016/b978-0-12-642760-8.50005-3 · Cited by 1,037
Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective
Virtue, S., & Vidal-Puig, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.12.006 · Cited by 1,013
Endoplasmic Reticulum Stress Signaling in Disease
Marciniak, S. J., & Ron, D. (2006) · Physiological Reviews · doi:10.1152/physrev.00015.2006 · Cited by 951
Insulin resistance and hypersecretion in obesity: European Group for the Study of Insulin Resistance (EGIR)
Ferrannini, E., Natali, A., Bell, P., Cavallo-Perin, P., Lalic, N., & Mingrone, G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119628 · Cited by 898
Reactive oxygen species and cell signaling: Respiratory burst in macrophage signaling
Forman, H. J., & Torres, M. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2206007 · Cited by 891 · cited 1×
“, H 2 O 2 , and HOCl), as part of the infl ammatory response [95,96].”
Background
Sitting time and all-cause mortality risk in 222,497 Australian adults
van der Ploeg, H. P. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.2174 · Cited by 884
Ceramides in insulin resistance and lipotoxicity
Summers, S. A. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.11.002 · Cited by 866
Insulin-sensitive obesity
Klöting, N., Fasshauer, M., Dietrich, A., Kovacs, P., Schön, M. R., Kern, M., Stumvoll, M., & Blüher, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00586.2009 · Cited by 856
The Advanced Glycation End Product, N∊-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions
Fu, M.-X., Requena, J. R., Jenkins, A. J., Lyons, T. J., Baynes, J. W., & Thorpe, S. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9982 · Cited by 822
Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species
García‐Ruiz, C., Colell, A., Marı́, M., Morales, A., & Fernández-Checa, J. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11369 · Cited by 808
Oxidative Stress as a Regulator of Gene Expression in the Vasculature
KUNSCH, C. A., & Medford, R. M. (1999) · Circulation Research · doi:10.1161/01.res.85.8.753 · Cited by 801
The epidemiology of obesity: the size of the problem
James, W. P. T. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01922.x · Cited by 785
Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury
Zhao, K., Zhao, G.-M., Wu, D., Soong, Y., Birk, A. V., Schiller, P. W., & Szeto, H. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402999200 · Cited by 782
Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex
Gao, Z., Hwang, D. H., Bataille, F., Lefevre, M., York, D. A., Quon, M. J., & Ye, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209459200 · Cited by 777
Effects of Different Doses of Physical Activity on Cardiorespiratory Fitness Among Sedentary, Overweight or Obese Postmenopausal Women With Elevated Blood Pressure: A Randomized Controlled Trial
Church, T. S., Earnest, C. P., Skinner, J. S., & Blair, S. N. (2007) · JAMA · doi:10.1001/jama.297.19.2081 · Cited by 756
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
Foretz, M., Guichard, C., Ferré, P., & Foufelle, F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12737 · Cited by 748
Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease
Bassuk, S. S., & Manson, J. E. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00160.2005 · Cited by 744
Ceramide in the eukaryotic stress response
Hannun, Y. A., & Luberto, C. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01694-3 · Cited by 727
Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity
Kang, K., Reilly, S. M., Karabacak, V., Gangl, M. R., Fitzgerald, K., Hatano, B., & Lee, C.-H. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.002 · Cited by 699
Adipose Tissue Dysfunction in Obesity
Blüher, M. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1192044 · Cited by 679
Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2
Deng, J., Lu, P. D., Zhang, Y., Scheuner, D., Kaufman, R. J., Sonenberg, N., Harding, H. P., & Ron, D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10161-10168.2004 · Cited by 665
From space to Earth: Advances in human physiology from 20 years of bed rest studies (1986–2006)
Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J., & Vernikos, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0474-z · Cited by 658
Amount of time spent in sedentary behaviors and cause-specific mortality in US adults
Matthews, C. E., George, S. M., Moore, S. C., Bowles, H. R., Blair, A., Park, Y., Troiano, R. P., Hollenbeck, A., & Schatzkin, A. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.019620 · Cited by 655
A Ceramide-Centric View of Insulin Resistance
Chavez, J. A., & Summers, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.002 · Cited by 637
Adipose Tissue IL-6 Content Correlates with Resistance to Insulin Activation of Glucose Uptake both in Vivo and in Vitro
Bastard, J., Maachi, M., Nhieu, J. T. V., Jardel, C., Bruckert, É., Grimaldi, A., Robert, J., Capeau, J., & Hainque, B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8450 · Cited by 636
Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling
Woo, H. A., Yim, S. H., Shin, D. H., Kang, D., Yu, D., & Rhee, S. G. (2010) · Cell · doi:10.1016/j.cell.2010.01.009 · Cited by 632
The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk
Pedersen, B. K. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179515 · Cited by 631
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
Chavez, J. A., Knotts, T. A., Wang, L.-P., Li, G., Dobrowsky, R. T., Florant, G. L., & Summers, S. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212307200 · Cited by 617
Insulin resistance and cancer risk: An overview of the pathogenetic mechanisms
Arcidiacono, B., Iiritano, S., Nocera, A., Possidente, K., Nevolo, M. T., Ventura, V., Foti, D., Chiefari, E., & Brunetti, A. (2012) · Experimental Diabetes Research · doi:10.1155/2012/789174 · Cited by 606
Phosphorylation of IRS proteins, insulin action, and insulin resistance
Boura-Halfon, S., & Zick, Y. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90437.2008 · Cited by 598
Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.
Goossens, V., Grooten, J., Vos, K. J. D., & Fiers, W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8115 · Cited by 595
Macrophage Infiltration into Omental Versus Subcutaneous Fat across Different Populations: Effect of Regional Adiposity and the Comorbidities of Obesity
Harman-Boehm, I., Blüher, M., Redel, H., Sion-Vardy, N., Ovadia, S., Avinoach, E., Shai, I., Klöting, N., Stumvoll, M., Bashan, N., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1811 · Cited by 574
A Molecular Basis for Insulin Resistance
Paz, K., Hemi, R., LeRoith, D., Karasik, A., Elhanany, E., Kanety, H., & Zick, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29911 · Cited by 556
Improved lifestyle and decreased diabetes risk over 13 years: long-term follow-up of the randomised Finnish Diabetes Prevention Study (DPS)
(DPS), F. T. F. D. P. S., Lindström, J., Peltonen, M., Eriksson, J. G., Ilanne-Parikka, P., Aunola, S., Keinänen-Kiukaanniemi, S., Uusitupa, M., & Tuomilehto, J. (2013) · Diabetologia · doi:10.1007/s00125-012-2752-5 · Cited by 551
The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals
Reaven, G. M. (2004) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2004.03.002 · Cited by 517
Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action Cascade
Mahadev, K., Zilbering, A., Zhu, L., & Goldstein, B. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100109200 · Cited by 509
PKC-θ knockout mice are protected from fat-induced insulin resistance
Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500
Adaptive immunity in obesity and insulin resistance
Sell, H., Habich, C., & Eckel, J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.114 · Cited by 486
Physical Inactivity Rapidly Induces Insulin Resistance and Microvascular Dysfunction in Healthy Volunteers
Hamburg, N. M., McMackin, C. J., Huang, A. L., Shenouda, S. M., Widlansky, M. E., Schulz, E., Gokce, N., Ruderman, N. B., Keaney, J. F., & Vita, J. A. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.153288 · Cited by 474
Involvement of Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes
Nakatani, Y., Kaneto, H., Kawamori, D., Yoshiuchi, K., Hatazaki, M., Matsuoka, T., Ozawa, K., Ogawa, S., Hori, M., Yamasaki, Y., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411860200 · Cited by 469
Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function
Wardenburg, J. B., Fu, C., Jackman, J. K., Flotow, H., Wilkinson, S. E., Williams, D. H., Johnson, R., Kong, G., Chan, A. C., & Findell, P. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.19641 · Cited by 464
4‐Hydroxynonenal: A membrane lipid oxidation product of medicinal interest
Poli, G., Schaur, R. J., Siems, W. G., & Leonarduzzi, G. (2007) · Medicinal Research Reviews · doi:10.1002/med.20117 · Cited by 439
Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation
Tanti, J.-F., & Jager, J. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.07.004 · Cited by 430
Reactive Oxygen Species Facilitate Adipocyte Differentiation by Accelerating Mitotic Clonal Expansion
Lee, H., Lee, Y. J., Choi, H., Ko, E. H., & Kim, J. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808742200 · Cited by 428
Oxidative Stress Mediates Tumor Necrosis Factor-α–Induced Mitochondrial DNA Damage and Dysfunction in Cardiac Myocytes
Suematsu, N., Tsutsui, H., Wen, J., Kang, D., Ikeuchi, M., Ide, T., Hayashidani, S., Shiomi, T., Kubota, T., Hamasaki, N., et al. (2003) · Circulation · doi:10.1161/01.cir.0000055318.09997.1f · Cited by 428
Adiponectin in insulin resistance: lessons from translational research
Ziemke, F., & Mantzoros, C. S. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28449c · Cited by 422
The Continuing Epidemic of Obesity in the United States
Mokdad, A. H., Serdula, M. K., Dietz, W. H., Bowman, B. A., Marks, J. S., & Koplan, J. P. (2000) · JAMA · doi:10.1001/jama.284.13.1650 · Cited by 415
Protection Against Oxidative Stress—Induced Insulin Resistance in Rat L6 Muscle Cells by Micromolar Concentrations of α-Lipoic Acid
Maddux, B. A., See, W., Lawrence, J. C., Goldfine, A. L., Goldfine, I. D., & Evans, J. L. (2001) · Diabetes · doi:10.2337/diabetes.50.2.404 · Cited by 405
Insulin resistance and Alzheimer's disease
De La Monte, S. M. (2009) · BMB Reports · doi:10.5483/bmbrep.2009.42.8.475 · Cited by 392
Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans.
Baron, A., Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., & Brechtel, G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118124 · Cited by 380
Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle
Lawler, J. M. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00186-2 · Cited by 370
Role of Exercise Training in the Prevention and Treatment of Insulin Resistance and Non-Insulin-Dependent Diabetes Mellitus
Ivy, J. L. (1997) · Sports Medicine · doi:10.2165/00007256-199724050-00004 · Cited by 369
Physical activity, sedentary behavior, and health: Paradigm paralysis or paradigm shift?
Katzmarzyk, P. T. (2010) · Diabetes · doi:10.2337/db10-0822 · Cited by 365
Rapid Reactive Oxygen Species Production by Mitochondria in Endothelial Cells Exposed to Tumor Necrosis Factor-α Is Mediated by Ceramide
Corda, S., Laplace, C., Vicaut, É., & Duranteau, J. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.6.4228 · Cited by 352
The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis
Bost, F., Aouadi, M., Caron, L., Even, P. C., Belmonte, N., Prot, M., Dani, C., Hofman, P. M., Pagès, G., Pouysségur, J., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.2.402 · Cited by 351
Minimal Intensity Physical Activity (Standing and Walking) of Longer Duration Improves Insulin Action and Plasma Lipids More than Shorter Periods of Moderate to Vigorous Exercise (Cycling) in Sedentary Subjects When Energy Expenditure Is Comparable
Duvivier, B. M. F. M., Schaper, N. C., Bremers, M. A., Crombrugge, G. V., Menheere, P. P. C. A., Kars, M., & Savelberg, H. H. C. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055542 · Cited by 350
The ASK1-MAP Kinase Cascades in Mammalian Stress Response
Matsukawa, J. (2004) · Journal of Biochemistry · doi:10.1093/jb/mvh134 · Cited by 343
Association of sedentary time with mortality independent of moderate to vigorous physical activity
Koster, A., Caserotti, P., Patel, K. V., Matthews, C. E., Berrigan, D., Van Domelen, D. R., Brychta, R. J., Chen, K. Y., & Harris, T. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037696 · Cited by 340
Physical Inactivity Increases Oxidative Stress, Endothelial Dysfunction, and Atherosclerosis
Laufs, U., Wassmann, S., Czech, T., Münzel, T., Eisenhauer, M., Böhm, M., & Nickenig, G. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000158311.24443.af · Cited by 327
The sphingosine kinase 1/sphingosine‐1‐phosphate pathway mediates COX‐2 induction and PGE 2 production in response to TNF‐α
Pettus, B. J., Bielawski, J., Porcelli, A. M., Reames, D. L., Johnson, K. R., Morrow, J. D., Chalfant, C. E., Obeid, L. M., & Hannun, Y. A. (2003) · The FASEB Journal · doi:10.1096/fj.02-1038com · Cited by 327
Endothelial Nitric Oxide Production and Insulin Sensitivity
Petrie, J. R., Ueda, S., Webb, D. J., Elliott, H. L., & Connell, J. (1996) · Circulation · doi:10.1161/01.cir.93.7.1331 · Cited by 321
IRS1-Independent Defects Define Major Nodes of Insulin Resistance
Hoehn, K. L., Hohnen-Behrens, C., Cederberg, A., Wu, L. E., Turner, N. A., Yuasa, T., Ebina, Y., & James, D. E. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.005 · Cited by 318
Linking mitochondrial bioenergetics to insulin resistance via redox biology
Fisher-Wellman, K. H., & Neufer, P. D. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.12.008 · Cited by 316
Pathophysiological implications of insulin resistance on vascular endothelial function
Wheatcroft, S. B., Williams, I. L., Shah, A. M., & Kearney, M. T. (2003) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.00869.x · Cited by 316
Physical Activity, Energy Expenditure and Fitness: An Evolutionary Perspective
Cordain, L., Gotshall, R. W., Eaton, S. B., & Eaton, S. B. (1998) · International Journal of Sports Medicine · doi:10.1055/s-2007-971926 · Cited by 314
Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders
Mattson, M. P. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.07.003 · Cited by 311
A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity
Krogh-Madsen, R., Thyfault, J. P., Broholm, C., Mortensen, O. H., Olsen, R. H., Mounier, R., Plomgaard, P., van Hall, G., Booth, F. W., & Pedersen, B. K. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00977.2009 · Cited by 311
Nutrition and physical activity in NAFLD: An overview of the epidemiological evidence
Zelber‐Sagi, S. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i29.3377 · Cited by 307
New insights into ER stress-induced insulin resistance
Flamment, M., Hajduch, E., Ferré, P., & Foufelle, F. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.06.003 · Cited by 306
Inflammation and impaired adipogenesis in hypertrophic obesity in man
Gustafson, B., Gogg, S., Hedjazifar, S., Jenndahl, L. E., Hammarstedt, A., & Smith, U. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00377.2009 · Cited by 298
Physical inactivity as the culprit of metabolic inflexibility: evidence from bed-rest studies
Bergouignan, A., Rudwill, F., Simon, C., & Blanc, S. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00698.2011 · Cited by 293
Physical Activity and Insulin Sensitivity
Balkau, B., Mhamdi, L., Oppert, J., Nolan, J. J., Golay, A., Porcellati, F., Laakso, M., Ferrannini, E., & on behalf of the EGIR-RISC Study Group (2008) · Diabetes · doi:10.2337/db07-1605 · Cited by 276
Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice
Ventre, J. R., Doebber, T. W., Wu, M. S., MacNaul, K. L., Stevens, K. A., Pasparakis, M., Kollias, G. A., & Moller, D. E. (1997) · Diabetes · doi:10.2337/diab.46.9.1526 · Cited by 275
Interleukin-6 depletion selectively improves hepatic insulin action in obesity.
Klover, P. J., Clementi, A. H., & Mooney, R. A. (2005) · Endocrinology · doi:10.1210/en.2004-1468 · Cited by 273
Nox4 Acts as a Switch Between Differentiation and Proliferation in Preadipocytes
Schröder, K., Wandzioch, K., Helmcke, I., & Brandes, R. P. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.174219 · Cited by 264
Association of Television Viewing With Fasting and 2-h Postchallenge Plasma Glucose Levels in Adults Without Diagnosed Diabetes
Dunstan, D. W., Salmon, J., Healy, G. N., Shaw, J. E., Jolley, D., Zimmet, P., & Owen, N. G. (2007) · Diabetes Care · doi:10.2337/dc06-1996 · Cited by 260
Effects of 1 day of inactivity on insulin action in healthy men and women: interaction with energy intake
Stephens, B. R., Granados, K. E., Zderic, T. W., Hamilton, M. T., & Braun, B. (2010) · Metabolism · doi:10.1016/j.metabol.2010.08.014 · Cited by 247
Non‐alcoholic fatty liver disease ( NAFLD ) is associated with low level of physical activity: a population‐based study
Gerber, L. H., Otgonsuren, M., Mishra, A., Escheik, C., Birerdinc, A., Stepanova, M., & Younossi, Z. M. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12038 · Cited by 240
Insulin Resistance: Cellular and Clinical Concepts
Cefalu, W. T. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600103 · Cited by 232
Oxysterols: A world to explore
Otaegui-Arrazola, A., Menéndez-Carreño, M., Ansorena, D., & Astiasarán, I. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.09.023 · Cited by 228
Roles of MAPKKK ASK1 in Stress-Induced Cell Death.
Takeda, K., Matsuzawa, A., Nishitoh, H., & Ichijo, H. (2003) · Cell Structure and Function · doi:10.1247/csf.28.23 · Cited by 224
The roles of ASK family proteins in stress responses and diseases
Hattori, K., Naguro, I., Runchel, C., & Ichijo, H. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-9 · Cited by 216
TNFα release by the nonfat cells of human adipose tissue
Fain, J. N., Bahouth, S. W., & Madan, A. K. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802594 · Cited by 211
Clinical Relevance of Adipokines
Blüher, M. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.5.317 · Cited by 210
Physical Fitness and Changes in Mortality
Erikssen, G. (2001) · Sports Medicine · doi:10.2165/00007256-200131080-00001 · Cited by 200
Oxidative alterations in the experimental glycation model of diabetes mellitus are due to protein-glucose adduct oxidation. Some fundamental differences in proposed mechanisms of glucose oxidation and oxidant production.
Hunt, J. V., Bottoms, M., & Mitchinson, M. (1993) · Biochemical Journal · doi:10.1042/bj2910529 · Cited by 195
Stressing harms of physical inactivity to promote exercise
Wen, C. P., & Wu, X. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60954-4 · Cited by 191
Influence of TNF-α and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans
Krogh‐Madsen, R., Plomgaard, P., Møller, K., Mittendorfer, B., & Pedersen, B. K. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00471.2005 · Cited by 185
Hydrogen peroxide activates IκB kinases through phosphorylation of serine residues in the activation loops
Kamata, H., Manabe, T., Oka, S., Kamata, K., & Hirata, H. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02712-6 · Cited by 179
Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice
Franckhauser, S., Elias, I., Sopasakis, V. R., Ferré, T., Nagaev, I., Andersson, C. X., Agudo, J., Ruberte, J., Bosch, F., & Smith, U. (2008) · Diabetologia · doi:10.1007/s00125-008-0998-8 · Cited by 175
Insulin resistance: An adaptive mechanism becomes maladaptive in the current environment—An evolutionary perspective
Tsatsoulis, A., Mantzaris, M. D., Bellou, S., & Andrikoula, M. (2013) · Metabolism · doi:10.1016/j.metabol.2012.11.004 · Cited by 174
Prevention of unloading-induced atrophy by vitamin E supplementation: Links between oxidative stress and soleus muscle proteolysis?
Servais, S., Letexier, D., Favier, R. J. M., Duchamp, C., & Dominique Desplanches, C. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.001 · Cited by 174
Acute Reversal of the Enhanced Insulin Action in Trained Athletes: Association with Insulin Receptor Changes
Burstein, R., Polychronakos, C., Toews, C. J., MacDougall, J. D., Guyda, H. J., & Posner, B. I. (1985) · Diabetes · doi:10.2337/diab.34.8.756 · Cited by 171
Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity
Gregorio, G. B. D., Hensley, L. L., Lü, T., Ranganathan, G., & Kern, P. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00189.2003 · Cited by 165
Protein carbonylation and metabolic control systems
Curtis, J. M., Hahn, W. S., Long, E. K., Burrill, J. S., Arriaga, E. A., & Bernlohr, D. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.05.008 · Cited by 164
Reactive species and diabetes: counteracting oxidative stress to improve health
Pérez‐Matute, P., Zulet, M. Á., & Martínez, J. A. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.08.005 · Cited by 162
Increased Cardiometabolic Risk Is Associated with Increased TV Viewing Time
WIJNDAELE, K., HEALY, G. N., DUNSTAN, D. W., BARNETT, A. G., SALMON, J., SHAW, J. E., ZIMMET, P. Z., & OWEN, N. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181d322ac · Cited by 161
Human IL6 enhances leptin action in mice
Sadagurski, M., Norquay, L., Farhang, J., D’Aquino, K. E., Copps, K. D., & White, M. F. (2009) · Diabetologia · doi:10.1007/s00125-009-1580-8 · Cited by 160
ReviewPTPs versus PTKs: The redox side of the coin
Chiarugi, P. (2005) · Free Radical Research · doi:10.1080/10715760400027987 · Cited by 155
Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide.
Hayes, G. R., & Lockwood, D. H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.8115 · Cited by 155
Immunohistochemical Detection of Myeloperoxidase and Its Oxidation Products in Kupffer Cells of Human Liver
Brown, K. E., Brunt, E. M., & Heinecke, J. W. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63059-3 · Cited by 141
Seven days of bed rest decrease insulin action on glucose uptake in leg and whole body
Mikines, K. J., Richter, E. A., Dela, F., & Galbo, H. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.3.1245 · Cited by 135
Insulin-Sensitive and Insulin-Resistant Variants in NIDDM
Banerji, M. A., & Lebovitz, H. E. (1989) · Diabetes · doi:10.2337/diab.38.6.784 · Cited by 134
Palmitate-Induced Interleukin 6 Production Is Mediated by Protein Kinase C and Nuclear-Factor κB Activation and Leads to Glucose Transporter 4 Down-Regulation in Skeletal Muscle Cells
Jové, M., Planavila, A., Laguna, J. C., & Vázquez-Carrera, M. (2005) · Endocrinology · doi:10.1210/en.2004-1560 · Cited by 133
Glycation of proteins as a source of superoxide.
Gillery, P., Monboisse, J. C., Maquart, F., & Jp, B. (1988) · PubMed · Cited by 130
Role of interleukin‐6 signalling in glucose and lipid metabolism
Glund, S., & Krook, A. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01779.x · Cited by 129
GLUT4 and Glycogen Synthase Are Key Players in Bed Rest–Induced Insulin Resistance
Biensø, R. S., Ringholm, S., Kiilerich, K., Aachmann‐Andersen, N. J., Krogh‐Madsen, R., Guerra, B., Plomgaard, P., van Hall, G., Treebak, J. T., Saltin, B., et al. (2012) · Diabetes · doi:10.2337/db11-0884 · Cited by 124
Mitogen-Activated Protein Kinases, Inhibitory-κB Kinase, and Insulin Signaling in Human Omental Versus Subcutaneous Adipose Tissue in Obesity
Bashan, N., Dorfman, K., Tarnovscki, T., Harman‐Boehm, I., Liberty, I. F., Blüher, M., Ovadia, S., Maymon-Zilberstein, T., Potashnik, R., Stümvoll, M., et al. (2007) · Endocrinology · doi:10.1210/en.2006-1369 · Cited by 123
Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase-3
Dokken, B. B., Saengsirisuwan, V., Kim, J. S., Teachey, M. K., & Henriksen, E. J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00578.2007 · Cited by 123
Oxidative stress and lipid peroxidation by-products at the crossroad between adipose organ dysregulation and obesity-linked insulin resistance
Murdolo, G., Piroddi, M., Luchetti, F., Tortoioli, C., Canonico, B., Zerbinati, C., Galli, F., & Iuliano, L. (2012) · Biochimie · doi:10.1016/j.biochi.2012.12.014 · Cited by 122
Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: Role of p38 MAPK
Archuleta, T. L., Lemieux, A. M., Saengsirisuwan, V., Teachey, M. K., Lindborg, K. A., Kim, J. S., & Henriksen, E. J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.08.014 · Cited by 122
Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading
Andrianjafiniony, T., Dupré-Aucouturier, S., Letexier, D., Couchoux, H., & Dominique Desplanches, C. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00069.2010 · Cited by 120
Physical Inactivity Differentially Alters Dietary Oleate and Palmitate Trafficking
Bergouignan, A., Trudel, G., Simon, C., Chopard, A., Schoeller, D. A., Momken, I., Votruba, S. B., Desage, M., Burdge, G. C., Gauquelin‐Koch, G., et al. (2008) · Diabetes · doi:10.2337/db08-0263 · Cited by 113
Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men
Knudsen, S. H., Hansen, L. S., Pedersen, M., Dejgaard, T., Hansen, J., Hall, G. V., Thomsen, C., Solomon, T. P. J., Pedersen, B. K., & Krogh-Madsen, R. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00189.2011 · Cited by 112
Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long‐Evans Tokushima Fatty (OLETF) rats
Rector, R. S., Thyfault, J. P., Laye, M. J., Morris, R. T., Borengasser, S. J., Uptergrove, G. M., Chakravarthy, M. V., Booth, F. W., & Ibdah, J. A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.156745 · Cited by 110
Isometric resistance exercise fails to counteract skeletal muscle atrophy processes during the initial stages of unloading
Haddad, F., Adams, G., Bodell, P. W., & Baldwin, K. M. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01203.2005 · Cited by 109
Inhibition of Xanthine Oxidase by Allopurinol Prevents Skeletal Muscle Atrophy: Role of p38 MAPKinase and E3 Ubiquitin Ligases
Derbré, F., Ferrando, B., Gómez‐Cabrera, M. C., Sanchis‐Gomar, F., Martinez-Bello, V. E., González, G. O., Díaz, A., Gratas‐Delamarche, A., Cerda, M., & Viña, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046668 · Cited by 108
Self-citation
Mortality in Relation to the Physical Activity of Work: A Preliminary Note on Experience in Middle Age
Morris, J. N., & Heady, J. A. (1953) · Occupational and Environmental Medicine · doi:10.1136/oem.10.4.245 · Cited by 108
Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction
Whidden, M. A., McClung, J. M., Falk, D. J., Hudson, M. B., Smuder, A. J., Nelson, W. B., & Powers, S. K. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91106.2008 · Cited by 107
Sphingolipid Metabolism, Oxidant Signaling, and Contractile Function of Skeletal Muscle
Nikolova‐Karakashian, M., & Reid, M. B. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3940 · Cited by 106
Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise
Kump, D. S., & Booth, F. W. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.073593 · Cited by 105
Activated Ask1-MKK4-p38MAPK/JNK Stress Signaling Pathway in Human Omental Fat Tissue May Link Macrophage Infiltration to Whole-Body Insulin Sensitivity
Blüher, M., Bashan, N., Shai, I., Harman‐Boehm, I., Tarnovscki, T., Avinaoch, E., Stümvoll, M., Dietrich, A., Klöting, N., & Rudich, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0002 · Cited by 99
Oxidative Stress Accumulates in Adipose Tissue during Aging and Inhibits Adipogenesis
Findeisen, H. M., Pearson, K. J., Gizard, F., Zhao, Y., 青华, Jones, K. L., Cohn, D. M., Heywood, E. B., de Cabo, R., & Bruemmer, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018532 · Cited by 92
Effect of Physical Inactivity on the Oxidation of Saturated and Monounsaturated Dietary Fatty Acids: Results of a Randomized Trial
Bergouignan, A., Schoeller, D. A., Normand, S., Gauquelin‐Koch, G., Laville, M., Shriver, T., Desage, M., Maho, Y. L., Ohshima, H., Gharib, C., et al. (2006) · PLoS Clinical Trials · doi:10.1371/journal.pctr.0010027 · Cited by 90
Attenuation of Insulin-stimulated Insulin Receptor Substrate-1 Serine 307 Phosphorylation in Insulin Resistance of Type 2 Diabetes
Danielsson, A., Öst, A., Nyström, F. H., & Strålfors, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500230200 · Cited by 89
Family history of diabetes identifies a group at increased risk for the metabolic consequences of obesity and physical inactivity in EPIC-Norfolk: a population-based study
Sargeant, L. A., Wareham, N., & Khaw, K. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801383 · Cited by 86
Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation
Mouche, S., Mkaddem, S. B., Wang, W., Katić, M., Tseng, Y., Carnésecchi, S., Steger, K., Foti, M., Meier, C. A., Muzzin, P., et al. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.03.003 · Cited by 84
Bowman-Birk inhibitor concentrate prevents atrophy, weakness, and oxidative stress in soleus muscle of hindlimb-unloaded mice
Arbogast, S., Smith, J. L., Matuszczak, Y., Hardin, B. J., Moylan, J. S., Smith, J. D., Ware, J. H., Kennedy, A. R., & Reid, M. B. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00538.2006 · Cited by 80
Effect of diffusion distance on measurement of rat skeletal muscle glucose transport in vitro
Henriksen, E. J., & Holloszy, J. O. (1991) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1991.tb09249.x · Cited by 79
A transient antioxidant stress response accompanies the onset of disuse atrophy in human skeletal muscle
Libera, L. D., Ravara, B., Gobbo, V., Tarricone, E., Vitadello, M., Biolo, G., Vescovo, G., & Gorza, L. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00280.2009 · Cited by 77
Circulating interleukin 6 concentrations and insulin resistance in patients with cancer
Makino, T., Noguchi, Y., Yoshikawa, T., Doi, C., & Nomura, K. (1998) · British journal of surgery · doi:10.1046/j.1365-2168.1998.00938.x · Cited by 77
Cessation of daily wheel running differentially alters fat oxidation capacity in liver, muscle, and adipose tissue
Laye, M. J., Rector, R. S., Borengasser, S. J., Naples, S. P., Uptergrove, G. M., Ibdah, J. A., Booth, F. W., & Thyfault, J. P. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91186.2008 · Cited by 77
Increase in IL-6, TNF-α, and MMP-9, but not sICAM-1, concentrations depends on exercise duration
Reihmane, D., Jurka, A., Tretjakovs, P., & Dela, F. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2491-9 · Cited by 76
Inactivity induces increases in abdominal fat
Laye, M. J., Thyfault, J. P., Stump, C. S., & Booth, F. W. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01018.2006 · Cited by 76
Transcriptome analysis of neutrophils after endurance exercise reveals novel signaling mechanisms in the immune response to physiological stress.
Neubauer, O., Sabapathy, S., Lazarus, R., Jowett, J., Desbrow, B., Peake, J., Cameron-Smith, D., Haseler, L., Wagner, K., & Bulmer, A. (2013) · Journal of applied physiology · doi:10.1152/japplphysiol.00143.2013 · Cited by 75
Hydrogen Peroxide Inhibits Insulin Signaling in Vascular Smooth Muscle Cells
Gardner, C. D., Eguchi, S., Reynolds, C. M., Eguchi, K., Frank, G. D., & Motley, E. D. (2003) · Experimental Biology and Medicine · doi:10.1177/15353702-0322807-09 · Cited by 70
Insulin Resistance, Small LDL Particles, and Risk for Atherosclerotic Disease
Toth, P. P. (2014) · Current Vascular Pharmacology · doi:10.2174/15701611113119990125 · Cited by 68
Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRβ/IRS-1 and Akt
Carvalho-Filho, M. A., Ropelle, E. R., Pauli, R. J., Cintra, D. E., Tsukumo, D. M. L., Silveira, L. R., Curi, R., Carvalheira, J. B. C., Velloso, L. A., & Saad, M. J. A. (2009) · Diabetologia · doi:10.1007/s00125-009-1498-1 · Cited by 63
Hindlimb unweighting decreases endothelium-dependent dilation and eNOS expression in soleus not gastrocnemius
Woodman, C. R., Schrage, W. G., Rush, J. W. E., Ray, C. A., Price, E. M., Hasser, E. M., & Laughlin, M. H. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1091 · Cited by 62
Sustained rise in triacylglycerol synthesis and increased epididymal fat mass when rats cease voluntary wheel running
Kump, D. S., & Booth, F. W. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.084525 · Cited by 58
Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue
Ferreira, L. F., Moylan, J. S., Gilliam, L. A. A., Smith, J. D., Nikolova‐Karakashian, M., & Reid, M. B. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00065.2010 · Cited by 54
TGF-β1and TNF-α are involved in the transcription of type I collagen α2gene in soleus muscle atrophied by mechanical unloading
Hirose, T., Nakazato, K., Song, H., & Ishii, N. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00463.2006 · Cited by 54
Physical activity and glucose tolerance in elderly men: the Zutphen Elderly study
van Dam, R. M., Schuit, A. J., Feskens, E. J. M., Seidell, J. C., & Kromhout, D. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200207000-00013 · Cited by 50
TNFα gene knockout differentially affects lipid deposition in liver and skeletal muscle of high-fat-diet mice
Salles, J., Tardif, N., Landrier, J., Mothe‐Satney, I., Guillet, C., Vaysse, C., Combaret, L., Giraudet, C., Patrac, V., Bertrand‐Michel, J., et al. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.12.001 · Cited by 50
Impact of Physical Inactivity on Adipose Tissue Low-Grade Inflammation in First-Degree Relatives of Type 2 Diabetic Patients
Højbjerre, L., Sonne, M. P., Alibegovic, A. C., Nielsen, N. B., Dela, F., Vaag, A. A., Bruun, J. M., & Stallknecht, B. M. (2011) · Diabetes Care · doi:10.2337/dc11-0631 · Cited by 50
Glutathione Depletion Prevents Diet‐Induced Obesity and Enhances Insulin Sensitivity
Findeisen, H. M., Gizard, F., Zhao, Y., 青华, Jones, K. L., Cohn, D. M., Heywood, E. B., & Bruemmer, D. (2011) · Obesity · doi:10.1038/oby.2011.298 · Cited by 47
Endotoxemia and hepatic injury in a rodent model of hindlimb unloading
Rivera, C. A., Tcharmtchi, M. H., Mendoza, L., & Smith, C. W. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00302.2003 · Cited by 46
Lack of muscle recovery after immobilization in old rats does not result from a defect in normalization of the ubiquitin–proteasome and the caspase‐dependent apoptotic pathways
Magne, H., Savary‐Auzeloux, I., Vazeille, E., Claustre, A., Attaix, D., Listrat, A., Santé-Lhoutellier, V., Gatellier, P., Dardevet, D. P., & Combaret, L. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.201707 · Cited by 45
Development of whole-body and skeletal muscle insulin resistance after one day of hindlimb suspension
O’Keefe, M. P., Perez, F. R., Kinnick, T. R., Tischler, M. E., & Henriksen, E. J. (2004) · Metabolism · doi:10.1016/j.metabol.2004.02.025 · Cited by 42
Effect of 7 days of bed rest on dose-response relation between plasma glucose and insulin secretion
Mikines, K. J., Dela, F., Tronier, B., & Galbo, H. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.1.e43 · Cited by 41
Acute reversal of the enhanced insulin action in trained athletes. Association with insulin receptor changes
Burstein, R., Polychronakos, C., Toews, C. J., et al. (1985) · Diabetes · doi:10.2337/diabetes.34.8.756 · Cited by 40
Carbohydrate and lipid metabolism after 20 days of bed rest.
Yanagibori, R., SUZUKI, Y., Kawakubo, K., Makita, Y., & Gunji, A. (1994) · PubMed · Cited by 35
Effects of low intensity exercise therapy on early phase insulin secretion in overweight subjects with impaired glucose tolerance and type 2 diabetes mellitus
Michishita, R., Shono, N., Kasahara, T., & Tsuruta, T. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.08.013 · Cited by 34
Evidence for markers of hypoxia and apoptosis in explanted human carotid atherosclerotic plaques
Bitto, A., Caridi, G. D., Polito, F., Calò, M., Irrera, N., Altavilla, D., Spinelli, F., & Squadrito, F. (2010) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2010.05.116 · Cited by 34
The Peroxide Dilemma: Opposing and Mediating Insulin Action
Szypowska, A. A., & Burgering, B. M. T. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3794 · Cited by 33
Insulin Resistance and Type 2 Diabetes - An Adipocentric View
Cederberg, A., & Enerbäck, S. (2003) · Current Molecular Medicine · doi:10.2174/1566524033361573 · Cited by 29
What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant?
Xu, X. J., Pories, W. J., Dohm, L. G., & Ruderman, N. B. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32835b465b · Cited by 28
Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia
Harding, S. J., Browne, G. J., Miller, B. W., Prigent, S. A., & Dickens, M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.06.005 · Cited by 26
[Obesity, physical activity and inactivity among adolescents in Morelos, Mexico: a longitudinal study].
Caballero, C., Hernández, B., Moreno, H., Hernández–Girón, C., Campero, L., Cruz, A. G., & Lazcano-Ponce, E. C. (2007) · PubMed · Cited by 22
Hydrogen Peroxide-Induced Activation of SAPK/JNK Regulated by Phosphatidylinositol 3-Kinase in Chinese Hamster V79 Cells
Inanami, O., Takahashi, K., Yoshito, A., & Kuwabara, M. (1999) · Antioxidants and Redox Signaling · doi:10.1089/ars.1999.1.1-113 · Cited by 22
Diaphragmatic nitric oxide synthase is not induced during mechanical ventilation
Gammeren, D. V., Falk, D. J., Deering, M. A., DeRuisseau, K. C., & Powers, S. K. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00043.2006 · Cited by 21
Sedentary individuals as “controls” in human studies: The correct approach?
Buford, T. W., & Manini, T. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008118107 · Cited by 19
Energy well spent fighting the diabetes epidemic
Stannard, S. R., & Johnson, N. A. (2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.574 · Cited by 18
Feeding a corn oil/sucrose-enriched diet enhances steatohepatitis in sedentary rats
Rivera, C. A., Abrams, S. H., Tcharmtchi, M. H., Allman, M., Ziba, T. T., Finegold, M. J., & Smith, C. W. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00229.2005 · Cited by 18
Immobilization increases interleukin‐6, but not tumour necrosis factor‐α, release from the leg during exercise in humans
Reihmane, D., Vigelsø, A., Gram, M., Kuhlman, A. B., Nørregaard, J., Pedersen, H. P., Lund, M. T., Helge, J. W., & Dela, F. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.069211 · Cited by 17
Rat tail suspension causes a decline in insulin receptors
Stuart, C. A., Kidder, L. S., Pietrzyk, R. A., Klein, G. L., & Simmons, D. J. (1993) · Experimental and Toxicologic Pathology · doi:10.1016/s0940-2993(11)80409-4 · Cited by 10
Alternative macrophage activation and the regulation of metabolism
Webb, P. (2009) · F1000 Biology Reports · doi:10.3410/b1-2 · Cited by 9

Research works printed but not linked: 12

Morris JN, 1953, Br J Ind Med, 10, 245
Caspersen CJ, 1985, Public Health Rep, 100, 126
10.1371/journal.pone.0037696.t005 · DOI
Toth PP, 2013, Curr Vasc Pharmacol
Petrie JR, 1996, A physiological link with implications for pathogenesis of cardiovascular disease. Circulation, 93, 1331
Sies H, 1985, Oxidative Stress
Garcia-Ruiz C, 1997, Role of mitochondrial glutathione. J Biol Chem, 272, 11369
Gillery P, 1988, Diabete Metab, 14, 25
Yanagibori R, 1994, Acta Physiol Scand Suppl, 616, 51
Caballero C, 2007, Arch Latinoam Nutr, 57, 231
Ferrannini E, 1997, European Group for the Study of Insulin Resistance (EGIR). J Clin Invest, 100, 1166
Mikines KJ, 1989, Am J Physiol, 257, E43

Sorted by citations

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation
Marchio, P., Guerra‐Ojeda, S., Vila, J. M., Aldasoro, M., Víctor, V. M., & Mauricio, M. D. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8563845 · Cited by 651
Role of mitochondrial reactive oxygen species in homeostasis regulation
Zhang, B., Pan, C., Feng, C., Yan, C., Yu, Y., Chen, Z., Guo, C., & Wang, X. (2022) · Redox Report · doi:10.1080/13510002.2022.2046423 · Cited by 405
Antioxidant and Anti‐Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus
Li, Z., Geng, Y., Jiang, J., & Kong, W. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/289264 · Cited by 400
Berberine and Its Role in Chronic Disease
Cicero, A. F. G., & Baggioni, A. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-41334-1_2 · Cited by 285
The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine
Ma, X., Chen, Z., Wang, L., Wang, G., Wang, Z., Dong, X., Wen, B., & Zhang, Z. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00782 · Cited by 202

See all 99

Authors: Gratas-Delamarche, A., Derbré, F., Vincent, S., & Cillard, J.
Affiliations: École Normale Supérieure Paris-Saclay (FR)
Corresponding author: Derbré, F.
ORCID: Derbré, F.
Venue: Free Radical Research
Publisher: Informa UK Limited
Published: 2013-10-17
Volume: 48
Issue: 1
Pages: 93-108
ISSN: 1029-2470 (ISSN-L)
1071-5762
DOI: 10.3109/10715762.2013.847528
OpenAlex: W2154187478
Cited by: 99
References: 202
Citations by year: 2026: 3 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 11 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 3 · 2013: 2
FWCI: 0.75
Type: journal article
Language: en
Open access: closed
Locations: Free Radical Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: physical inactivity, insulin resistance, oxidative stress, inflammation, skeletal muscle insulin sensitivity, adipose tissue dysfunction, obesity, energy imbalance, endothelial dysfunction, liver dysfunction, energy storage
MeSH terms: Animals, Humans, Inflammation, Insulin Resistance, Motor Activity, Oxidation-Reduction, Sedentary Behavior

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Physical inactivity, insulin resistance, and the oxidative-inflammatory loop

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks